LOCUS       NM_008716               8054 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus notch 3 (Notch3), mRNA.
ACCESSION   NM_008716
VERSION     NM_008716.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8054)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   2  (bases 1 to 8054)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   3  (bases 1 to 8054)
  AUTHORS   Sanketi,B.D., Mantri,M., Huang,L., Tavallaei,M.A., Hu,S.,
            Wang,M.F.Z., De Vlaminck,I. and Kurpios,N.A.
  TITLE     Villus myofibroblasts are developmental and adult progenitors of
            mammalian gut lymphatic musculature
  JOURNAL   Dev Cell 59 (9), 1159-1174 (2024)
   PUBMED   38537630
REFERENCE   4  (bases 1 to 8054)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 8054)
  AUTHORS   Dupre,N., Gueniot,F., Domenga-Denier,V., Dubosclard,V., Nilles,C.,
            Hill-Eubanks,D., Morgenthaler-Roth,C., Nelson,M.T., Keime,C.,
            Danglot,L. and Joutel,A.
  TITLE     Protein aggregates containing wild-type and mutant NOTCH3 are major
            drivers of arterial pathology in CADASIL
  JOURNAL   J Clin Invest 134 (8), e175789 (2024)
   PUBMED   38386425
  REMARK    GeneRIF: Protein aggregates containing wild-type and mutant NOTCH3
            are major drivers of arterial pathology in CADASIL.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8054)
  AUTHORS   Joutel,A., Corpechot,C., Ducros,A., Vahedi,K., Chabriat,H.,
            Mouton,P., Alamowitch,S., Domenga,V., Cecillion,M., Marechal,E.,
            Maciazek,J., Vayssiere,C., Cruaud,C., Cabanis,E.A., Ruchoux,M.M.,
            Weissenbach,J., Bach,J.F., Bousser,M.G. and Tournier-Lasserve,E.
  TITLE     Notch3 mutations in CADASIL, a hereditary adult-onset condition
            causing stroke and dementia
  JOURNAL   Nature 383 (6602), 707-710 (1996)
   PUBMED   8878478
REFERENCE   7  (bases 1 to 8054)
  AUTHORS   Williams,R., Lendahl,U. and Lardelli,M.
  TITLE     Complementary and combinatorial patterns of Notch gene family
            expression during early mouse development
  JOURNAL   Mech Dev 53 (3), 357-368 (1995)
   PUBMED   8645602
REFERENCE   8  (bases 1 to 8054)
  AUTHORS   Mitsiadis,T.A., Lardelli,M., Lendahl,U. and Thesleff,I.
  TITLE     Expression of Notch 1, 2 and 3 is regulated by
            epithelial-mesenchymal interactions and retinoic acid in the
            developing mouse tooth and associated with determination of
            ameloblast cell fate
  JOURNAL   J Cell Biol 130 (2), 407-418 (1995)
   PUBMED   7615640
REFERENCE   9  (bases 1 to 8054)
  AUTHORS   Larsson,C., Lardelli,M., White,I. and Lendahl,U.
  TITLE     The human NOTCH1, 2, and 3 genes are located at chromosome
            positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of
            neoplasia-associated translocation
  JOURNAL   Genomics 24 (2), 253-258 (1994)
   PUBMED   7698746
REFERENCE   10 (bases 1 to 8054)
  AUTHORS   Lardelli,M., Dahlstrand,J. and Lendahl,U.
  TITLE     The novel Notch homologue mouse Notch 3 lacks specific epidermal
            growth factor-repeats and is expressed in proliferating
            neuroepithelium
  JOURNAL   Mech Dev 46 (2), 123-136 (1994)
   PUBMED   7918097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033755.6 and CT033797.5.
