LOCUS       NM_153057               4277 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus nodal modulator 1 (Nomo1), mRNA.
ACCESSION   NM_153057
VERSION     NM_153057.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4277)
  AUTHORS   Perez-Garcia,J., Martel-Martel,A., Garcia-Valles,P., Corchete,L.A.,
            Garcia,J.L., Gestoso-Uzal,N., Vidal-Tocino,R., Blanco,O.,
            Mendez,L., Sanchez-Martin,M., Fuentes,M., Herrero,A.B.,
            Holowatyj,A.N., Perea,J. and Gonzalez-Sarmiento,R.
  TITLE     Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in
            Early-Onset Colorectal Cancer and Is Involved in the Regulation of
            Cell Migration
  JOURNAL   Cancers (Basel) 14 (16), 4029 (2022)
   PUBMED   36011023
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4277)
  AUTHORS   Garcia-Tunon,I., Vuelta,E., Lozano,L., Herrero,M., Mendez,L.,
            Palomero-Hernandez,J., Perez-Caro,M., Perez-Garcia,J.,
            Gonzalez-Sarmiento,R. and Sanchez-Martin,M.
  TITLE     Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9
            technology
  JOURNAL   Mol Biol Rep 47 (2), 1381-1391 (2020)
   PUBMED   31833031
REFERENCE   3  (bases 1 to 4277)
  AUTHORS   Zhang,H., Xu,C., Yang,R., Chen,H., Kong,X., Qian,L., Sheng,Y. and
            Sun,W.
  TITLE     Silencing of nodal modulator 1 inhibits the differentiation of P19
            cells into cardiomyocytes
  JOURNAL   Exp Cell Res 331 (2), 369-376 (2015)
   PUBMED   25576386
  REMARK    GeneRIF: NOMO1 gene knockdown inhibits the differentiation of P19
            cells into cardiomyocytes, which highlights a potential role for
            NOMO1 in early cardiogenesis.
REFERENCE   4  (bases 1 to 4277)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   5  (bases 1 to 4277)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 4277)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115036.10, BC072630.1 and BI135246.1.
            
            On Apr 28, 2009 this sequence version replaced NM_153057.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072630.1, AK082963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC115036.10        76082-76135         c
            55-4255             BC072630.1         1-4201
            4256-4277           BI135246.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..4277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.66 cM"
     gene            1..4277
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /note="nodal modulator 1"
                     /db_xref="GeneID:211548"
                     /db_xref="MGI:MGI:2385850"
     exon            1..277
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..3781
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /note="BOS complex subunit NOMO1"
                     /codon_start=1
                     /product="BOS complex subunit NOMO1 precursor"
                     /protein_id="NP_694697.3"
                     /db_xref="CCDS:CCDS21273.1"
                     /db_xref="GeneID:211548"
                     /db_xref="MGI:MGI:2385850"
                     /translation="MRAGRCAAALLLLLLSGAGRAIGSEDIVVGCGGFVKSDVEINYS
                     LIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTNVELRVD
                     GVSDICTKGGDINFLFTGFSVNGKVLSKGQPLGPAGVQVSLRSTGADSKIQSTVTQPG
                     GKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSD
                     GEPMKGVKFLLFSSLVNKEDVLGCNVSPVSGFQPPDESLVYLCYAVSKEDGSFSFYSL
                     PSGGYTVVPFYRGERITFDVAPSRLDFTVEHDSLRIEPVFHVMGFSVTGRVLNGPDGE
                     GVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFEMVTIKIAPNTPQL
                     ADLIATGFSICGQIAIVRSPDTIKQMSKYRVVLSSQDKDKALLTVDSDAHGSFCFKAK
                     PGAYKVQVVVPEAETRAGLMLKPQVFPLTVTNRPVMDVAFVQFLASVSGKVSCLDTCG
                     DLLVTLQSLSRQGEKRSLQLSGKVNSMTFTFDKVLPGRYKISIMHEDWCWRNKSLEVE
                     VLEDDVSAVEFRQTGYMLRCALSHAITLEFHQDGNGPENVGIYNLSRGVNRFCLSKPG
                     VYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTIITDKMMDVTVTIKSSIDS
                     EPALVLGPLKSAQELRREQQLAEIETRRQEREKNGKEEGEEGRARPPGQEMVDELQGP
