LOCUS       NM_008713               4140 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus nitric oxide synthase 3, endothelial cell (Nos3),
            mRNA.
ACCESSION   NM_008713
VERSION     NM_008713.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4140)
  AUTHORS   Jang,J., Bentsen,M., Kim,Y.J., Kim,E., Garg,V., Cai,C.L., Looso,M.
            and Li,D.
  TITLE     Endocardial HDAC3 is required for myocardial trabeculation
  JOURNAL   Nat Commun 15 (1), 4166 (2024)
   PUBMED   38755146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4140)
  AUTHORS   Wang,H.Y., Takagi,H., Stoney,P.N., Echeverria,A., Kuhn,B., Hsu,K.S.
            and Takahashi,T.
  TITLE     Anoxia-induced hippocampal LTP is regeneratively produced by
            glutamate and nitric oxide from the neuro-glial-endothelial axis
  JOURNAL   iScience 27 (4), 109515 (2024)
   PUBMED   38591010
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4140)
  AUTHORS   Hu,Q., Qu,W., Zhang,T., Feng,J., Dong,X., Nie,R., Chen,J., Wang,X.,
            Peng,C. and Ke,X.
  TITLE     C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel
            Vasculoprotective Cytokine That Restores High Glucose-Suppressed
            Endothelial Progenitor Cell Functions by Activating the Endothelial
            Nitric Oxide Synthase
  JOURNAL   J Am Heart Assoc 13 (4), e030054 (2024)
   PUBMED   38348774
  REMARK    GeneRIF: C1q/Tumor Necrosis Factor-Related Protein-9 Is a Novel
            Vasculoprotective Cytokine That Restores High Glucose-Suppressed
            Endothelial Progenitor Cell Functions by Activating the Endothelial
            Nitric Oxide Synthase.
REFERENCE   5  (bases 1 to 4140)
  AUTHORS   Smeir,M., Chumala,P., Katselis,G.S. and Liu,L.
  TITLE     Lymphocyte-Specific Protein 1 Regulates Expression and Stability of
            Endothelial Nitric Oxide Synthase
  JOURNAL   Biomolecules 14 (1), 111 (2024)
   PUBMED   38254711
  REMARK    GeneRIF: Lymphocyte-Specific Protein 1 Regulates Expression and
            Stability of Endothelial Nitric Oxide Synthase.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4140)
  AUTHORS   Laubach,V.E., Shesely,E.G., Smithies,O. and Sherman,P.A.
  TITLE     Mice lacking inducible nitric oxide synthase are not resistant to
            lipopolysaccharide-induced death
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10688-10692 (1995)
   PUBMED   7479866
REFERENCE   7  (bases 1 to 4140)
  AUTHORS   Hubner,N., Kreutz,R., Rubattu,S., Lee,Y.A., Ganten,D., Allen,P.D.
            and Lindpaintner,K.
  TITLE     The gene encoding endothelial nitric oxide synthase, Nos3, maps to
            rat chromosome 4
  JOURNAL   Mamm Genome 6 (10), 758-759 (1995)
   PUBMED   8563182
REFERENCE   8  (bases 1 to 4140)
  AUTHORS   Huang,P.L., Huang,Z., Mashimo,H., Bloch,K.D., Moskowitz,M.A.,
            Bevan,J.A. and Fishman,M.C.
  TITLE     Hypertension in mice lacking the gene for endothelial nitric oxide
            synthase
  JOURNAL   Nature 377 (6546), 239-242 (1995)
   PUBMED   7545787
REFERENCE   9  (bases 1 to 4140)
  AUTHORS   Gregg,A.R., Lee,C.G., Herman,G.E. and O'Brien,W.E.
  TITLE     Endothelial nitric oxide synthase (Nos3) maps to the proximal
            region of mouse chromosome 5
  JOURNAL   Mamm Genome 6 (2), 152 (1995)
   PUBMED   7539311
REFERENCE   10 (bases 1 to 4140)
  AUTHORS   O'Dell,T.J., Huang,P.L., Dawson,T.M., Dinerman,J.L., Snyder,S.H.,
            Kandel,E.R. and Fishman,M.C.
  TITLE     Endothelial NOS and the blockade of LTP by NOS inhibitors in mice
            lacking neuronal NOS
  JOURNAL   Science 265 (5171), 542-546 (1994)
   PUBMED   7518615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077896.1, U53142.1 and AW489695.1.