            
            On Jul 14, 2018 this sequence version replaced NM_008716.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74760.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               CT033755.6         47778-47992         c
            216-297             CT033755.6         45265-45346         c
            298-440             CT033755.6         39942-40084         c
            441-779             CT033755.6         39521-39859         c
            780-902             CT033755.6         39313-39435         c
            903-1136            CT033755.6         38993-39226         c
            1137-1292           CT033755.6         37354-37509         c
            1293-1478           CT033755.6         37060-37245         c
            1479-1592           CT033755.6         35840-35953         c
            1593-1706           CT033755.6         35416-35529         c
            1707-1940           CT033755.6         34855-35088         c
            1941-2051           CT033755.6         34627-34737         c
            2052-2244           CT033755.6         32618-32810         c
            2245-2396           CT033755.6         32388-32539         c
            2397-2510           CT033755.6         31705-31818         c
            2511-2666           CT033755.6         31077-31232         c
            2667-2892           CT033755.6         28867-29092         c
            2893-3094           CT033755.6         28364-28565         c
            3095-3242           CT033755.6         28083-28230         c
            3243-3427           CT033755.6         27509-27693         c
            3428-3560           CT033755.6         25804-25936         c
            3561-3818           CT033755.6         25469-25726         c
            3819-3937           CT033755.6         25270-25388         c
            3938-4503           CT033755.6         24346-24911         c
            4504-4836           CT033755.6         22319-22651         c
            4837-4991           CT033755.6         20747-20901         c
            4992-5214           CT033755.6         20233-20455         c
            5215-5299           CT033755.6         18918-19002         c
            5300-5462           CT033755.6         16487-16649         c
            5463-5767           CT033755.6         14490-14794         c
            5768-5915           CT033755.6         13304-13451         c
            5916-6013           CT033755.6         5384-5481           c
            6014-7975           CT033755.6         2001-3962           c
            7976-8054           CT033797.5         177048-177126       c
FEATURES             Location/Qualifiers
     source          1..8054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.37 cM"
     gene            1..8054
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /note="notch 3"
                     /db_xref="GeneID:18131"
                     /db_xref="MGI:MGI:99460"
     exon            1..215
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            216..297
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            298..440
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..779
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..902
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1136
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1292
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1478
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1592
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1706
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1940
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2051
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2244
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2396
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2510
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2666
