LOCUS       NM_010927               4164 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus nitric oxide synthase 2, inducible (Nos2), transcript
            variant 1, mRNA.
ACCESSION   NM_010927 XM_001001508
VERSION     NM_010927.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4164)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4164)
  AUTHORS   Kohler,I., Bivik Eding,C., Kasic,N.K., Verma,D. and Enerback,C.
  TITLE     NOS2-derived low levels of NO drive psoriasis pathogenesis
  JOURNAL   Cell Death Dis 15 (6), 449 (2024)
   PUBMED   38926337
  REMARK    GeneRIF: NOS2-derived low levels of NO drive psoriasis
            pathogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4164)
  AUTHORS   van Elsas,M.J., Middelburg,J., Labrie,C., Roelands,J., Schaap,G.,
            Sluijter,M., Tonea,R., Ovcinnikovs,V., Lloyd,K., Schuurman,J.,
            Riesenfeld,S.J., Gajewski,T.F., de Miranda,N.F.C.C., van Hall,T.
            and van der Burg,S.H.
  TITLE     Immunotherapy-activated T cells recruit and skew late-stage
            activated M1-like macrophages that are critical for therapeutic
            efficacy
  JOURNAL   Cancer Cell 42 (6), 1032-1050 (2024)
   PUBMED   38759656
REFERENCE   5  (bases 1 to 4164)
  AUTHORS   Lin,M., Xian,H., Chen,Z., Wang,S., Liu,M., Liang,W., Tang,Q.,
            Liu,Y., Huang,W., Che,D., Guo,C., Idiiatullina,E., Fang,R.,
            Al-Azab,M., Chang,J., Wang,R., Li,X., Zuo,X., Zhang,Y., Zhao,J.,
            Tang,Y., Jin,S., He,Z., Feng,D., Lu,L., Zhang,K., Wu,Y., Bai,F.,
            Lew,A.M., Cui,J., Wu,Y., Gu,X. and Zhang,Y.
  TITLE     MCM8-mediated mitophagy protects vascular health in response to
            nitric oxide signaling in a mouse model of Kawasaki disease
  JOURNAL   Nat Cardiovasc Res 2 (8), 778-792 (2023)
   PUBMED   39195969
REFERENCE   6  (bases 1 to 4164)
  AUTHORS   Stuehr,D.J. and Ikeda-Saito,M.
  TITLE     Spectral characterization of brain and macrophage nitric oxide
            synthases. Cytochrome P-450-like hemeproteins that contain a flavin
            semiquinone radical
  JOURNAL   J Biol Chem 267 (29), 20547-20550 (1992)
   PUBMED   1383204
REFERENCE   7  (bases 1 to 4164)
  AUTHORS   Lowenstein,C.J., Glatt,C.S., Bredt,D.S. and Snyder,S.H.
  TITLE     Cloned and expressed macrophage nitric oxide synthase contrasts
            with the brain enzyme
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6711-6715 (1992)
   PUBMED   1379716
REFERENCE   8  (bases 1 to 4164)
  AUTHORS   Xie,Q.W., Cho,H.J., Calaycay,J., Mumford,R.A., Swiderek,K.M.,
            Lee,T.D., Ding,A., Troso,T. and Nathan,C.
  TITLE     Cloning and characterization of inducible nitric oxide synthase
            from mouse macrophages
  JOURNAL   Science 256 (5054), 225-228 (1992)
   PUBMED   1373522
REFERENCE   9  (bases 1 to 4164)
  AUTHORS   Lyons,C.R., Orloff,G.J. and Cunningham,J.M.
  TITLE     Molecular cloning and functional expression of an inducible nitric
            oxide synthase from a murine macrophage cell line
  JOURNAL   J Biol Chem 267 (9), 6370-6374 (1992)
   PUBMED   1372907
REFERENCE   10 (bases 1 to 4164)
  AUTHORS   Liew,F.Y., Li,Y., Moss,D., Parkinson,C., Rogers,M.V. and Moncada,S.
