LOCUS       NM_001039353            3662 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus nucleolar and coiled-body phosphoprotein 1 (Nolc1),
            transcript variant 4, mRNA.
ACCESSION   NM_001039353
VERSION     NM_001039353.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3662)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3662)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3662)
  AUTHORS   Yuan,F., Zhang,Y., Ma,L., Cheng,Q., Li,G. and Tong,T.
  TITLE     Enhanced NOLC1 promotes cell senescence and represses
            hepatocellular carcinoma cell proliferation by disturbing the
            organization of nucleolus
  JOURNAL   Aging Cell 16 (4), 726-737 (2017)
   PUBMED   28493459
  REMARK    GeneRIF: Enhanced NOLC1 promotes cell senescence and represses
            hepatocellular carcinoma cell proliferation by disturbing the
            organization of nucleolus.
REFERENCE   4  (bases 1 to 3662)
  AUTHORS   Kone,M.C., Fleurot,R., Chebrout,M., Debey,P., Beaujean,N. and
            Bonnet-Garnier,A.
  TITLE     Three-Dimensional Distribution of UBF and Nopp140 in Relationship
            to Ribosomal DNA Transcription During Mouse Preimplantation
            Development
  JOURNAL   Biol Reprod 94 (4), 95 (2016)
   PUBMED   26984997
  REMARK    GeneRIF: UBF and Nopp140 dynamic redistribution between the
            two-cell and blastocyst stages (time of implantation) is correlated
            with morphological and structural modifications that occur in
            embryonic nucleolar compartments.
REFERENCE   5  (bases 1 to 3662)
  AUTHORS   Rao,F., Cha,J., Xu,J., Xu,R., Vandiver,M.S., Tyagi,R., Tokhunts,R.,
            Koldobskiy,M.A., Fu,C., Barrow,R., Wu,M., Fiedler,D., Barrow,J.C.
            and Snyder,S.H.
  TITLE     Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death
            pathway by regulating CK2 phosphorylation of Tti1/Tel2
  JOURNAL   Mol Cell 54 (1), 119-132 (2014)
   PUBMED   24657168
  REMARK    Erratum:[Mol Cell. 2020 Aug 20;79(4):702. doi:
            10.1016/j.molcel.2020.07.021.. PMID: 32822581]
REFERENCE   6  (bases 1 to 3662)
  AUTHORS   Hwang,Y.C., Lu,T.Y., Huang,D.Y., Kuo,Y.S., Kao,C.F., Yeh,N.H.,
            Wu,H.C. and Lin,C.T.
  TITLE     NOLC1, an enhancer of nasopharyngeal carcinoma progression, is
            essential for TP53 to regulate MDM2 expression
  JOURNAL   Am J Pathol 175 (1), 342-354 (2009)
   PUBMED   19541936
REFERENCE   7  (bases 1 to 3662)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   8  (bases 1 to 3662)
  AUTHORS   Tucker,K.E., Berciano,M.T., Jacobs,E.Y., LePage,D.F.,
            Shpargel,K.B., Rossire,J.J., Chan,E.K., Lafarga,M., Conlon,R.A. and
            Matera,A.G.
  TITLE     Residual Cajal bodies in coilin knockout mice fail to recruit Sm
            snRNPs and SMN, the spinal muscular atrophy gene product
  JOURNAL   J Cell Biol 154 (2), 293-307 (2001)
   PUBMED   11470819
REFERENCE   9  (bases 1 to 3662)
  AUTHORS   Baran,V., Brochard,V., Renard,J.P. and Flechon,J.E.
  TITLE     Nopp 140 involvement in nucleologenesis of mouse preimplantation
            embryos
  JOURNAL   Mol Reprod Dev 59 (3), 277-284 (2001)
   PUBMED   11424213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY031361.1, AK147118.1, AK034817.1 and BE992617.1.
            
            On Nov 7, 2013 this sequence version replaced NM_001039353.1.
            
            Transcript Variant: This variant (4) uses an alternate in-frame
            splice site in the central coding region, compared to variant 3.
