LOCUS       NM_145857               4621 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus nucleotide-binding oligomerization domain containing 2
            (Nod2), mRNA.
ACCESSION   NM_145857 XM_989552
VERSION     NM_145857.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4621)
  AUTHORS   Rodrigues E-Lacerda,R., Barra,N.G., Fang,H., Anhe,G.F. and
            Schertzer,J.D.
  TITLE     NOD2 protects against allergic lung inflammation in obese female
            mice
  JOURNAL   iScience 27 (11), 111130 (2024)
   PUBMED   39507249
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4621)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4621)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4621)
  AUTHORS   Vasquez Ayala,A., Hsu,C.Y., Oles,R.E., Matsuo,K., Loomis,L.R.,
            Buzun,E., Carrillo Terrazas,M., Gerner,R.R., Lu,H.H., Kim,S.,
            Zhang,Z., Park,J.H., Rivaud,P., Thomson,M., Lu,L.F., Min,B. and
            Chu,H.
  TITLE     Commensal bacteria promote type I interferon signaling to maintain
            immune tolerance in mice
  JOURNAL   J Exp Med 221 (1) (2024)
   PUBMED   38085267
REFERENCE   5  (bases 1 to 4621)
  AUTHORS   Li,C., Ouyang,Z., Huang,Y., Lin,S., Li,S., Xu,J., Liu,T., Wu,J.,
            Guo,P., Chen,Z., Wu,H. and Ding,Y.
  TITLE     NOD2 attenuates osteoarthritis via reprogramming the activation of
            synovial macrophages
  JOURNAL   Arthritis Res Ther 25 (1), 249 (2023)
   PUBMED   38124066
  REMARK    GeneRIF: NOD2 attenuates osteoarthritis via reprogramming the
            activation of synovial macrophages.
            Erratum:[Arthritis Res Ther. 2024 Jan 13;26(1):22. doi:
            10.1186/s13075-024-03261-5.. PMID: 38218983]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4621)
  AUTHORS   Caetano,B.C., Biswas,A., Lima,D.S. Jr., Benevides,L., Mineo,T.W.,
            Horta,C.V., Lee,K.H., Silva,J.S., Gazzinelli,R.T., Zamboni,D.S. and
            Kobayashi,K.S.
  TITLE     Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary
            for the development of cell-mediated immunity and host resistance
            to Toxoplasma gondii
  JOURNAL   Eur J Immunol 41 (12), 3627-3631 (2011)
   PUBMED   22002196
  REMARK    GeneRIF: Nod2-deficient mice were fully capable of inducing Th1
            immune responses and did not show enhanced susceptibility to
            infection.
REFERENCE   7  (bases 1 to 4621)
  AUTHORS   Iwanaga,Y., Davey,M.P., Martin,T.M., Planck,S.R., DePriest,M.L.,
            Baugh,M.M., Suing,C.M. and Rosenbaum,J.T.
  TITLE     Cloning, sequencing and expression analysis of the mouse
            NOD2/CARD15 gene
  JOURNAL   Inflamm Res 52 (6), 272-276 (2003)
   PUBMED   12835899
  REMARK    GeneRIF: the murine form of NOD2 was cloned and its tissue
            distribution, function and response to inflammatory stimuli
            characterized
REFERENCE   8  (bases 1 to 4621)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   9  (bases 1 to 4621)
  AUTHORS   Ogura,Y., Saab,L., Chen,F.F., Benito,A., Inohara,N. and Nunez,G.
  TITLE     Genetic variation and activity of mouse Nod2, a susceptibility gene
            for Crohn's disease
  JOURNAL   Genomics 81 (4), 369-377 (2003)
   PUBMED   12676561
REFERENCE   10 (bases 1 to 4621)
  AUTHORS   Girardin,S.E., Boneca,I.G., Viala,J., Chamaillard,M., Labigne,A.,
            Thomas,G., Philpott,D.J. and Sansonetti,P.J.
  TITLE     Nod2 is a general sensor of peptidoglycan through muramyl dipeptide
            (MDP) detection
  JOURNAL   J Biol Chem 278 (11), 8869-8872 (2003)
   PUBMED   12527755
  REMARK    GeneRIF: Nod2 is a general sensor of peptidoglycan through muramyl
            dipeptide (MDP) detection
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156937.4.
            
            On or before May 4, 2006 this sequence version replaced
            XM_989552.1, NM_145857.1.