  TITLE     Resistance to Leishmania major infection correlates with the
            induction of nitric oxide synthase in murine macrophages
  JOURNAL   Eur J Immunol 21 (12), 3009-3014 (1991)
   PUBMED   1721024
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M87039.1 and AL592185.35.
            
            On Sep 11, 2015 this sequence version replaced NM_010927.3.
            
            Summary: Nitric oxide is a reactive free radical which acts as a
            biologic mediator in several processes, including neurotransmission
            and antimicrobial and antitumoral activities. This gene encodes a
            nitric oxide synthase that is inducible by a combination of
            lipopolysaccharide and certain cytokines. Three transcript variants
            encoding two different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M87039.1, M84373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3690              M87039.1           1-3690
            3691-4164           AL592185.35        168393-168866
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..4164
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /note="nitric oxide synthase 2, inducible"
                     /db_xref="GeneID:18126"
                     /db_xref="MGI:MGI:97361"
     exon            1..209
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            210..365
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..3690
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /EC_number="1.14.13.39"
                     /note="isoform a is encoded by transcript variant 1;
                     nitric oxide synthase, inducible; inducible nitric oxide
                     synthase; NOS type II; inducible NOS; macrophage NOS;
                     inducible NO synthase; peptidyl-cysteine S-nitrosylase
                     NOS2; nitric oxide synthase 2, inducible, macrophage"
                     /codon_start=1
                     /product="nitric oxide synthase, inducible isoform a"
                     /protein_id="NP_035057.1"
                     /db_xref="CCDS:CCDS25115.1"
                     /db_xref="GeneID:18126"
                     /db_xref="MGI:MGI:97361"
                     /translation="MACPWKFLFKVKSYQSDLKEEKDINNNVKKTPCAVLSPTIQDDP
                     KSHQNGSPQLLTGTAQNVPESLDKLHVTSTRPQYVRIKNWGSGEILHDTLHHKATSDF
                     TCKSKSCLGSIMNPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARL
                     EAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMF
                     QHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAA
                     TLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQ
                     ELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRR
                     MGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGG
                     CPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQNEKLRPRRREIR
                     FRVLVKVVFFASMLMRKVMASRVRATVLFATETGKSEALARDLATLFSYAFNTKVVCM
                     DQYKASTLEEEQLLLVVTSTFGNGDCPSNGQTLKKSLFMLRELNHTFRYAVFGLGSSM
                     YPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFDVRS
                     KHHIQIPKRFTSNATWEPQQYRLIQSPEPLDLNRALSSIHAKNVFTMRLKSQQNLQSE
                     KSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERVVDCPTPHQTVCLE
                     VLDESGSYWVKDKRLPPCSLSQALTYFLDITTPPTQLQLHKLARFATDETDRQRLEAL
                     CQPSEYNDWKFSNNPTFLEVLEEFPSLHVPAAFLLSQLPILKPRYYSISSSQDHTPSE
                     VHLTVAVVTYRTRDGQGPLHHGVCSTWIRNLKPQDPVPCFVRSVSGFQLPEDPSQPCI
                     LIGPGTGIAPFRSFWQQRLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQEEMQEMVRKR
                     VLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLHGEQGHLYICGDVRMARDVATT
                     LKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGSALEEPKATRL"
     exon            366..435
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            436..555
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            556..704
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            705..867
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            868..959
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1101
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1241
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1416
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1518
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1713
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1796
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1941
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2046
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2096
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2271
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2404
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2483
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2665
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2829
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3037
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3125
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3247
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3396
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3591
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..4164
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /note="hexamer: AATACA"
     polyA_site      4164
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /note="major polyA site"
ORIGIN      
        1 ctggaggggt ataaatacct gatggctgct gccagggtca caactttaca gggagttgaa
       61 gactgagact ctggccccac gggacacagt gtcactggtt tgaaacttct cagccacctt
      121 ggtgaaggga ctgagctgtt agagacactt ctgaggctcc tcacgcttgg gtcttgttca
      181 ctccacggag tagcctagtc aactgcaaga gaacggagaa cgttggattt ggagcagaag
      241 tgcaaagtct cagacatggc ttgcccctgg aagtttctct tcaaagtcaa atcctaccaa
      301 agtgacctga aagaggaaaa ggacattaac aacaacgtga agaaaacccc ttgtgctgtt
      361 ctcagcccaa caatacaaga tgaccctaag agtcaccaaa atggctcccc gcagctcctc
      421 actgggacag cacagaatgt tccagaatcc ctggacaagc tgcatgtgac atcgacccgt
      481 ccacagtatg tgaggatcaa aaactggggc agtggagaga ttttgcatga cactcttcac
      541 cacaaggcca catcggattt cacttgcaag tccaagtctt gcttggggtc catcatgaac
      601 cccaagagtt tgaccagagg acccagagac aagcctaccc ctctggagga gctcctgcct
      661 catgccattg agttcatcaa ccagtattat ggctccttta aagaggcaaa aatagaggaa
      721 catctggcca ggctggaagc tgtaacaaag gaaatagaaa caacaggaac ctaccagctc
      781 actctggatg agctcatctt tgccaccaag atggcctgga ggaatgcccc tcgctgcatc
      841 ggcaggatcc agtggtccaa cctgcaggtc tttgacgctc ggaactgtag cacagcacag
      901 gaaatgtttc agcacatctg cagacacata ctttatgcca ccaacaatgg caacatcagg
      961 tcggccatca ctgtgttccc ccagcggagt gacggcaaac atgacttcag gctctggaat
     1021 tcacagctca tccggtacgc tggctaccag atgcccgatg gcaccatcag aggggatgct
     1081 gccaccttgg agttcaccca gttgtgcatc gacctaggct ggaagccccg ctatggccgc
     1141 tttgatgtgc tgcctctggt cttgcaagct gatggtcaag atccagaggt ctttgaaatc
     1201 cctcctgatc ttgtgttgga ggtgaccatg gagcatccca agtacgagtg gttccaggag
     1261 ctcgggttga agtggtatgc actgcctgcc gtggccaaca tgctactgga ggtgggtggc
