LOCUS       NP_032740               2531 aa            linear   ROD 04-MAR-2025
DEFINITION  neurogenic locus notch homolog protein 1 precursor [Mus musculus].
ACCESSION   NP_032740
VERSION     NP_032740.3
DBSOURCE    REFSEQ: accession NM_008714.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2531)
  AUTHORS   Feng,W., Hong,N., Wu,Y., Huang,J., Zhang,Q., Liu,G., Qian,Z.,
            Chen,Y., Jin,L., Ding,X., Zhao,P., Chen,A.F. and Yu,Y.
  TITLE     Deficiency of Sox7 leads to congenital aortic stenosis via abnormal
            valve remodeling
  JOURNAL   J Mol Cell Cardiol 199, 81-94 (2025)
   PUBMED   39746830
REFERENCE   2  (residues 1 to 2531)
  AUTHORS   Raudales,A., Schager,B., Hancock,D., Narayana,K., Sharma,S.,
            Reeson,P., Oshanyk,A., Cheema,M., Korbelin,J. and Brown,C.E.
  TITLE     Angiogenesis in the mature mouse cortex is governed in a regional-
            and Notch1-dependent manner
  JOURNAL   Cell Rep 43 (12), 115029 (2024)
   PUBMED   39612246
REFERENCE   3  (residues 1 to 2531)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2531)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   5  (residues 1 to 2531)
  AUTHORS   Choudhury,T.Z., Greskovich,S.C., Girard,H.B., Rao,A.S.,
            Budhathoki,Y., Cameron,E.M., Conroy,S., Li,D., Zhao,M.T. and
            Garg,V.
  TITLE     Impact of genetic factors on antioxidant rescue of maternal
            diabetes-associated congenital heart disease
  JOURNAL   JCI Insight 9 (23), e183516 (2024)
   PUBMED   39437002
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2531)
  AUTHORS   Higuchi,M., Kiyama,H., Hayakawa,T., Hamada,Y. and Tsujimoto,Y.
  TITLE     Differential expression of Notch1 and Notch2 in developing and
            adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 29 (2), 263-272 (1995)
   PUBMED   7609614
REFERENCE   7  (residues 1 to 2531)
  AUTHORS   Reaume,A.G., Conlon,R.A., Zirngibl,R., Yamaguchi,T.P. and
            Rossant,J.
  TITLE     Expression analysis of a Notch homologue in the mouse embryo
  JOURNAL   Dev Biol 154 (2), 377-387 (1992)
   PUBMED   1426644
REFERENCE   8  (residues 1 to 2531)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   9  (residues 1 to 2531)
  AUTHORS   Del Amo,F.F., Smith,D.E., Swiatek,P.J., Gendron-Maguire,M.,
            Greenspan,R.J., McMahon,A.P. and Gridley,T.
  TITLE     Expression pattern of Motch, a mouse homolog of Drosophila Notch,
            suggests an important role in early postimplantation mouse
            development
  JOURNAL   Development 115 (3), 737-744 (1992)
   PUBMED   1425352
REFERENCE   10 (residues 1 to 2531)
  AUTHORS   Weinmaster,G., Roberts,V.J. and Lemke,G.
  TITLE     A homolog of Drosophila Notch expressed during mammalian
            development
  JOURNAL   Development 113 (1), 199-205 (1991)
   PUBMED   1764995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY233933.1, BC138441.1 and BF318436.1.
            
            On Mar 13, 2009 this sequence version replaced NP_032740.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138441.1, AK090118.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2531
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.91 cM"
     Protein         1..2531
                     /product="neurogenic locus notch homolog protein 1
                     precursor"
                     /note="neurogenic locus notch homolog protein 1; major
                     type A protein; mT14; p300; Motch A; Notch gene homolog 1"
                     /calculated_mol_wt=268905
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1950
     mat_peptide     19..2531
                     /product="Neurogenic locus notch homolog protein 1.
                     /id=PRO_0000007677"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
                     /calculated_mol_wt=268905
     Site            65
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            73
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            116
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          142..175
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            146
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          178..216
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(178,181,197)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            194
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            232
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine, alternate.
                     /evidence=ECO:0000269|PubMed:28089369; O-linked
                     (GalNAc...) threonine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P46531; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          257..293
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(257,260,274)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          295..332
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(295,298,314)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            311
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          335..370
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(335,338,352)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            341
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            349
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            378
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          412..450
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(412,415,431)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          420..421
                     /region_name="Interaction with DLL4.
                     /evidence=ECO:0000250|UniProtKB:Q07008"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Site            435
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:30127001; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          448..452
                     /region_name="Interaction with DLL4.
                     /evidence=ECO:0000250|UniProtKB:Q07008"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          452..488
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(452,455,469)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            458
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            466
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            469
                     /site_type="other"
                     /note="Interaction with DLL4.