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2892
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3094
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3242
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3427
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3560
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3818
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            3819..3937
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4503
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            4504..4836
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            4837..4991
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            4992..5214
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            5215..5299
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5462
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            5463..5767
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            5768..5915
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            5916..6013
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     exon            6014..8054
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8031..8036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /note="hexamer: AATAAA"
     polyA_site      8054
                     /gene="Notch3"
                     /gene_synonym="hpbk; N3"
                     /note="major polyA site"
ORIGIN      
        1 acttcggcga agttggcggc gcggaggctg gcccgggacg tgcccggagc cctgggaaag
       61 agggaggagg gaggagggag ggtcgtggcc ggccgccatg gggctggggg cccggggccg
      121 ccgccgccgt cgtcgcctga tggccttgcc accgccacca ccgcccatgc gggcgctgcc
      181 cctgctgctg ctgctagcgg ggctgggggc tgcagcaccc ccttgtctgg atggaagccc
      241 atgtgcaaat ggaggtcggt gcacccacca gcagccctcc ctggaggctg cttgcctgtg
      301 cctgccaggc tgggtgggtg agcggtgcca gctggaagac ccttgccact caggcccttg
      361 tgctggccga ggcgtttgcc agagttcagt ggtggcgggc accgcccgat tctcctgtcg
      421 ttgtctccgt ggcttccaag gcccagactg ctcccagcca gacccctgcg tcagcaggcc
      481 ctgtgttcat ggtgccccct gctcagtggg gccggatggc cgatttgcct gtgcctgccc
      541 acctggctac cagggtcaaa gctgccaaag tgacatagat gagtgccgat ctggtacaac
      601 ttgccgtcat ggtggtacct gtctcaatac acctggatcc ttccgctgcc agtgtcctct
      661 tggttataca gggctgctgt gtgagaaccc cgtagtgccc tgtgcccctt ccccgtgtcg
      721 taatggtggc acctgtaggc agagcagtga tgtcacatat gactgtgctt gccttcctgg
      781 cttcgagggc cagaactgtg aagtcaacgt ggatgactgt cctggacatc ggtgtctcaa
      841 tgggggaacg tgtgtagacg gtgtcaatac ttacaactgc cagtgccctc cggagtggac
      901 aggccagttc tgtacagaag atgtggatga gtgtcagctg cagcccaatg cctgccacaa
      961 tgggggtacc tgcttcaacc tactgggtgg ccacagctgt gtatgtgtca atggctggac
     1021 gggtgagagc tgcagtcaga atatcgatga ctgtgctaca gccgtgtgtt tccatggggc
     1081 cacctgccat gaccgtgtgg cctctttcta ctgtgcctgc cctatgggga agacaggcct
     1141 cttgtgtcat ctggatgatg catgtgtcag caacccctgc catgaggatg ctatctgtga
     1201 cacaaaccct gtgagtggcc gggccatctg cacctgccca cctggcttca ctggaggggc
     1261 atgtgaccag gatgtggatg agtgctcgat tggtgccaac ccctgtgaac atttgggtcg
     1321 gtgtgtgaat acacagggct cattcttgtg ccaatgtggc cgtggctata ctggacctcg
     1381 ctgtgagact gatgtcaatg agtgtctctc cgggccctgc cgcaaccagg ccacgtgtct
     1441 tgaccgaatt ggccagttta cttgcatctg catggcaggc ttcacaggga cctactgtga
     1501 ggtggacatc gacgaatgtc agagcagccc atgtgtcaat ggtggtgtct gcaaggacag
     1561 agtcaatggc ttcagctgca cctgcccatc aggattcagt gggtccatgt gtcagctgga
     1621 tgtggatgag tgtgcaagca ctccctgccg gaatggtgcc aagtgtgtgg accagcctga
     1681 cggctatgag tgtcgctgtg cagagggctt tgagggcact ttgtgtgagc gaaacgtgga
     1741 tgactgctct ccggatccct gccaccacgg gcgctgtgtc gatggcattg ctagcttctc
     1801 gtgtgcttgt gccccaggct atacgggcat acgctgtgag agccaggtgg atgagtgccg
     1861 cagccagccc tgtcgatatg ggggcaaatg tctagacttg gtggacaagt acctctgccg
