LOCUS       NM_010929               6604 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus notch 4 (Notch4), mRNA.
ACCESSION   NM_010929
VERSION     NM_010929.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6604)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   2  (bases 1 to 6604)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6604)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   4  (bases 1 to 6604)
  AUTHORS   Sargis,T., Youn,S.W., Thakkar,K., Naiche,L.A., Paik,N.Y.,
            Pajcini,K.V. and Kitajewski,J.K.
  TITLE     Notch1 and Notch4 core binding domain peptibodies exhibit distinct
            ligand-binding and anti-angiogenic properties
  JOURNAL   Angiogenesis 26 (2), 249-263 (2023)
   PUBMED   36376768
  REMARK    GeneRIF: Notch1 and Notch4 core binding domain peptibodies exhibit
            distinct ligand-binding and anti-angiogenic properties.
REFERENCE   5  (bases 1 to 6604)
  AUTHORS   Saeki,K., Qiu,W., Friedman,R.A., Pan,S., Lu,J., Ichimiya,S.,
            Chio,I.I.C., Shawber,C.J., Kitajewski,J., Hu,J. and Su,G.H.
  TITLE     Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice
  JOURNAL   Cancer Res Commun 2 (12), 1601-1616 (2022)
   PUBMED   36970723
  REMARK    GeneRIF: Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis
            in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6604)
  AUTHORS   Robbins,J., Blondel,B.J., Gallahan,D. and Callahan,R.
  TITLE     Mouse mammary tumor gene int-3: a member of the notch gene family
            transforms mammary epithelial cells
  JOURNAL   J Virol 66 (4), 2594-2599 (1992)
   PUBMED   1312643
REFERENCE   7  (bases 1 to 6604)
  AUTHORS   Jhappan,C., Gallahan,D., Stahle,C., Chu,E., Smith,G.H., Merlino,G.
            and Callahan,R.
  TITLE     Expression of an activated Notch-related int-3 transgene interferes
            with cell differentiation and induces neoplastic transformation in
            mammary and salivary glands
  JOURNAL   Genes Dev 6 (3), 345-355 (1992)
   PUBMED   1372276
REFERENCE   8  (bases 1 to 6604)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
REFERENCE   9  (bases 1 to 6604)
  AUTHORS   Prochazka,M., Serreze,D.V., Worthen,S.M. and Leiter,E.H.
  TITLE     Genetic control of diabetogenesis in NOD/Lt mice. Development and
            analysis of congenic stocks
  JOURNAL   Diabetes 38 (11), 1446-1455 (1989)
   PUBMED   2576007
REFERENCE   10 (bases 1 to 6604)
  AUTHORS   Gallahan,D., Kozak,C. and Callahan,R.
  TITLE     A new common integration region (int-3) for mouse mammary tumor
            virus on mouse chromosome 17
  JOURNAL   J Virol 61 (1), 218-220 (1987)
   PUBMED   3023699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009767.6.
            
            On Sep 14, 2006 this sequence version replaced NM_010929.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M80456.1, BC138044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               CT009767.6         121722-121936
            216-297             CT009767.6         122728-122809
            298-593             CT009767.6         122900-123195
            594-941             CT009767.6         124769-125116
            942-1064            CT009767.6         125591-125713
            1065-1301           CT009767.6         125820-126056
            1302-1457           CT009767.6         126144-126299
            1458-1652           CT009767.6         127462-127656
            1653-1766           CT009767.6         129164-129277
            1767-1880           CT009767.6         129923-130036
            1881-2003           CT009767.6         130105-130227
            2004-2163           CT009767.6         131176-131335
            2164-2309           CT009767.6         132490-132635
