LOCUS       NM_001109985            4952 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus nitric oxide synthase 1 (neuronal) adaptor protein
            (Nos1ap), transcript variant 1, mRNA.
ACCESSION   NM_001109985
VERSION     NM_001109985.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4952)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4952)
  AUTHORS   Smith,A., Auer,D., Johnson,M., Sanchez,E., Ross,H., Ward,C.,
            Chakravarti,A. and Kapoor,A.
  TITLE     Cardiac muscle-restricted partial loss of Nos1ap expression has
            limited but significant impact on electrocardiographic features
  JOURNAL   G3 (Bethesda) 13 (11) (2023)
   PUBMED   37708408
  REMARK    GeneRIF: Cardiac muscle-restricted partial loss of Nos1ap
            expression has limited but significant impact on
            electrocardiographic features.
REFERENCE   3  (bases 1 to 4952)
  AUTHORS   Choi,J.S., Ayupe,A.C., Beckedorff,F., Catanuto,P., McCartan,R.,
            Levay,K. and Park,K.K.
  TITLE     Single-nucleus RNA sequencing of developing superior colliculus
            identifies neuronal diversity and candidate mediators of circuit
            assembly
  JOURNAL   Cell Rep 42 (9), 113037 (2023)
   PUBMED   37624694
REFERENCE   4  (bases 1 to 4952)
  AUTHORS   Candemir,E., Fattakhov,N., Leary,A.O., Slattery,D.A.,
            Courtney,M.J., Reif,A. and Freudenberg,F.
  TITLE     Disrupting the nNOS/NOS1AP interaction in the medial prefrontal
            cortex impairs social recognition and spatial working memory in
            mice
  JOURNAL   Eur Neuropsychopharmacol 67, 66-79 (2023)
   PUBMED   36513018
  REMARK    GeneRIF: Disrupting the nNOS/NOS1AP interaction in the medial
            prefrontal cortex impairs social recognition and spatial working
            memory in mice.
REFERENCE   5  (bases 1 to 4952)
  AUTHORS   Jansch,M., Lubomirov,L.T., Trum,M., Williams,T., Schmitt,J.,
            Schuh,K., Qadri,F., Maier,L.S., Bader,M. and Ritter,O.
  TITLE     Inducible over-expression of cardiac Nos1ap causes short QT
            syndrome in transgenic mice
  JOURNAL   FEBS Open Bio 13 (1), 118-132 (2023)
   PUBMED   36352324
  REMARK    GeneRIF: Inducible over-expression of cardiac Nos1ap causes short
            QT syndrome in transgenic mice.
REFERENCE   6  (bases 1 to 4952)
  AUTHORS   Auer,D.R., Sysa-Shah,P., Bedja,D., Simmers,J.L., Pak,E., Dutra,A.,
            Cohn,R., Gabrielson,K.L., Chakravarti,A. and Kapoor,A.
  TITLE     Generation of a cre recombinase-conditional Nos1ap over-expression
            transgenic mouse
  JOURNAL   Biotechnol Lett 36 (6), 1179-1185 (2014)
   PUBMED   24563304
REFERENCE   7  (bases 1 to 4952)
  AUTHORS   Treuer,A.V. and Gonzalez,D.R.
  TITLE     NOS1AP modulates intracellular Ca(2+) in cardiac myocytes and is
            up-regulated in dystrophic cardiomyopathy
  JOURNAL   Int J Physiol Pathophysiol Pharmacol 6 (1), 37-46 (2014)
   PUBMED   24665357
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4952)
  AUTHORS   Beigi,F., Oskouei,B.N., Zheng,M., Cooke,C.A., Lamirault,G. and
            Hare,J.M.
  TITLE     Cardiac nitric oxide synthase-1 localization within the
            cardiomyocyte is accompanied by the adaptor protein, CAPON
  JOURNAL   Nitric Oxide 21 (3-4), 226-233 (2009)
   PUBMED   19800018
REFERENCE   9  (bases 1 to 4952)
  AUTHORS   Balda,M.A., Anderson,K.L. and Itzhak,Y.
  TITLE     Development and persistence of long-lasting behavioral
            sensitization to cocaine in female mice: role of the nNOS gene
  JOURNAL   Neuropharmacology 56 (3), 709-715 (2009)
   PUBMED   19114050
  REMARK    GeneRIF: long-term expression of cocaine-induced behavioral
            sensitization in females (adolescent and adult) is
            nNOS-independent, unlike previous finding in adult males.
