LOCUS       NM_010928              10506 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus notch 2 (Notch2), mRNA.
ACCESSION   NM_010928
VERSION     NM_010928.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10506)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10506)
  AUTHORS   Yang,S., Xiong,L., Yang,G., Xiang,J., Li,L., Kang,L. and Liang,Z.
  TITLE     KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle
            atrophy
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (5), 1869-1882 (2024)
   PUBMED   38973459
  REMARK    GeneRIF: KLF13 restrains Dll4-muscular Notch2 axis to improve the
            muscle atrophy.
REFERENCE   3  (bases 1 to 10506)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   4  (bases 1 to 10506)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   5  (bases 1 to 10506)
  AUTHORS   Jash,A., Pridmore,T., Collins,J.B., Hay,A.M., Hudson,K.E.,
            Luckey,C.J. and Zimring,J.C.
  TITLE     Complement C3 and marginal zone B cells promote IgG-mediated
            enhancement of RBC alloimmunization in mice
  JOURNAL   J Clin Invest 134 (8), e167665 (2024)
   PUBMED   38618959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10506)
  AUTHORS   Mitsiadis,T.A., Lardelli,M., Lendahl,U. and Thesleff,I.
  TITLE     Expression of Notch 1, 2 and 3 is regulated by
            epithelial-mesenchymal interactions and retinoic acid in the
            developing mouse tooth and associated with determination of
            ameloblast cell fate
  JOURNAL   J Cell Biol 130 (2), 407-418 (1995)
   PUBMED   7615640
REFERENCE   7  (bases 1 to 10506)
  AUTHORS   Higuchi,M., Kiyama,H., Hayakawa,T., Hamada,Y. and Tsujimoto,Y.
  TITLE     Differential expression of Notch1 and Notch2 in developing and
            adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 29 (2), 263-272 (1995)
   PUBMED   7609614
REFERENCE   8  (bases 1 to 10506)
  AUTHORS   Larsson,C., Lardelli,M., White,I. and Lendahl,U.
  TITLE     The human NOTCH1, 2, and 3 genes are located at chromosome
            positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of
            neoplasia-associated translocation
  JOURNAL   Genomics 24 (2), 253-258 (1994)
   PUBMED   7698746
REFERENCE   9  (bases 1 to 10506)
  AUTHORS   Lardelli,M., Dahlstrand,J. and Lendahl,U.
  TITLE     The novel Notch homologue mouse Notch 3 lacks specific epidermal
            growth factor-repeats and is expressed in proliferating
            neuroepithelium
  JOURNAL   Mech Dev 46 (2), 123-136 (1994)
   PUBMED   7918097
REFERENCE   10 (bases 1 to 10506)
  AUTHORS   Weinmaster,G., Roberts,V.J. and Lemke,G.
  TITLE     Notch2: a second mammalian Notch gene
  JOURNAL   Development 116 (4), 931-941 (1992)
   PUBMED   1295745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D32210.1, AC164091.3 and AC154173.3.
            
            On Mar 30, 2007 this sequence version replaced NM_010928.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence data because no single transcript
            from the same strain was available for the full length of the gene.