            2310-2462           CT009767.6         132834-132986
            2463-2580           CT009767.6         133836-133953
            2581-2668           CT009767.6         134196-134283
            2669-2819           CT009767.6         134845-134995
            2820-3004           CT009767.6         135375-135559
            3005-3257           CT009767.6         138347-138599
            3258-3370           CT009767.6         138806-138918
            3371-3894           CT009767.6         139826-140349
            3895-4278           CT009767.6         140777-141160
            4279-4454           CT009767.6         141256-141431
            4455-4674           CT009767.6         141839-142058
            4675-4744           CT009767.6         142208-142277
            4745-4883           CT009767.6         142418-142556
            4884-5188           CT009767.6         143332-143636
            5189-5336           CT009767.6         143954-144101
            5337-5434           CT009767.6         144544-144641
            5435-6604           CT009767.6         144801-145970
FEATURES             Location/Qualifiers
     source          1..6604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.15 cM"
     gene            1..6604
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /note="notch 4"
                     /db_xref="GeneID:18132"
                     /db_xref="MGI:MGI:107471"
     exon            1..215
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..6046
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /note="neurogenic locus notch homolog protein 4; Notch
                     gene homolog 4"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 4
                     precursor"
                     /protein_id="NP_035059.2"
                     /db_xref="CCDS:CCDS28647.1"
                     /db_xref="GeneID:18132"
                     /db_xref="MGI:MGI:107471"
                     /translation="MQPQLLLLLLLPLNFPVILTRELLCGGSPEPCANGGTCLRLSRG
                     QGICQCAPGFLGETCQFPDPCRDTQLCKNGGSCQALLPTPPSSRSPTSPLTPHFSCTC
                     PSGFTGDRCQTHLEELCPPSFCSNGGHCYVQASGRPQCSCEPGWTGEQCQLRDFCSAN
                     PCANGGVCLATYPQIQCRCPPGFEGHTCERDINECFLEPGPCPQGTSCHNTLGSYQCL
                     CPVGQEGPQCKLRKGACPPGSCLNGGTCQLVPEGHSTFHLCLCPPGFTGLDCEMNPDD
                     CVRHQCQNGATCLDGLDTYTCLCPKTWKGWDCSEDIDECEARGPPRCRNGGTCQNTAG
                     SFHCVCVSGWGGAGCEENLDDCAAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDM
                     CLSQPCHVNAQCSTNPLTGSTLCICQPGYSGSTCHQDLDECQMAQQGPSPCEHGGSCI
                     NTPGSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGRLCE
                     VEVNECTSNPCLNQAACHDLLNGFQCLCLPGFTGARCEKDMDECSSTPCANGGRCRDQ
                     PGAFYCECLPGFEGPHCEKEVDECLSDPCPVGASCLDLPGAFFCLCRPGFTGQLCEVP
                     LCTPNMCQPGQQCQGQEHRAPCLCPDGSPGCVPAEDNCPCHHGHCQRSLCVCDEGWTG
                     PECETELGGCISTPCAHGGTCHPQPSGYNCTCPAGYMGLTCSEEVTACHSGPCLNGGS
                     CSIRPEGYSCTCLPSHTGRHCQTAVDHCVSASCLNGGTCVNKPGTFFCLCATGFQGLH
                     CEEKTNPSCADSPCRNKATCQDTPRGARCLCSPGYTGSSCQTLIDLCARKPCPHTARC
                     LQSGPSFQCLCLQGWTGALCDFPLSCQKAAMSQGIEISGLCQNGGLCIDTGSSYFCRC
                     PPGFQGKLCQDNVNPCEPNPCHHGSTCVPQPSGYVCQCAPGYEGQNCSKVLDACQSQP
                     CHNHGTCTSRPGGFHCACPPGFVGLRCEGDVDECLDRPCHPSGTAACHSLANAFYCQC
                     LPGHTGQRCEVEMDLCQSQPCSNGGSCEITTGPPPGFTCHCPKGFEGPTCSHKALSCG
                     IHHCHNGGLCLPSPKPGSPPLCACLSGFGGPDCLTPPAPPGCGPPSPCLHNGTCTETP
                     GLGNPGFQCTCPPDSPGPRCQRPGASGCEGRGGDGTCDAGCSGPGGDWDGGDCSLGVP
                     DPWKGCPPHSQCWLLFRDGRCHPQCDSEECLFDGYDCEIPLTCIPAYDQYCRDHFHNG
                     HCEKGCNNAECGWDGGDCRPEGEDSEGRPSLALLVVLRPPALDQQLLALARVLSLTLR
