LOCUS       NM_172203               2563 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus NADPH oxidase 1 (Nox1), mRNA.
ACCESSION   NM_172203
VERSION     NM_172203.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2563)
  AUTHORS   Larion,S., Padgett,C.A., Mintz,J.D., Thompson,J.A., Butcher,J.T.,
            Belin de Chantemele,E.J., Haigh,S., Khurana,S., Fulton,D.J. and
            Stepp,D.W.
  TITLE     NADPH oxidase 1 promotes hepatic steatosis in obese mice and is
            abrogated by augmented skeletal muscle mass
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (3), G264-G273 (2024)
   PUBMED   38258487
  REMARK    GeneRIF: NADPH oxidase 1 promotes hepatic steatosis in obese mice
            and is abrogated by augmented skeletal muscle mass.
REFERENCE   2  (bases 1 to 2563)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2563)
  AUTHORS   Ward,J., Zhang,S., Sikora,A., Michalski,R., Yin,Y., D'Alessio,A.,
            McLoughlin,R.M., Jaquet,V., Fieschi,F. and Knaus,U.G.
  TITLE     VEO-IBD NOX1 variant highlights a structural region essential for
            NOX/DUOX catalytic activity
  JOURNAL   Redox Biol 67, 102905 (2023)
   PUBMED   37820403
REFERENCE   4  (bases 1 to 2563)
  AUTHORS   Arakawa,N., Katsuyama,M., Matsuno,K., Urao,N., Tabuchi,Y.,
            Okigaki,M., Matsubara,H. and Yabe-Nishimura,C.
  TITLE     Novel transcripts of Nox1 are regulated by alternative promoters
            and expressed under phenotypic modulation of vascular smooth muscle
            cells
  JOURNAL   Biochem J 398 (2), 303-310 (2006)
   PUBMED   16724959
  REMARK    GeneRIF: expression of the Nox1 gene is regulated by alternative
            promoters and that the novel c-type transcript is induced under
            phenotypic modulation of vascular smooth muscle cells
REFERENCE   5  (bases 1 to 2563)
  AUTHORS   Gavazzi,G., Banfi,B., Deffert,C., Fiette,L., Schappi,M.,
            Herrmann,F. and Krause,K.H.
  TITLE     Decreased blood pressure in NOX1-deficient mice
  JOURNAL   FEBS Lett 580 (2), 497-504 (2006)
   PUBMED   16386251
  REMARK    GeneRIF: Results establish a role for NOX1 in blood pressure
            regulation and vascular angiotensin II response.
REFERENCE   6  (bases 1 to 2563)
  AUTHORS   Matsuno,K., Yamada,H., Iwata,K., Jin,D., Katsuyama,M., Matsuki,M.,
            Takai,S., Yamanishi,K., Miyazaki,M., Matsubara,H. and
            Yabe-Nishimura,C.
  TITLE     Nox1 is involved in angiotensin II-mediated hypertension: a study
            in Nox1-deficient mice
  JOURNAL   Circulation 112 (17), 2677-2685 (2005)
   PUBMED   16246966
  REMARK    GeneRIF: A pivotal role for ROSs derived from Nox1/NADPH oxidase
            was suggested in the pressor response to angiotensin II by reducing
            the bioavailability of nitric oxide.
REFERENCE   7  (bases 1 to 2563)
  AUTHORS   Go,Y.M., Gipp,J.J., Mulcahy,R.T. and Jones,D.P.
  TITLE     H2O2-dependent activation of GCLC-ARE4 reporter occurs by
            mitogen-activated protein kinase pathways without oxidation of
            cellular glutathione or thioredoxin-1
  JOURNAL   J Biol Chem 279 (7), 5837-5845 (2004)
   PUBMED   14638694
  REMARK    Erratum:[J Biol Chem. 2004 Apr 9;279(15):15701]
REFERENCE   8  (bases 1 to 2563)
  AUTHORS   Schneider,B., Mutel,V., Pietri,M., Ermonval,M., Mouillet-Richard,S.
            and Kellermann,O.
  TITLE     NADPH oxidase and extracellular regulated kinases 1/2 are targets
            of prion protein signaling in neuronal and nonneuronal cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13326-13331 (2003)
   PUBMED   14597699
  REMARK    GeneRIF: NADPH oxidase-dependent ROS production controls ERK1/2
            activation in neuroprogenitor, hypothalamic, and lymphoid cells
REFERENCE   9  (bases 1 to 2563)
  AUTHORS   Geiszt,M., Lekstrom,K., Brenner,S., Hewitt,S.M., Dana,R.,
            Malech,H.L. and Leto,T.L.
