LOCUS       NM_008714               9497 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus notch 1 (Notch1), mRNA.
ACCESSION   NM_008714
VERSION     NM_008714.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9497)
  AUTHORS   Feng,W., Hong,N., Wu,Y., Huang,J., Zhang,Q., Liu,G., Qian,Z.,
            Chen,Y., Jin,L., Ding,X., Zhao,P., Chen,A.F. and Yu,Y.
  TITLE     Deficiency of Sox7 leads to congenital aortic stenosis via abnormal
            valve remodeling
  JOURNAL   J Mol Cell Cardiol 199, 81-94 (2025)
   PUBMED   39746830
REFERENCE   2  (bases 1 to 9497)
  AUTHORS   Raudales,A., Schager,B., Hancock,D., Narayana,K., Sharma,S.,
            Reeson,P., Oshanyk,A., Cheema,M., Korbelin,J. and Brown,C.E.
  TITLE     Angiogenesis in the mature mouse cortex is governed in a regional-
            and Notch1-dependent manner
  JOURNAL   Cell Rep 43 (12), 115029 (2024)
   PUBMED   39612246
REFERENCE   3  (bases 1 to 9497)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9497)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   5  (bases 1 to 9497)
  AUTHORS   Choudhury,T.Z., Greskovich,S.C., Girard,H.B., Rao,A.S.,
            Budhathoki,Y., Cameron,E.M., Conroy,S., Li,D., Zhao,M.T. and
            Garg,V.
  TITLE     Impact of genetic factors on antioxidant rescue of maternal
            diabetes-associated congenital heart disease
  JOURNAL   JCI Insight 9 (23), e183516 (2024)
   PUBMED   39437002
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9497)
  AUTHORS   Higuchi,M., Kiyama,H., Hayakawa,T., Hamada,Y. and Tsujimoto,Y.
  TITLE     Differential expression of Notch1 and Notch2 in developing and
            adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 29 (2), 263-272 (1995)
   PUBMED   7609614
REFERENCE   7  (bases 1 to 9497)
  AUTHORS   Reaume,A.G., Conlon,R.A., Zirngibl,R., Yamaguchi,T.P. and
            Rossant,J.
  TITLE     Expression analysis of a Notch homologue in the mouse embryo
  JOURNAL   Dev Biol 154 (2), 377-387 (1992)
   PUBMED   1426644
REFERENCE   8  (bases 1 to 9497)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   9  (bases 1 to 9497)
  AUTHORS   Del Amo,F.F., Smith,D.E., Swiatek,P.J., Gendron-Maguire,M.,
            Greenspan,R.J., McMahon,A.P. and Gridley,T.
  TITLE     Expression pattern of Motch, a mouse homolog of Drosophila Notch,
            suggests an important role in early postimplantation mouse
            development
  JOURNAL   Development 115 (3), 737-744 (1992)
   PUBMED   1425352
REFERENCE   10 (bases 1 to 9497)
  AUTHORS   Weinmaster,G., Roberts,V.J. and Lemke,G.
  TITLE     A homolog of Drosophila Notch expressed during mammalian
            development
  JOURNAL   Development 113 (1), 199-205 (1991)
   PUBMED   1764995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY233933.1, BC138441.1 and BF318436.1.
