LOCUS       NM_023144               2468 bp    mRNA    linear   ROD 24-SEP-2023
DEFINITION  Mus musculus non-POU-domain-containing, octamer binding protein
            (Nono), transcript variant 1, mRNA.
ACCESSION   NM_023144
VERSION     NM_023144.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2468)
  AUTHORS   Chen S, Wang J, Zhang K, Ma B, Li X, Wei R and Nian H.
  TITLE     LncRNA Neat1 targets NonO and miR-128-3p to promote
            antigen-specific Th17 cell responses and autoimmune inflammation
  JOURNAL   Cell Death Dis 14 (9), 610 (2023)
   PUBMED   37716986
  REMARK    GeneRIF: LncRNA Neat1 targets NonO and miR-128-3p to promote
            antigen-specific Th17 cell responses and autoimmune inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2468)
  AUTHORS   Zhang Y, Cui D, Huang M, Zheng Y, Zheng B, Chen L and Chen Q.
  TITLE     NONO regulates B-cell development and B-cell receptor signaling
  JOURNAL   FASEB J 37 (4), e22862 (2023)
   PUBMED   36906291
  REMARK    GeneRIF: NONO regulates B-cell development and B-cell receptor
            signaling.
REFERENCE   3  (bases 1 to 2468)
  AUTHORS   Niu Y, Xu G, Zhu S, Wei X, Wu C, Zhang R, Chen C, Yan L, Luo H,
            Deng S, Wu W, Li Y, Liu M, Jiang Y and Zhang X.
  TITLE     NONO regulates multiple cytokine production in sepsis via the
            ERK1/2 signaling pathway
  JOURNAL   Mol Immunol 153, 94-105 (2023)
   PUBMED   36459792
  REMARK    GeneRIF: NONO regulates multiple cytokine production in sepsis via
            the ERK1/2 signaling pathway.
REFERENCE   4  (bases 1 to 2468)
  AUTHORS   Wang X, Han M, Wang S, Sun Y, Zhao W, Xue Z, Liang X, Huang B, Li
            G, Chen A, Li X and Wang J.
  TITLE     Targeting the splicing factor NONO inhibits GBM progression through
            GPX1 intron retention
  JOURNAL   Theranostics 12 (12), 5451-5469 (2022)
   PUBMED   35910786
  REMARK    GeneRIF: Targeting the splicing factor NONO inhibits GBM
            progression through GPX1 intron retention.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2468)
  AUTHORS   Li Z, Wang T, Xin C, Song Y, Kong J, Xu J, Liu Q, Teng Y, Hou N,
            Cheng X, Yang G, Liu W, Zhou B, Zhang Y, Yang X and Wang J.
  TITLE     Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting
            Proteostasis
  JOURNAL   Int J Biol Sci 18 (5), 2018-2031 (2022)
   PUBMED   35342336
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2468)
  AUTHORS   Mathur M, Tucker PW and Samuels HH.
  TITLE     PSF is a novel corepressor that mediates its effect through Sin3A
            and the DNA binding domain of nuclear hormone receptors
  JOURNAL   Mol Cell Biol 21 (7), 2298-2311 (2001)
   PUBMED   11259580
REFERENCE   7  (bases 1 to 2468)
  AUTHORS   Karhumaa P, Parkkila S, Waheed A, Parkkila AK, Kaunisto K, Tucker
            PW, Huang CJ, Sly WS and Rajaniemi H.
  TITLE     Nuclear NonO/p54(nrb) protein is a nonclassical carbonic anhydrase
  JOURNAL   J Biol Chem 275 (21), 16044-16049 (2000)
   PUBMED   10821857
REFERENCE   8  (bases 1 to 2468)
  AUTHORS   Basu A, Dong B, Krainer AR and Howe CC.
  TITLE     The intracisternal A-particle proximal enhancer-binding protein
            activates transcription and is identical to the RNA- and
            DNA-binding protein p54nrb/NonO
  JOURNAL   Mol Cell Biol 17 (2), 677-686 (1997)
   PUBMED   9001221
REFERENCE   9  (bases 1 to 2468)
  AUTHORS   Hallier M, Tavitian A and Moreau-Gachelin F.
  TITLE     The transcription factor Spi-1/PU.1 binds RNA and interferes with
            the RNA-binding protein p54nrb
  JOURNAL   J Biol Chem 271 (19), 11177-11181 (1996)
   PUBMED   8626664
REFERENCE   10 (bases 1 to 2468)
  AUTHORS   Yang YS, Hanke JH, Carayannopoulos L, Craft CM, Capra JD and Tucker
            PW.
  TITLE     NonO, a non-POU-domain-containing, octamer-binding protein, is the
            mammalian homolog of Drosophila nonAdiss
  JOURNAL   Mol Cell Biol 13 (9), 5593-5603 (1993)
   PUBMED   8355702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ180326.1, BC083074.1 and AL831722.8.
            
            [WARNING] On Dec 7, 2023 this sequence was replaced by NM_023144.3.
