LOCUS       NM_138747               2626 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus NOP2 nucleolar protein (Nop2), mRNA.
ACCESSION   NM_138747 XM_982076
VERSION     NM_138747.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2626)
  AUTHORS   Wang,M., Cheng,R., He,H., Han,Z., Zhang,Y. and Wu,Q.
  TITLE     N4-acetylcytidine of Nop2 mRNA is required for the transition of
            morula-to-blastocyst
  JOURNAL   Cell Mol Life Sci 80 (10), 307 (2023)
   PUBMED   37768430
  REMARK    GeneRIF: N[4]-acetylcytidine of Nop2 mRNA is required for the
            transition of morula-to-blastocyst.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2626)
  AUTHORS   Wang,H., Wang,L., Wang,Z., Dang,Y., Shi,Y., Zhao,P. and Zhang,K.
  TITLE     The nucleolar protein NOP2 is required for nucleolar maturation and
            ribosome biogenesis during preimplantation development in mammals
  JOURNAL   FASEB J 34 (2), 2715-2729 (2020)
   PUBMED   31908012
  REMARK    GeneRIF: The nucleolar protein NOP2 is required for nucleolar
            maturation and ribosome biogenesis during preimplantation
            development in mammals.
REFERENCE   3  (bases 1 to 2626)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2626)
  AUTHORS   Cui,W., Pizzollo,J., Han,Z., Marcho,C., Zhang,K. and Mager,J.
  TITLE     Nop2 is required for mammalian preimplantation development
  JOURNAL   Mol Reprod Dev 83 (2), 124-131 (2016)
   PUBMED   26632338
  REMARK    GeneRIF: results demonstrate that Nop2 is an essential gene for
            blastocyst formation, and is required for RNA processing and/or
            stability in vivo during preimplantation embryo development in the
            mouse.
REFERENCE   5  (bases 1 to 2626)
  AUTHORS   Kosi,N., Alic,I., Kolacevic,M., Vrsaljko,N., Jovanov Milosevic,N.,
            Sobol,M., Philimonenko,A., Hozak,P., Gajovic,S., Pochet,R. and
            Mitrecic,D.
  TITLE     Nop2 is expressed during proliferation of neural stem cells and in
            adult mouse and human brain
  JOURNAL   Brain Res 1597, 65-76 (2015)
   PUBMED   25481415
  REMARK    GeneRIF: Findings suggest a newly discovered role of Nop2 in both
            mature neurons and in cells possibly involved in the regeneration
            of nervous tissue
REFERENCE   6  (bases 1 to 2626)
  AUTHORS   Mitrecic,D., Malnar,T. and Gajovic,S.
  TITLE     Nucleolar protein 1 (Nol1) expression in the mouse brain
  JOURNAL   Coll Antropol 32 Suppl 1, 123-126 (2008)
   PUBMED   18405070
REFERENCE   7  (bases 1 to 2626)
  AUTHORS   Khanna-Gupta,A., Sun,H., Zibello,T., Lozovatsky,L., Ghosh,P.K.,
            Link,D.C., McLemore,M.L. and Berliner,N.
  TITLE     p120 nucleolar-proliferating antigen is a direct target of G-CSF
            signaling during myeloid differentiation
  JOURNAL   J Leukoc Biol 79 (5), 1011-1021 (2006)
   PUBMED   16641140
  REMARK    GeneRIF: Inappropriate expression of the p120 gene can result in
            aberrant neutrophil maturation.
REFERENCE   8  (bases 1 to 2626)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2626)
  AUTHORS   Gajovic,S., Chowdhury,K. and Gruss,P.
  TITLE     Genes expressed after retinoic acid-mediated differentiation of
            embryoid bodies are likely to be expressed during embryo
            development
  JOURNAL   Exp Cell Res 242 (1), 138-143 (1998)
   PUBMED   9665811
REFERENCE   10 (bases 1 to 2626)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY244994.1, AK079914.1 and AI325393.1.