  TITLE     NAD(P)H oxidase 1, a product of differentiated colon epithelial
            cells, can partially replace glycoprotein 91phox in the regulated
            production of superoxide by phagocytes
  JOURNAL   J Immunol 171 (1), 299-306 (2003)
   PUBMED   12817011
  REMARK    GeneRIF: In situ hybridization in mouse colon reveals high Nox1
            expression within the lower two-thirds of colon crypts, where
            epithelial cells undergo proliferation and differentiation.
REFERENCE   10 (bases 1 to 2563)
  AUTHORS   Banfi,B., Clark,R.A., Steger,K. and Krause,K.H.
  TITLE     Two novel proteins activate superoxide generation by the NADPH
            oxidase NOX1
  JOURNAL   J Biol Chem 278 (6), 3510-3513 (2003)
   PUBMED   12473664
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB206383.1, AK136432.1 and
            BY437800.1.
            
            On Jun 5, 2013 this sequence version replaced NM_172203.1.
            
            Summary: This gene encodes a subunit of the NADPH oxidase enzyme,
            which is a membrane-bound, multisubunit protein. This complex
            catalyzes the transfer of electrons from NADPH to molecular oxygen
            to produce superoxide or hydrogen peroxide and may have a role in
            antimicrobial killing and cell signaling. This protein binds other
            subunits in order to produce superoxide. In mouse, deficiency of
            this enzyme may be associated with changes in blood pressure.
            [provided by RefSeq, Jun 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136432.1, AF539799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AB206383.1         1-86
            87-2035             AK136432.1         2-1950
            2036-2457           AK136432.1         1952-2373
            2458-2563           BY437800.1         20-125              c
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 55.69 cM"
     gene            1..2563
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /note="NADPH oxidase 1"
                     /db_xref="GeneID:237038"
                     /db_xref="MGI:MGI:2450016"
     exon            1..191
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1838
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /note="NADH/NADPH mitogenic oxidase subunit p65-mox; NADPH
                     oxidase 1 alpha; GP91 phox homolog"
                     /codon_start=1
                     /product="NADPH oxidase 1"
                     /protein_id="NP_757340.1"
                     /db_xref="CCDS:CCDS30390.1"
                     /db_xref="GeneID:237038"
                     /db_xref="MGI:MGI:2450016"
                     /translation="MGNWLVNHWLSVLFLVSWLGLNIFLFVYAFLNYEKSDKYYYTRE
                     ILGTALALARASALCLNFNSMMILIPVCRNLLSFLRGTCSFCNRTLRKPLDHNLTFHK
                     LVAYMICIFTVIHIIAHLFNFERYRRSQQAMDGSLASVLSSLSHPEKEDSWLNPIQSP
                     NMTVMYAAFTSIAGLTGVIATVALVLMVTSAMEFIRRNYFELFWYTHHLFIVYIICLG
                     IHGLGGIVRGQTEESLGESHPHNCSHSFHEWDDHKGSCRHPHFAGHPPESWKWILAPI
                     AFYIFERILRFYRSQQKVVITKVVMHPSNVLELQMRKRGFSMEVGQYIFVNCPSISFL
                     EWHPFTLTSAPEEEFFSVHIRAAGDWTRNLIRTFEQQHSPMPRIEVDGPFGTVSEDVF
                     QYEVAVLVGAGIGVTPFASILKSIWYKFQRADNKLKTQKIYFYWICRETGAFAWFNNL
                     LNSLEQEMEELGKMDFLNYRLFLTGWDSNIAGHAALNFDRATDILTGLKQKTSFGRPM
                     WDNEFSRIATAHPKSAVGVFLCGPRTLAKSLRKRCQRYSSLDPRKVQFYFNKETF"
     exon            192..287
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            288..398
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            399..483
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            484..632
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            633..814
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            815..947