            The extent of this transcript is supported by transcript
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D32210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               D32210.1           1-168
            169-169             AC164091.3         32429-32429         c
            170-788             D32210.1           170-788
            789-891             AC154173.3         125428-125530       c
            892-1474            D32210.1           886-1468
            1475-1475           AC154173.3         98080-98080         c
            1476-2860           D32210.1           1470-2854
            2861-2861           AC154173.3         81036-81036         c
            2862-3988           D32210.1           2856-3982
            3989-3989           AC154173.3         66959-66959         c
            3990-4185           D32210.1           3984-4179
            4186-4187           AC154173.3         62983-62984         c
            4188-5277           D32210.1           4182-5271
            5278-5309           AC154173.3         59548-59579         c
            5310-5561           D32210.1           5301-5552
            5562-5562           AC154173.3         56781-56781         c
            5563-5870           D32210.1           5554-5861
            5871-5923           AC154173.3         55157-55209         c
            5924-7103           D32210.1           5915-7094
            7104-10506          AC154173.3         47962-51364         c
FEATURES             Location/Qualifiers
     source          1..10506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.42 cM"
     gene            1..10506
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /note="notch 2"
                     /db_xref="GeneID:18129"
                     /db_xref="MGI:MGI:97364"
     exon            1..234
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..7583
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /note="neurogenic locus notch homolog protein 2; Motch B;
                     Notch gene homolog 2"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 2
                     precursor"
                     /protein_id="NP_035058.2"
                     /db_xref="CCDS:CCDS51013.1"
                     /db_xref="GeneID:18129"
                     /db_xref="MGI:MGI:97364"
                     /translation="MPALRPAALRALLWLWLCGAGPAHALQCRGGQEPCVNEGTCVTY
                     HNGTGFCRCPEGFLGEYCQHRDPCEKNRCQNGGTCVPQGMLGKATCRCAPGFTGEDCQ
                     YSTSHPCFVSRPCQNGGTCHMLSRDTYECTCQVGFTGKQCQWTDACLSHPCENGSTCT
                     SVASQFSCKCPAGLTGQKCEADINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHC
                     DSPYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHKCQNGGVCV
                     DGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDD
                     CSENIDDCAYASCTPGSTCIDRVASFSCLCPEGKAGLLCHLDDACISNPCHKGALCDT
                     NPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG
                     PRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEVNECQSNPCVNNGQ
                     CVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGIL
                     CDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCID
                     LVNGYQCNCQPGTSGLNCEINFDDCASNPCMHGVCVDGINRYSCVCSPGFTGQRCNID
                     IDECASNPCRKGATCINDVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSG
                     YKCLCDAGWVGVNCEVDKNECLSNPCQNGGTCNNLVNGYRCTCKKGFKGYNCQVNIDE
                     CASNPCLNQGTCFDDVSGYTCHCMLPYTGKNCQTVLAPCSPNPCENAAVCKEAPNFES
                     FSCLCAPGWQGKRCTVDVDECISKPCMNNGVCHNTQGSYVCECPPGFSGMDCEEDIND
