LOCUS       NM_001007472            1602 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus notochord homeobox (Noto), mRNA.
ACCESSION   NM_001007472 XM_357654
VERSION     NM_001007472.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Ling,Z., Crane,J., Hu,H., Chen,Y., Wan,M., Ni,S., Demehri,S.,
            Mohajer,B., Peng,X., Zou,X. and Cao,X.
  TITLE     Parathyroid hormone treatment partially reverses endplate
            remodeling and attenuates low back pain in animal models of spine
            degeneration
  JOURNAL   Sci Transl Med 15 (722), eadg8982 (2023)
   PUBMED   37967203
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Szenker-Ravi,E., Ott,T., Khatoo,M., Moreau de Bellaing,A.,
            Goh,W.X., Chong,Y.L., Beckers,A., Kannesan,D., Louvel,G.,
            Anujan,P., Ravi,V., Bonnard,C., Moutton,S., Schoen,P., Fradin,M.,
            Colin,E., Megarbane,A., Daou,L., Chehab,G., Di Filippo,S.,
            Rooryck,C., Deleuze,J.F., Boland,A., Arribard,N., Eker,R.,
            Tohari,S., Ng,A.Y., Rio,M., Lim,C.T., Eisenhaber,B., Eisenhaber,F.,
            Venkatesh,B., Amiel,J., Crollius,H.R., Gordon,C.T., Gossler,A.,
            Roy,S., Attie-Bitach,T., Blum,M., Bouvagnet,P. and Reversade,B.
  TITLE     Discovery of a genetic module essential for assigning left-right
            asymmetry in humans and ancestral vertebrates
  JOURNAL   Nat Genet 54 (1), 62-72 (2022)
   PUBMED   34903892
  REMARK    Erratum:[Nat Genet. 2022 Jun;54(6):906. doi:
            10.1038/s41588-022-01053-8.. PMID: 35304595]
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Maerker,M., Getwan,M., Dowdle,M.E., McSheene,J.C., Gonzalez,V.,
            Pelliccia,J.L., Hamilton,D.S., Yartseva,V., Vejnar,C., Tingler,M.,
            Minegishi,K., Vick,P., Giraldez,A.J., Hamada,H., Burdine,R.D.,
            Sheets,M.D., Blum,M. and Schweickert,A.
  TITLE     Bicc1 and Dicer regulate left-right patterning through
            post-transcriptional control of the Nodal inhibitor Dand5
  JOURNAL   Nat Commun 12 (1), 5482 (2021)
   PUBMED   34531379
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Minegishi,K., Rothe,B., Komatsu,K.R., Ono,H., Ikawa,Y.,
            Nishimura,H., Katoh,T.A., Kajikawa,E., Sai,X., Miyashita,E.,
            Takaoka,K., Bando,K., Kiyonari,H., Yamamoto,T., Saito,H.,
            Constam,D.B. and Hamada,H.
  TITLE     Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the
            mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
  JOURNAL   Nat Commun 12 (1), 4071 (2021)
   PUBMED   34210974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   Guo,S.S., Au,T.Y.K., Wynn,S., Aszodi,A., Chan,D., Fassler,R. and
            Cheah,K.S.E.
  TITLE     beta1 Integrin regulates convergent extension in mouse notogenesis,
            ensures notochord integrity and the morphogenesis of vertebrae and
            intervertebral discs
  JOURNAL   Development 147 (22) (2020)
   PUBMED   33051257
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Abdelkhalek,H.B., Beckers,A., Schuster-Gossler,K., Pavlova,M.N.,
            Burkhardt,H., Lickert,H., Rossant,J., Reinhardt,R., Schalkwyk,L.C.,
            Muller,I., Herrmann,B.G., Ceolin,M., Rivera-Pomar,R. and Gossler,A.
  TITLE     The mouse homeobox gene Not is required for caudal notochord
            development and affected by the truncate mutation
  JOURNAL   Genes Dev 18 (14), 1725-1736 (2004)
   PUBMED   15231714
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Dietrich,S., Schubert,F.R., Gruss,P. and Lumsden,A.
  TITLE     The role of the notochord for epaxial myotome formation in the
            mouse
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 601-616 (1999)
   PUBMED   10512192
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Pavlova,M.N., Clark,A.M. and Gossler,A.
  TITLE     High-resolution mapping of the truncate (tc) locus on mouse
            chromosome 6
  JOURNAL   Mamm Genome 9 (10), 843-845 (1998)
   PUBMED   9745042
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Dietrich,S., Schubert,F.R. and Gruss,P.
  TITLE     Altered Pax gene expression in murine notochord mutants: the
            notochord is required to initiate and maintain ventral identity in
            the somite
  JOURNAL   Mech Dev 44 (2-3), 189-207 (1993)
   PUBMED   8155581
REFERENCE   10 (bases 1 to 1602)
  AUTHORS   THEILER,K.