REFERENCE   10 (bases 1 to 4952)
  AUTHORS   Segalat,L., Grisoni,K., Archer,J., Vargas,C., Bertrand,A. and
            Anderson,J.E.
  TITLE     CAPON expression in skeletal muscle is regulated by position,
            repair, NOS activity, and dystrophy
  JOURNAL   Exp Cell Res 302 (2), 170-179 (2005)
   PUBMED   15561099
  REMARK    GeneRIF: Capon expression is increased in skeletal muscle by
            position, repair, NOS activity, and dystrophy.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125021.12, AC125017.12 and AC119431.13.
            
            On Oct 20, 2022 this sequence version replaced NM_001109985.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.26829.1,
                                           SRR7652917.715520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-543               AC125021.12        40398-40940         c
            544-615             AC125017.12        116887-116958       c
            616-708             AC119431.13        64573-64665
            709-767             AC119431.13        80090-80148
            768-876             AC119431.13        105893-106001
            877-1018            AC119431.13        117142-117283
            1019-1185           AC119431.13        126089-126255
            1186-1365           AC119431.13        127699-127878
            1366-1531           AC119431.13        134809-134974
            1532-4952           AC119431.13        136506-139926
FEATURES             Location/Qualifiers
     source          1..4952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 76.84 cM"
     gene            1..4952
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /note="nitric oxide synthase 1 (neuronal) adaptor protein"
                     /db_xref="GeneID:70729"
                     /db_xref="MGI:MGI:1917979"
     exon            1..543
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1950
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /note="isoform 1 is encoded by transcript variant 1;
                     C-terminal PDZ domain ligand of neuronal nitric oxide
                     synthase; carboxyl-terminal PDZ ligand of neuronal nitric
                     oxide synthase protein; C-terminal PDZ ligand of neuronal
                     nitric oxide synthase protein"
                     /codon_start=1
                     /product="carboxyl-terminal PDZ ligand of neuronal nitric
                     oxide synthase protein isoform 1"
                     /protein_id="NP_001103455.1"
                     /db_xref="CCDS:CCDS48438.1"
                     /db_xref="GeneID:70729"
                     /db_xref="MGI:MGI:1917979"
                     /translation="MPSKTKYNLVDDGHDLRIPLHNEDAFQHGISFEAKYVGSLDVPR
                     PNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKML
                     VMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAF
                     EVCHKLSLQHTQQNADGQEDGESERNSDGSGDPGRQLTGAERVSTAAAEETDIDAVEV
                     PLPGNDILEFSRGVTDLDAVGKDGGSHIDSTVSPHPQEPMLTASPRMLLPSSSSKPPG
                     LGTGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQL
                     LLQNKDMLQHISLLVKQVQELELKLSGQNTMGSQDSLLEITFRSGALPVLCESTTPKP
                     EDLHSPLLGAGLADFAHPAGSPLGRHDCLVKLECFRFLPPEDTQPMMAQGEPLLGGLE
                     LIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQELGDSLDDEIAV"
     exon            544..615
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            616..708
