LOCUS       NM_181547               1820 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus nitric oxide synthase trafficker (Nostrin), mRNA.
ACCESSION   NM_181547
VERSION     NM_181547.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1820)
  AUTHORS   Chakraborty,S. and Ain,R.
  TITLE     Nitric-oxide synthase trafficking inducer is a pleiotropic
            regulator of endothelial cell function and signaling
  JOURNAL   J Biol Chem 292 (16), 6600-6620 (2017)
   PUBMED   28235804
  REMARK    GeneRIF: the SH3 domain of NOSTRIN is involved in the NOSTRIN-TRAF6
            interaction and is required for NOSTRIN-induced down-regulation of
            endothelial cell proteins
REFERENCE   2  (bases 1 to 1820)
  AUTHORS   Kovacevic,I., Muller,M., Kojonazarov,B., Ehrke,A.,
            Randriamboavonjy,V., Kohlstedt,K., Hindemith,T., Schermuly,R.T.,
            Fleming,I., Hoffmeister,M. and Oess,S.
  TITLE     The F-BAR Protein NOSTRIN Dictates the Localization of the
            Muscarinic M3 Receptor and Regulates Cardiovascular Function
  JOURNAL   Circ Res 117 (5), 460-469 (2015)
   PUBMED   26169369
  REMARK    GeneRIF: NOSTRIN is crucial for the localization and function of
            the muscarinic M3 receptor at the plasma membrane in the aorta.
REFERENCE   3  (bases 1 to 1820)
  AUTHORS   Bae,S.H., Choi,Y.J., Kim,K.H. and Park,S.S.
  TITLE     Identification of the cis-element and bZIP DNA binding motifs for
            the autogenous negative control of mouse NOSTRIN
  JOURNAL   Biochem Biophys Res Commun 443 (3), 924-931 (2014)
   PUBMED   24361894
  REMARK    GeneRIF: mouse NOSTRIN acts as a transcriptional repressor by
            binding to the cis-element through its bZIP motif.
REFERENCE   4  (bases 1 to 1820)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   5  (bases 1 to 1820)
  AUTHORS   Kovacevic,I., Hu,J., Siehoff-Icking,A., Opitz,N., Griffin,A.,
            Perkins,A.C., Munn,A.L., Muller-Esterl,W., Popp,R., Fleming,I.,
            Jungblut,B., Hoffmeister,M. and Oess,S.
  TITLE     The F-BAR protein NOSTRIN participates in FGF signal transduction
            and vascular development
  JOURNAL   EMBO J 31 (15), 3309-3322 (2012)
   PUBMED   22751148
  REMARK    GeneRIF: NOSTRIN participates in FGF signal transduction and
            vascular development.
REFERENCE   6  (bases 1 to 1820)
  AUTHORS   McCormick,M.E., Goel,R., Fulton,D., Oess,S., Newman,D. and Tzima,E.
  TITLE     Platelet-endothelial cell adhesion molecule-1 regulates endothelial
            NO synthase activity and localization through signal transducers
            and activators of transcription 3-dependent NOSTRIN expression
  JOURNAL   Arterioscler Thromb Vasc Biol 31 (3), 643-649 (2011)
   PUBMED   21183735
  REMARK    GeneRIF: Results reveal an elegant mechanism of eNOS regulation by
            PECAM-1 through signal transducers and activators of transcription
            3-mediated transcriptional control of NOSTRIN.
REFERENCE   7  (bases 1 to 1820)
  AUTHORS   Kim,H.W., Choi,Y.J., Kim,J.A., Bae,S.H., Kim,K.R. and Park,S.S.
  TITLE     Mouse disabled 2 interacting protein 2 functions as a
            transcriptional repressor through direct binding onto its own
            promoter
  JOURNAL   Biochem Biophys Res Commun 337 (1), 75-81 (2005)
   PUBMED   16171775
  REMARK    GeneRIF: The disabled 2 interacting protein 2 represses the
            expression of its own gene, via a feedback mechanism which involves
            binding to the promoter region.
REFERENCE   8  (bases 1 to 1820)
  AUTHORS   Choi,Y.J., Cho,S.Y., Kim,H.W., Kim,J.A., Bae,S.H. and Park,S.S.
  TITLE     Cloning and characterization of mouse disabled 2 interacting
            protein 2, a mouse orthologue of human NOSTRIN
  JOURNAL   Biochem Biophys Res Commun 326 (3), 594-599 (2005)
   PUBMED   15596140
  REMARK    GeneRIF: shares 82% identity with human NOSTRIN; functions in a
            different fashion from NOSTRIN and its function may be concerted
            with that of disabled 2(disabled 2 interacting protein 2)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY061165.1 and BC069942.1.