  TITLE     Anatomy and development of the 'truncate' (boneless) mutation in
            the mouse
  JOURNAL   Am J Anat 104, 319-343 (1959)
   PUBMED   13837681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135886.1.
            
            On Dec 17, 2009 this sequence version replaced NM_001007472.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135886.1, AJ862875.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1602              AK135886.1         1-1602
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.44 cM"
     gene            1..1602
                     /gene="Noto"
                     /gene_synonym="Flh; MmNot; Not; tc"
                     /note="notochord homeobox"
                     /db_xref="GeneID:384452"
                     /db_xref="MGI:MGI:3053002"
     exon            1..469
                     /gene="Noto"
                     /gene_synonym="Flh; MmNot; Not; tc"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..828
                     /gene="Noto"
                     /gene_synonym="Flh; MmNot; Not; tc"
                     /note="truncate; Not homeodomain protein; floating head
                     homolog; notochord homolog"
                     /codon_start=1
                     /product="homeobox protein notochord"
                     /protein_id="NP_001007473.1"
                     /db_xref="CCDS:CCDS20293.1"
                     /db_xref="GeneID:384452"
                     /db_xref="MGI:MGI:3053002"
                     /translation="MSSPAPSGTQVQPGSLRPCPGAVSPVVPRRLARGRLESSFSVEA
                     ILARPKTRELAATSLPLSTCTSLNLLGAVSQYGVLPWVCSTGSWLPAYLSVGVYPLCS
                     MSCVPGLNVTHHQQGLRLTGSELPYCLGPLKWAPTVDLRDHGTERHTKRVRTTFNLQQ
                     LQELEKVFAKQHNLVGKERAQLAARLHLTENQVRIWFQNRRVKYQKQQKLKLPSSSVM
                     EEPSSSSDGNIQSEDAELGIGS"
     exon            470..681
                     /gene="Noto"
                     /gene_synonym="Flh; MmNot; Not; tc"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1602
                     /gene="Noto"
                     /gene_synonym="Flh; MmNot; Not; tc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggatcctg attcacaagt ctcccgttcc tttagtaagg tgaccacctc tctctctccc
       61 attgagctcc ttgcacagcc tgggaggtcc cctcagggtc gcgcaatgtc cagccctgct
      121 ccctcaggca ctcaggtcca gcccgggagc ctgcgcccct gtccgggagc tgtttcccca
      181 gttgtcccgc gccgactagc tcggggacgc ctggagtcat ccttctctgt cgaggccatc
      241 ctggcgagac ccaagacccg agagctggcg gccacctctc tgccgctctc tacctgcacc
      301 agtctgaacc tcctcggtgc ggtgtcgcag tacggggtcc tgccctgggt gtgctccaca
      361 gggtcttggc tgcctgccta cctgagcgtg ggcgtctacc cgctgtgctc catgtcctgc
      421 gtgcccggac tgaatgtcac tcaccaccag cagggcctca ggctcacagg atcagagcta
      481 ccttactgtc taggccctct gaaatgggca cccaccgtgg accttcggga ccacgggacc
      541 gagagacaca caaagagggt tcgcacaacg tttaacttgc agcagctgca agagttggag
      601 aaggtgtttg caaagcagca caacctggtg gggaaggaga gagcccagct ggctgccagg
      661 ctgcacctga cggagaatca ggtgaggatc tggttccaaa atcgcagggt gaagtatcag
      721 aagcagcaaa aactgaaatt gccttcctcc tctgtcatgg aggagccctc cagcagctca
      781 gatggcaaca tccagagtga agatgctgag ttgggaattg gcagttaagg accgagcaag
      841 aggctttagt tatatgggct agttcttcct gtggtacctg ctggccctcc ctgtcccaca
      901 tctcagtgaa gagcttcctt aaggtcaaag gacaccaaat gtacttggac aatcaagcaa
      961 gggaactctg gaagcagcat aatggattga cctatgtcct tggccaggtt ttatgtcttg
     1021 cggatagagg tatattgata acttacacat ctctcccagg gtgagttaag gtctgtaaag
     1081 cacttacaga gtaccagctg gtgaggttta tgggatagac gctgtcccag ctctgccctg
     1141 aagatggatt catcagctct ctcctggcct ggctatggag aataggcagc cttgaatcag
     1201 catcacagtg tggaaagact ctccccaaag tctagagaga aggagatttc ttagctcgct
     1261 tcaaacaaag tttcctgcat ttcaacccta tttcttttcc tcttgtcacc ctcctctgta
     1321 tctggggatg actttggatt cctgaccctc tacttcccac gtgctgggat tacagctgct
     1381 tttttttttt ttttttttgg aggggtgggg agattacaga ttctcattat gtggcacaga
     1441 ttggcttcaa atgcatggaa attctcctgt tttaacctct ctagtgttga ggtaatgggt
     1501 aaaagcctcc atgctttgcc caaagttttc ttgtctgaga ctactttcaa taggagtcca
     1561 tgtcatagtg agctcaggtt tatggtaact ggttccttgg aa
//