                     CLANPCQNGGSCVDHVNTFSCQCHPGFIGDKCQTDMNECLSEPCKNGGTCSDYVNSYT
                     CTCPAGFHGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGPFCLHDINECS
                     SNPCLNAGTCVDGLGTYRCICPLGYTGKNCQTLVNLCSRSPCKNKGTCVQEKARPHCL
                     CPPGWDGAYCDVLNVSCKAAALQKGVPVEHLCQHSGICINAGNTHHCQCPLGYTGSYC
                     EEQLDECASNPCQHGATCNDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCID
                     LVNHFKCSCPPGTRGLLCEENIDECAGGPHCLNGGQCVDRIGGYTCRCLPGFAGERCE
                     GDINECLSNPCSSEGSLDCVQLKNNYNCICRSAFTGRHCETFLDVCPQKPCLNGGTCA
                     VASNMPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCIHTDSGPRCFCLNPKDCESGC
                     ASNPCQHGGTCYPQRQPPHYSCRCPPSFGGSHCELYTAPTSTPPATCQSQYCADKARD
                     GICDEACNSHACQWDGGDCSLTMEDPWANCTSTLRCWEYINNQCDEQCNTAECLFDNF
                     ECQRNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCASDQPENLAEGTLIIVVL
                     LPPEQLLQDSRSFLRALGTLLHTNLRIKQDSQGALMVYPYFGEKSAAMKKQKMTRRSL
                     PEEQEQEQEVIGSKIFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSV
                     FSELESPRNAQLLYLLAVAVVIILFFILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNH
                     KRREPVGQDAVGLKNLSVQVSEANLIGSGTSEHWVDDEGPQPKKAKAEDEALLSEDDP
                     IDRRPWTQQHLEAADIRHTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGS
                     SDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDA
                     GADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVE
                     GMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLF
                     LAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPG
                     TVLTSALSPVLCGPNRSFLSLKHTPMGKKARRPNTKSTMPTSLPNLAKEAKDAKGSRR
                     KKCLNEKVQLSESSVTLSPVDSLESPHTYVSDATSSPMITSPGILQASPTPLLAAAAP
                     AAPVHTQHALSFSNLHDMQPLAPGASTVLPSVSQLLSHHHIAPPGSSSAGSLGRLHPV
                     PVPADWMNRVEMNETQYSEMFGMVLAPAEGAHPGIAAPQSRPPEGKHMSTQREPLPPI
                     VTFQLIPKGSIAQAAGAPQTQSSCPPAVAGPLPSMYQIPEMPRLPSVAFPPTMMPQQE
                     GQVAQTIVPTYHPFPASVGKYPTPPSQHSYASSNAAERTPSHGGHLQGEHPYLTPSPE
                     SPDQWSSSSPHSASDWSDVTTSPTPGGGGGGQRGPGTHMSEPPHSNMQVYA"
     exon            235..316
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..576
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..912
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1035
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1269
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1425
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1614
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1728
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1842
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2076
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2187
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2380
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2526
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2640
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2760
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2913
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3142
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3344
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3498
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3683
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..3816
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            3817..4053
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4166