            
            On Mar 13, 2009 this sequence version replaced NM_008714.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138441.1, AK090118.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               BY233933.1         1-185
            186-9193            BC138441.1         1-9008
            9194-9497           BF318436.1         1-304               c
FEATURES             Location/Qualifiers
     source          1..9497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.91 cM"
     gene            1..9497
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /note="notch 1"
                     /db_xref="GeneID:18128"
                     /db_xref="MGI:MGI:97363"
     exon            1..325
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..7860
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /note="neurogenic locus notch homolog protein 1; major
                     type A protein; mT14; p300; Motch A; Notch gene homolog 1"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 1
                     precursor"
                     /protein_id="NP_032740.3"
                     /db_xref="CCDS:CCDS15806.1"
                     /db_xref="GeneID:18128"
                     /db_xref="MGI:MGI:97363"
                     /translation="MPRLLTPLLCLTLLPALAARGLRCSQPSGTCLNGGRCEVANGTE
                     ACVCSGAFVGQRCQDSNPCLSTPCKNAGTCHVVDHGGTVDYACSCPLGFSGPLCLTPL
                     DNACLANPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFES
                     SYICRCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELP
                     YVPCSPSPCQNGGTCRPTGDTTHECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGV
                     NTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSE
                     NIDDCASAACFQGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPV
                     NGKAICTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCE
                     IDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGHCMDK
                     INEFQCQCPKGFNGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVD
                     IDECDPDPCHYGSCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRHGGTCQDRDNS
                     YLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKIDGYECACEPGYTGSMCNVNIDEC
                     AGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNECNSNPCIHGACRDGLNGYKCD
                     CAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN
                     PCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCV
                     CPTGWQGQTCEVDINECVKSPCRHGASCQNTNGSYRCLCQAGYTGRNCESDIDDCRPN
                     PCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDCVDSYTCTCP
                     VGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQYDVNECDSRPC
                     LHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQYHCECRSG
                     WTGVNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCVDEGDKHYCHCQAGYTGSYCEDEV
                     DECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNS
                     YKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTCTCPPGFVGE
                     RCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCKNGG
                     VCAVASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSF
                     TGPECQFPASSPCVGSNPCYNQGTCEPTSENPFYRCLCPAKFNGLLCHILDYSFTGGA
                     GRDIPPPQIEEACELPECQVDAGNKVCNLQCNNHACGWDGGDCSLNFNDPWKNCTQSL
                     QCWKYFSDGHCDSQCNSAGCLFDGFDCQLTEGQCNPLYDQYCKDHFSDGHCDQGCNSA
                     ECEWDGLDCAEHVPERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDA
                     QGQQMIFPYYGHEEELRKHPIKRSTVGWATSSLLPGTSGGRQRRELDPMDIRGSIVYL
                     EIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSEPVEPPLPSQLHL
                     MYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGL
