LOCUS       NM_001415776            2184 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus notum palmitoleoyl-protein carboxylesterase (Notum),
            transcript variant 4, mRNA.
ACCESSION   NM_001415776
VERSION     NM_001415776.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Adasooriya,D., Jeong,J.K., Kyeong,M., Kan,S., Kim,J., Cho,E.S. and
            Cho,S.W.
  TITLE     Notum regulates the cusp and root patterns in mouse molar
  JOURNAL   Sci Rep 14 (1), 13633 (2024)
   PUBMED   38871845
  REMARK    GeneRIF: Notum regulates the cusp and root patterns in mouse molar.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2184)
  AUTHORS   Russell,N.X., Burra,K., Shah,R.M., Bottasso-Arias,N.,
            Mohanakrishnan,M., Snowball,J., Ediga,H.H., Madala,S.K. and
            Sinner,D.
  TITLE     Wnt signaling regulates ion channel expression to promote smooth
            muscle and cartilage formation in developing mouse trachea
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L788-L802 (2023)
   PUBMED   37873566
REFERENCE   4  (bases 1 to 2184)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   5  (bases 1 to 2184)
  AUTHORS   Akkuratova,N., Faure,L., Kameneva,P., Kastriti,M.E. and Adameyko,I.
  TITLE     Developmental heterogeneity of embryonic neuroendocrine chromaffin
            cells and their maturation dynamics
  JOURNAL   Front Endocrinol (Lausanne) 13, 1020000 (2022)
   PUBMED   36237181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2184)
  AUTHORS   Fan,Y., Richelme,S., Avazeri,E., Audebert,S., Helmbacher,F.,
            Dono,R. and Maina,F.
  TITLE     Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell
            Vulnerability during Embryogenesis
  JOURNAL   PLoS Genet 11 (9), e1005533 (2015)
   PUBMED   26393505
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2184)
  AUTHORS   Zhang,X., Cheong,S.M., Amado,N.G., Reis,A.H., MacDonald,B.T.,
            Zebisch,M., Jones,E.Y., Abreu,J.G. and He,X.
  TITLE     Notum is required for neural and head induction via Wnt
            deacylation, oxidation, and inactivation
  JOURNAL   Dev Cell 32 (6), 719-730 (2015)
   PUBMED   25771893
REFERENCE   8  (bases 1 to 2184)
  AUTHORS   Naillat,F., Yan,W., Karjalainen,R., Liakhovitskaia,A.,
            Samoylenko,A., Xu,Q., Sun,Z., Shen,B., Medvinsky,A., Quaggin,S. and
            Vainio,S.J.
  TITLE     Identification of the genes regulated by Wnt-4, a critical signal
            for commitment of the ovary
  JOURNAL   Exp Cell Res 332 (2), 163-178 (2015)
   PUBMED   25645944
REFERENCE   9  (bases 1 to 2184)
  AUTHORS   Dunty,W.C. Jr., Kennedy,M.W., Chalamalasetty,R.B., Campbell,K. and
            Yamaguchi,T.P.
  TITLE     Transcriptional profiling of Wnt3a mutants identifies Sp
            transcription factors as essential effectors of the
            Wnt/beta-catenin pathway in neuromesodermal stem cells
  JOURNAL   PLoS One 9 (1), e87018 (2014)
   PUBMED   24475213
  REMARK    Erratum:[PLoS One. 2014;9(4):e95947]
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2184)
  AUTHORS   Torisu,Y., Watanabe,A., Nonaka,A., Midorikawa,Y., Makuuchi,M.,
            Shimamura,T., Sugimura,H., Niida,A., Akiyama,T., Iwanari,H.,
            Kodama,T., Zeniya,M. and Aburatani,H.
  TITLE     Human homolog of NOTUM, overexpressed in hepatocellular carcinoma,
            is regulated transcriptionally by beta-catenin/TCF
  JOURNAL   Cancer Sci 99 (6), 1139-1146 (2008)
   PUBMED   18429952
  REMARK    GeneRIF: Describes the human ortholog, and analyzes both the human
            and mouse promoters.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663030.12.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.229352.1,
                                           SRR10662774.2259320.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               AL663030.12        115809-116392       c
            585-637             AL663030.12        114639-114691       c
            638-733             AL663030.12        114464-114559       c
            734-794             AL663030.12        114145-114205       c
            795-853             AL663030.12        113700-113758       c
            854-956             AL663030.12        113307-113409       c
            957-1148            AL663030.12        112374-112565       c
            1149-1249           AL663030.12        112146-112246       c
            1250-1397           AL663030.12        111578-111725       c
            1398-1445           AL663030.12        110578-110625       c
            1446-2184           AL663030.12        109602-110340       c
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.38 cM"
     gene            1..2184
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /note="notum palmitoleoyl-protein carboxylesterase"
                     /db_xref="GeneID:77583"
                     /db_xref="MGI:MGI:1924833"
     exon            1..584
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1752
