LOCUS       NM_024193               1904 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus NOP56 ribonucleoprotein (Nop56), transcript variant 1,
            mRNA.
ACCESSION   NM_024193 XM_622755
VERSION     NM_024193.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1904)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1904)
  AUTHORS   Wang,X., Li,Z.T., Yan,Y., Lin,P., Tang,W., Hasler,D., Meduri,R.,
            Li,Y., Hua,M.M., Qi,H.T., Lin,D.H., Shi,H.J., Hui,J., Li,J., Li,D.,
            Yang,J.H., Lin,J., Meister,G., Fischer,U. and Liu,M.F.
  TITLE     LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and
            Spermatogenesis in Mice
  JOURNAL   Mol Cell 77 (5), 999-1013 (2020)
   PUBMED   32017896
REFERENCE   3  (bases 1 to 1904)
  AUTHORS   Brandis,K.A., Gale,S., Jinn,S., Langmade,S.J., Dudley-Rucker,N.,
            Jiang,H., Sidhu,R., Ren,A., Goldberg,A., Schaffer,J.E. and Ory,D.S.
  TITLE     Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular
            cholesterol trafficking
  JOURNAL   J Biol Chem 288 (50), 35703-35713 (2013)
   PUBMED   24174535
REFERENCE   4  (bases 1 to 1904)
  AUTHORS   Miyazaki,K., Yamashita,T., Morimoto,N., Sato,K., Mimoto,T.,
            Kurata,T., Ikeda,Y. and Abe,K.
  TITLE     Early and selective reduction of NOP56 (Asidan) and RNA processing
            proteins in the motor neuron of ALS model mice
  JOURNAL   Neurol Res 35 (7), 744-754 (2013)
   PUBMED   23582672
  REMARK    GeneRIF: The study suggests a progressive loss of nuclear proteins
            and subsequent RNA processing problems including a novel gene
            relating to amyotrophic lateral sclerosis (NOP56) under the motor
            neuron degeneration.
REFERENCE   5  (bases 1 to 1904)
  AUTHORS   van Dijk,T.B., Gillemans,N., Stein,C., Fanis,P., Demmers,J., van de
            Corput,M., Essers,J., Grosveld,F., Bauer,U.M. and Philipsen,S.
  TITLE     Friend of Prmt1, a novel chromatin target of protein arginine
            methyltransferases
  JOURNAL   Mol Cell Biol 30 (1), 260-272 (2010)
   PUBMED   19858291
REFERENCE   6  (bases 1 to 1904)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   7  (bases 1 to 1904)
  AUTHORS   Okubo,T., Knoepfler,P.S., Eisenman,R.N. and Hogan,B.L.
  TITLE     Nmyc plays an essential role during lung development as a
            dosage-sensitive regulator of progenitor cell proliferation and
            differentiation
  JOURNAL   Development 132 (6), 1363-1374 (2005)
   PUBMED   15716345
REFERENCE   8  (bases 1 to 1904)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 1904)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1904)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ162437.1, AK150258.1 and AI115137.1.
            
            On Feb 23, 2007 this sequence version replaced NM_024193.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021355.1, AK009799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CJ162437.1         4-37
            35-1803             AK150258.1         2-1770
            1804-1904           AI115137.1         1-101               c
FEATURES             Location/Qualifiers
     source          1..1904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.2 cM"
     gene            1..1904
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /note="NOP56 ribonucleoprotein"
                     /db_xref="GeneID:67134"
                     /db_xref="MGI:MGI:1914384"
     exon            1..65
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1805
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /note="nucleolar protein 5A; 56kDa with KKE/D repeat;
                     NOP56 ribonucleoprotein homolog"
                     /codon_start=1
                     /product="nucleolar protein 56"
                     /protein_id="NP_077155.2"
                     /db_xref="CCDS:CCDS16737.1"
                     /db_xref="GeneID:67134"
                     /db_xref="MGI:MGI:1914384"
                     /translation="MVLLHVLFEHAVGYALLALKEVEEISLLLPQVEECVLNLGKFHN
                     VVRLVAFCPFSSSQVALENANAVSEGVVHEDLRLLLETYLPSKKKKVLLGVGDPKIGA