                     /evidence=ECO:0000250|UniProtKB:Q07008; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          490..526
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(490,493,507)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            496
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          528..564
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(528,531,545)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            534
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          566..601
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(566,569,582)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          603..639
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(603,606,620)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            609
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            617
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          641..675
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(641,644,657)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            647
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          678..713
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(678,681,695)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            692
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          717..750
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            722
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          755..789
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            759
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            767
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            784
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          791..827
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(791,794,808)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            797
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            805
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          869..905
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(869,872,886)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            888
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            900
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          907..943
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(907,910,924)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            921
                     /site_type="glycosylation"
                     /note="O-linked (Fuc) serine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          945..981
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(945,948,962)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            951
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            959
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          988..1019
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            997
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1021..1057
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(1021,1024,1038)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1027
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1035
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1065
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          <1067..1094
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          1146..1180
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            1159
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1179
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1184..1219
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            1189
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1197
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1221..1265
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(1221,1224,1246)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1241
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1267..1305
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(1267,1270,1286)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1273
                     /site_type="glycosylation"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:21757702; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1362
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:21757702,
                     ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1379
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc...) threonine.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1402
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine, alternate.
                     /evidence=ECO:0000269|PubMed:28089369; O-linked
                     (GalNAc...) threonine, alternate.
                     /evidence=ECO:0000269|PubMed:28089369; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1442..1479
                     /region_name="NL"
                     /note="Domain found in Notch and Lin-12; smart00004"
                     /db_xref="CDD:197463"
     Region          1449..1489
                     /region_name="LNR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1487..1522
                     /region_name="Notch"
                     /note="LNR domain; pfam00066"
                     /db_xref="CDD:459658"
     Site            1489
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1490..1531
                     /region_name="LNR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1525..1561
                     /region_name="Notch"
                     /note="LNR domain; pfam00066"
                     /db_xref="CDD:459658"
     Region          1532..1571
                     /region_name="LNR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1566..1621
                     /region_name="NOD"
                     /note="NOTCH protein; pfam06816"
                     /db_xref="CDD:462014"
     Site            1587
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1654..1655
                     /site_type="cleavage"
                     /note="Cleavage, by furin-like protease.
                     /evidence=ECO:0000269|PubMed:9653148; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1661..1719
                     /region_name="NODP"
                     /note="NOTCH protein; pfam07684"
                     /db_xref="CDD:462229"
     Region          1710..1789
                     /region_name="JMTM_Notch1"
                     /note="juxtamembrane and transmembrane (JMTM) domain found
                     in neurogenic locus notch homolog protein 1 (Notch1) and
                     similar proteins; cd21702"
                     /db_xref="CDD:411985"
     Site            1710..1711
                     /site_type="cleavage"
                     /note="Cleavage, by ADAM17.
                     /evidence=ECO:0000269|PubMed:10882062,
                     ECO:0000269|PubMed:10882063; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            order(1711..1713,1716..1718,1729..1730,1732,1734..1751)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:411985"
     Region          1718..1750
                     /region_name="Interaction with PSEN1.
                     /evidence=ECO:0000250|UniProtKB:P46531"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1726..1746
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1770..1798
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1851
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Site            order(1870,1872,1876..1877,1880..1882,1897..1898,1902,
                     1905,1915,1917,1919,1923..1924,1927..1929,1931..1932,1936,
                     1939,1948,1950,1952,1956..1957,1960..1962,1964..1965,1969,
                     1972)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          1870..1915
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <1894..2108
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          1917..1948
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1917..1946
                     /region_name="ANK 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1937..1945
                     /region_name="HIF1AN-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Site            1945
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial.
                     /evidence=ECO:0000269|PubMed:17573339,
                     ECO:0000269|PubMed:18299578; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1950..1981
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1950..1980
                     /region_name="ANK 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          1984..2015
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1984..2013
                     /region_name="ANK 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          2004..2012
                     /region_name="HIF1AN-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Site            2012
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial.