            
            On Nov 27, 2007 this sequence version replaced NM_008713.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077896.1, BC052636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1518              AK077896.1         3-1520
            1519-1953           U53142.1           1507-1941
            1954-3789           AK077896.1         1956-3791
            3790-4106           AW489695.1         36-352              c
            4107-4140           AW489695.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..4140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.32 cM"
     gene            1..4140
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /note="nitric oxide synthase 3, endothelial cell"
                     /db_xref="GeneID:18127"
                     /db_xref="MGI:MGI:97362"
     exon            1..183
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..3628
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /EC_number="1.14.13.39"
                     /note="nitric oxide synthase, endothelial; endothelial
                     nitric oxide synthase; cNOS; EC-NOS; NOSIII; NOS type III;
                     endothelial NOS; constitutive NOS"
                     /codon_start=1
                     /product="nitric oxide synthase 3"
                     /protein_id="NP_032739.3"
                     /db_xref="CCDS:CCDS19117.1"
                     /db_xref="GeneID:18127"
                     /db_xref="MGI:MGI:97362"
                     /translation="MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPAP
                     PSPTRPAPDHSPPLTRPPDGPRFPRVKNWEVGSITYDTLSAQAQQDGPCTSRRCLGSL
                     VFPRKLQSRPTQGPSPTEQLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVAATG
                     TYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYAT
                     NRGNLRSAITVFPQRCPGRGDFRIWNSQLIRYAGYRQQDGSVRGDPANVEITELCIQH
                     GWTPGNGRFDVLPLLLQAPDEPPELFTLPPEMVLEVPLEHPTLEWFAALGLRWYALPA
                     VSNMLLEIGGLEFPAAPFSGWYMSSEIGMRDLCDPHRYNILEDVAVCMDLDTRTTSSL
                     WKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPP
                     ISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGAGITRKKTFKEVANAVKISASL
                     MGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALV
                     LVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSS
                     WRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLG
                     QGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSTQA
                     ESLQLLPGLTHVHRRKMFQATILSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHI
                     GVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQ
                     ALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYEEWKWFSCPTLLEVL
                     EQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTIAVLAYRTQDGLGPLHY
                     GVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQDRLHD
                     IEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDPGSPKTYVQ
                     DLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGGMELDEAGDVIG
                     VLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPGPEIPGS"
     exon            184..286
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            287..435
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..598
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            599..690
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..832
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..972
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1147
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1249
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1444
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1518
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1663
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1768
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1836
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1953
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2128
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2261
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2340
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2528
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2701
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2912
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3000
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3122
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3271
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3466
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..4123
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3948..3953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /note="hexamer: CATAAA"
     polyA_site      3979
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /note="major polyA site"
     polyA_site      4034
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
     regulatory      4046..4051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
                     /note="hexamer: AATAAT"
     polyA_site      4064
                     /gene="Nos3"