                     FSYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIHGKAGLFLEGQ
                     IHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVNSQKEGYVLTAVE
                     GTVGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPG
                     QYYFKPMMKEFRFEPSSQMIEVQEGQNLRITITGFRTAYSCYGTVSSLNGEPEQGVAV
                     EAVGQKDCSIYGEDTVTDEEGKFRLRGLLPGCMYHVQLKAEGNDHIERALPHHRVIEV
                     GNNDVDDVNIIVFRQINQFDLSGNVITSSEYLSTLWVKLYKSESLDNPIQTVSLGQSL
                     FFHFPPLLRDGENYVVLLDTTLPRSQYDYVLPQVSFTAVGYHKHITLVFSPTRKLPEQ
                     DIAQGSYIALPLTLLLLLAGYNHDKLIPLLLQLTSRLQGVRALGQAASDSSGPEDMKR
                     QTKKQKTRRT"
     exon            278..367
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            368..413
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            414..514
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            515..621
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            622..694
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            695..847
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            848..985
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1075
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1181
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1332
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1507
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1649
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1781
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1918
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2006
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2070
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2166
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2385
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2468
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2628
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2755
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2869
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..2997
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3139
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3223
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3334
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3436
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3556
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3649
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..4259
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4226..4231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /note="hexamer: AATAAA"
     polyA_site      4255
                     /gene="Nomo1"
                     /gene_synonym="D7Ertd156e; Nomo; pM5"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcctgc gcagagcagc tccggggcgg gtcctgggct tgtcagccca gcgaggagaa
       61 ggaaggagcc ggctgcgtgc ggtgtgaggg gcgggaccgg gcgggttgcg gagggtaggc
      121 acgcggaggc cgggccatgc gtgcgggccg gtgtgccgcg gcgctgctgc tgctgctact
      181 gagcggcgcg gggcgcgcga tcggctccga ggacatcgtg gtaggctgcg ggggtttcgt
      241 gaagtcggac gtggagatca actactcgct catcgagata aagttataca ccaagcatgg
      301 gactttgaaa tatcagacgg actgtgctcc taacaacggc tactttatga tccccttgta
      361 tgataagggg gatttcatcc tgaagatcga acctcctctg ggctggagtt ttgagccaac
      421 caacgtggag ctgcgagtgg atggtgtgag cgacatctgc acgaagggcg gggacatcaa
      481 cttcctgttc actggcttct ctgtgaatgg caaggtcctc agcaaagggc agcccctggg
      541 cccagcagga gttcaggtat ccctgagaag caccggtgct gactcgaaga tccagtctac
      601 agtcacgcag cctggcggaa agtttgcgtt tttcaaagtt cttcctggag attatgaaat
      661 ccttgcaact cacccgacct gggcgctgaa ggaggcaagt accacggtgc gtgtgacgaa
      721 ctcgaatgct aacgcagctg gtcccctcat agtggctggc tataatgtgt ccggctctgt
      781 ccgcagtgac ggggagccca tgaaaggggt gaagtttctt ctcttttctt ctttagtgaa
      841 caaagaggat gtcctgggct gcaatgtgtc cccagtgtcc gggttccagc ccccagatga
      901 gagcctggtt tatctgtgct atgcggtctc caaagaagac ggctcatttt ctttctattc
      961 cttgccgagt gggggctaca ctgtggtgcc cttctaccga ggagaaagga tcaccttcga