                     /evidence=ECO:0000269|PubMed:17573339,
                     ECO:0000269|PubMed:18299578; propagated from
                     UniProtKB/Swiss-Prot (Q01705.3)"
     Region          2017..2081
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          2017..2046
                     /region_name="ANK 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          2050..2079
                     /region_name="ANK 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          2140..2185
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          2183..>2492
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2382..2428
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     Region          2440..2531
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01705.3)"
     CDS             1..2531
                     /gene="Notch1"
                     /gene_synonym="9930111A19Rik; lin-12; Mis6; N1; Tan1"
                     /coded_by="NM_008714.3:265..7860"
                     /db_xref="CCDS:CCDS15806.1"
                     /db_xref="GeneID:18128"
                     /db_xref="MGI:MGI:97363"
ORIGIN      
        1 mprlltpllc ltllpalaar glrcsqpsgt clnggrceva ngteacvcsg afvgqrcqds
       61 npclstpckn agtchvvdhg gtvdyacscp lgfsgplclt pldnaclanp crnggtcdll
      121 tlteykcrcp pgwsgkscqq adpcasnpca nggqclpfes syicrcppgf hgptcrqdvn
      181 ecsqnpglcr hggtchneig syrcacrath tgphcelpyv pcspspcqng gtcrptgdtt
      241 hecaclpgfa gqnceenvdd cpgnnckngg acvdgvntyn crcppewtgq yctedvdecq
      301 lmpnacqngg tchnthggyn cvcvngwtge dcseniddca saacfqgatc hdrvasfyce
      361 cphgrtgllc hlndacisnp cnegsncdtn pvngkaictc psgytgpacs qdvdecalga
      421 npcehagkcl ntlgsfecqc lqgytgprce idvnecisnp cqndatcldq igefqcicmp
      481 gyegvycein tdecasspcl hnghcmdkin efqcqcpkgf nghlcqydvd ecastpckng
      541 akcldgpnty tcvctegytg thcevdidec dpdpchygsc kdgvatftcl cqpgytghhc
      601 etninechsq pcrhggtcqd rdnsylclcl kgttgpncei nlddcasnpc dsgtcldkid
      661 gyecacepgy tgsmcnvnid ecagspchng gtcedgiagf tcrcpegyhd ptclsevnec
      721 nsnpcihgac rdglngykcd capgwsgtnc dinnnecesn pcvnggtckd mtsgyvctcr
      781 egfsgpncqt ninecasnpc lnqgtciddv agykcncplp ytgatcevvl apcatspckn
      841 sgvckesedy esfscvcptg wqgqtcevdi necvkspcrh gascqntngs yrclcqagyt
      901 grncesdidd crpnpchngg sctdgintaf cdclpgfqga fceedineca snpcqnganc
      961 tdcvdsytct cpvgfngihc enntpdctes scfnggtcvd ginsftclcp pgftgsycqy
     1021 dvnecdsrpc lhggtcqdsy gtykctcpqg ytglncqnlv rwcdsapckn ggrcwqtntq
     1081 yhcecrsgwt gvncdvlsvs cevaaqkrgi dvtllcqhgg lcvdegdkhy chcqagytgs
     1141 ycedevdecs pnpcqngatc tdylggfsck cvagyhgsnc seeineclsq pcqnggtcid
     1201 ltnsykcscp rgtqgvhcei nvddchppld pasrspkcfn ngtcvdqvgg ytctcppgfv
     1261 gercegdvne clsnpcdprg tqncvqrvnd fhcecraght grrcesving crgkpckngg
     1321 vcavasntar gficrcpagf egatcendar tcgslrclng gtcisgprsp tclclgsftg
     1381 pecqfpassp cvgsnpcynq gtceptsenp fyrclcpakf ngllchildy sftggagrdi
     1441 pppqieeace lpecqvdagn kvcnlqcnnh acgwdggdcs lnfndpwknc tqslqcwkyf
     1501 sdghcdsqcn sagclfdgfd cqltegqcnp lydqyckdhf sdghcdqgcn saecewdgld
     1561 caehvperla agtlvlvvll ppdqlrnnsf hflrelshvl htnvvfkrda qgqqmifpyy
     1621 gheeelrkhp ikrstvgwat ssllpgtsgg rqrreldpmd irgsivylei dnrqcvqsss
     1681 qcfqsatdva aflgalaslg slnipykiea vksepveppl psqlhlmyva aaafvllffv
     1741 gcgvllsrkr rrqhgqlwfp egfkvseask kkrreplged svglkplkna sdgalmddnq
     1801 newgdedlet kkfrfeepvv lpdlsdqtdh rqwtqqhlda adlrmsamap tppqgevdad
     1861 cmdvnvrgpd gftplmiasc sgggletgns eeeedapavi sdfiyqgasl hnqtdrtget
     1921 alhlaarysr sdaakrllea sadaniqdnm grtplhaavs adaqgvfqil lrnratdlda
     1981 rmhdgttpli laarlavegm ledlinshad vnavddlgks alhwaaavnn vdaavvllkn
     2041 gankdmqnnk eetplflaar egsyetakvl ldhfanrdit dhmdrlprdi aqermhhdiv
     2101 rlldeynlvr spqlhgtalg gtptlsptlc spngylgnlk satqgkkark pstkglacgs
     2161 keakdlkarr kksqdgkgcl ldsssmlspv dslesphgyl sdvasppllp spfqqspsmp
     2221 lshlpgmpdt hlgishlnva akpemaalag gsrlafeppp prlshlpvas sastvlstng
     2281 tgamnftvga paslngqcew lprlqngmvp sqynplrpgv tpgtlstqaa glqhsmmgpl
     2341 hsslstntls piiyqglpnt rlatqphlvq tqqvqpqnlq lqpqnlqpps qphlsvssaa
     2401 nghlgrsfls gepsqadvqp lgpsslpvht ilpqesqalp tslpssmvpp mtttqfltpp
     2461 sqhsyssspv dntpshqlqv pehpfltpsp espdqwssss phsnisdwse gissppttmp
     2521 sqithipeaf k
//