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            709..767
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            768..876
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1018
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1185
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1365
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1531
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..4952
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4929..4934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /note="hexamer: AATAAA"
     polyA_site      4952
                     /gene="Nos1ap"
                     /gene_synonym="6330408P19Rik; Capon"
                     /note="major polyA site"
ORIGIN      
        1 accctgctcc gccgccaccg ccaccaccgc cgccgctgcc tttcttcctc gtcccgggcc
       61 gtgcgcgccg agctcgggat cggactcccg gtctagtccc gcttctggcc gtgcgccctt
      121 cgctcggcgt cccggtccgg ggctccgcgc cgctcgctcc cgcctgcccg gccgcctggc
      181 cgcctccccg tagtcagagc gcggccaccg agctgctcgc gccagccgca tccgcgccgc
      241 ccctgccgct cggccctcgg gaggctcggc tcccggttca cccctgccac ctcctggcac
      301 ccaggctgcc cacctcacga cccgggtcct cgccgccgcc tcgcccggcc ccactgttct
      361 ctgcacaggg tctcgccagc tctttctcgt cgccgccacc gccgccccct tggagcagcg
      421 ggtccgccgc gggtcaccat gcccagcaaa accaagtaca accttgtgga cgatgggcac
      481 gatctacgga tccctttgca caacgaggac gccttccagc acggcatctc ttttgaggcc
      541 aagtacgtgg gaagcctgga tgtgcccaga cccaacagca gggttgagat cgtggctgcc
      601 atgcgcagaa tccggtatga gtttaaagcc aagaacatca agaagaagaa agtaagcatc
      661 atggtctctg tggacggtgt caaggtgatt ctgaagaaga agaaaaagaa aaaggagtgg
      721 acgtgggatg agagcaagat gctggtgatg caggacccta tctacaggat cttctatgtc
      781 tctcatgact cccaagactt gaaaatcttc agctatattg ccagagatgg tgccagcaat
      841 atcttcagat gtaacgtctt taaatccaaa aagaagagtc aagctatgag aatcgtgcgg
      901 acagtgggac aggccttcga agtctgccac aagctgagcc tgcagcacac acagcagaat
      961 gcagatggcc aggaagatgg ggagagcgag aggaacagtg atggctcagg agacccaggc
     1021 cggcagctca cgggagctga gagggtctcc acagccgctg cagaggagac agacattgac
     1081 gccgtggagg tcccactccc tgggaatgac attctggaat tcagccgagg tgtgactgat
     1141 ctggatgccg tagggaagga tggaggctcc cacatagact caacggtctc accccaccct
     1201 caggagccca tgctgacagc ctcccctcga atgctgctcc cttcctcttc ctcgaagccg
     1261 ccaggcttgg gcacggggac gcccctgtcc actcaccacc agatgcagct cctccagcag
     1321 ctcctccagc agcagcaaca acagacacaa gtggctgtgg cccaggtaca cttactgaag
     1381 gatcagttgg ctgctgaggc tgcggcgcgg ctggaggccc aggcacgagt gcaccagctc
     1441 ctgctgcaga acaaagacat gctccagcac atctctctgc tggtcaagca ggtgcaggag
     1501 ctggagctga agctgtcagg acagaacacc atgggctccc aggacagctt gctggagatc
     1561 accttccgtt caggtgccct gcctgtgctc tgtgaatcca ccacccctaa gccagaggac
     1621 ctacactcac cactgctggg cgctggcttg gctgactttg cccacccagc gggcagccct
     1681 ttaggtaggc atgactgctt ggtgaagctg gagtgctttc gcttcctccc acctgaggat
     1741 acccagccga tgatggcaca gggtgagccg ctcctaggtg gcctggagct catcaagttc
     1801 cgagagtcgg gcatcgcctc tgagtatgag tccaacacag acgaaagcga ggagcgtgac
     1861 tcatggtcac aggaagagct gccacgcctg ctcaatgtct tacagcggca ggagttgggt
     1921 gacagtttgg atgatgagat cgccgtgtag gtgcagggcg aggagctggt gaaggtggta
     1981 gcatggtgcc aagtgggggg tcaagtctgc ctgtccctgg ctggggatgc ccaggggaaa
     2041 gcgctgctga gaacaacacc cagggtggag agtgtagggt ttcagaagag ggttgggatt
     2101 ttgctttgga aggtaaatgg gggggaagaa attggattct tagagacagg aatcagcacc
     2161 tgtcttctgc taatgtctga atggggtgga agcagggctt tccagaaccc agggccttgg