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4672
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            4673..5026
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5169
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            5170..5380
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            5381..5477
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            5478..5643
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            5644..5945
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            5946..6093
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            6094..6191
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     exon            6192..10506
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10383..10388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /note="hexamer: AATATA"
     polyA_site      10402
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /note="major polyA site"
     regulatory      10479..10484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /note="hexamer: AATAAA"
     polyA_site      10506
                     /gene="Notch2"
                     /gene_synonym="N2"
                     /note="major polyA site"
ORIGIN      
        1 gccaaacttc gggcggcggc ctggctgcgc ggagtgcagg ggcggcgcag cgggagctcc
       61 aggactcagc gagccgcggg ggcagggtag agcacgcgag agccgggctc ctggtcggga
      121 cccgctcccc atgcggatct gctctggctg cggccccgaa gatgcccgct ctgcgtcccg
      181 ccgcgctgcg ggcgctgctg tggctctggc tgtgcggcgc gggccccgcg cacgctttgc
      241 agtgtcgagg tggtcaagag ccctgtgtaa atgaagggac ctgtgttacc taccacaacg
      301 gcacaggctt ctgccgatgt ccagagggct tcttgggaga atattgccaa catcgagacc
      361 cctgtgagaa aaaccgctgt cagaatggtg gtacttgtgt gccgcagggc atgttgggga
      421 aagctacctg ccgatgtgct ccaggattca caggagagga ctgccaatac tccacctctc
      481 acccctgctt tgtgtcccgc ccttgtcaga atgggggtac ctgtcacatg ctcagccggg
      541 acacctacga gtgcacctgc caagtcggct tcacagggaa gcagtgtcag tggacagatg
      601 cctgtctatc tcatccctgc gaaaatggaa gcacctgtac atctgtggcc agccagttct
      661 cctgcaaatg ccctgcaggc ctcacagggc agaagtgtga agctgatatc aatgagtgtg
      721 acattccagg acgctgccaa catggtggca cctgcctcaa ccttcctggt tcctacagat
      781 gccaatgtcc tcagggcttc acaggccagc actgtgacag cccttatgtg ccctgtgcac
      841 cctcgccctg cgtcaacgga ggcacctgtc gtcagactgg cgacttcact ttcgaatgca
      901 actgcctgcc aggttttgaa gggagcacct gtgagcggaa tatcgacgac tgccccaacc
      961 acaagtgtca gaatggagga gtttgtgtgg atggtgtcaa tacctacaat tgccgctgtc
     1021 cccctcagtg gactgggcag ttctgcacag aagatgtgga cgagtgtctg ttgcagccca
     1081 acgcttgtca gaatggaggc acctgcacca accgaaacgg aggctatggc tgcgtgtgtg
     1141 tgaacggctg gagcggagat gactgcagcg agaatatcga tgactgtgcc tatgcttcct
     1201 gcacgccagg gtccacctgc attgaccgcg tggcctcctt ctcctgcctg tgtccggagg
     1261 gaaaggcggg tctcctgtgc catctggatg atgcctgtat cagcaaccct tgtcacaagg
     1321 gggcgctgtg tgacaccaac cccctgaacg ggcagtacat ttgcacctgc ccacagggct
     1381 acaagggcgc tgactgcaca gaagacgtgg atgagtgtgc tatggccaac agtaaccctt
     1441 gtgagcatgc aggaaagtgt gtgaatacag atggcgcctt ccactgtgag tgtctgaagg
     1501 gctacgcagg gcctcgctgt gagatggaca tcaacgagtg tcattcagac ccctgccaga
     1561 acgacgccac ctgcctggat aagatcggag gcttcacctg tctgtgcatg ccaggtttca
     1621 aaggtgtgca ttgtgagctg gaggtaaatg aatgccagag caacccgtgt gtgaacaacg
     1681 ggcagtgtgt ggacaaagtc aaccgcttcc agtgtctgtg tccccctggc ttcacaggac
     1741 cagtgtgcca gatcgacatt gatgactgct ccagtactcc ctgcctgaat ggggccaagt
     1801 gcatcgatca cccgaatggc tatgaatgcc agtgtgccac aggtttcact ggcatattgt
     1861 gtgatgagaa catcgacaac tgtgacccag atccttgcca ccatggccag tgccaggatg