                     VGLWVRKDSEGRNMVFPYPGTRAKEELSGARDSSSWERQAPPTQPLGKETESLGAGFV
                     VVMGVDLSRCGPEHPASRCPWDSGLLLRFLAAMAAVGALEPLLPGPLLAAHPQAGTRP
                     SANQLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQQAPH
                     RRRPPLGEDNIGLKALKPEAEVDEDGVAMCSGPEEGEAEETASASRCQLWPLNSGCGE
                     LPQAAMLTPPQECESEVLDVDTCGPDGVTPLMSAVFCGGVQSTTGASPQRLGLGNLEP
                     WEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHT
                     AVAADAREVCQLLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARD
                     KRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLEL
                     GAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQEARAHARTTPGGGAAPRCRT
                     LSAGARPRGGGACLQARTWSVDLGARGGKVYARCRSRSGSCGGPTTRGRRFSAGSRGR
                     RGARASQDDWPRDWVALEACGSACSAPIPPPSLTPSPERGSPQVAWGLPVHQEIPLNS
                     VVRNLN"
     exon            216..297
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            298..593
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            594..941
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1064
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1301
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1457
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1652
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1766
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1880
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2003
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2163
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2309
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2462
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2580
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2668
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2819
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..3004
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3257
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3370
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3894
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..4278
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4454
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4674
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4744
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4883
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            4884..5188
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            5189..5336
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            5337..5434
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     exon            5435..6604
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6537..6542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /note="hexamer: AATAAA"
     polyA_site      6559
                     /gene="Notch4"
                     /gene_synonym="Int-3; Int3; N4"
                     /note="major polyA site"
ORIGIN      
        1 tcaggaaaca gctcagactg aggcgtgcag caggctcagg aggaagaagg gcggtagagg
       61 cagaggaggt ggccttgcct ggccacaagg gctctgaggg tccctgcctg aagagggaga
      121 ggagatccgg gccaggggca ggcgctctgg aatgcagccc cagttgctgc tgctgctgct
      181 cttgccactc aatttccctg tcatcctgac cagagagctt ctgtgtggag gatccccaga
      241 gccctgtgcc aacggaggca cctgcctgag gctatctcgg ggacaaggga tctgccagtg
      301 tgcccctgga tttctgggtg agacttgcca gtttcctgac ccctgcaggg atacccaact
      361 ctgcaagaat ggtggcagct gccaagccct gctccccaca cccccaagct cccgtagtcc
      421 tacttctcca ctgacccctc acttctcctg cacctgcccc tctggcttca ccggtgatcg
      481 atgccaaacc catctggaag agctctgtcc accttctttc tgttccaacg ggggtcactg
      541 ctatgttcag gcctcaggcc gcccacagtg ctcctgcgag cctgggtgga caggtgagca