                     AIQEELGYNCQTGGVIAEILRGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFN
                     VNRVDNMIIQSISLLDQLDKDINTFSMRVREWYGYHFPELVKIVNDNATYCRLAQFIG
                     NRRELNEEKLEKLEEITMDGAKAKAILDASRSSMGMDISAIDLINIESFSSRVVSLSE
                     YRQSLHTYLRSKMSQVAPSLSALIGEAVGARLIAHAGSLTNLAKYPASTVQILGAEKA
                     LFRALKTRGNTPKYGLIFHSTFIGRAAAKNKGRISRYLANKCSIASRIDCFSEVPTSV
                     FGEKLREQVEERLSFYETGEIPRKNLDVMKEAVVQAEEAAAEITRKLEKQEKKRLKKE
                     KKRLAALALASSENSSTPEECEEVNEKSKKKKKLKPQENGMEDPPVSLPKSKKKKAPK
                     EELASDLEEMATSSAKRKKSSPKEEVASEPEEAASPTTPKKKRKFSEEPEVAANFTKS
                     STKKKKKSQKAQED"
     exon            66..155
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            156..270
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            271..432
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            433..631
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            632..819
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            820..971
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1072
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1221
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1343
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1478
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1895
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /note="hexamer: AATAAA"
     polyA_site      1890
                     /gene="Nop56"
                     /gene_synonym="2310044F10Rik; Nol5a"
                     /note="major polyA site"
ORIGIN      
        1 agtctggttc cgcgcgccag agcgcgctag ccgcattgcg agctgggcac ggagcaggcg
       61 ccatggttct gctgcacgtg ctgttcgagc atgcggtcgg ctacgcgctg ttggcgctga
      121 aggaagtgga ggagatcagc ctgctgctgc cgcaggtgga ggaatgtgtg cttaaccttg
      181 gcaaattcca caatgtcgtt cgtctggtgg ccttctgtcc cttctcttca tcccaggtgg
      241 ccttggaaaa tgccaatgct gtgtctgaag gtgttgttca cgaggacctc cgcctgctcc
      301 tggagacata cctgccatct aaaaagaaga aagtacttct gggggttgga gaccccaaga
      361 ttggtgctgc aatacaggaa gagttggggt acaactgcca gactggtggt gtgatagctg
      421 agatccttcg aggagttcgt ctgcatttcc ataatctggt gaagggtctg acagatcttt
      481 ctgcttgtaa ggcccagcta gggctgggac acagctactc tcgtgccaaa gttaaattta
      541 atgtgaaccg agtggacaac atgattattc agtccataag cctcctggac caactggata
      601 aagatatcaa taccttctcg atgcgcgtca gggagtggta tgggtaccac tttccagagc
      661 tggtgaagat cgtcaatgac aacgccacat actgtcgctt ggctcagttc attgggaacc
      721 gcagggagct gaatgaagag aagttagaga aactggaaga aattacgatg gacggggcca
      781 aggctaaggc catcttggat gcttctcggt cctccatggg catggacata tctgctatcg
      841 acttgataaa catcgagagc ttctccagtc gtgtggtgtc tttgtcagag tatcgccaga
      901 gcctacacac ttaccttcgc tccaagatga gccaagtagc ccccagcctg tcagccttaa
      961 ttggggaagc ggtaggtgca cgcctcattg ctcatgctgg cagcctcacc aacctggcca
     1021 agtatccagc gtccacagta cagatccttg gggctgaaaa ggccctgttc agagccctga
     1081 agacaagggg taacacacca aaatatggac tcatttttca ttccaccttc attggccgag
     1141 cagctgcaaa gaacaaaggc cgtatctccc gatacctagc aaacaaatgc agtattgcct
     1201 caagaattga ttgcttctct gaggtcccca caagtgtatt tggggaaaaa ctccgagaac
     1261 aagttgagga acggctgtct ttctatgaga ctggagagat cccacggaag aacctggatg
     1321 tcatgaagga agctgtggtt caggcagagg aagcggctgc tgaaatcacc agaaagctgg
     1381 aaaaacagga gaagaagcgc ttgaagaagg aaaagaagcg actggctgca ctggccctgg
     1441 cctcgtcaga aaacagcagt accccagagg agtgtgagga ggtaaatgaa aaatctaaga
     1501 agaaaaagaa gttaaaaccc caggaaaatg gaatggaaga cccacctgtc tctctaccta
     1561 aatccaagaa aaagaaagct cccaaggagg agttggccag tgaccttgaa gagatggcca
     1621 ctagcagtgc taagagaaag aagtcctcac ctaaggagga agtggccagt gaaccagaag
     1681 aggcagcaag ccccaccacc cctaagaaga aaaggaaatt ttctgaggag cctgaagttg
     1741 ctgctaactt cacaaagagc agcacaaaga aaaagaaaaa gtcccagaaa gcacaggagg
     1801 attagaacgg acctgcttgg tgggaggggc ataccttgtg gcagctcctg cccatgaatg
     1861 ataaaacccc aataaaaaca caaaaccaga tagtaaaaaa aaaa
//
