LOCUS       NM_030152               2869 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nucleolar protein 3 (apoptosis repressor with CARD
            domain) (Nol3), mRNA.
ACCESSION   NM_030152
VERSION     NM_030152.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2869)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2869)
  AUTHORS   Templin,A.T., Schmidt,C., Hogan,M.F., Esser,N., Kitsis,R.N.,
            Hull,R.L., Zraika,S. and Kahn,S.E.
  TITLE     Loss of apoptosis repressor with caspase recruitment domain (ARC)
            worsens high fat diet-induced hyperglycemia in mice
  JOURNAL   J Endocrinol 251 (2), 125-135 (2021)
   PUBMED   34382577
  REMARK    GeneRIF: Loss of apoptosis repressor with caspase recruitment
            domain (ARC) worsens high fat diet-induced hyperglycemia in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2869)
  AUTHORS   McKimpson,W.M., Chen,Y., Irving,J.A., Zheng,M., Weinberger,J.,
            Tan,W.L.W., Tiang,Z., Jagger,A.M., Chua,S.C. Jr., Pessin,J.E.,
            Foo,R.S., Lomas,D.A. and Kitsis,R.N.
  TITLE     Conversion of the death inhibitor ARC to a killer activates
            pancreatic beta cell death in diabetes
  JOURNAL   Dev Cell 56 (6), 747-760 (2021)
   PUBMED   33667344
REFERENCE   4  (bases 1 to 2869)
  AUTHORS   Wang,Q., Zhang,T., Chang,X., Lim,D.Y., Wang,K., Bai,R., Wang,T.,
            Ryu,J., Chen,H., Yao,K., Ma,W.Y., Boardman,L.A., Bode,A.M. and
            Dong,Z.
  TITLE     ARC Is a Critical Protector against Inflammatory Bowel Disease
            (IBD) and IBD-Associated Colorectal Tumorigenesis
  JOURNAL   Cancer Res 80 (19), 4158-4171 (2020)
   PUBMED   32816906
REFERENCE   5  (bases 1 to 2869)
  AUTHORS   Aryal,S., Anand,D., Hernandez,F.G., Weatherbee,B.A.T., Huang,H.,
            Reddy,A.P., Wilmarth,P.A., David,L.L. and Lachke,S.A.
  TITLE     MS/MS in silico subtraction-based proteomic profiling as an
            approach to facilitate disease gene discovery: application to lens
            development and cataract
  JOURNAL   Hum Genet 139 (2), 151-184 (2020)
   PUBMED   31797049
REFERENCE   6  (bases 1 to 2869)
  AUTHORS   Park,E., Han,J., Son,G.H., Lee,M.S., Chung,S., Park,S.H., Park,K.,
            Lee,K.H., Choi,S., Seong,J.Y. and Kim,K.
  TITLE     Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA
            splicing of the gonadotropin-releasing hormone gene transcript
  JOURNAL   J Biol Chem 281 (1), 401-409 (2006)
   PUBMED   16249178
REFERENCE   7  (bases 1 to 2869)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   8  (bases 1 to 2869)
  AUTHORS   Nam,Y.J., Mani,K., Ashton,A.W., Peng,C.F., Krishnamurthy,B.,
            Hayakawa,Y., Lee,P., Korsmeyer,S.J. and Kitsis,R.N.
  TITLE     Inhibition of both the extrinsic and intrinsic death pathways
            through nonhomotypic death-fold interactions
  JOURNAL   Mol Cell 15 (6), 901-912 (2004)
   PUBMED   15383280
REFERENCE   9  (bases 1 to 2869)
  AUTHORS   Abmayr,S., Crawford,R.W. and Chamberlain,J.S.
  TITLE     Characterization of ARC, apoptosis repressor interacting with CARD,
            in normal and dystrophin-deficient skeletal muscle
  JOURNAL   Hum Mol Genet 13 (2), 213-221 (2004)
   PUBMED   14645204
REFERENCE   10 (bases 1 to 2869)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124584.5.