            
            Sequence Note: This RefSeq record was created using sequence from
            the reference genome strain C57BL/6J because transcripts from the
            reference strain were not available for the full length of the
            gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 22002196
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC156937.4         103528-103590       c
            64-530              AC156937.4         97606-98072         c
            531-636             AC156937.4         90293-90398         c
            637-2452            AC156937.4         85424-87239         c
            2453-2536           AC156937.4         80443-80526         c
            2537-2620           AC156937.4         80191-80274         c
            2621-2704           AC156937.4         78179-78262         c
            2705-2788           AC156937.4         75948-76031         c
            2789-2872           AC156937.4         75407-75490         c
            2873-2956           AC156937.4         69240-69323         c
            2957-3040           AC156937.4         66408-66491         c
            3041-3706           AC156937.4         63642-64307         c
            3707-4621           AC156937.4         62463-63377         c
FEATURES             Location/Qualifiers
     source          1..4621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 43.51 cM"
     gene            1..4621
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /note="nucleotide-binding oligomerization domain
                     containing 2"
                     /db_xref="GeneID:257632"
                     /db_xref="MGI:MGI:2429397"
     exon            1..63
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            64..530
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..3113
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /note="caspase recruitment domain family, member 15;
                     caspase recruitment domain-containing protein 15"
                     /codon_start=1
                     /product="nucleotide-binding oligomerization
                     domain-containing protein 2"
                     /protein_id="NP_665856.2"
                     /db_xref="CCDS:CCDS52632.1"
                     /db_xref="GeneID:257632"
                     /db_xref="MGI:MGI:2429397"
                     /translation="MCSQEEFQAQRSQLVALLISGSLEGFESILDWLLSWDVLSREDY
                     EGLSLPGQPLSHSARRLLDTVWNKGVWGCQKLLEAVQEAQANSHTFELYGSWDTHSLH
                     PTRDLQSHRPAIVRRLYNHVEAMLELAREGGFLSQYECEEIRLPIFTSSQRARRLLDL
                     AAVKANGLAAFLLQHVRELPAPLPLPYEAAECQKFISKLRTMVLTQSRFLSTYDGSEN
                     LCLEDIYTENILELQTEVGTAGALQKSPAILGLEDLFDTHGHLNRDADTILVVGEAGS
                     GKSTLLQRLHLLWATGRSFQEFLFIFPFSCRQLQCVAKPLSLRTLLFEHCCWPDVAQD
                     DVFQFLLDHPDRVLLTFDGLDEFKFRFTDRERHCSPIDPTSVQTLLFNLLQGNLLKNA
                     CKVLTSRPDAVSALLRKFVRTELQLKGFSEEGIQLYLRKHHREPGVADRLIQLIQATS
                     ALHGLCHLPVFSWMVSRCHRELLLQNRGFPTTSTDMYLLILQHFLLHASPPDSSPLGL
                     GPGLLQSRLSTLLHLGHLALRGLAMSCYVFSAQQLQAAQVDSDDISLGFLVRAQSSVP
                     GSKAPLEFLHITFQCFFAAFYLAVSADTSVASLKHLFSCGRLGSSLLGRLLPNLCIQG
                     SRVKKGSEAALLQKAEPHNLQITAAFLAGLLSQQHRDLLAACQVSERVLLQRQARARS
                     CLAHSLREHFHSIPPAVPGETKSMHAMPGFIWLIRSLYEMQEEQLAQEAVRRLDIGHL
                     KLTFCRVGPAECAALAFVLQHLQRPVALQLDYNSVGDVGVEQLRPCLGVCTALYLRDN
                     NISDRGARTLVECALRCEQLQKLALFNNKLTDACACSMAKLLAHKQNFLSLRVGNNHI
                     TAAGAEVLAQGLKSNTSLKFLGFWGNSVGDKGTQALAEVVADHQNLKWLSLVGNNIGS
                     MGAEALALMLEKNKSLEELCLEENHICDEGVYSLAEGLKRNSTLKFLKLSNNGITYRG
                     AEALLQALSRNSAILEVWLRGNTFSLEEIQTLSSRDARLLL"
     exon            531..636
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..2452
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2536
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2620
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2704
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2788
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2872
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2956
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3040
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3706
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..4621
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4530..4535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /note="hexamer: TATAAA"
