LOCUS       NM_021361               3611 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus NOVA alternative splicing regulator 1 (Nova1),
            transcript variant 1, mRNA.
ACCESSION   NM_021361 XM_001472258 XM_001472291 XM_001472321 XM_912494
            XM_922411
VERSION     NM_021361.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3611)
  AUTHORS   Ibrahim,L.A., Wamsley,B., Alghamdi,N., Yusuf,N., Sevier,E.,
            Hairston,A., Sherer,M., Jaglin,X.H., Xu,Q., Guo,L.,
            Khodadadi-Jamayran,A., Favuzzi,E., Yuan,Y., Dimidschstein,J.,
            Darnell,R.B. and Fishell,G.
  TITLE     Nova proteins direct synaptic integration of somatostatin
            interneurons through activity-dependent alternative splicing
  JOURNAL   Elife 12, e86842 (2023)
   PUBMED   37347149
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3611)
  AUTHORS   Tajima,Y., Ito,K., Yuan,Y., Frank,M.O., Saito,Y. and Darnell,R.B.
  TITLE     NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons
  JOURNAL   Cell Rep 42 (2), 112050 (2023)
   PUBMED   36716149
  REMARK    GeneRIF: NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons.
REFERENCE   3  (bases 1 to 3611)
  AUTHORS   Brahma,M.K., Xiao,P., Popa,M., Negueruela,J., Vandenbempt,V.,
            Demine,S., Cardozo,A.K. and Gurzov,E.N.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3611)
  AUTHORS   Krach,F., Wheeler,E.C., Regensburger,M., Boerstler,T., Wend,H.,
            Vu,A.Q., Wang,R., Reischl,S., Boldt,K., Batra,R., Aigner,S.,
            Ravits,J., Winkler,J., Yeo,G.W. and Winner,B.
  TITLE     Aberrant NOVA1 function disrupts alternative splicing in early
            stages of amyotrophic lateral sclerosis
  JOURNAL   Acta Neuropathol 144 (3), 413-435 (2022)
   PUBMED   35778567
  REMARK    GeneRIF: Aberrant NOVA1 function disrupts alternative splicing in
            early stages of amyotrophic lateral sclerosis.
REFERENCE   5  (bases 1 to 3611)
  AUTHORS   Li,D., Shen,M., Deng,X. and Bai,Y.
  TITLE     MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting
            neuro-oncological ventral antigen 1
  JOURNAL   Bioengineered 13 (4), 8982-8993 (2022)
   PUBMED   35348441
  REMARK    GeneRIF: MicroRNA miR-27a-3p accelerates cardiac hypertrophy by
            targeting neuro-oncological ventral antigen 1.
REFERENCE   6  (bases 1 to 3611)
  AUTHORS   Jensen,K.B., Dredge,B.K., Stefani,G., Zhong,R., Buckanovich,R.J.,
            Okano,H.J., Yang,Y.Y. and Darnell,R.B.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (bases 1 to 3611)
  AUTHORS   Yang,Y.Y., Yin,G.L. and Darnell,R.B.
  TITLE     The neuronal RNA-binding protein Nova-2 is implicated as the
            autoantigen targeted in POMA patients with dementia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13254-13259 (1998)
   PUBMED   9789075
REFERENCE   8  (bases 1 to 3611)
  AUTHORS   Fletcher,C.F., Okano,H.J., Gilbert,D.J., Yang,Y., Yang,C.,
            Copeland,N.G., Jenkins,N.A. and Darnell,R.B.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (bases 1 to 3611)
  AUTHORS   Buckanovich,R.J. and Darnell,R.B.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   10 (bases 1 to 3611)
  AUTHORS   Buckanovich,R.J., Yang,Y.Y. and Darnell,R.B.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM942596.1, AW491473.1, AC108802.15 and CT009504.11.
            
            On Jun 26, 2018 this sequence version replaced NM_021361.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF232828.1, SRR6116558.152448.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               BM942596.1         9-471
            464-535             AW491473.1         234-305             c
            536-2274            AC108802.15        154104-155842       c
            2275-3611           CT009504.11        189009-190345       c
FEATURES             Location/Qualifiers
     source          1..3611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.46 cM"
     gene            1..3611
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /note="NOVA alternative splicing regulator 1"
                     /db_xref="GeneID:664883"
                     /db_xref="MGI:MGI:104297"
     exon            1..152
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            153..296
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..463
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..535
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..3611
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3583..3588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /note="hexamer: TATAAA"
     polyA_site      3608