                     KPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLSDQTDHRQWTQQHLDAAD
                     LRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVI
                     SDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAA
                     VSADAQGVFQILLRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDD
                     LGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHF
                     ANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGTALGGTPTLSPTLCSP
                     NGYLGNLKSATQGKKARKPSTKGLACGSKEAKDLKARRKKSQDGKGCLLDSSSMLSPV
                     DSLESPHGYLSDVASPPLLPSPFQQSPSMPLSHLPGMPDTHLGISHLNVAAKPEMAAL
                     AGGSRLAFEPPPPRLSHLPVASSASTVLSTNGTGAMNFTVGAPASLNGQCEWLPRLQN
                     GMVPSQYNPLRPGVTPGTLSTQAAGLQHSMMGPLHSSLSTNTLSPIIYQGLPNTRLAT
                     QPHLVQTQQVQPQNLQLQPQNLQPPSQPHLSVSSAANGHLGRSFLSGEPSQADVQPLG
                     PSSLPVHTILPQESQALPTSLPSSMVPPMTTTQFLTPPSQHSYSSSPVDNTPSHQLQV
                     PEHPFLTPSPESPDQWSSSSPHSNISDWSEGISSPPTTMPSQITHIPEAFK"
     exon            326..404
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..667
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1006
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1129
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1363
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1519
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1705
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1819
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1933
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2167
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2278
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2471
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2617
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2731
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2851
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..3004
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3233
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3435
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3589
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3774
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            3775..3907
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..4165
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4278
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4850
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            4851..5252
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5401
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            5402..5618
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            5619..5706
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            5707..5872
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            5873..6168
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            6169..6316
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            6317..6414
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     exon            6415..9489
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8113..8118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /note="hexamer: AATAAA"
     polyA_site      8137
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
     polyA_site      8255
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
     regulatory      9450..9455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /note="hexamer: AATAAA"
     polyA_site      9488
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /note="major polyA site"
ORIGIN      
        1 tagtgcctct gccgcgggag ggagcgcagg ggcgtggggc gcagggcgcg ggcgctgggc
       61 gcgggtgcga gcgcagtgaa ggaacgagcc cgggtgcctt gtagggccca gcgccgctga
      121 gagcccagcg ccgcccaccc gccaggaaag agggcatcag agggtggacg cctgcgggac