     1921 ttgtcctccc ggaaccacag gtgtgaactg tgaagtcaac attgatgact gtgccagtaa
     1981 cccctgtacc tttggagttt gccgtgatgg catcaaccgt tatgactgtg tctgtcagcc
     2041 tggattcaca gggcccctct gcaacgtgga gatcaatgag tgtgcatcca gcccatgtgg
     2101 agagggtggc tcctgtgtgg atggggaaaa tggcttccac tgcctctgtc cacctggctc
     2161 cctgcctcca ctttgcctac ctgcgaacca tccctgtgcc cacaagccct gtagtcatgg
     2221 agtctgccat gatgcaccag gcgggttccg ctgtgtttgt gagcccgggt ggagtggccc
     2281 tcgctgtagc cagagcctgg ctccagatgc ctgtgagtcc cagccctgcc aggctggtgg
     2341 cacctgcacc agtgatggaa taggctttcg ctgcacctgt gcccctggat tccagggcca
     2401 tcagtgtgag gtgctgtccc cctgtactcc aagcctctgt gagcacggag gccactgtga
     2461 gtctgaccct gaccggctga ctgtctgttc ctgtccccca ggctggcaag gcccacgatg
     2521 ccagcaggat gtggatgaat gtgccggtgc ctcaccctgc ggcccccatg gtacctgcac
     2581 caacctgcca gggaatttca ggtgcatctg ccacagggga tacactggcc ccttctgtga
     2641 tcaagacatt gacgactgtg accccaaccc gtgcctccat ggtggctcct gccaggatgg
     2701 cgtgggctcc ttttcctgtt cttgcctcga cggctttgct ggtcctcgct gtgcccgaga
     2761 tgtggacgaa tgtctgagca gcccctgtgg ccctggcacc tgtactgatc acgtggcctc
     2821 cttcacctgt gcctgtccac ctggttatgg aggcttccac tgtgagattg acttgccgga
     2881 ctgcagcccc agttcctgct tcaatggagg gacctgtgtg gatggcgtga gctccttcag
     2941 ctgtctgtgt cgccccggct acacaggcac acactgccaa tacgaggctg acccctgctt
     3001 ttcccggccc tgtctgcacg ggggcatctg caaccccacc cacccaggat ttgaatgcac
     3061 ctgccgggag ggcttcactg ggagtcagtg tcagaaccca gtggactggt gcagccaggc
     3121 accctgtcag aatgggggtc gctgtgtcca gactggggct tactgcattt gtccacctgg
     3181 atggagtggc cgcctgtgcg acatacaaag cctgccctgc acggaggccg cagcccagat
     3241 gggggtgagg ttggagcagc tgtgtcagga aggtggaaag tgcatagaca agggccgctc
     3301 ccactactgt gtgtgtccag agggccgtac gggtagtcac tgtgaacacg aggtggatcc
     3361 ctgcacggcc cagccttgcc agcacggggg cacttgccgt ggttacatgg ggggctatgt
     3421 gtgtgagtgt ccagctggct atgctggtga cagttgtgag gataatatag atgagtgtgc
     3481 ttcccagccc tgccagaacg gaggctcctg tatcgatctt gtggcccgct atctctgttc
     3541 ctgtccccct ggcacactgg gagttctctg tgagatcaat gaggacgact gtgacctagg
     3601 cccatccttg gactcaggcg ttcagtgcct acacaatggc acctgtgtgg acctggtggg
     3661 tggcttccgc tgtaactgtc ccccaggata cacaggtctg cactgtgagg cagacatcaa
     3721 tgagtgtcgc ccgggtgcct gccatgcagc gcatactcgg gactgcctac aagatccagg
     3781 tgggcatttc cgctgcgtct gccatcctgg cttcacaggg cctcgctgtc agattgctct
     3841 gtccccctgt gagtcccagc catgtcagca tggaggccag tgccgtcaca gcctaggccg
     3901 tggaggtggg ctgaccttca cctgtcactg tgtcccgcca ttctggggtc tgcgttgtga
     3961 gcgggtggca cgctcttgcc gagagctgca gtgcccagtg ggtatcccat gccagcagac
     4021 agcccgtgga ccacgctgcg cttgtcctcc ggggctgtcc gggccctcct gccgggtttc
     4081 tagggcgtca ccctcaggag ctactaacgc cagctgcgcc tctgcccctt gtctgcatgg
     4141 gggctcatgc ctacctgtac agagtgtccc tttcttccgc tgtgtgtgcg ctccgggctg
     4201 gggcggcccg cgttgtgaga ccccttccgc agcccctgag gtccccgagg agccacggtg
     4261 cccgcgagcg gcttgccagg ccaagcgagg ggaccagaac tgcgatcgtg agtgcaacac
     4321 cccaggctgt ggctgggatg gcggtgactg ctcactgaac gtggacgacc cctggaggca
     4381 gtgtgaggca ctgcagtgct ggcgtctctt caacaacagc cggtgtgacc cggcctgcag
     4441 ctctccagcc tgcctctatg acaactttga ctgctactct ggtggccgcg accgcacctg
     4501 caaccctgtt tatgagaagt actgcgccga ccactttgca gatggccgtt gtgaccaggg
     4561 ctgcaacact gaggaatgcg gctgggatgg gctggactgt gccagcgagg tcccggccct
     4621 tttggcccga ggggttctgg tcctcacagt tcttctgcct cctgaagagt tgctgcgctc
     4681 cagtgccgac tttctgcagc gactcagcgc tattctgcgc acctcactgc gcttccgctt
     4741 ggacgcacgt ggccaggcca tggtcttccc ctatcaccgg ccaagccctg gctctgaatc
     4801 ccgggtccgt cgtgagctgg gtcctgaggt gatcggctct gtggtgatgc tggagattga
     4861 caaccggctc tgtctgcagt cagctgagaa tgaccactgc ttccctgatg cccagagtgc
     4921 tgctgactac ctgggagcct tgtcagcagt ggagcgactt gatttcccat acccacttcg