            
            On May 1, 2007 this sequence version replaced NM_030152.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053846.1, AK079536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC124584.5         116866-117032       c
            168-464             AC124584.5         114209-114505       c
            465-824             AC124584.5         113704-114063       c
            825-2869            AC124584.5         111540-113584       c
FEATURES             Location/Qualifiers
     source          1..2869
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2869
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
                     /note="nucleolar protein 3 (apoptosis repressor with CARD
                     domain)"
                     /db_xref="GeneID:78688"
                     /db_xref="MGI:MGI:1925938"
     exon            1..167
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
                     /inference="alignment:Splign:2.1.0"
     exon            168..464
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..832
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
                     /note="apoptosis repressor with CARD"
                     /codon_start=1
                     /product="nucleolar protein 3"
                     /protein_id="NP_084428.1"
                     /db_xref="CCDS:CCDS52657.1"
                     /db_xref="GeneID:78688"
                     /db_xref="MGI:MGI:1925938"
                     /translation="MGNVQERPSETIDRERKRLVETLQADSGLLLDALVARGVLTGPE
                     YEALDALPDAERRVRRLLLLVQSKGEAACQELLRCAQQTVRMPDPAWDWQHVGPGYRN
                     RSYDPSCPGHWTPEAPSSGTTCPELPRASEQEEVGGPEGSEALQPRTPEEPELEAEAT
                     EGDEPDLEQEMNPEQEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPDFQEEDESE
                     DS"
     exon            465..824
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
                     /inference="alignment:Splign:2.1.0"
     exon            825..2869
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      936..941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
                     /note="hexamer: AATAAA"
     polyA_site      981
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
                     /note="major polyA site"
     polyA_site      997
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
     regulatory      2842..2847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
                     /note="hexamer: CATAAA"
     polyA_site      2863
                     /gene="Nol3"
                     /gene_synonym="ARC; B430311C09Rik; MYC; NOP; Nop30"
ORIGIN      
        1 cgctcgcttg gccctttctg cactgtcatc tgccccggtg aggctcaact ccggagtggg
       61 actatccgaa acgctccgga ccacaagccc gactccaccc agcagggagg gaaaggagac
      121 agattgggca gaatcccagg cctcaccacc agcagcggag ttcgaagaaa tgggcaacgt
      181 gcaggagcgc ccatcagaga ccattgaccg ggaacggaaa cggctggtag agacattgca
      241 ggctgactct gggctgctgc tggatgcgct ggtggcccgg ggcgtcctca ctgggcccga
      301 gtacgaagcc ttggatgcgc tgcccgatgc agagcgcagg gtgcgccgcc tactgctgtt
      361 ggtgcagagc aagggcgagg cagcctgcca ggagctactg cgctgtgccc agcaaacagt
      421 gcgcatgcca gacccggcct gggattggca gcacgtgggg cccggctacc ggaaccgcag
      481 ctatgaccct tcatgcccag gccactggac gccagaagca cccagttcag ggaccacatg
      541 tcctgagctg ccaagagcgt cagagcaaga ggaggtcgga ggtcctgagg gctctgaggc
      601 actgcagcct cgaactccag aggagccaga actagaagct gaagctactg aaggggatga
      661 gccagacctg gaacaagaaa tgaatccaga acaagagccg gagccggagc ccgagccaga
      721 acccgaaccc gagcccgagc cggaacccga gcccgagcca gaacccgagc ccgagccgga
      781 acccgaaccc gagcccgact tccaagaaga ggatgaatct gaagattcct gaaggccaga
      841 atccttagct gtccaatcct atttgtgctg gataagacct ggaaacctgc cagagcttga
      901 ccccatcgat gcaccgagac acctactgcc aaatgaataa actcaggagg gtcagtctgt
      961 tcctgactct ccacaagtct ggctctttgc tcaagaactg agggtgagcg tgggtctgaa
     1021 tcccactgac ctgagcaggc ttgtgtgaaa atacccccat cccctcaaaa acattccact
     1081 tcccaaagag cccaagctgt aattctggag atctcagatg caggccccca aatctgaccc
     1141 tccctcaccc actttattcc cctcaggggc catttgggag gccgagtggg caacacttct
     1201 aatccatgga aatcactcgg cttggtgtac caagcaagtg aagggggatg tccatccaca
     1261 catggagaga agtcttggcg ctcacagtct tgcagggagg acctgagagg aaacttgagt
     1321 agacagaagc cacacacatc attgtaactg ctgtttaatt gtctggcttt cctctgaact
     1381 gggagctcag tgaggggcgt ggggtctaac cagtcacaga catacacaag gagctctgca
     1441 catatctact aagtaaatga atacaaactt cccagctgtg tttccaagct tcacagatgg
     1501 aaacattaac tgaaaagcca gggttaggac agtactagct cactctccca ccgctgaatc
     1561 tgaagtgaaa tgaaagcctt aaccagctct gtactaatcc tggcctgaac gtgggataac
     1621 aaaccctagg gcctgccctg taggtttgat tgtggttgct cccgcctgtc ctaaccactg
     1681 ccagagacca gctgtgaggc tgtggttaaa gacaggcaca accaagacta acatggggac
     1741 tgagggtggg accaggtgct ggactcacaa gacacaagac acagtgtgtc tgtgtgagtg
     1801 ataagaaagg gggtctaggg ggctggagag atggctcagt ggttaagagc actgactgct
     1861 ttcccagagg tcctgagttc tactcccagc aaccacatgg cggctcacaa ccatctgtaa
     1921 tggaatctga tgccctcttc tagtgtgtct gaagacagct acagtgtact cgtatacata
     1981 aaataaataa gtctttgaaa gaaaagaagg aaggaaggaa ggaaggaagg aaggaaggaa
     2041 ggaagagaga gagagagagg gagagggagg gagggaggaa ggaaggaagg aaggaaggaa
     2101 ggaaggaagg aaggaagagg gagagaggga ggaaggaagg aaggaagagg gagagaggga
     2161 gagggaagga aggaaggaag gaaggaagga aggaaggaag gaaggaaaga aggaaggaag
     2221 gaaggaagga aggaaggggt ctaggaacat acggtacttt tccaaaggat cctgccccta
     2281 catggaacta ctactactac tactactact actactacta ctactactac tacttccggg
     2341 ccccgcctgg aggcatgaaa tgaccccatg agggcgacta tggaacaatg catgaccagt
     2401 gagacagaca gaatgctgaa aggcaaagcc cagcccagct gggtctctga gcctgagtga
     2461 cagccggaac cccatgctca ggcaaatcac ctcagagggg ttcccaactc ctgctggccc
     2521 cagtgagagg tagaggtatg agtgtagaag gagcaccaat cggccaggta gggggaaggg
     2581 aaggagtggt accagacacc caaagccatc tcatgcagga acaagtttct attcccaaac
     2641 caacccacat ttctattcac actcagctcc catctcatcg ccctcccatc tcccctgctc
     2701 aggagtttat gtgacatgct gctgcagttc acaggcccca ggaagggtag caaggacaaa
     2761 aaccttctaa cgttgcttct catctgccca cgatgctcct ggcctcccaa atgcccccaa
     2821 gaaacaccta ggctatggaa ccataaagaa cttcatattc cgatctgtg
//