      181 cgccggtggt gtgcgtcaac gtccgatccc cgccggccac cccaagaggc cgccgcccgg
      241 gctgcgggca gctggcgagc aggcatgcca cggctcctga cgcccttgct ctgcctaacg
      301 ctgctgcccg cgctcgccgc aagaggcttg agatgctccc agccaagtgg gacctgcctg
      361 aatggaggga ggtgcgaagt ggccaacggc actgaagcct gtgtctgcag cggagccttt
      421 gtgggccaac gatgccagga ctccaatcct tgcctcagca caccgtgtaa gaatgctgga
      481 acgtgccacg ttgtggacca tggtggcact gtggattatg cctgcagctg tcccctgggt
      541 ttctctgggc ccctctgcct gacacctctg gacaacgcct gcctggccaa cccctgccgc
      601 aatgggggca cctgtgacct gctcactctc acagagtaca agtgccgctg cccaccaggg
      661 tggtcaggaa aatcatgtca gcaggctgac ccctgtgcct ccaacccctg tgccaatggt
      721 ggccagtgcc tgccctttga gtcttcatac atctgtcgct gcccgcctgg cttccatggc
      781 cccacctgca ggcaagatgt taatgagtgc agccagaacc ctgggctgtg ccgccatgga
      841 ggcacctgcc acaatgagat cggctcctat cgctgtgcct gccgtgccac ccatactggt
      901 ccccactgtg aactgcccta tgtgccctgc agcccctcac cctgccagaa tggaggcacc
      961 tgccgtccta caggggacac cacccacgag tgtgcctgct tgccaggttt tgctggacag
     1021 aactgtgaag aaaatgtgga tgactgtcca ggaaacaact gcaagaatgg gggtgcctgt
     1081 gtggacggcg tgaataccta caattgccgc tgcccaccgg agtggacggg tcagtactgt
     1141 acagaggatg tggacgaatg tcagctcatg cccaatgcct gccagaatgg cggaacctgc
     1201 cacaacacac acggcggcta caactgtgtg tgtgtcaatg ggtggactgg cgaggactgc
     1261 agtgagaaca ttgatgactg tgccagtgcc gcctgtttcc agggtgccac ttgccacgac
     1321 cgtgtggctt ccttctactg cgaatgtccg catgggcgca caggtctgct gtgccacctc
     1381 aacgatgcgt gcatcagcaa cccctgcaac gagggctcca actgtgacac caaccctgtc
     1441 aacggcaaag ccatctgcac ctgcccctcg gggtacacag ggccagcctg cagccaggac
     1501 gtggatgagt gtgctctggg tgccaaccct tgtgagcacg caggcaaatg cctcaacaca
     1561 ctgggttctt ttgagtgcca gtgtctacag ggctacacgg gaccccgctg tgagattgat
     1621 gttaatgagt gcatctccaa cccatgtcag aatgatgcca cttgcctgga ccagattggg
     1681 gagttccaat gcatatgtat gccaggttat gaaggtgtat actgtgaaat caacacggat
     1741 gagtgcgcca gcagcccctg tctgcacaat ggccactgca tggacaagat caatgagttc
     1801 caatgtcagt gccccaaagg cttcaacggg cacctgtgcc agtatgatgt ggatgagtgt
     1861 gccagcacac catgcaagaa cggtgccaag tgcctggatg ggcccaacac ctatacctgc
     1921 gtgtgtacag aaggttacac agggacccac tgcgaagtgg acattgacga gtgtgaccct
     1981 gacccctgcc actatggttc ctgtaaggat ggtgtggcca cctttacctg cctgtgccag
     2041 ccaggctaca caggccatca ctgtgagacc aacatcaatg agtgccacag ccaaccgtgc
     2101 cgccatgggg gcacctgcca ggaccgtgac aactcctacc tctgcttatg cctcaaggga
     2161 accacagggc ccaactgtga gatcaacctg gatgactgcg ccagcaaccc ctgtgactct
     2221 ggcacctgtc tggacaagat tgatggctac gaatgtgcct gtgaaccagg ctacacagga
     2281 agcatgtgta acgtcaacat tgacgaatgt gcgggcagcc cctgccacaa cgggggcact
     2341 tgtgaggatg gcatcgcggg cttcacttgc cgctgccccg agggctacca tgaccccacg
     2401 tgcctgtccg aggtcaacga gtgcaacagt aacccctgca tccacggagc ttgccgggat
     2461 ggcctcaatg ggtacaagtg tgactgtgcc cctgggtgga gtggaacaaa ctgtgacatc
     2521 aacaacaacg agtgtgagtc caacccttgt gtcaacggtg gcacctgcaa ggacatgacc
     2581 agtggctacg tatgcacctg ccgagaaggc ttcagtggcc ctaattgcca gaccaacatc
     2641 aacgaatgtg cctccaaccc ctgcctgaac caggggacct gcattgatga tgtcgctgga
     2701 tacaagtgca actgtcctct gccatataca ggagccacgt gtgaggtggt gttggcccca
     2761 tgtgctacca gcccctgcaa aaacagcggg gtatgcaagg agtctgaaga ctatgagagt
     2821 ttttcctgtg tctgtcccac aggctggcaa ggtcaaacct gcgaggttga catcaatgag
     2881 tgtgtgaaaa gcccatgtcg ccatggggcc tcctgccaga acaccaatgg cagctaccgc
     2941 tgcctctgcc aggccggcta tacaggtcgc aactgtgaga gtgacatcga tgactgccgc
     3001 cccaacccgt gtcacaatgg gggttcctgc accgatggca tcaacacagc cttctgcgac
     3061 tgcctgcccg gcttccaggg tgccttctgt gaggaggaca tcaatgaatg tgccagcaat
     3121 ccctgccaaa atggtgccaa ttgcactgac tgtgtggaca gctacacatg tacctgcccc
     3181 gtgggcttca atggcatcca ctgcgagaac aacacacctg actgtactga gagctcctgc
     3241 ttcaatggtg gtacctgtgt ggatggtatc aactccttca cctgtctgtg tccacctggc