      601 atgccagctc cgagacttct gctcagccaa cccctgtgcc aacggaggcg tgtgcctggc
      661 cacatacccc cagatccagt gccgctgtcc acctgggttc gagggtcaca cctgtgaacg
      721 cgacatcaac gagtgcttcc tggagccggg accctgccct cagggcacct cctgccataa
      781 caccttgggt tcctaccagt gtctctgccc tgtggggcag gaaggtcccc agtgcaagct
      841 caggaaggga gcctgccctc ctggaagctg tctcaatggg ggcacctgcc agctggtccc
      901 agagggacac tccacctttc atctctgcct ctgtccccca ggtttcacgg ggctggactg
      961 tgagatgaac ccagatgact gtgtcaggca ccagtgtcag aacggggcca cctgtctgga
     1021 tgggctggac acctacacct gcctctgccc caagacatgg aagggctggg actgctctga
     1081 agatatagat gaatgtgaag cccggggtcc ccctcgctgc aggaacggtg gcacctgcca
     1141 gaacacagct ggcagctttc actgtgtgtg cgtgagtggc tggggaggcg caggctgtga
     1201 ggagaacctg gatgactgtg cagctgccac ctgtgccccg ggatccacct gcatcgaccg
     1261 tgtgggctcc ttctcctgcc tctgcccacc tggacgcaca ggcctcctgt gccacctgga
     1321 agacatgtgt ttgagtcagc cgtgccacgt gaatgcccag tgcagcacca accctctgac
     1381 aggctccacc ctctgcatat gccagcctgg ctactcagga tccacctgtc accaagatct
     1441 ggatgagtgc caaatggccc agcaaggacc cagtccctgc gaacatggcg gctcctgcat
     1501 caacacccct ggctccttca actgcctctg cctgcctggt tacacgggct cccgctgtga
     1561 agctgaccac aatgagtgcc tgtcacagcc ctgccaccca ggcagcacct gcctggacct
     1621 gcttgcaacc ttccactgcc tctgcccacc aggcttggaa gggaggctct gtgaggtgga
     1681 ggtcaatgag tgcacctcta atccctgcct gaaccaagct gcctgccatg acctgctcaa
     1741 cggcttccag tgcctctgcc ttcctggatt caccggcgcc cgatgtgaga aagacatgga
     1801 cgagtgtagc agcaccccct gtgccaatgg ggggcgctgc cgagaccagc ctggagcctt
     1861 ctactgcgag tgtctcccag gctttgaagg gccacactgt gagaaagaag tggacgaatg
     1921 tctgagtgac ccctgccccg tgggagccag ctgccttgat ctccccggag cattcttctg
     1981 cctctgccgt cctggtttca caggtcaact ttgtgaggtt cccttgtgca cccccaacat
     2041 gtgccaacct ggacagcaat gccaaggtca ggaacacaga gccccctgcc tctgccctga
     2101 cggaagtcct ggctgtgttc ctgccgagga caactgcccc tgtcaccatg gccattgcca
     2161 gagatccttg tgtgtgtgtg atgagggctg gactggacca gaatgcgaga cagaactggg
     2221 tggctgcatc tccacaccct gtgcccatgg ggggacctgc cacccacagc catctggcta
     2281 caactgtacc tgccctgcag gctacatggg gttgacctgt agtgaggagg tgacagcttg
     2341 tcactcaggg ccctgtctca atggtggctc ctgcagcatc cgtcctgagg gctattcctg
     2401 cacctgcctt ccaagtcaca caggtcgcca ctgccagact gccgtggacc actgtgtgtc
     2461 tgcctcgtgc ctcaatgggg gtacctgtgt gaacaagcct ggcactttct tctgcctctg
     2521 tgccactggc ttccaggggc tgcactgtga ggagaagact aaccccagct gtgcagacag
     2581 cccctgcagg aacaaggcaa cctgccaaga cacacctcga ggggcccgct gcctctgcag
     2641 ccctggctat acaggaagca gctgccagac tctgatagac ttgtgtgccc ggaagccctg
     2701 tccacacact gctcgatgcc tccagagtgg gccctcgttc cagtgcctgt gcctccaggg
     2761 atggacaggg gctctctgtg acttcccact gtcctgccag aaggccgcga tgagccaagg
     2821 catagagatc tctggcctgt gccagaatgg aggcctctgt attgacacgg gctcctccta
     2881 tttctgccgc tgccctcctg gattccaagg caagttatgc caggataatg tgaacccctg
     2941 tgagcccaat ccctgccatc acgggtctac ctgtgtgcct cagcccagtg gctatgtctg
     3001 ccagtgtgcc ccaggctatg agggacagaa ctgctcaaaa gtacttgacg cttgtcagtc
     3061 ccagccctgc cacaaccacg gaacctgtac ctccaggcct ggaggcttcc actgtgcctg
     3121 ccctccaggc ttcgtgggac tgcgctgtga gggagatgtg gatgagtgtc tggaccggcc
     3181 ctgtcacccc tcgggcactg cagcttgcca ctctttagcc aacgccttct actgccagtg
     3241 tctgcctggg cacacaggcc agcggtgtga ggtggagatg gacctctgtc agagccaacc
     3301 ctgctccaat ggaggatcct gtgagatcac aacagggcca ccccctggct tcacctgtca
     3361 ctgccccaag ggttttgaag gccccacctg cagccacaaa gccctttcct gcggcatcca
     3421 tcactgccac aatggaggcc tatgtctgcc ctcccctaag ccagggtcac caccactctg
     3481 tgcctgcctc agtggttttg ggggccctga ctgtctgaca cctccagctc caccgggctg
     3541 cggtcccccc tcaccctgcc tgcacaatgg tacctgcact gagacccctg ggttgggcaa