     2221 gatggtccat cttcagaacc acagttctgg aaggcccgtt gctgccaccg ctatcgtcag
     2281 gttctaccca atctgtcctc cacgtctcag tgacctacgc tctcctgtct ctgtggtgca
     2341 gaccataaaa ggaagccatt ggtaccttct caggtactta gctttttgga tatcaggatg
     2401 ctacaagttg cctaaccctc ccttccactg taggagaatc ccttccccag gccctggctg
     2461 agatcgtaga cgttggacaa ttcccagggc tgctgggaaa gtgagctctg ccattcagtg
     2521 agcatggagg tgaccggagt cacaagtcac agtgaaaaaa ctaggaattg actctagctg
     2581 ggtgttgggt gttgcttctg aggacgctgg gggtgttaat aggattgaag accctgctgg
     2641 gaaagcctag ggaagggtta gcctaggggt gcttatgaga ttgctgcagc tcatgtaggt
     2701 ttgattcttc agtttggaaa ccctgccccg acctatctcc tgcctgcaac ccagctcata
     2761 taaatgagtc taagagctat cctattatcc cttttcctgc ctcgggggct gtgcctgcct
     2821 aagctttggc agtactatgc ctttgtgtaa gtctcataga cccagaaccc cctgccttag
     2881 ctttctacct gtcccctcca ctgggcagta gtggtcggtt tttactgaaa aaaaaaaaaa
     2941 gaaagaaaaa agagagaaag aaatggatgt aagctgatag ctgaggctgt ctacccttca
     3001 gaatcactgc cacttagatc agatcaggga ccacagctgt gccaccccag cctagctctc
     3061 tgcaggtgtg tgccttgagc acaggtgtta aaagtgcaac cttaatctct taccatctag
     3121 gtcttgccta gggggtctcc actcaatagt tggctggcta ggtccacaag aaaagttcct
     3181 ttccccctgt aagaccttaa ctgcttaata gttatttcaa cctctgaaga gaacactgat
     3241 acccgttcca agtcatatga tgtggggagg aggccctgtt catcctacaa gccgtaggcc
     3301 agagtgcagt gttatcaaag ggactgtaag gaaggatgga gttcttcagc ccaagctttg
     3361 cttcgaaatg tatcaaaatg caaacatggc cctttttata gccacagtgg ggtctctttt
     3421 aaacgaaaca ggcagtagag ttaaaggaaa ttaacacagc tttatactat cactccctag
     3481 tgcatgggga tgttgatagt aatagaatgg agcgggtgtg tgtgtgtgtg tgtgtgtctg
     3541 tgtctgtgtc tgtgtgtctg tgtgtgtatg tgtagtaata gaatgaagtg tgtgtgtata
     3601 tagtaataga atggggtgac tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtggt
     3661 gtggacatac ttttggacat ctgagaagtg actagaaaga ttctccaggg tgttcagata
     3721 aatggtaggg ttgtatcctt ttcccaccct gattttattg acaaggtaga attctgttag
     3781 ttttctaatt aaccattgga aggaggtcct gatacacaag gaagggagaa ttcccagtgt
     3841 gaggtccaca aaactgaagg gggcagatgg cggggattca agacaggctg agctgaattt
     3901 actcaatccc aatccagggt tccttgagtc taggaccttc agatgtaggc ttttgtgtat
     3961 cagagagagt gggatgtctg tttcctcgag gtctacttcc tgtgagtggg ggctgagagt
     4021 aaaatcagaa acaagtggaa gtgtgtggac tgtgggtgga aagggctttg taggatacag
     4081 tgaagagagt atgtgggcaa gatgatggct tttaaaactc tgtaaaggag aaggaaggaa
     4141 tgaagagatg ggagaactgg agaaatggct aatggatgga tagatgccga ctcaagactc
     4201 atgtaagact ttgtttgccc ttggtttctg tcttttttga ccttcccctt tccctgatta
     4261 aagacatccc tggagaattc attcatgtgc cacatcctcc ccagtaagac ccaaatctgg
     4321 acacatttgg tatgtggaga tgagaaacca agaaaagatg taggggcctt gtggggtcac
     4381 cagccaccga ccctccattt aggccaatga acaagacagg aaatgtcaca gacctgattc
     4441 cccgcagcag catccttcct tgcttcttgc tctgctaact caaccctgcc ttcctccttt
     4501 tcatccttct gctctgccct atgtggagga cacatggaca ccaaggggtt ccttagtggt
     4561 gcccgcccca ggtgcaagaa agctctcggg catacaaggc ttcgcaattg cagaggcagg
     4621 acagatctct gcccaggatg gactgcacat gggaactgga aaccgtattc cttacattcc
     4681 tgcttctact gatgctgtct gtaagaacct ttctgagcct cgctctcagc tgaccttgtt
     4741 tacggattgt gttccttgat ttactctttg cttgactgct ctcccctctc ctccctccca
     4801 cctaccctag ccttctgctt cctaaaactg ttttgtcatt aactgttggg tcagctctct
     4861 gggaaacggt tctgttgctg taagtgcact tacccttgga tggtgtcact agttagtggc
     4921 ttttgctaaa taaacctttc tgatttctaa aa
//