     3301 ttcacgggca gctactgtca gtatgatgtc aatgagtgtg attcacggcc ctgtctgcac
     3361 ggtggtacct gccaagacag ctatggtact tataagtgta cctgcccaca gggctacact
     3421 ggtctcaact gccagaacct tgtgcgctgg tgcgactcgg ctccctgcaa gaatggtggc
     3481 aggtgctggc agaccaacac gcagtaccac tgtgagtgcc gcagcggctg gactggcgtc
     3541 aactgcgacg tgctcagtgt gtcctgtgag gtggctgcac agaagcgagg cattgacgtc
     3601 actctcctgt gccagcatgg agggctctgt gtggatgagg gagataaaca ttactgccac
     3661 tgccaggcag gctacacggg cagctactgt gaggacgagg tggacgagtg ctcacctaac
     3721 ccctgccaga atggagctac ctgcactgac tatctcggcg gcttttcctg caagtgtgtg
     3781 gctggctacc atgggtctaa ctgctccgag gagatcaacg agtgcctgtc ccagccctgc
     3841 cagaatgggg gtacctgcat tgatctgacc aactcctaca agtgttcctg cccccggggg
     3901 acacagggtg tacactgtga gatcaatgtt gatgactgcc atccccccct tgaccctgcc
     3961 tcccgaagcc ccaagtgctt caacaatggc acctgtgtgg accaggtggg tggctatacc
     4021 tgcacctgcc caccaggctt cgtcggggag cggtgtgagg gtgatgtcaa tgaatgtctc
     4081 tccaacccct gtgacccacg tggcacccag aactgtgtgc agcgtgttaa tgacttccac
     4141 tgcgagtgcc gggctggcca cactggacgc cgctgtgagt cagtcatcaa tggctgcagg
     4201 ggcaaacctt gcaagaatgg gggtgtctgt gccgtggcct ccaacaccgc ccgtggattc
     4261 atctgtaggt gccctgcggg cttcgagggt gccacatgtg agaatgatgc ccgcacttgt
     4321 ggcagcttac gctgcctcaa cggtggtaca tgcatctcgg gcccacgtag tcccacctgc
     4381 ctatgcctgg gatccttcac cggccctgag tgccagttcc cagccagcag cccctgtgtg
     4441 ggtagcaacc cctgctacaa tcagggcacc tgtgagccca catccgagaa ccctttctac
     4501 cgctgtctat gccctgccaa attcaacggg ctactgtgcc acatcctgga ctacagcttc
     4561 acaggtggcg ctgggcgcga cattccccca ccgcagattg aggaggcctg tgagctgcct
     4621 gagtgccagg tggatgcagg caataaggtc tgcaacctgc agtgtaataa tcacgcatgt
     4681 ggctgggatg gtggcgactg ctccctcaac ttcaatgacc cctggaagaa ctgcacgcag
     4741 tctctacagt gctggaagta ttttagcgac ggccactgtg acagccagtg caactcggcc
     4801 ggctgcctct ttgatggctt cgactgccag ctcaccgagg gacagtgcaa ccccctgtat
     4861 gaccagtact gcaaggacca cttcagtgat ggccactgcg accagggctg taacagtgcc
     4921 gaatgtgagt gggatggcct agactgtgct gagcatgtac ccgagcggct ggcagccggc
     4981 accctggtgc tggtggtgct gcttccaccc gaccagctac ggaacaactc cttccacttt
     5041 ctgcgggagc tcagccacgt gctgcacacc aacgtggtct tcaagcgtga tgcgcaaggc
     5101 cagcagatga tcttcccgta ctatggccac gaggaagagc tgcgcaagca cccaatcaag
     5161 cgctctacag tgggttgggc cacctcttca ctgcttcctg gtaccagtgg tgggcgccag
     5221 cgcagggagc tggaccccat ggacatccgt ggctccattg tctacctgga gatcgacaac
     5281 cggcaatgtg tgcagtcatc ctcgcagtgc ttccagagtg ccaccgatgt ggctgccttc
     5341 ctaggtgctc ttgcgtcact tggcagcctc aatattcctt acaagattga ggccgtgaag
     5401 agtgagccgg tggagcctcc gctgccctcg cagctgcacc tcatgtacgt ggcagcggcc
     5461 gccttcgtgc tcctgttctt tgtgggctgt ggggtgctgc tgtcccgcaa gcgccggcgg
     5521 cagcatggcc agctctggtt ccctgagggt ttcaaagtgt cagaggccag caagaagaag
     5581 cggagagagc ccctcggcga ggactcagtc ggcctcaagc ccctgaagaa tgcctcagat
     5641 ggtgctctga tggacgacaa tcagaacgag tggggagacg aagacctgga gaccaagaag
     5701 ttccggtttg aggagccagt agttctccct gacctgagtg atcagactga ccacaggcag
     5761 tggacccagc agcacctgga cgctgctgac ctgcgcatgt ctgccatggc cccaacaccg
     5821 cctcaggggg aggtggatgc tgactgcatg gatgtcaatg ttcgaggacc agatggcttc
     5881 acacccctca tgattgcctc ctgcagtgga gggggccttg agacaggcaa cagtgaagaa
     5941 gaagaagatg cacctgctgt catctctgac ttcatctacc agggcgccag cttgcacaac
     6001 cagacagacc gcaccgggga gaccgccttg cacttggctg cccgatactc tcgttcagat
     6061 gctgcaaagc gcttgctgga ggccagtgca gatgccaaca tccaggacaa catgggccgt
     6121 actccgttac atgcagcagt ttctgcagat gctcagggtg tcttccagat cctgctccgg
     6181 aacagggcca cagatctgga tgcccgaatg catgatggca caactccact gatcctggct
     6241 gcgcgcctgg ccgtggaggg catgctggag gacctcatca actcacatgc tgacgtcaat
     6301 gccgtggatg acctaggcaa gtcggctttg cattgggcgg ccgcggtgaa caatgtggat
     6361 gctgctgttg tgctcctgaa gaacggagcc aacaaggaca tgcagaacaa caaggaggag