     3601 cccgggcttt caatgcacct gccctcctga ctctccaggg ccccggtgtc aaaggccagg
     3661 ggcaagtggg tgtgagggcc gaggtggtga tgggacctgc gatgctggct gcagtggccc
     3721 aggaggagac tgggatggag gggactgttc cctgggggtc ccagacccct ggaagggctg
     3781 tcccccgcat tcccagtgct ggcttctgtt ccgggacgga cggtgtcacc cgcagtgtga
     3841 ctctgaggag tgtctctttg atggctacga ctgtgaaatc cctctaacct gcatcccagc
     3901 ctatgaccag tactgccgag atcacttcca caacgggcac tgtgagaaag gctgcaataa
     3961 cgctgaatgt ggctgggacg ggggagactg cagaccagaa ggggaagact cagaggggag
     4021 gccctccctg gccctgctgg tggtgctgag gcccccagcc ctggatcagc agctgcttgc
     4081 cctggcacga gtgctgtccc tgactctgag ggtcggtctc tgggtgagga aggacagtga
     4141 aggcaggaac atggtgttcc cctatcctgg gacccgggcc aaagaggagc tgagtggagc
     4201 tagggattcc tcttcatggg aaagacaagc ccctcccact cagcccctgg gcaaggagac
     4261 agagtctctt ggtgcagggt ttgtggtagt gatgggagtg gatctgtccc gctgtggtcc
     4321 ggaacatcct gcgtcccgct gcccctggga ctctggactc ctgctgcgct tccttgcagc
     4381 aatggcagca gtgggagctc tggagcccct gctgcctgga cccttgctgg cggctcaccc
     4441 tcaagcaggg accaggccct ctgccaacca gcttccctgg cccattctat gttcaccagt
     4501 ggttggggtg cttctcctgg cccttggggc ccttctcgtc ctccagctca ttcggcgacg
     4561 gcgacgagaa catggggccc tgtggctgcc ccctggtttc attcgaaggc ctcagacaca
     4621 gcaggcaccc caccggcgga ggcccccact gggcgaggac aacattggtc ttaaggcact
     4681 gaagccagag gccgaagtgg atgaggatgg agtggccatg tgctcgggcc ctgaagaggg
     4741 agaggctgaa gaaacagcct cagcctccag gtgccagctt tggccgctca acagcggctg
     4801 tggagagctc ccccaggcag ccatgctgac ccctcctcag gagtgtgaat cggaggttct
     4861 ggatgtggac acctgtggac ctgatggggt gacacccctg atgtcagccg tcttctgtgg
     4921 gggagtgcag tccacgactg gggctagtcc acagagactg gggctaggaa atctggaacc
     4981 ctgggaacca ctgctggata gaggggcctg cccccaggct cacactgtgg gcactggaga
     5041 gacgcctctg cacctagctg ccagattctc tcggccaacc gctgcccgcc gcctccttga
     5101 ggctggagcc aaccccaacc agccagaccg cgctgggcgc accccacttc acactgctgt
     5161 ggctgccgac gctcgggagg tttgccagct cctattggcc agcagacaga ctacggtgga
     5221 cgcccgcaca gaggacggga ctacaccttt gatgctggct gccaggctgg ccgtggagga
     5281 cctggttgaa gaattgatcg cagcccgagc agatgtagga gccagggata aaaggggaaa
     5341 aactgcactg cactgggccg ctgctgtgaa caacgcccga gccgcccgct ctctcctcca
     5401 ggctggagcg gataaagatg cccaggacag tagggaacag acgccgcttt tcctggcagc
     5461 gcgcgaagga gccgtggagg tggcgcagct gttgctggag ctcggggcgg cccggggact
     5521 gcgagaccag gccgggctgg ccccaggaga tgtggcccgc cagcgcagtc actgggacct
     5581 gctaacgctg ctggaagggg ctggaccgac tacgcaggag gcccgtgcgc acgcacgcac
     5641 cacgccgggg ggcggggccg cgccgcgctg ccggacgctg tctgcgggag cgcgcccgcg
     5701 cgggggcgga gcctgtctgc aggctcgcac ttggtcggtg gacttgggag cgcgcggagg
     5761 gaaggtgtat gctcgctgcc ggagccgatc tggaagctgc ggaggcccca ccacgcgcgg
     5821 ccgcaggttc tccgcgggct cccgtggacg acgcggggct agggcatcac aggatgactg
     5881 gcctcgcgac tgggtggccc tggaagcctg cggctccgcc tgcagtgcgc cgatcccgcc
     5941 tcccagcctg accccgtccc cagaacgtgg atcccctcaa gttgcctggg gtcttccagt
     6001 tcaccaagag attcccttaa actcggttgt aagaaatctg aactaggcag ctgcgtggaa
     6061 ggaaggaagc gacacgtacg agtctggaag actccggact tttaaggcca aaataaccgt
     6121 taagctcact tgtctccccc atagagtatg cacagcaatg ggaagagggt ttaggatgtc
     6181 cggttgagat agaccgtgat tttcctggaa aatagggcag cttcaagagg acaaagttga
     6241 tttcgagaat ccctaaactc tggaaccaag aactgtgggc gaattgggtg taaaatgttt
     6301 cttgtgtatg gtttcccaaa aggagcctct gctatctact gcccacaagt agctggcaac
     6361 tatttattaa gcacctacga tgtgccgggt gttgtgtaga tgaacagtaa gtaaccagtg
     6421 gcccatccag ctgatgactc cttgccctct ctctgcctcc ccacaaggac actggtgcag
     6481 ggatgaggcc atgttctcca gtcactgcta tctccgagaa ccccaaactc atggataata
     6541 aagctaattt gaagtgctac tttatcttct gagggactaa agggtgagat ggaaaaagtg
     6601 cata
//