     1021 cgtggcgccc tcccggcttg acttcacggt ggagcacgac agcctgagaa tcgagcctgt
     1081 attccacgtc atgggcttct ctgtcaccgg gagagtcttg aatggacctg acggagaagg
     1141 cgtcccagag gctgtggtca ccctgaacaa ccagattaaa gtcaaaacga aggctgacgg
     1201 ctccttccgc ctggagaaca taacgacagg gacatacacc atccacgctc agaaggagca
     1261 cctctacttc gagatggtca ccatcaaaat tgcccccaac accccacagc tggctgacct
     1321 catcgctaca gggttcagca tctgtggtca gatcgccatc gtccgctccc ccgacaccat
     1381 caagcagatg agtaaataca gagtggtcct gtcctcccaa gacaaggaca aggctttgct
     1441 cactgtggac agcgatgccc atggatcatt ttgctttaaa gcaaaaccag gggcctacaa
     1501 agtccaggtg gtggtacccg aggctgagac cagagcaggg ctgatgttga agccgcaggt
     1561 attccccctc actgtgacca acaggcctgt gatggatgtg gccttcgtgc agtttctggc
     1621 atcggtttcc gggaaagtct cctgtctgga tacctgcggt gacctgttgg tgaccctgca
     1681 gtccctgagc cgccagggtg agaaacgcag cctccagctc tcaggcaaag tcaactccat
     1741 gactttcacc tttgacaaag ttctgcctgg gagatacaaa ataagcatca tgcatgagga
     1801 ctggtgctgg aggaacaaga gtctggaagt ggaagtgctg gaggacgacg tgtctgcggt
     1861 ggagttcagg cagaccggtt acatgctgcg ctgcgcactc tcacacgcca tcactctgga
     1921 atttcatcag gacggaaatg gccctgaaaa tgtggggatt tacaatctct ccaggggagt
     1981 gaaccgcttc tgcctgtcca agcctggtgt gtacaaagtg actccccgct cctgccaccg
     2041 gtttgagcaa gccttttaca cctatgacac gtcttcaccc agtatcctga cgctgacagc
     2101 cattcgtcac catgttcttg gaacaatcat tactgacaaa atgatggacg tcacagtgac
     2161 tatcaagtct tccatcgaca gcgagccagc cttggtcttg ggacctctga agtctgcaca
     2221 ggagctgcgg agggaacagc agctggcaga gatcgagact cgcaggcagg agagggagaa
     2281 gaatggcaaa gaagagggcg aagaaggcag ggcccggcct cctgggcagg agatggtgga
     2341 tgagttacag ggccccttct cctacgactt ctcctactgg gcccggtctg gagagaaaat
     2401 cactgttaca ccctcgtcca aagagctcct cttttatccc ccatccatgg aagccactgt
     2461 cagtggagaa agctgtccag ggaagttaat tgagatccat gggaaggcgg gcttgttcct
     2521 ggaaggccag attcacccag agctggaggg agtcgagatt gtcatcagcg agaagggagc
     2581 aagttcaccc ttgatcactg tcttcaccga tgacaaaggt gcctacagtg ttggtcccct
     2641 acacagtgac ctggagtata ctgtgaactc acagaaggag ggctacgtgc tgactgccgt
     2701 ggaaggaacc gtgggagact tcaaggctta tgccttggcc ggcgtgagct tcgagattaa
     2761 agctgaagac gaccagccgc tccctggggt cctcttatcc ctcagtggtg gcgtgtttcg
     2821 ttccaacctc ctgacccaag acaacggcat tctgactttc tcaaacctga gccctggaca
     2881 gtactacttt aaacccatga tgaaggagtt ccgctttgag ccatcctcac agatgataga
     2941 agtgcaggag gggcagaacc tgaggatcac catcactggc tttcgaactg cctacagctg
     3001 ctacggcact gtgtcgtctt taaatggaga gccagagcag ggtgtcgcgg tggaggctgt
     3061 ggggcagaaa gactgcagca tctatggaga agacacggtg acagacgagg aggggaagtt
     3121 ccggttacgt gggctgctgc cagggtgcat gtaccacgtg cagctgaagg cagaaggcaa
     3181 tgaccacatc gagcgggcgc tgccccacca ccgggtgatt gaggttggga acaatgacgt
     3241 ggatgacgta aacatcatag ttttccggca gatcaaccag tttgacctga gtggaaacgt
     3301 aatcacttcc tccgagtatc tgtctacctt gtgggtgaag ctgtacaaaa gcgagagtct
     3361 cgacaacccc atccagacgg tgtctctggg ccagtcgctc ttcttccact tcccaccgct
     3421 gctccgagat ggcgagaact atgtggtgct gctggacacc acgctcccca gatcccagta
     3481 cgactacgtc ctgccgcaag tctctttcac tgcagtgggc taccacaagc acatcactct
     3541 ggttttcagt cccacgagga agctccctga acaagacatt gcgcaggggt cctatattgc
     3601 cctgcctctg acgctgctgc tcctgttggc gggctacaac catgacaagc tcattccttt
     3661 gctgctgcag ctgacgagtc gtcttcaggg agtcagagcc cttggccagg cggcctctga
     3721 cagcagcggc ccagaagaca tgaagagaca aaccaagaaa cagaagacca gacgcacgtg
     3781 aggaagaagg aggccccgtc tcctgcagat gacacagcca gggctgccgc ctgcctgggg
     3841 acaaaggcac atgctcactc acttcaggca ggccctgggc cctgtcaccc ttgtgttggt
     3901 gtcctgcctg tctgtcctct cctgtgtagc cctgtggtgc aatgcgacga atggaccctc
     3961 ctgtcaccct gctgaacaca atttattttc tgagttgaag ataatttatt attattattt
     4021 ttgtcagaga agtatttaag ctgagctggt ggcgtgagaa cataatctaa tcttccacat
     4081 tcgtttgcaa gaagagtcca ggaaacatgg cgttggtctg ctgtgccttc tggactttcc
     4141 ccaaaccgcc ccctgcactc gaggcccgtg ccagaagctg cagcaacatc tgtccctccc
     4201 agaagggtct gtcaacagct ggatgaataa agtcagccac tcgtttgtgt tgtaacttga
     4261 aaaaaaaaaa aaaaaaa
//