     1921 ggatcgactc ctacacctgc atctgcaacc ctgggtacat gggagccatc tgtagtgacc
     1981 agattgatga atgctacagc agcccttgct tgaacgatgg gcgctgcatt gacctggtga
     2041 atggttacca gtgcaactgc caaccaggca catcaggcct taattgtgaa attaattttg
     2101 atgactgtgc cagcaaccct tgtatgcacg gagtctgtgt ggacggcatc aatcgctaca
     2161 gctgtgtgtg ctctccggga ttcacaggcc agaggtgcaa tattgacatt gatgagtgtg
     2221 cctccaaccc ctgtcgcaag ggtgcgacgt gcatcaatga tgtgaatggt ttccggtgta
     2281 tatgccccga gggaccgcat catcctagct gctactcaca ggtgaacgag tgcctgagca
     2341 atccctgcat ccacggaaac tgtactggag gtctcagtgg ctataagtgc ctctgcgatg
     2401 caggctgggt tggtgtcaac tgtgaggtgg acaaaaatga gtgtctttct aacccatgcc
     2461 agaatggagg aacgtgcaat aacctggtga atggctacag gtgtacctgc aagaaggggt
     2521 tcaaaggcta caactgccag gtgaatatag atgagtgtgc ctccaacccg tgtctgaacc
     2581 aaggaacctg ctttgatgac gtcagtggct acacttgcca ctgcatgttg ccttacacag
     2641 gcaagaactg tcaaacagtg ttggctccct gttccccaaa cccgtgtgag aatgctgctg
     2701 tttgtaaaga ggcacccaat tttgagagct tcagctgctt gtgtgctcct ggctggcaag
     2761 gtaaacgatg tacagttgac gttgatgagt gtatctccaa gccgtgtatg aacaatggtg
     2821 tctgccacaa cactcagggc agctacgtgt gtgagtgtcc tcccggcttc agtgggatgg
     2881 actgtgaaga ggacatcaat gattgccttg ccaacccctg ccagaacgga ggctcctgtg
     2941 tggaccatgt gaataccttc tcctgccagt gccatcctgg cttcataggg gacaagtgcc
     3001 agacagacat gaatgagtgt ctgagcgagc cctgtaagaa tggggggacc tgctccgact
     3061 atgtcaacag ttacacctgc acatgccctg cgggcttcca cggagtccac tgtgaaaaca
     3121 acattgacga gtgcactgag agctcctgct tcaatggcgg cacgtgtgtt gatggaatca
     3181 actctttctc ttgcttgtgc cccgtgggtt tcactggtcc cttctgcctc catgatatca
     3241 atgagtgcag ctctaacccg tgcctgaatg ctggaacgtg tgttgatggt ctgggtacct
     3301 accgatgcat ctgtcccttg ggctacaccg ggaaaaactg tcagaccctg gtgaacctct
     3361 gcagccggtc tccgtgtaaa aacaaaggaa cttgtgttca ggaaaaggca aggccccact
     3421 gtctgtgtcc gcctggatgg gatggtgcat actgtgatgt gctcaacgtg tcctgtaagg
     3481 cggcagcctt gcagaaagga gtacctgttg aacacttgtg ccagcactcg ggcatctgta
     3541 tcaatgctgg caacacccat cactgccagt gccccctggg ctacacgggg agctactgcg
     3601 aggagcagct tgatgagtgt gcatccaatc catgccagca cggtgccacc tgcaatgact
     3661 tcatcggagg atacagatgt gagtgtgttc caggatatca gggtgtcaac tgtgagtatg
     3721 aagtggacga gtgccagaac caaccctgcc agaatggagg cacctgcatc gaccttgtga
     3781 accatttcaa gtgttcgtgt cccccaggca cccggggcct gctgtgtgaa gagaacatcg
     3841 atgaatgtgc tgggggcccc cactgcctta acggtggcca gtgcgtggac cggattggag
     3901 gctacacttg tcgctgtttg cctggctttg ctggggagcg gtgtgagggg gacatcaacg
     3961 aatgcctgtc caacccttgc agctcagagg gcagcctgga ctgcgttcag ctcaaaaata
     4021 actacaactg tatctgccgc agcgccttca cgggccggca ctgtgaaacc ttcctagatg
     4081 tgtgtcccca gaagccttgc ctgaacggag ggacttgtgc cgtggctagc aacatgcccg
     4141 atggcttcat ctgtcgttgt cccccagggt tctctggggc gagatgccag agcagctgtg
     4201 gacaagtgaa gtgcaggaga ggggagcagt gtatccacac tgactcggga cctcgctgct
     4261 tctgcctgaa ccccaaggac tgcgagtcag gatgtgccag taacccctgc cagcatgggg
     4321 gcacctgcta tcctcagcgc cagcctcctc actattcctg ccgctgccct ccgtcgttcg
     4381 ggggcagcca ctgcgaactc tacacagccc ccaccagcac ccctcctgct acctgtcaga
     4441 gtcagtactg cgccgacaag gctcgggatg gcatctgtga cgaggcctgc aatagtcatg
     4501 cctgccagtg ggatggaggt gactgttccc tcactatgga ggacccctgg gccaactgca
     4561 cctccactct tcgctgctgg gaatacatca acaaccagtg tgatgagcag tgcaacaccg
     4621 cagagtgcct gtttgacaac tttgagtgcc agaggaatag caagacgtgc aagtatgaca
     4681 aatactgtgc agaccacttc aaagacaacc actgtgatca gggatgcaac agcgaggagt