            
            On Aug 14, 2009 this sequence version replaced NM_023144.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005465.2, AK028338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               CJ180326.1         1-163
            164-2462            BC083074.1         1-2299
            2463-2468           AL831722.8         53345-53350
FEATURES             Location/Qualifiers
     source          1..2468
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 44.14 cM"
     gene            1..2468
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /note="non-POU-domain-containing, octamer binding protein"
                     /db_xref="GeneID:53610"
                     /db_xref="MGI:MGI:1855692"
     exon            1..112
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            113..172
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            173..341
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1603
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /codon_start=1
                     /product="non-POU domain-containing octamer-binding
                     protein"
                     /protein_id="NP_075633.2"
                     /db_xref="CCDS:CCDS30316.1"
                     /db_xref="GeneID:53610"
                     /db_xref="MGI:MGI:1855692"
                     /translation="MQSNKAFNLEKQNHTPRKHHQHHHQQHHQQQQQQQQQQPPPPIP
                     ANGQQASSQNEGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKA
                     GEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNLPQY
                     VSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSEGSFLLT
                     TFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPGSFEYEYAMRWKAL
                     IEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEELRRMEELHNQ
                     EVQKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMGQMAMG
                     GAMGINNRGAMPPAPVPPGTPAPPGPATMMPDGTLGLTPPTTERFGQAATMEGIGAIG
                     GTPPAFNRPAPGAEFAPNKRRRY"
     exon            342..535
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            536..837
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            838..933
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1130
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1215
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1318
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1358
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1468
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..2468
                     /gene="Nono"
                     /gene_synonym="nonA; NRB54; P54NRB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggtacc gagctccgtc ggctcgtttc cggcggtcgc gcgctctttt ctcgggacgg
       61 tggaggccgt gcagcgtcgc ccatactccg agcaaagaac tgtggccaga ggcagtcgag
      121 gttagtgagg actgcgaggc agacactttg ctgtgttcaa atccaagtca agggtacaaa
      181 aatgcagagc aataaagcct ttaacttgga gaagcagaat catactccaa ggaagcatca
      241 tcagcatcac caccagcagc accatcagca gcaacagcag cagcagcagc aacagccacc
      301 cccaccaata cctgcaaatg gccagcaggc cagcagccag aatgaaggct tgactattga
      361 cctgaagaat tttaggaaac caggagagaa gacctttaca cagcgtagcc gtctctttgt
      421 gggcaatctt ccccctgata tcactgagga ggaaatgagg aaactatttg agaaatatgg
      481 aaaagcaggc gaagttttca ttcataagga taaaggcttt ggctttattc gcttggaaac
      541 acgaacccta gcggaaattg ccaaagtgga gctggacaac atgcccctcc gtgggaagca
      601 gctgcgagtg cgctttgcct gtcacagtgc atcccttaca gtccgcaacc ttcctcagta
      661 cgtgtcgaac gaactgctgg aagaagcctt ttctgtgttc ggccaggtgg agagggctgt
      721 agtcattgtg gatgaccgag gaaggccctc agggaaaggc attgttgagt tctcagggaa
      781 gccagctgct cggaaagctc tggacagatg cagtgaaggc tccttcttgc tgactacatt
      841 tcctcggcct gtgactgtgg agcctatgga ccagttagat gatgaagagg gacttccaga
      901 gaaactggtt ataaaaaacc agcaattcca caaggagaga gaacagccac ccagatttgc
      961 acaacctggc tcctttgagt atgagtatgc catgcgctgg aaggcactca ttgagatgga
     1021 gaagcaacag caggatcaag tggatcggaa catcaaggag gctcgtgaga agctggagat
     1081 ggagatggag gctgcacgtc atgagcacca ggttatgcta atgaggcagg atttgatgag
     1141 acgtcaagaa gagcttcgga gaatggagga gctgcataac caagaggttc agaagcgaaa
     1201 gcagttagaa ctcaggcagg aagaggaacg caggcgccgt gaggaagaga tgcggcgaca
     1261 gcaagaggaa atgatgcgcc gacagcagga aggattcaag ggaaccttcc ctgatgcgag
     1321 agaacaagag atacggatgg gccaaatggc tatgggaggt gctatgggca taaacaatag
     1381 aggcgcgatg ccccctgctc ctgtgccacc tggtactcca gctcctccag gacctgccac
     1441 tatgatgcca gatggaaccc ttggattgac cccaccaaca actgaacgtt ttggccaagc
     1501 tgcaacaatg gaaggaattg gagcaattgg tggaactcct cctgcattca accgtccagc
     1561 tccgggagct gaatttgctc caaataaacg ccgccgatat tagataaagt tgcattgtct
     1621 agtttcctgc agcccttaaa agaagggccc tttttggact agccagaatt ctaccctgga
     1681 aaagtgttag gggttcttcc caatagatag gccttccctg cttgtactac tctagggagc
     1741 atgcttgaag gcagaggggc aagggagggg tggtattcaa caagtcaaag tctgtggtat
     1801 attgctttat caagactgtc tggtgcattc ctgaactata ttgattgttg agggcctgga
     1861 gaaccatggg aaaatgaact cagagctcca ttaatcttga tcattccttc tctctctttc
     1921 tctctctctt gttttaatta ctttctcatc tttattcccc tcaacccctg agacactgcc
     1981 atatatacca caaaccataa acatcctcca atgacctagc cccatccctc cattcactcc
     2041 caggtaagaa ttcagacaaa tgtccacaga ggttacagca tacgtacggt tgtgttatat
     2101 ctcatatatg accccttcat gtcctaagga agacattttc tcttagaggt tttcatttta
     2161 gtatatctta aaagaatctt gtgttacctt gcctccatct ttttcttggg taaggactac
     2221 actttgtgtc tctgatgttg ctgttcacag cttttcttga taggcctagt acaatcttgg
     2281 gaacagggtt gctgtgtggt gaaggtctga cagtagctct tagtcttgcc tatcttaggt
     2341 agctacgctg tgcattttta ttggtatact atgaattgtt ccagatacct tcagtttgga
     2401 aagttttctg agaaatggag acgtcatgca gcatcacctt attaaaatac atttgaagcc
     2461 ttttcatt
//