                     /gene_synonym="2310065A03Rik; ecNOS; eNOS; Nos-3"
ORIGIN      
        1 agagttgagg tcagctggca tgggcaactt gaagagtgtg ggccaggagc ctgggccacc
       61 ctgtggccta gggctcgggc tgggtttagg gctgtgcggc aagcagggcc cagcctctcc
      121 agcaccggag cctagccagg cgccagcacc cccgtcccca acccgaccag caccagacca
      181 cagccccccg ctaacccggc ccccagacgg acccaggttt cctcgagtaa agaattggga
      241 agtgggcagc atcacctacg acaccctcag tgcccaggct cagcaggatg ggccctgtac
      301 ctcaagacgc tgcttgggat ccctggtgtt tccaaggaag ttacagagcc ggcccaccca
      361 gggcccttca cccactgagc agctattggg tcaagcccgg gacttcatca atcagtacta
      421 taactccatc aaaaggagtg gctcccaggc tcatgagcag cggcttcagg aagtggaggc
      481 tgaggtggca gccacaggca cctaccagct ccgggagagc gagctggtgt ttggggccaa
      541 gcaggcctgg cgcaatgctc cccgctgtgt gggccggatc cagtggggaa agctgcaggt
      601 atttgatgct cgggactgca ggactgcaca ggaaatgttc acctacatct gtaaccacat
      661 taaatacgca acaaatagag gcaatcttcg ttcagccatc acagtgttcc cccagcgctg
      721 ccctggccgg ggagacttcc ggatctggaa cagccagctg atacgctatg cgggctatag
      781 gcagcaggat ggctccgtgc gaggggaccc cgccaacgtg gagatcactg agctctgtat
      841 ccaacatggc tggaccccag gaaatggccg ctttgatgtg ctgcccctgt tactccaggc
      901 tcctgatgag cccccagaac tcttcactct gcccccagag atggtcctcg aggtgcctct
      961 ggagcacccc acgctcgagt ggtttgctgc ccttggcctg cgctggtatg ccctcccagc
     1021 tgtgtccaac atgctgctag aaatcggggg cctggagttt cctgctgccc ctttcagcgg
     1081 ctggtacatg agttcagaga ttggcatgag ggacctgtgt gaccctcacc gctacaacat
     1141 acttgaggat gtggctgtgt gcatggatct ggacaccagg acaacctcat ccctgtggaa
     1201 agacaaggca gcggtggaaa ttaatgtggc cgtgttgcac agttaccagc tggccaaagt
     1261 gaccatagtg gaccaccacg ccgccacagc ctccttcatg aagcacctgg aaaatgagca
     1321 gaaggccaga gggggctgcc ctgccgattg ggcctggatt gtgcccccca tctcaggcag
     1381 cctaactcct gtcttccatc aagagatggt caactatttc ctgtcccctg ccttccgcta
     1441 ccagccagac ccctggaagg gaagtgcagc aaagggggca ggcatcacca ggaagaagac
     1501 ctttaaggaa gtagccaatg cagtgaagat ctctgcctca ctcatgggca cggtgatggc
     1561 gaagcgtgtg aaggcaacca ttctgtatgg ctctgagact ggccgggccc agagctacgc
     1621 acagcagctg ggaagactct tccggaaggc gtttgatccc cgggtcctgt gcatggatga
     1681 gtatgatgtg gtgtccctag agcacgaggc actggtgttg gtggtgacca gcacatttgg
     1741 caatggggat cctccggaga atggagagag ctttgcagca gcgctcatgg aaatgtcagg
     1801 cccgtacaac agctccccta ggcctgagca gcacaagagc tacaaaatcc gattcaacag
     1861 tgtctcctgc tcagacccac tggtatcctc ttggcggcgc aagaggaagg agtctagcaa
     1921 cacagacagt gcaggagccc tgggcaccct caggttctgt gtgtttgggc tgggctcccg
     1981 agcatacccc cacttctgtg cctttgctcg agcggtggac acaaggctgg aggagctggg
     2041 cggggagcga ctactgcagc tgggccaagg tgatgagctc tgtggccagg aggaggcttt
     2101 ccgaggctgg gcccaggccg ccttccaggc tgcctgtgaa accttctgtg tgggagaaga
     2161 tgccaaagct gctgcccgag atatcttcag ccccaaacgc agctggaagc gccagaggta
     2221 ccggctgagt acccaggctg agagcctgca attactacca gggctgactc acgtgcacag
     2281 gcggaagatg ttccaggcta caatcctctc tgtggaaaac ctacagagca gcaaatccac
     2341 ccgagccacg atcctggtgc gtctggacac cggaggccag gagggactgc agtaccagcc
     2401 aggggaccac ataggtgtgt gcccacccaa ccgtcctggc ctagtggagg cactgctgag
     2461 ccgagtggag gaccctccgc catccacaga acctgtggct gtggaacaac tggagaaagg
     2521 cagccctggt ggccctcccc ccggctgggt acgggacccc cggctacccc catgtacgct
     2581 gcggcaggct ctcacctact tcctggacat cacttccccg cctagtcctc gcctccttcg
     2641 actgctcagc accctggcag aagagtccag cgaacagcag gagctagagg ctctcagcca
     2701 ggacccccgg cgctacgaag aatggaagtg gttcagctgc cccacactgc tagaggtgct
     2761 ggagcaattt ccttcagtgg cactgcctgc cccgctgatc ctcacccagc tgcccttgct
     2821 ccagccccgg tactactctg tcagttcagc acccagcgcc cacccaggag agatccacct
     2881 caccatagct gtgctggctt acagaaccca ggatgggctg ggccctctgc actacggtgt
     2941 ctgctccacg tggatgagcc agctcaaggc gggagatcca gtgccctgct tcatcagggg
     3001 ggctccctcc ttccggctgc cacctgatcc taacttgccc tgcatcctgg tgggcccagg
     3061 gactggcatt gcacccttcc ggggattctg gcaagacaga ctacacgaca ttgagatcaa
     3121 agggctacaa cctgccccca tgactttggt gtttggctgc cgatgctccc aactggacca
     3181 tctctaccgg gacgaggtac tggacgccca gcagcgtggg gtgtttggac aagtcctcac
     3241 cgccttttcc agggatcctg gcagccccaa gacctacgtg caagacctcc tgaggacaga
     3301 gctagccgcg gaggttcacc gtgtgctgtg ccttgagcaa ggacatatgt ttgtctgcgg
     3361 cgatgtcact atggcaacca gcgtcctgca aaccgtgcag agaattctgg caacagaggg
     3421 cggcatggag ctggatgaag ccggtgacgt catcggcgtg ctgcgggatc agcaacgcta
     3481 ccacgaggac attttcggac tcacattgcg cacccaggag gtgacaagcc gcatacgcac
     3541 ccagagcttt tctttgcagg agcgacagct gaggggcgca gtgccctggt cctttgaccc
     3601 gcctggccca gaaatacctg gttcctgaca gtcttcctcc cctccagttc ccggaaagag
     3661 ggattgtgtc acttcgttcg gttgaccaag gctagccacc ctctctgaag aatgcctaca
     3721 gcattggttg caaggctgcc aatttaagat ctttcttctc tctccagttt acctaggctg
     3781 gggggggggg gtcggcctaa atcttgaagg ttcctccggc tgtggtagtt agggcatcct
     3841 gctgccctct tcatatgctt tgatggactg tagactccct ttaactctct ctctggagta
     3901 tcttacgttt aaagtctaag tcatcccggt atttattgaa aaattatcat aaaagaccat
     3961 gccagatgcc caacccaaac cttgtgagtt acaatgattg aaaatgagac ttgttcaatg
     4021 ctttaatgtg taaagatgtt gggataataa ttctttgaca gtgagtccca gacacctctc
     4081 tgtaacccag tactctgcaa aaaaaaaaaa gtttctaacc aggaaaaaaa aaaaaaaaaa
//