     1321 ctcgaattcc cagcctgccc cttcaatggt tggtacatgg gcaccgagat tggagttcga
     1381 gacttctgtg acacacagcg ctacaacatc ctggaggaag tgggccgaag gatgggcctg
     1441 gagacccaca cactggcctc cctctggaaa gaccgggctg tcacggagat caatgtggct
     1501 gtgctccata gtttccagaa gcagaatgtg accatcatgg accaccacac agcctcagag
     1561 tccttcatga agcacatgca gaatgagtac cgggcccgtg gaggctgccc ggcagactgg
     1621 atttggctgg tccctccagt gtctgggagc atcacccctg tgttccacca ggagatgttg
     1681 aactatgtcc tatctccatt ctactactac cagatcgagc cctggaagac ccacatctgg
     1741 cagaatgaga agctgaggcc caggaggaga gagatccgat ttagagtctt ggtgaaagtg
     1801 gtgttctttg cttccatgct aatgcgaaag gtcatggctt cacgggtcag agccacagtc
     1861 ctctttgcta ctgagacagg gaagtctgaa gcactagcca gggacctggc caccttgttc
     1921 agctacgcct tcaacaccaa ggttgtctgc atggaccagt ataaggcaag caccttggaa
     1981 gaggagcaac tactgctggt ggtgacaagc acatttggga atggagactg tcccagcaat
     2041 gggcagactc tgaagaaatc tctgttcatg cttagagaac tcaaccacac cttcaggtat
     2101 gctgtgtttg gccttggctc cagcatgtac cctcagttct gcgcctttgc tcatgacatc
     2161 gaccagaagc tgtcccacct gggagcctct cagcttgccc caacaggaga aggggacgaa
     2221 ctcagtgggc aggaggatgc cttccgcagc tgggctgtac aaaccttccg ggcagcctgt
     2281 gagacctttg atgtccgaag caaacatcac attcagatcc cgaaacgctt cacttccaat
     2341 gcaacatggg agccacagca atataggctc atccagagcc cggagccttt agacctcaac
     2401 agagccctca gcagcatcca tgcaaagaac gtgtttacca tgaggctgaa atcccagcag
     2461 aatctgcaga gtgaaaagtc cagccgcacc accctcctcg ttcagctcac cttcgagggc
     2521 agccgagggc ccagctacct gcctggggaa cacctgggga tcttcccagg caaccagacc
     2581 gccctggtgc agggaatctt ggagcgagtt gtggattgtc ctacaccaca ccaaactgtg
     2641 tgcctggagg ttctggatga gagcggcagc tactgggtca aagacaagag gctgcccccc
     2701 tgctcactca gccaagccct cacctacttc ctggacatta cgacccctcc cacccagctg
     2761 cagctccaca agctggctcg ctttgccacg gacgagacgg ataggcagag attggaggcc
     2821 ttgtgtcagc cctcagagta caatgactgg aagttcagca acaaccccac gttcctggag
     2881 gtgcttgaag agttcccttc cttgcatgtg cccgctgcct tcctgctgtc gcagctccct
     2941 atcttgaagc cccgctacta ctccatcagc tcctcccagg accacacccc ctcggaggtt
     3001 cacctcactg tggccgtggt cacctaccgc acccgagatg gtcagggtcc cctgcaccat
     3061 ggtgtctgca gcacttggat caggaacctg aagccccagg acccagtgcc ctgctttgtg
     3121 cgaagtgtca gtggcttcca gctccctgag gacccctccc agccttgcat cctcattggg
     3181 cctggtacgg gcattgctcc cttccgaagt ttctggcagc agcggctcca tgactcccag
     3241 cacaaagggc tcaaaggagg ccgcatgagc ttggtgtttg ggtgccggca cccggaggag
     3301 gaccacctct atcaggaaga aatgcaggag atggtccgca agagagtgct gttccaggtg
     3361 cacacaggct actcccggct gcccggcaaa cccaaggtct acgttcagga catcctgcaa
     3421 aagcagctgg ccaatgaggt actcagcgtg ctccacgggg agcagggcca cctctacatt
     3481 tgcggagatg tgcgcatggc tcgggatgtg gctaccacat tgaagaagct ggtggccacc
     3541 aagctgaact tgagcgagga gcaggtggaa gactatttct tccagctcaa gagccagaaa
     3601 cgttatcatg aagatatctt cggtgcagtc ttttcctatg gggcaaaaaa gggcagcgcc
     3661 ttggaggagc ccaaagccac gaggctctga cagcccagag ttccagcttc tggcactgag
     3721 taaagataat ggtgaggggc ttggggagac agcgaaatgc aatccccccc aagcccctca
     3781 tgtcattccc ccctcctcca ccctaccaag tagtattgta ctattgtgga ctactaaatc
     3841 tctctcctct cctccctccc ctctctccct ttcctccctt cttctccact ccccagctcc
     3901 ctccttctcc ttctcctcct ttgcctctca ctcttccttg gagctgagag cagagaaaaa
     3961 ctcaacctcc tgactgaagc actttgggtg accaccagga ggcaccatgc cgccgctcta
     4021 atacttagct gcactatgta cagatattta tacttcatat ttaagaaaac agatactttt
     4081 gtctactccc aatgatggct tgggcctttc ctgtataatt ccttgatgaa aaatatttat
     4141 ataaaataca ttttatttta atca
//