            The encoded isoform (D) is shorter, compared to isoform C.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147118.1, SRR7345562.4590843.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               BY031361.1         2-129
            129-2021            AK147118.1         2-1894
            2022-3646           AK034817.1         1899-3523
            3647-3662           BE992617.1         19-34               c
FEATURES             Location/Qualifiers
     source          1..3662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..3662
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /note="nucleolar and coiled-body phosphoprotein 1"
                     /db_xref="GeneID:70769"
                     /db_xref="MGI:MGI:1918019"
     exon            1..303
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2289
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /note="isoform D is encoded by transcript variant 4; 140
                     kDa nucleolar phosphoprotein"
                     /codon_start=1
                     /product="nucleolar and coiled-body phosphoprotein 1
                     isoform D"
                     /protein_id="NP_001034442.1"
                     /db_xref="GeneID:70769"
                     /db_xref="MGI:MGI:1918019"
                     /translation="MADTGLRRVVPSDLYPLVLRFLRDSQLSEVASKFAKATGATQQD
                     ANASSLLDIYSFWLKSTKAPKVKLQSNGPVTKKAKKETSSSDSSEDSSEDEDKKAQGL
                     PTQKAAAQVKRASVPQHAGKAAAKASESSSSEESSEEEEEDKKKKPVQQKAAKPQAKA
                     VRPPAKKAESSESDSDSDSDSSSEEETPQTQKPKAAVAAKAQTKAEAKPGTPAKAQPK
                     VANGKAAASSSSSSSSDDSEEEKKAAAPPKKTVPKKQVVAKAPVKVAAAPTQKSSSSE
                     DSSSEEEEGQRQPMKKKAGPYSSVPPPSVPLPKKSPGTQAPKKAAAQTQPADSSDDSS
                     DDSDSSSEEEKKPPAKTVVSKTPAKAAPVKKKAESSSDSSDSDSSEDEAPAKPVSTTK
                     SPKPAVTPKPSAAKAVTTPKQPAGSNQKPQSRKADSSSSEEESSSSEEEEASKKSATT
                     PKAKVTAKAAPAKQAPQAAGDSSSDSDSSSSEEEEKTPKPPAKKKAAGGAVSTPAPGK
                     KAEAKSSSSSSSSSSEDSSEEEKKKKPKATTPKIQASKANGTPASLNGKAAKESEEEE
                     EEEETEEKKKAAGTKPGSGKKRKQNETADEATTPQAKKVKLETPNTFPKRKKGERRAS
                     SPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRG
                     SYRGGSISVQVNSVKFDSE"
     exon            304..359
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            360..505
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            506..633
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            634..811
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            812..930
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1066
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1195
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1306
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1930
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2037
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2130
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..3662
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2562..2567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /note="hexamer: ATTAAA"
     polyA_site      2581
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /note="major polyA site"
     regulatory      2616..2621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /note="hexamer: ATTAAA"
     polyA_site      2654
                     /gene="Nolc1"
                     /gene_synonym="NOPP130; NOPP140; P130"
                     /note="major polyA site"
ORIGIN      
        1 tagatttagt ctgggtctct cctcccgggt ggagggtacg cgacctcgtg tgcgccactc
       61 ttttccgctg cgcgccgcgc gcgacttgat gacgacactg gacccgccct cgacccgggc
      121 tgtgctttgg tgttcttaag tcgtgccgcg tgcgcaacgg tagtgacgcg ttttacccgg
      181 agcatggcgg ataccggctt gcgccgcgtg gttcccagcg acctttatcc ccttgtgctc
      241 agatttctgc gggatagcca actctcggag gtggccagta aatttgcaaa agcgaccggc
      301 gctacacagc aggacgccaa tgcctcgtcc ctcttggaca tctatagctt ctggctcaag
      361 tccaccaaag ccccaaaggt gaagttacag tcaaatggac cagtgaccaa gaaggctaag