     4741 gtggctggga tgggctggac tgcgcttcgg accagcctga gaacctggca gagggcaccc
     4801 tgatcatcgt ggtgctcctg ccccctgaac agctgctgca ggattcgcga agcttcttga
     4861 gggccctggg caccctgctc cacaccaact tgcgcattaa acaagattct cagggcgctc
     4921 tcatggtgta cccctacttt ggggagaagt cagctgccat gaagaagcag aagatgacac
     4981 gcaggtctct tcctgaggag caggagcagg agcaggaggt gataggctct aagatatttc
     5041 tggagatcga caaccgacag tgtgttcaag attcagacca gtgcttcaaa aacacagatg
     5101 cggcagctgc tctcctggct tctcatgcca tccaagggac cctatcctac cctctagtgt
     5161 ctgttttcag tgaactggag agtccaagaa acgcccagct tctctatctg ctcgcggtcg
     5221 ctgttgtcat catcctgttc ttcatcctgc tgggggtcat catggccaag cggaagcgca
     5281 agcatggctt cctctggctg ccggaagggt tcaccctccg ccgagactct agcaatcaca
     5341 agcgccgtga acctgtggga caggatgccg tggggctgaa aaatctctcc gtgcaagtgt
     5401 cagaggctaa cctgattggt tctgggacaa gtgaacattg ggttgatgat gaaggacccc
     5461 agccaaagaa agccaaggct gaggatgagg ctttgctgtc ggaagatgac cccatcgatc
     5521 gacggccctg gacacagcag caccttgaag ctgcagacat ccgccacact ccatccctgg
     5581 cactcactcc tcctcaggca gaacaggagg tggacgtgct ggacgtgaat gtccgaggcc
     5641 cagatgggtg tactccactg atgctggctt ctctccgagg aggcagctca gacctgagtg
     5701 atgaagacga agatgctgag gactcttctg ccaacatcat cacagacttg gtctaccaag
     5761 gtgccagcct tcaagcacag acagaccgca ctggcgagat ggccctgcac cttgcagccc
     5821 gctattcgag agctgatgct gccaaacgcc tcctggatgc tggtgcggat gcaaatgccc
     5881 aggacaacat gggccgatgt cctcttcacg ctgcggtggc agcagacgcc caaggtgtct
     5941 ttcagattct gatccgcaac cgtgtaaccg atctggatgc cagaatgaac gatggtacta
     6001 cccccctgat cctggctgcc cgcctggctg tggaaggaat ggtggcagag ttgatcaatt
     6061 gccaagcaga tgtcaatgca gtggatgacc atggaaaatc tgccctccac tgggcagctg
     6121 ctgtcaataa tgtggaggcg actcttctgc tgttgaagaa tggggccaac agagatatgc
     6181 aggacaataa ggaagagaca cctttgtttc ttgctgcccg agagggaagt tatgaagcgg
     6241 ccaaaatcct gttagaccat tttgccaacc gggacatcac tgaccacatg gaccgccttc
     6301 cccgggatgt ggctcgggac cgcatgcacc atgacatcgt tcgcctcctg gacgagtata
     6361 acgtgactcc cagccctccg ggaacggtct tgacttctgc gctctcacct gtcctctgtg
     6421 ggcccaacag gtctttcctc agtctgaagc acaccccaat gggtaagaag gctaggcggc
     6481 ccaacaccaa gagcaccatg cccacgagcc tgcctaacct tgccaaggag gccaaggatg
     6541 ccaagggcag caggaggaag aagtgtctga acgagaaggt ccagctgtcc gagagctcag
     6601 tgactctatc ccccgtcgat tcgctcgagt ctcctcacac gtatgtctcc gatgccacat
     6661 cctctcccat gatcacatcc cctggaatct tacaggcctc gcccaccccc ctgctggctg
     6721 ctgccgcccc ggctgcccca gtgcacacac agcatgcgct gtctttctct aaccttcatg
     6781 acatgcagcc tttggctcct ggagccagca ccgtgctccc ctcggtcagc cagctgctat
     6841 cccaccacca catcgcgccc ccaggtagta gcagtgcagg aagcttgggc aggttacatc
     6901 cagttcctgt cccagcagac tggatgaacc gtgtggagat gaacgagacc cagtacagtg
     6961 aaatgtttgg catggtcctg gctcctgcag agggagccca ccctggcata gcagctcccc
     7021 agagcagacc tccggaaggg aagcacatgt ccacccagcg ggagcccttg cctcccatcg
     7081 tgactttcca gcttatccca aaaggcagca ttgcccaggc agccggagct ccccagacgc
     7141 agtccagttg ccctccagct gttgcaggcc ccttgccctc tatgtaccag atcccagaga
     7201 tgccccgttt gcccagtgtg gctttcccac ctaccatgat gccccagcag gaggggcagg
     7261 tagctcagac cattgtgcca acctatcatc ctttcccagc ctctgtgggc aagtacccca
     7321 cacccccttc ccaacacagt tacgcctcct caaatgctgc tgagcgaacc cccagtcatg
     7381 gtggtcacct ccagggcgag cacccatacc tgacaccatc cccagagtct cctgaccaat
     7441 ggtcaagctc ttcaccacac tctgcatctg actggtcaga tgtgaccacc agcccaactc
     7501 ctggaggtgg tggaggcggt cagcggggac ccggaacaca catgtccgag ccaccacaca
     7561 gcaacatgca ggtgtatgca tgaagagtct gcctcagcct tagagatgga agtgcctatc