     6421 actcccctgt tcctggccgc ccgtgagggc agctatgaga ctgccaaagt gttgctggac
     6481 cactttgcca accgggacat cacggatcac atggaccgat tgccgcggga catcgcacag
     6541 gagcgtatgc accacgatat cgtgcggctt ttggatgagt acaacctggt gcgcagccca
     6601 cagctgcatg gcactgccct gggtggcaca cccactctgt ctcccacact ctgctcgccc
     6661 aatggctacc tgggcaatct caagtctgcc acacagggca agaaggcccg caagcccagc
     6721 accaaagggc tggcttgtgg tagcaaggaa gctaaggacc tcaaggcacg gaggaagaag
     6781 tcccaggatg gcaagggctg cctgttggac agctcgagca tgctgtcgcc tgtggactcc
     6841 ctcgagtcac cccatggcta cttgtcagat gtggcctcgc cacccctcct cccctcccca
     6901 ttccagcagt ctccatccat gcctctcagc cacctgcctg gtatgcctga cactcacctg
     6961 ggcatcagcc acttgaatgt ggcagccaag cctgagatgg cagcactggc tggaggtagc
     7021 cggttggcct ttgagccacc cccgccacgc ctctcccacc tgcctgtagc ctccagtgcc
     7081 agcacagtgc tgagtaccaa tggcacgggg gctatgaatt tcaccgtggg tgcaccggca
     7141 agcttgaatg gccagtgtga gtggcttccc cggctccaga atggcatggt gcccagccag
     7201 tacaacccac tacggccggg tgtgacgccg ggcacactga gcacacaggc agctggcctc
     7261 cagcatagca tgatggggcc actacacagc agcctctcca ccaatacctt gtccccgatt
     7321 atttaccagg gcctgcccaa cacacggctg gcaacacagc ctcacctggt gcagacccag
     7381 caggtgcagc cacagaactt acagctccag cctcagaacc tgcagccacc atcacagcca
     7441 cacctcagtg tgagctcggc agccaatggg cacctgggcc ggagcttctt gagtggggag
     7501 cccagtcagg cagatgtaca accgctgggc cccagcagtc tgcctgtgca caccattctg
     7561 ccccaggaaa gccaggccct gcccacatca ctgccatcct ccatggtccc acccatgacc
     7621 actacccagt tcctgacccc tccttcccag cacagttact cctcctcccc tgtggacaac
     7681 acccccagcc accagctgca ggtgccagag caccccttcc tcaccccatc ccctgagtcc
     7741 cctgaccagt ggtccagctc ctccccgcat tccaacatct ctgattggtc cgagggcatc
     7801 tccagcccgc ccaccaccat gccgtcccag atcacccaca ttccagaggc atttaaataa
     7861 acagagatgt gggatgcagg accccagctt ccgttcccaa gccctgttgg gagtcctttc
     7921 cagtgcttca ggatgctggg gcgaccaaag gagcctttta aaaaatgttt ttatacaaaa
     7981 taagaggaca agaatttcca tttttttttt tagtatttat ttatgtactt ttattttcca
     8041 cagaaacact gcctttttat ttatatgtat tgttttctat ggcactaggg aaaaacatat
     8101 ctgttccaag aaaataaact agttctcaga gccttgattt tcctggtcag ggtgaagttc
     8161 cctgtgtgtc tgtaaaatat gaacaaggat tcatgatttg taaatgctgt ttatttattg
     8221 attgcttctt tccaaaatcg aaaagaaaga aaaaagaacg tgacaggaga agggaagctg
     8281 gaaactgcca tggccagaat tgcccctccc ccacactcac tgcccctccc cccagcgtca
     8341 cctgggattt gcagatgtgt ttagaaacac gcccagacct tgaaccttgg gttcatggat
     8401 tagttttgta tctaaaacag gaaacaagtc agatgatgtg gtttgtacac tttctgtaac
     8461 caccagtgtg gacttgaaga agtgtcctca gcatgtgcag agtctactac ccagtaccag
     8521 tcgtgagtct gcaggctcca gtgttctgta gtagtgttta tgggccttgg gagtacttct
     8581 cccctgccct gccccactgt ccccttcctg acaacttgag ccagtaagcc atgcagggtg
     8641 tggtgcctcc tagagaaaac actgcctgga ctgttctgtg catccctcca aacagcatca
     8701 tccaaatcca actgaggaca gacggactgt cccggcctgg gcctgggctc ctaacacctg
     8761 actgccaaag ggctccaatg tgcattgtgg actcgccaga gtagcctgca ttgagactcc
     8821 aagaaaacag aagctatgtg gcctctgatc cccaaactgg cctgggtggg gacatgcctt
     8881 gagtgtgctg gaatgtgggt ggagcctgct tctgggccac ccctcctggt tcagggctgt
     8941 gctcacagca gattcttgca gtatcaagta tacgcctgtg gcagaataag tatctgtaaa
     9001 tacatgttta aagatggatt ttgtttaaaa aatctaaagg aacaagtgtg tcgtgtgtca
     9061 agctgatgag gactgtcaga ctgtggctta gctcagtgtg acccagacct tgtgacctgt
     9121 agctgccgaa ccagtagctc ctaagagcac aacccaggat ggcccatctg ctgcccacca
     9181 agtccctttc cagccactgt gtgctggggg ctttcggggg cagttgccca cctcctcagg
     9241 gcagctcttt ctggcctttt ggggggcagt gtctgtgcca tgcctaatag atatgaccag
     9301 acgcatccta agatgttgat tcttactgtg ttgtataaaa taaagtgtag tttacaaaaa
     9361 aaagaaacgt aaaaaaaaaa aactacatgc aaaactgtag gtaatgaaaa tgatgtattt
     9421 ttttcatctt tttttgttaa ctaatttgca ataaaaatga tactgatggt tgtccacatt
     9481 ttgctaaaca aaaaaaa
//