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1040
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1276
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1439
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1586
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1711
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..2563
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
     polyA_site      2563
                     /gene="Nox1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1a;
                     NOX1alpha"
ORIGIN      
        1 catttttttg gaagctttct gagtaggtgt gcatatgggt gtcataaaga ctcatatacc
       61 ttgagctagt cagaagtttc tctcccgaag gacctctcca gagaatccag attgctccta
      121 gggaggctcc aaacctccat ttgacaatgg gaaactggct ggttaaccac tggctctcag
      181 ttttgtttct ggtttcctgg ttggggctga acatttttct gtttgtgtat gccttcctga
      241 attatgagaa gtctgacaag tactattaca cgagagaaat tcttgggact gccttggcct
      301 tggccagagc atctgctctg tgcttgaatt ttaacagcat gatgatcctg attcctgtgt
      361 gtcgaaatct gctgtccttc ttgaggggca cctgctcatt ttgcaaccgt acactgagaa
      421 agccattgga tcacaacctc accttccata agctggtggc atatatgatc tgcatattca
      481 cagttattca tatcattgca cacctattta acttcgaacg ctacagaaga agccaacagg
      541 ccatggatgg atctctcgct tctgttctct ccagcctatc tcatcctgag aaagaagatt
      601 cttggctaaa tcccatccag tctccaaaca tgacagtgat gtatgcagca tttaccagta
      661 ttgctggcct tactggagtg attgccactg tagctttggt tctcatggta acgtcagcta
      721 tggagtttat ccgcaggaat tattttgagc tcttttggta tacacatcac ctttttatcg
      781 tctatatcat ctgcttaggg atccatggcc tgggtgggat tgtccggggt caaacagagg
      841 agagcttggg tgaaagccat cctcacaatt gttcccattc ttttcacgag tgggatgacc
      901 ataaggggag ttgcaggcat cctcattttg cggggcaccc ccctgagtct tggaagtgga
      961 tccttgcacc gattgctttt tatatatttg aaaggatcct tcgcttttat cgctcccagc
     1021 agaaggtcgt gattaccaag gttgtcatgc acccatctaa tgttttggaa ttgcagatga
     1081 ggaagcgagg ctttagcatg gaagtaggac agtatatatt tgtaaattgc ccctccattt
     1141 ccttcctgga gtggcatccc ttcactctga cttctgctcc agaggaagaa tttttctccg
     1201 ttcatattcg agcagcaggg gactggacac gaaatctcat aaggacattt gaacaacagc
     1261 actcaccaat gcccaggatc gaggtggacg gtccctttgg cacagtcagt gaggatgttt
     1321 tccagtatga agtggctgta ctggttgggg cagggattgg ggtcactccc tttgcttcca
     1381 tcttgaaatc tatctggtac aaattccagc gtgccgacaa caagctcaaa acacaaaaga
     1441 tctatttcta ctggatctgt agagagacag gtgcctttgc ctggttcaac aacttattga
     1501 attccctgga acaagagatg gaggaattag gcaaaatgga ttttctaaac taccgtctct
     1561 tcctcactgg ctgggatagc aacattgctg gtcatgcagc attaaacttt gacagagcca
     1621 ctgacatcct gacaggtctg aagcagaaaa cttcctttgg gagaccaatg tgggacaatg
     1681 agttttctag aatagctact gcccacccca agtctgcggt gggggttttc ttatgtggcc
     1741 ctcggacttt ggcaaaaagc ctgcgcaaac gctgtcagcg atactcgagt ctggatccta
     1801 ggaaggttca gttctacttc aacaaagaaa cgttctgact tggaggaagc agcacagctt
     1861 ccacactttc ctttgctctt cactaacttg ggggtcagtt actagataac cctttgcctc
     1921 acaaggcctt ccctcccaac ttcaagtttg atcatacatg ggcttggccg acctgagagc
     1981 tgcataattc acaagtgcaa aacacatgaa ttggttttta ttgggggggg gggggctgta
     2041 aatcctggga acctgccttt agctgaattt tgctggctga cacttgcaca atttaacatc
     2101 aggtgtcttg cttgataatc ttccctccca cttgtccctc acaaaagatt tctaagtagg
     2161 gtgactttta aaatatttat tgaatccacg acagaacaac aatcataaat aaacaacata
     2221 gaacgaccaa gcttcccact cccatatcac ccactaagta cattgttaca tgagttaatc
     2281 cagtgtgacc aacaatttac acgttacttt gtcaaaataa ttgactttcc tttttgctta
     2341 ttgaacaatt tcctagtaat atcttaagta tattaactgt aatcaaattt gtactatagt
     2401 tagaagccaa ctatattgtc actttgtatt gtttggaata actggaaagg cctgacgtac
     2461 atcatgagat aattgaactg aagctctttt atgctttttg ttgttgttaa aggagtttgt
     2521 taatgaatgt attataaaaa gaaaaaagtt ataattttgg cta
//