     7621 acacatactg ctgaggggcg agtgaaggtt atccggagag aaatgaagag acgtcccgtc
     7681 cgtgaccatc tttcggaggc aggagagaga ggctccaaac ctgaggcaag cgtgagaagc
     7741 cttctctcca tcttccctcg ctctctgtgc agttttaggg gaggacgcag ctcctactga
     7801 ccttcaccca tcctgcaagt tcatggagat gcaagatgag tgacaagcct tgagacccct
     7861 tgctctcttt taatttggag aataccgtgg atgcctttta tcgcccagac attctcgcag
     7921 cctgagtaac attttaagcc ccggggcttc tgactgagtg ccccgggact ctgtccaggc
     7981 tgacgtgtcc agtcttctca gccctggaag tggccttgac gtcactcggt gctttcctct
     8041 ctgcgcccgt ctgtggttga tccccgtcag tgtgtcataa gcgagatgtc tgtgctctta
     8101 atcattcctg acctggaaac cgacttcagc ctcctgttcc cacattcccg gcacctcaca
     8161 ggtgcctcac agggtttact ctggccatgg gtctcagccc tggcctctga agtatgcttc
     8221 tatggaaaat gcacacacta gtcttcatgt cttattccta gaaggaaaga ggaagcaaaa
     8281 tatttgggga ctagaagcct ccttctgaac ctgcacctta atttctctcc cctgcatgtg
     8341 gggccccata tacactcatc agggggaagg atctgaattg ttcttctgtc agttggccta
     8401 gtcagtataa aattgaactc taggaggctt aggtactgtg atattcctct cattttgttg
     8461 taaagtagga aaagtgggtg agtgttggaa tgtccaagaa ataagctaac ttgctcaaga
     8521 agcaatcgcc cccctccagg ccctccattg actgccactg tgaagcacat ttatcacctg
     8581 atcttaggac tcattgatcc agcagatgaa ggtactcttg gctgctgcac tgctcctcat
     8641 agatgcccgc agaagaaaat gcctctccat ttgcccttgc catttaggac agaacttgcc
     8701 tggggcacag gggacccagt gactgccaac ttccttagga ccactttgct ttccgatcag
     8761 aagccagttt ctttccacag cgtgtgatct gagagactgg tgcacacaca gtaggttctc
     8821 agtgaagacg tggagtctgt atttgggttc cagatgtgga gaagggacag tctcctgagc
     8881 tcacgaggca gcctttgcta gtcgatgctg cattctcttc cttccctaga gtccccttcc
     8941 gatgatgacg gctccccatt gtccttgtgt tcagattaag attgtacctc atccgaacct
     9001 gcttcctgca gtgtggtctc agtgacttct cagactctca agagcagaaa catttttatc
     9061 tgtggtaatc taggatgata gttttctcct cagtcatagg gctaataatt gcccctatgg
     9121 ccatgccatc agtcactgct tcctggtgcc atggcaccca ggacacagga aaatgagttc
     9181 tgctggagca tttgtgtata ttattagggg gaccacctgg gggtgtttgt tttatgggtt
     9241 ttgttgttgt tgttttaata atagtcttta ttcctgtgat agttaaaata agtgcccttc
     9301 gcctcattca tcagtttgtg aacttagtaa gtctgtgtat ctgttacaca gcagtctata
     9361 aacaagtgag gattttagtc ccattcaagt tcactgaatc aacaaaaata atttgttctg
     9421 tcctggtcta tggcagatta agtttgatca tttgacttta ttctcatgtg gtgacatcat
     9481 cttaccagcc cctttcatgg aatagagaca ttttattgcc ctaaatggtg actgtctgcc
     9541 ctaaagctct agtgccactg cctgcgaaca gtaaccaaga atccagccac tgggtctggt
     9601 cactggacct accccagaca cagagaagaa caaacttgct gtttctcctt caaggatccc
     9661 tcaaagagga tcctttggga tttaggagga gggatgtgaa aactgccgtg acagacaaca
     9721 gactacagag atgaagaaga caacactgcc agtcatacat ctatctgatc agtcccttag
     9781 gtgttagaat tcttgacctg tgtagtgtcc aggaaaagaa agggggatgg gcagtccctt
     9841 actccgggac ctgagtcaag aggccgaggt tgtatgaggc acatccttta ttccatacac
     9901 agagccctgt tttgggcttt tttttttttt ttttttttta ttcctatgaa atcttccttt
     9961 gacttttacc tgcctttaag gatatttttt tttaatttgt tcttttttgt tttaagcata
    10021 attttctgac ttatgcgatg gtggggggat tgaaggaaag aaagactgag ttaaagattt
    10081 tcaagaaagc cgtcagcacg agttggttat atcattttgt taaacttggc cacttgaagt
    10141 cttgcataga aatgaaccaa aggtgttcag tgttcacgtg tgatttcagg acccggactt
    10201 taaccagcgc gttgaatgta cgaggactgt ttggaaggac acgtgtctat gtcctgaggc
    10261 ccccaccctt aactgttttg gtactatggc aacttcctcg tgtatatttc cctgaaaagt
    10321 gacattatat ctgtttgtat gagaaactca gtaaccagaa aatgacttcg tgttcctgac
    10381 taaatatagg aaggaatatg cacactgttt ttacttttta aagtttcatt ctaaaagtag
    10441 attaagatga aatttatatg aaaacatttt tatcacaaaa taaaaaaggt tccatgtcaa
    10501 agctca
//