     4981 ggatgtgcga ggagagccgc tggaggcccc agagcagagc gtgccactgc tgccactgct
     5041 ggtggcaggg gctgtctttc tactcatcat cttcatcctg ggtgtcatgg ttgccaggcg
     5101 aaagcgagaa cacagcaccc tctggttccc tgagggtttt gcattacaca aggacatagc
     5161 tgctggccac aagggccgga gggagcctgt gggacaagat gcactgggaa tgaagaacat
     5221 ggccaagggt gagagtctga tgggggaggt ggtcacagac ttgaatgact cagaatgtcc
     5281 agaggccaag agactgaagg tagaggagcc gggcatgggt gcagaggagc ctgaggactg
     5341 tcgccagtgg acccaacacc acctggttgc tgctgatatc cgtgtggcac cagccacagc
     5401 gctgactcct cctcagggag atgcagatgc agacggagtg gatgtcaacg tccgagggcc
     5461 tgatggcttc accccactta tgctggcctc cttctgtggg ggagccctgg agccgatgcc
     5521 agctgaggag gatgaggcgg atgacacatc agccagcatt atctcagatc tgatctgtca
     5581 aggggcccag ctcggggcac ggactgaccg cactggcgag accgccctgc atttggctgc
     5641 ccgctatgct agagcggatg cagccaagcg tctcctggat gctggggcgg acaccaacgc
     5701 ccaggatcat tcgggccgca cccccctgca caccgcagtg acagctgatg cccagggtgt
     5761 cttccagatt ctcatcagga accgctccac tgacctggat gcccgaatgg cagatggctc
     5821 tactgcactg atcctggcag cccgcctggc agtggagggc atggtggaag agctcatcgc
     5881 cagccatgcc gatgtcaatg cagtggatga gcttgggaaa tctgccttac actgggctgc
     5941 agctgtgaac aacgtggagg ctaccttggc tctgctgaaa aatggagcca acaaggacat
     6001 gcaggacagc aaggaagaga cgccgctgtt cttggccgct cgggagggca gctatgaggc
     6061 tgccaagctg ctgctggatc atctcgccaa ccgggagatc acagatcact tggacaggct
     6121 gccccgggac gtggcccagg agcggctgca ccaggacatt gtgcggttgc tggaccagcc
     6181 cagtggacct cgaagtccct ctggtcccca tggcttaggg ccattgctct gcccaccagg
     6241 ggccttcctt cctggcctca aagcggtgca gtctgggacc aagaagagca ggaggccacc
     6301 tggcaagacc gggctggggc cacagggaac tcgtggtcgg ggcaagaagc tgacactagc
     6361 ctgtccagga cctctggcag acagctctgt cacactgtca ccggtggact ctctggactc
     6421 accacggcct ttcagtgggc cccctgcttc ccctggaggc ttccccttgg agggccccta
     6481 tgccaccacg gccaccgcgg tgtccttggc acagctaggc gcaagtaggg cgggtcctct
     6541 ggggcgccag cctcctgggg gctgtgtgct cagctttggt ctgctcaatc ctgtagctgt
     6601 tcccctcgac tgggccaggc tgcctccacc tgcccctcca gggccctcat tcctgctgcc
     6661 cctggctccg ggaccccagt tgctcaaccc aggagcccca gtttctcccc aagagcggcc
     6721 cccaccctac ctggctgctc caggacatgg agaggaatat cctgcagcag gaacccgcag
     6781 tagccccacc aaggcccgct tcctgcgggt tcccagcgag catccttatt tgaccccgtc
     6841 tcctgagtcc ccagagcact gggccagccc atccccccca tccctctcag actggtctga
     6901 ctcaacacct agcccagcaa ctgctaccaa tgccacagcc tctggagccc tgcctgctca
     6961 gccacacccc atatctgttc cctccctccc tcagtcccag actcagctgg gaccccaacc
     7021 agaagttacc cccaagaggc aggtgatggc ctaagttctt ggatttgagg ggtgctgaag
     7081 tgacactcct ctatgacttc tttcttcctc ctttttaatc ttactctcat ccctttctct
     7141 ctgtcccagc cttcctgcac ctctctgtct tgtagtgtga ccaagttggt caccagccca
     7201 gacccccagt cttcctttat ttataatggg taggggctga ccttccacca ccttggcccc
     7261 ctaagggatc tgggacctcc ttttgatccc tctccctgcc tcaacttcct cccccccctc
     7321 tttctgcttc tcattgtctc acactctgac aagagtgagt tattattttt ttctttttta
     7381 cattttgtat agagacaaat tcatttaaac aaacttatta ttattattat tttttacaaa
     7441 atatatatat ggagttgctc ccttcccccc gctgcaaatt cctccagcgc ccccgtgggg
     7501 ctgagtctgt gggcccgttt ggccaatccg gactctgtgt actgagtaca cagatatgac
     7561 tagggctcca cgtactgagt atgtggccct cgtatgtacc aagtagccag ccttgggcac
     7621 accctcccct ggggtcaggg gacatttggg agcctccttc ccctccccat tccccttcct
     7681 cacttcactg cattccagat aagacgtgta gactcactgg gaaaggggtc ttgtctgctc
     7741 aaagcctcaa ctccaggctc acctcccaga gcctggctca ccttttaggg cctggggtgg
     7801 gggggcacgt caggggagat gtattttgta tgcattccac ttctaattgt aaatacaggg
     7861 cagaaggtgg gagtggctct ccctcttcct gttgttctct tggctcagcc tgcctaatag
     7921 aaatgttttt aggctgtttt tgtaatatgg cacctggtca cagtcctttg tagctgaatt
     7981 cccaggtcct gcactgtaca accctcacct tctcagttcc cttaccacct aataaaggaa
     8041 tagttaatac ccaa
//