            
            On Nov 1, 2007 this sequence version replaced NM_138747.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007151.1, AK079914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY244994.1         1-26
            27-2194             AK079914.1         1-2168
            2195-2241           AK079914.1         2170-2216
            2242-2626           AI325393.1         1-385               c
FEATURES             Location/Qualifiers
     source          1..2626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.32 cM"
     gene            1..2626
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /note="NOP2 nucleolar protein"
                     /db_xref="GeneID:110109"
                     /db_xref="MGI:MGI:107891"
     exon            1..121
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..232
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2511
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /note="putative ribosomal RNA methyltransferase NOP2;
                     nucleolar protein 2 homolog; proliferating-cell nucleolar
                     antigen p120; proliferation-associated nucleolar protein
                     p120; nucleolar protein 1, 120 kDa; NOP2 nucleolar protein
                     homolog; probable 28S rRNA
                     (cytosine-C(5))-methyltransferase"
                     /codon_start=1
                     /product="28S rRNA (cytosine-C(5))-methyltransferase"
                     /protein_id="NP_620086.2"
                     /db_xref="CCDS:CCDS51912.1"
                     /db_xref="GeneID:110109"
                     /db_xref="MGI:MGI:107891"
                     /translation="MGRKLDPTKKEKRGPGRKARKQKGAETELVRFLPAAGDENSKRL
                     SSRARKRAAKRRAGSVDVPKPNKSPGIKTLPGELSKGAVQARGKKRPAPIQNSDGDEE
                     EDSGEDDVVTQGDLWGSEDSDEDMVDDYGAASNSEDEEEKLLPIERAALKQKAQDATA
                     GVLWNEEDTDEDEDDDGVSPESHPRKDDKAEGDLQINVEDEEAFVLPPAGETDQDGQA
                     PDLQRVHKRIQDIVGVLRDFGAQREEGRSRAEYLSRLQKDLATYYSYGDFLLSKLMEL
                     FPLSELIEFLEANEVPRPITLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKSGLVVY
                     DSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMK
                     NTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSG
                     TGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVNAASKTGGYLVYCTCSITVEE
                     NEWVVDYALKKRNVRLVPTGLDFGQEGFTRFQARRFHPTLRSTRRFYPHTHNMDGFFI
                     AKFKKFSNSIPQPHAGNSAAATPTEPDLKDQVTPKSENGSQPTKKARGAVKAKQQLLR
                     QPHSKKPFQKLNGIAKGPGLSTEPSVPDAQVSTRPSQSAGNADVNSKRKRSEKLKQRG
                     PKWKPSKEAAVPKPSAPSRVEDSRTPPVPTPSEIRAAPRPKDCAPSLGEAKKKQKGKQ
                     QLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAKRRKSMTKGNSQPLLS"
     exon            233..278
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..367
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..552
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..608
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..769
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..969
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1059
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1147
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1288
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1428
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1518
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1641
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1870
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2623