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /EC_number="3.1.1.98"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4; protein notum homolog; palmitoleoyl-protein
                     carboxylesterase NOTUM; notum pectinacetylesterase
                     homolog"
                     /codon_start=1
                     /product="palmitoleoyl-protein carboxylesterase NOTUM
                     isoform 1 precursor"
                     /protein_id="NP_001402705.1"
                     /db_xref="GeneID:77583"
                     /db_xref="MGI:MGI:1924833"
                     /translation="MGGEVRVLLLLGLLHWVGGSEGRKTWRRRGQQPPQPPPPPPLPQ
                     RAEVEPGAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLL
                     NTSVTCNDGSPAGYYLKESKGSRRWLLFLEGGWYCFNRENCDSRYSTMRRLMSSKDWP
                     HTRTGTGILSSQPEENPHWWNANMVFIPYCSSDVWSGASPKSDKNEYAFMGSLIIQEV
                     VRELLGKGLSGAKVLLLAGSSAGGTGVLLNVDRVAELLEELGYPSIQVRGLADSGWFL
                     DNKQYRRSDCIDTINCAPTDAIRRGIRYWSGMVPERCQRQFKEGEEWNCFFGYKVYPT
                     LRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGQWLYIQNLGRELRGTLKDVQASFAPA
                     CLSHEIIIRSYWTDVQVKGTSLPRALHCWDRSFHDSHKASKTPMKGCPFHLVDSCPWP
                     HCNPSCPTIRDQFTGQEMNVAQFLMHMGFDVQTVAQQQGMEPSKLLGMLSNGN"
     exon            585..637
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            638..733
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            734..794
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            795..853
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            854..956
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1148
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1249
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1397
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1445
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..2184
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2165..2170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /note="hexamer: AACAAA"
     polyA_site      2184
                     /gene="Notum"
                     /gene_synonym="5730593N15Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagtctgca ttgccctcgg ccggctacgc gcggagcccg agctgcggag gccggtagcg
       61 cccgactcca gagcctcgac gccgagagcc cacactgccg cccggggcag ggacaacgca
      121 cgggagcccg agccgaggag cagcagtgtc ttgcgcgccc cctggcccgg cgccccgcgc
      181 tgctgacgcc tcacggccgt ccgctctccg caggtggcca caggccggag tgacattgcc
      241 atgggaggag aggtgcgcgt gctgctactg ctgggcctgc tgcattgggt tgggggcagc
      301 gagggcagga agacctggag gcgccgtggc cagcagccac cccagccgcc gcccccgccg
      361 ccgctcccgc agcgggctga ggtggagccg ggcgccgggc agccggtgga gagcttcccg
      421 ctggacttca cggcagtgga gggcaacatg gacagcttta tggcgcaagt caagagcctg
      481 gcacagtccc tgtatccctg ctctgcgcag cagctcaatg aggacctgcg ccttcacctc
      541 ctgctgaaca cgtcggtgac ctgcaatgac ggcagccccg ccggctacta tttgaaggag
      601 tccaagggca gtcggcggtg gttactcttt ctggaaggcg gctggtattg cttcaaccgg
      661 gagaactgtg attccagata cagcaccatg cggcgcctca tgagctccaa agactggcca
      721 cacacacgca caggtactgg tattctatcc tcccagccag aggagaaccc ccactggtgg
      781 aatgccaata tggtcttcat cccttactgc tccagtgacg tttggagtgg ggcttcaccc
      841 aagtctgaca agaatgaata tgccttcatg ggctccctca tcatccagga ggtggtacgg
      901 gagctcctgg gcaaagggct gagcggggca aaggtgctgc tgttggccgg gagcagcgct
      961 gggggcaccg gggtgctgtt gaatgtagac cgcgtggctg agctgctgga ggagttgggc
     1021 tacccgtcta tccaggtgcg gggcctggct gactcaggct ggttcctgga caacaagcag
     1081 taccggcgat cagactgcat tgatactatc aactgtgcac ccacagacgc catccgccgt
     1141 ggcatcaggt actggagtgg gatggtccca gagcgttgcc agcgccagtt caaggaagga
     1201 gaggaatgga attgcttctt tggctacaaa gtatatccga ctctgcgctg tccggtgttc
     1261 gtggtacagt ggcttttcga tgaggcccag cttaccgtgg ataacgtgca tctcaccgga
     1321 cagccggttc aggaaggcca gtggctatac atccagaatc tgggccgaga actgcgtggt
     1381 acactcaagg atgtgcaggc cagctttgcc cccgcctgcc tgtctcatga gatcatcata
     1441 cggagctatt ggacggacgt ccaggtgaag gggacctcac tgcccagggc actgcactgc
     1501 tgggaccgga gcttccatga cagccataag gccagcaaaa cccccatgaa gggctgccct
     1561 ttccacctgg tagacagctg cccctggccc cactgcaatc cctcatgccc taccatccgg
     1621 gaccagttca cagggcaaga gatgaacgtg gcacagttcc ttatgcatat gggcttcgat
     1681 gtgcagacgg tggctcagca gcaggggatg gagcccagca agctgctagg gatgctgagt
     1741 aatgggaact agagggtgtg gtactgaggg gctggcccac tcactgcccc agggtgactc
     1801 acctcgactt ctaggtactt cttcctctcc cagggcccac ctggctgtgg atgtctgact
     1861 gcctattctc tcccactgcc tggctagagg agtggtctgc cctgagtcca gggacccttc
     1921 ccaccccgta tctgtttccc tagccccccc agcccagctt ggggagggag ccagaagcaa
     1981 agcgtgcact ggacccctga gccagtcagc gcagacagtc cctcccagcc cccactgatc
     2041 atgttcgttt gtattatttt ataaagtgac ttttttatta ccttaatttt taaaaaaaat
     2101 ggaaattaag aaatatatga tggatgatat tgttttgtaa catatttttt tcttaataat
     2161 taaaaacaaa aacaaaaaaa caaa
//