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /note="major polyA site"
ORIGIN      
        1 ggcaggaact gcaagcatga tggcggcagc tcccattcag cagaacggga cccatacggg
       61 ggttcccata gatctggacc cgccggactc gcggaaaagg ccgcttgaag cgccccctga
      121 agccggcagc accaagagga ccaacacggg cgaagacggc cagtactttc taaaggttct
      181 catacctagt tatgctgctg gatctataat tgggaaggga ggacagacaa ttgttcagtt
      241 gcaaaaagaa actggagcca ctatcaagct gtctaaatcc aaagattttt atccaggtac
      301 tactgagagg gtttgcttga tccagggaac aattgaagcg ctgaacgcag ttcatggatt
      361 cattgcagaa aaaatccgag aaatgcccca aaatgttgcc aagacagaac cagtcagtat
      421 cctacaacct cagaccaccg ttaatcctga tcgcatcaaa caaacattgc catcttcccc
      481 aactaccacc aagtcctctc catctgaccc catgaccacc tccagagcca atcaggtaaa
      541 gattatagtt cccaacagca cagcaggtct gataataggg aagggaggtg ctactgtgaa
      601 ggctataatg gagcagtcag gggcttgggt gcagctttcc cagaaacccg atgggatcaa
      661 cttgcaagag agggttgtca ctgtgagtgg agaacctgaa caaaaccgaa aagctgttga
      721 acttatcatc cagaagatac aagaggatcc acagagtggc agctgtctca atatcagtta
      781 tgccaatgtg acaggtccag tggcaaattc caatccaacc ggatctcctt atgcaaacac
      841 tgctgaagtg ttaccaactg ccgcagcagc cgcagggcta ttaggacatg ctaaccttgc
      901 tggcgttgcg gcctttccag cagttttatc tggcttcaca ggcaatgacc tggtggccat
      961 cacctctgca cttaatacat tagccagcta tggatataat ctcaacacat taggtttagg
     1021 tctcagccaa gcagcagcaa cgggggcttt ggctgccgca gctgccagtg ccaacccagc
     1081 agcagcagca gccaatttgt tggccaccta tgccagtgaa gcctcagcca gcggcagcac
     1141 ggctggtgga acggcgggga catttgcatt aggtagcctg gctgctgcta ctgctgcaac
     1201 caatggatac tttggagctg cctcgcccct agctgccagt gccattctag ggacagagaa
     1261 atccacagat ggatcaaagg atgtagttga aatagcagtt ccagaaaact tagttggtgc
     1321 aatacttggc aaaggaggga aaaccttagt ggaataccag gagttgactg gtgcaaggat
     1381 acagatctcc aaaaagggag aattcgtacc tggcacaagg aatcggaagg taaccattac
     1441 tggaacacca gctgcaacac aggctgctca gtatttaatt acacagagga tcacatatga
     1501 gcaaggagtt cgggctgcca atcctcagaa agtgggttga gtgtccccat tatacgtcag
     1561 agtgttttaa cccctccttt gccccatttg gaagaaggat gtactgtact ttgcagaagt
     1621 gaagtttttc tgttattaat atataattat gcaaatgaat gcgactatgt tgacaatgtg
     1681 tatatgtaaa taatatgtgt tttaccagat gtttcataga attttttctt gatctgtttt
     1741 gttctctata ctttgcttgt gtatatttgt cagaggtgtt tctagtgtaa gatttaagcc
     1801 tgccatttta ccagcattat tgtagtttaa tgattgaatg tagacaggga tatgcgtata
     1861 gttttcagta ttagttctag ataacactaa attaactact gttaggttga gtatggtggg
     1921 gtcagtgacc taaactggag tgaggccaaa gcactgtcat gtatgtctta cttcctgctt
     1981 agggcacaga gaagtaggaa acaatatttt gaaaaataag ttttcaattt aaaatgatca
     2041 aaaagcaata tagttgcata aaagcactgt aaaatattta aaaggttaaa actgtggaaa
     2101 attacattgg taagtttaca gatcaataaa agcacctgtt ctccatctga actagacaat
     2161 ggaaataatg ctgcatgctg gccagggccc attcttcatc atttgtaagt tcaacaaaag
     2221 ttctcacatg gagtcccacc tcttccgagg tttgtacatt tgtttttaag cactgaattc
     2281 actactgatc ccatcgcctg gccagtagaa cagtcattac tccatgaaca tcctcactgt
     2341 ttagacacat aactgtggta cagtgtattg gaaattttat aaacaaaagt gaaagtgcca
     2401 acacattatt gatagctgat aatgtttcat tatctgcaac tgctggataa gtatgttgca
     2461 ttttaagagc ttataattgt gtataatttg ttaacactag caacctatta gtattgtgaa
     2521 tgtagagttt actgtgaagc tatctgtgac ttagctgtct gctccatgac ggagttcttg
     2581 cagcatggcg ctagcagcca gtgcagtttc taatactcgg taatttgcat gttttgtgga
     2641 gcatttttat gtcaccaacc agacagtatt tcctgcatgc ttatttagaa gaggcagttt
     2701 atcttgagag gtagtgtgat ctacctttgt caggcttttt gacaggtcat ttcagagtaa
     2761 gcctttgttc ccaagaccca acaactgtca ccctcttctg tacctctcct gagtgccaac
     2821 tgtccaggcc atttgacaca ccatctgtta acctctgagt ttgcccactc aaggccactc
     2881 ataggggcat ccatccccag cacctcctca tgctgtgcat gcagtcttaa attcaatgga
     2941 caaaactaaa atgctggcta cctctggatc atctggctga gcaactgaat tacaaaagag
     3001 aattacttcc atctcaactt cagcccattg gttacgtcca tcctagcaag ctaaatggca
     3061 tcccagctgc tcctttctgt gcaaccaatt aaagaacaat gagtgtgatg ctccatgtct
     3121 gaatttcgtc cagcctctct ctgaactgtg atctttgtcc tcatgaactt tcccttttgt
     3181 tcattgaact atatggactc ttcatttcat attgatttac tgtgcaattt acttttggac
     3241 attgagaact tgaaattatt tcctgatccc ttccccttcc actattaata attcatttct
     3301 gtcaaactgt aagagtagga ctcatttttt ttttttttta gtttttaaca ttggactgtt
     3361 atttcattta gagttctcta tctctaaata tttatttaga gaatgatttt caaagggaat
     3421 gatatgcttg tttaaatgaa agagaaaagc tgtagtaaac tgtgttaatt ggtaatgact
     3481 atttatcgtc gatactctgt agctgtgtaa gttttgacaa atagtgtatc tcgtggaatc
     3541 agtggttagc attgccgcta ttatatttac tcattttatc attataaatg tgcttagttc
     3601 atcatgtagc a
//