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2602..2607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /note="hexamer: AATATA"
     polyA_site      2623
                     /gene="Nop2"
                     /gene_synonym="120kDa; A530002O17; Nol1"
                     /note="major polyA site"
ORIGIN      
        1 ttgcgcgatt cactttcgcg gtgtgcgacc tctgagttct tccccccagt gcacgtggag
       61 cgggccttga ctggaggtgc cgggtcagcc ggaaccaggt ctaggcgagc cgagccttca
      121 gttatcatgg ggcgcaagtt ggatcctacg aagaaggaga agcgtggacc cggccgaaag
      181 gcccgaaaac agaagggtgc ggagaccgaa ttggtcagat ttttgcctgc agctggcgat
      241 gagaattcca agaggctgtc gagtcgtgcc cgaaagcggg cagccaagag gagggcaggg
      301 tctgttgacg tccctaagcc aaataagtct cctgggatca aaacattgcc tggagagtta
      361 tccaaaggag cagtccaggc tcgaggtaag aagcgcccag caccaattca aaacagtgat
      421 ggggacgagg aggaagactc gggggaagac gatgtggtga cccaggggga cctttggggc
      481 tctgaggaca gtgatgaaga tatggtggat gactatggag ctgcctctaa ctcggaggat
      541 gaggaggaaa agctgttgcc tattgaaaga gctgccctga agcagaaagc ccaggatgcc
      601 acagctgggg tcctgtggaa tgaagaggac actgatgaag atgaagatga tgatggtgtg
      661 tcccctgagt cccaccccag aaaggatgac aaagcagagg gggatttgca gattaatgtg
      721 gaagatgagg aagcctttgt gctgccccct gctggggaga cggaccagga tggccaggct
      781 ccagacctgc agcgagttca caagcggatc caggacatcg tgggagtgct gcgggatttc
      841 ggagctcagc gagaagaggg ccggtctcga gctgagtatc taagtcggct tcagaaggac
      901 ctggccactt actattctta tggagacttc ctgctgagca agctcatgga gctgttccct
      961 ctgtctgagt tgatcgagtt cttagaagct aatgaggtgc cccggccaat cacccttcgg
     1021 accaacacct tgaaaacccg tcgccgagac cttgctcagg ctctgatcaa tcgtggggtt
     1081 aatctggatc cactggggaa gtggtcaaag tctggacttg tggtatatga ttcttcagtg
     1141 cctattggcg ctacccctga gtacctcgct ggacactata tgctgcaggg agcttccagt
     1201 atgttgcccg tcatggccct ggcacctcag gagcatgagc ggatcttaga catgtgctgt
     1261 gctcctgggg ggaagaccag ctacatagct cagctgatga agaacacagg agtgatcctt
     1321 gccaacgatg ccaatgcaga ccggctcaag agcgtggtgg gcaacctgca ccgcttggga
     1381 gtcaccaaca ccatcatcag ccactatgat gggcgccagt tccccaaggt ggtagggggc
     1441 tttgatcgag tgctactgga tgctccttgt agtggcacag gagtcatctc caaagaccct
     1501 gctgtgaaga cgaacaagga tgagaaagac atccagcgct gtgcccacct tcagaaggaa
     1561 ctgctgctca gtgctatcga ctcagtgaac gctgcctcca agaccggagg ctacctggtc
     1621 tactgcacct gttccattac ggtggaagag aacgagtggg tggtagacta tgccttgaag
     1681 aagaggaatg tgcggctggt gcccaccggc ctggacttcg gccaggaagg ttttacccgc
     1741 ttccaagcaa ggcgctttca ccccactctg cgttccaccc ggcgcttcta ccctcacact
     1801 cacaatatgg acggtttctt tatcgccaag ttcaagaaat tttccaattc tattccccag
     1861 ccccatgcag gaaactcggc agcagctacc cctacagagc ctgacctgaa ggatcaggtc
     1921 accccaaagt ctgagaacgg tagtcagccc accaagaaag cccgtggggc tgtgaaggca
     1981 aagcagcagt tgctgagaca gccacattcc aagaagccct tccagaagtt gaacggcatc
     2041 gccaaagggc caggcttgtc cactgaacct tctgtcccag atgcccaagt gtctaccagg
     2101 cccagtcagt ctgctgggaa tgctgacgtg aacagcaaac gaaagaggtc tgagaagctg
     2161 aagcagcggg gacctaagtg gaagccctct aaggaggctg ctgtcccaaa gccgagcgcc
     2221 ccttccaggg ttgaggactc gagaacacct cctgtgccga ctccctctga aatccgtgct
     2281 gccccaaggc ctaaggactg tgctccatcc cttggggaag ccaaaaagaa acagaaagga
     2341 aagcagcagt tagcacagca gcctgctaat ggagctgctc ccctgaaaga agatgctgtt
     2401 tccaagggac cctcagcccc ctttgtgtct ccccacagtt ccaccaggcc cccaccagca
     2461 aaaaggagga aatcaatgac aaagggcaac agccagcctc tgttgtctta aatggacttg
     2521 gaaacttgac attgtctctg ggttggaact tttagatcct gatgcaaggc tggcctcccc
     2581 ctgtgcatac atatgaaatt taatatacat attaccactc ctaaaa
//