            
            On Mar 17, 2009 this sequence version replaced NM_181547.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069942.1, AY280963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY061165.1         1-23
            24-1820             BC069942.1         1-1797
FEATURES             Location/Qualifiers
     source          1..1820
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 39.58 cM"
     gene            1..1820
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /note="nitric oxide synthase trafficker"
                     /db_xref="GeneID:329416"
                     /db_xref="MGI:MGI:3606242"
     exon            1..117
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1611
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /note="Dab2-interacting protein 2; probable ortholog of
                     human nitric oxide synthase trafficker (NOSTRIN); disabled
                     homolog 2-interacting protein 2; eNOS-trafficking inducer"
                     /codon_start=1
                     /product="nostrin"
                     /protein_id="NP_853525.3"
                     /db_xref="CCDS:CCDS16087.1"
                     /db_xref="GeneID:329416"
                     /db_xref="MGI:MGI:3606242"
                     /translation="MRDPLTDCSYNKVYKSLKEFAQHGDNFCKQITSVLQQRANLEIS
                     YAKGLQKLAVRLSKALQSTKKNCLSTAWAWASESMKSAADLHQKLGKAIELEAIKPTH
                     QVLSMQEKKRKSLDNEVEKTANLVINNWNQQIKAKKKLMMSTKKHEALFHLVESSKQS
                     LTQKEKQKLLNKLKKSTEKLEKEDESYYQKNMAGYSTRLKWESTLENCYKSMLELEKE
                     RIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKVDVEKDIQALMEETAILSIENK
                     SELLLADYFEEDPKNPMDKERRKSLLKPKLGRLQRDIEKASRDKEGLERKLKALASSS
                     SFSDAKSQKDMETLMDENSLKLDLLQANSYKLSSVLADLEQRPKPCHPCSTCIFKWKE
                     KEHSHTYVKISRPLLTKRLEKAESKAPAGGQNNPSSSPSGSTVSQASKHLCKALYTFQ
                     ARQDDELNLEKGDIVTVHEKKEEGWWFGSLKGKRGHFPAAYVEELPPKAGNTATQA"
     exon            118..203
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            204..287
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..350
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..432
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..495
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..594
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..720
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..819
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..945
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1054
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1143
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1269
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1384
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1474
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1808
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /note="hexamer: AATAAA"
     polyA_site      1804
                     /gene="Nostrin"
                     /gene_synonym="Daip2; mDaIP2"
                     /note="major polyA site"
ORIGIN      
        1 gaagtccaga acacacccaa cctgattgat tgcagcgtcc agcatgctgg atcgagcgta
       61 ggtaaaagaa aaagcagaca gcatttcaac atgagggacc cactgacgga ctgttcgtac
      121 aataaagtat acaagagcct gaaagagttt gcccaacatg gagacaattt ctgcaagcag
      181 atcacatctg ttcttcagca aagggccaac ctggagatta gctacgccaa agggcttcag
      241 aaactggccg tcaggctcag caaagcacta cagagcacaa agaaaaactg tctcagcact
      301 gcttgggcct gggcctcaga gagcatgaag tctgcagcag acctccatca aaaacttggc
      361 aaagcaattg agttggaagc gataaagcca acacaccagg tcctgagtat gcaagagaag
      421 aagagaaagt cgcttgataa tgaagtggaa aagacagcaa atcttgttat taataactgg
      481 aatcagcaaa tcaaggctaa gaaaaaatta atgatgagta ccaagaagca tgaagcactt
      541 ttccaccttg tagaaagctc caagcaatcc ctgacccaga aggagaagca gaagctcctc
      601 aacaaactga aaaaatcaac tgaaaaactg gaaaaagaag atgaaagtta ctaccaaaaa
      661 aacatggcag gctattctac caggctgaag tgggaaagca ccctggaaaa ctgctacaag
      721 agcatgctgg agctggagaa ggaaagaatt caacttttat gcaataactt aaaccagtac
      781 agccaacata tttctctttt tggacaaacg ctgaccacat gccacacaca gatccactgt
      841 gccatcagca aggttgatgt tgaaaaagat atccaggctc taatggaaga aactgcaatc
      901 ctgtctatag aaaacaaatc ggagcttctc ctggctgact attttgaaga agatccaaag
      961 aacccaatgg acaaagagcg acggaagtct ttattaaaac ccaaattggg gagactgcaa
     1021 agagacattg aaaaggcctc aagagacaaa gaaggcttgg agcggaagct taaagcactc
     1081 gccagcagct cctccttttc tgatgccaag agccagaaag acatggagac cctaatggat
     1141 gagaacagtt tgaaactaga ccttttgcaa gcgaactcct acaaactgtc gtcagtgttg
     1201 gcagacctgg agcaacggcc aaagccctgc catccctgta gcacctgcat tttcaagtgg
     1261 aaagaaaagg agcactctca tacttatgtg aaaatatccc ggcctctttt gacgaagaga
     1321 ttagagaaag ctgagagcaa agcacctgcg ggtgggcaga acaatccaag ctcttcacct
     1381 tcaggctcta ctgtgtccca agccagcaag catctttgca aagccttata tacgttccaa
     1441 gccaggcaag atgatgagtt gaatttggaa aaaggagaca tcgtgaccgt ccatgagaag
     1501 aaagaagaag gatggtggtt cggctcttta aaagggaaga gaggccattt tcctgctgcc
     1561 tatgtggagg agctacctcc aaaggctgga aacacagcta cacaggcata aaacaagaat
     1621 ggatggacac acagaatggc ctttgcacat tctgtaaaca atgtgatgca aaaaagggaa
     1681 gttatcctct ttgcagattt ttcttatgca gtgggtggta gaggcctgcc tgcatttcac
     1741 agtgctctgt acatgggtta ttaacttcaa acagttaaat aaaagacagt tgggttgaat
     1801 gagacaaaaa aaaaaaaaaa
//