      421 aaagagactt catccagtga cagcagtgag gacagcagtg aggacgagga caaaaaagcc
      481 cagggacttc ccacacagaa ggctgccgca caggtcaagc gagccagtgt gcctcagcat
      541 gctggaaagg cagcagccaa agcttcagag agcagcagta gtgaagaatc cagtgaggaa
      601 gaggaagagg acaaaaagaa aaagcctgtc cagcagaagg cagctaagcc ccaagccaag
      661 gcagtcagac ctcctgcgaa gaaggcagag agctctgagt cggactcaga ctcggattcg
      721 gactccagct cagaggaaga aacaccacag acccagaagc caaaggcagc tgtggcagca
      781 aaagctcaga ctaaagccga agccaaacca ggtacaccag cgaaagcaca gcctaaggta
      841 gccaatggca aagcagccgc cagcagcagc agcagcagca gcagcgatga ctcagaggaa
      901 gagaagaagg cagctgcacc tcccaagaag actgtaccaa aaaagcaagt cgtggccaag
      961 gccccagtga aagtagctgc cgcccccacc cagaagagct ccagcagtga ggattcttcc
     1021 agtgaagagg aggagggaca gagacaaccc atgaagaaaa aagcaggtcc ctacagttca
     1081 gttccaccac cctctgttcc tttaccaaag aagtccccgg gaacccaggc tccaaagaaa
     1141 gctgctgcgc agacacagcc tgcagacagc agtgacgaca gcagtgacga ttctgattca
     1201 agttctgagg aagagaaaaa acctccagct aagacggtcg tctccaagac acccgccaaa
     1261 gcagctccag tgaagaagaa agcagaaagc tcttcagaca gctcggattc tgacagttct
     1321 gaggatgaag ctcctgccaa gccagtcagt acaaccaaga gtcccaagcc agctgtcact
     1381 ccgaagccat ctgcagcaaa ggcagtgaca actcctaagc aacctgcagg cagtaaccag
     1441 aaacctcaga gcaggaaggc tgacagcagc tccagcgagg aggaaagcag ctccagcgag
     1501 gaggaggagg cctccaagaa aagtgccaca acccccaagg ccaaggtgac tgctaaagca
     1561 gcacccgcca aacaggcccc tcaggctgct ggggacagca gctctgactc agatagttcc
     1621 agcagtgaag aggaggagaa gactcctaag cccccagcta agaagaaggc agcaggtgga
     1681 gccgtttcta caccagcccc tgggaagaaa gcagaggcca agagcagcag cagcagcagc
     1741 agcagcagct ccgaagattc cagtgaagag gagaaaaaaa agaagcccaa agctactacc
     1801 cctaaaatac aggcaagcaa ggccaatggc actccagctt ctctgaatgg aaaagcagcc
     1861 aaggaaagtg aggaggaaga ggaggaggaa gaaacagaag agaagaaaaa ggcagctggg
     1921 accaagccag gttcaggcaa aaaacggaag cagaatgaga ccgcagatga agcaacaact
     1981 cctcaagcta agaaagttaa gctcgagacc cccaatacgt ttccaaaaag gaagaaggga
     2041 gaaagaaggg cgtcttcccc tttccgaagg gtcagggagg aggagattga ggtggactct
     2101 cgagtggcgg acaattcctt tgatgccaag cgaggtgcag ctggagactg gggggagcga
     2161 gccaatcagg ttctgaagtt caccaaaggc aagtccttcc ggcatgaaaa aacgaagaag
     2221 aagcgaggca gctaccgggg aggctccatc tctgtccagg tcaattccgt caaattcgac
     2281 agcgagtgac acgtggtcat cctttggcaa aggaagggtg attttgggag actggcactc
     2341 aactccagtg gacccagaaa ctccgtgtta ggagacagtt gtgacaagga cggtgtggag
     2401 caggtcctga ggtgtgtcag cctgcagtcc tctcaggctc ctttttctgg acagctgaat
     2461 atcaaggaca aaaaggattt ttttttttaa agaaacccat tcagttgtca attgccttcc
     2521 tgttctgtgg gtcttcatac tgagagattt gtatatttta tattaaatca tgtcatacag
     2581 atttttgttg tgattttcag agatgacttc cacagattaa agtcttagct gttgcctaag
     2641 gcaaagcaaa acaacacatg gtaataattt tccctactgg aggattctct ttatgtgaaa
     2701 gccctggtgg gcaatgacat aagtcttgtg atgattgtct gctaagcata ctctgtgctc
     2761 atcttcatcc attgggcccg gcaccaaagc ttctagaagc cagcgtggat ctaccaactt
     2821 tgggggataa aattgccatt cttggtgcag taacctacta attggcaggc aggattctcg
     2881 agtgtgtgaa tgccatgcag ctgtctttgt tttgttcttg gtagctgtta ctgctacatg
     2941 tttacagtac ttttagtttt aatttcgaag taagcttttc tgacagacat tttgcaacaa
     3001 cttgactgtt gtatattgac aagttcatgg atgtatttga ttcttattaa catcaaggac
     3061 aggctggtaa gtacctgcat ggttgagtca ctggtcaagg aaatggagat gacctatgaa
     3121 ccctggtgtg aagtagatac actggatctc ctgggcacct ggagcagcag caggagacag
     3181 cccaaggagg caggagggct ctaactaagc aggaccattt tgtcttgaag tcggtacaca
     3241 ggagtaatta tgccctgttc aagttggtcc cctggactca ctattagtac cttacctata
     3301 atgttactga tacagactag ccaggaggca gggaggcata gctgggtggt agtgtgcttg
     3361 cttagcattc atagaccaag tgtgatctct atcaccgcag gaagtaaaga gcagagagat
     3421 tcctgggcca agggagtgga ttataaagct gtaggatgtg accattggca gtgagggcag
     3481 gggtgggacg tggctggcct ggtgagaaac ggataccggg cattgcctcc cctgtttggt
     3541 gtccacgctc acctggtaac ctgctaaaag ctgtggcagc tccttgtgga aggctgcatg
     3601 gtcaaagttc tgtgtcttac cacaaaacaa taaagtgaat ggttcctaat gtgttcagag
     3661 tt
//