     polyA_site      4554
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /note="major polyA site"
     regulatory      4599..4604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /note="hexamer: AATAAT"
     polyA_site      4621
                     /gene="Nod2"
                     /gene_synonym="ACUG; BLAU; Card15; CD; F830032C23Rik;
                     IBD1; Nlrc2"
                     /note="major polyA site"
ORIGIN      
        1 tgagggagtc ctagtgtgga gtcaccgcaa aactggcgag ggatccccac gctgcagctg
       61 gcggttgtga catgtgctca caggaagagt tccaggcaca gaggagccag ctggtggcac
      121 tgctgatctc agggtccttg gagggctttg agagcatctt agactggctg ctgtcttggg
      181 atgtgctctc cagggaggac tatgagggcc tcagcctccc tggccaacct ctctcccatt
      241 ctgccaggcg tctgctggac acagtctgga acaagggtgt ttggggctgt cagaagctcc
      301 tcgaagctgt gcaggaggca caggccaaca gtcatacctt tgaactgtat gggtcctggg
      361 acactcactc ccttcatcca accagagacc tgcagagtca ccggccagcc attgtgagga
      421 gactctacaa ccatgtagaa gccatgctgg agctggcaag ggaggggggg tttctgagcc
      481 agtacgagtg tgaggagatc aggctgccaa tcttcacgtc gtctcagagg gcaagaaggc
      541 tgcttgatct cgctgcggtg aaggccaatg gactggctgc cttccttcta cagcacgtca
      601 gggaactacc agctccactg cctctgcctt acgaggctgc tgagtgtcag aagttcatat
      661 ctaagctgag gaccatggtg ttgactcagt ctcgcttcct cagtacttac gatgggtcgg
      721 agaatctttg cctggaggat atatacacgg agaacatctt ggagctgcag actgaagtgg
      781 gcacagccgg ggccttgcag aagagccctg ccatcctggg cctggaggac ctctttgata
      841 cccatggtca cctgaacaga gatgccgaca ccatactggt ggtgggcgaa gcaggcagtg
      901 gcaagagcac tcttctgcag cgtttgcacc tgctgtgggc aacagggagg agcttccagg
      961 agtttctctt cattttccca ttcagctgcc gacagttgca atgcgtggcc aaaccgctgt
     1021 ccctgaggac gctgctcttt gagcactgct gctggcctga tgtcgctcag gacgatgtct
     1081 tccagttcct tcttgaccat cctgaccgtg tcctgttaac ctttgatggc ttggacgagt
     1141 tcaagttccg gttcaccgac cgggagcgcc actgctctcc aattgacccc acgtcagtcc
     1201 agactctgct cttcaacctt ctccagggga acctgctgaa gaatgcctgc aaggtgctga
     1261 ccagccgtcc ggatgctgtg tcagcgctcc tcaggaagtt cgttcgcaca gagttgcaac
     1321 tgaagggctt ctctgaagag ggcatccaac tgtacctgag aaagcaccac cgggaacctg
     1381 gggtggcaga ccgcctcatc cagctgatcc aagccacctc agccctgcat ggtttgtgcc
     1441 acctccctgt cttctcttgg atggtgtcca gatgccaccg ggaacttctg ctgcagaaca
     1501 ggggcttccc aacaaccagc acggacatgt acctcctgat cctgcagcat ttcctgctgc
     1561 atgcctcccc tccggactcc tccccactcg gtctgggacc tggactcctc caaagccggc
     1621 tctccaccct cctgcacctt ggccacctgg ctctccgggg cctggccatg agctgctatg
     1681 tgttctcagc ccagcagctc caggcagctc aggttgactc tgatgatatt tctcttggtt
     1741 tcctggtacg tgcccaaagt agtgtgcccg ggagcaaggc gcccctggag ttcctgcaca
     1801 ttaccttcca gtgctttttt gccgctttct acttggctgt cagtgctgac acatcggtgg
     1861 cctctctcaa gcaccttttc agctgtggcc ggctgggcag ctcactgctg ggaaggctgc
     1921 tgcccaacct gtgtatccag ggctccagag tcaagaaggg cagcgaagca gccctgctgc
     1981 agaaggctga gccacacaac ctgcaaatca cagcagcctt cctagcaggt ctgttgtccc
     2041 agcagcatcg ggacctgttg gctgcatgcc aggtctccga gagggtactg ctccagcgtc
     2101 aggcacgtgc ccgctcgtgt ctggcccaca gcctccgcga gcacttccat tccatcccgc
     2161 ctgccgtgcc cggtgagacc aagagcatgc atgctatgcc gggcttcatt tggctcatcc
     2221 gtagcctgta cgagatgcag gaggagcagt tggcccagga ggctgtccgt cgcttggaca
     2281 tcgggcacct gaagttgaca ttttgcagag tgggccctgc agagtgtgct gcactggcct
     2341 ttgtactgca acatctccag cggcctgtgg ccctacagct ggattacaac tctgtgggag
     2401 atgttggagt ggaacagctg cgaccgtgcc ttggggtctg cacagctctg tatttgcgag
     2461 ataacaatat ctcagaccga ggtgcccgca cgctggttga gtgtgctctt cgctgtgagc
     2521 agctgcagaa actagctctc ttcaacaaca aactcacgga tgcgtgcgcc tgctccatgg
     2581 ccaagctcct tgcacacaag cagaacttct tgtccctgag ggtggggaac aatcacatca
     2641 cagccgctgg agccgaggtg ctggcccagg gactcaagag caacacctcc ctgaagttcc
     2701 tggggttctg gggcaacagc gtgggtgata agggcaccca agccctggct gaagttgtag
     2761 ccgaccacca gaacctaaag tggctcagcc tggtaggaaa caacattggc agcatgggtg
     2821 ccgaagccct agcactgatg ctggagaaga acaagtcact agaggaactc tgcctagagg
     2881 aaaaccatat ctgtgacgaa ggggtatatt ctctcgcaga aggactcaag agaaattcaa
     2941 ctttgaaatt cttgaaactg tccaacaatg gcatcaccta ccggggtgca gaagccctcc
     3001 tgcaggccct cagcaggaac agtgccattc tggaggtttg gcttcgaggg aacacattct
     3061 ctttggagga aatccaaaca ctgagctcca gggacgccag actcttgttg tgatgtctcc
     3121 gtttgtgagt ggactgtagg ggcctggact ctggaggctg agtaacatca ggcagaatcc
     3181 ctctgctgcg cagggctggt ttgcttttct ggatgcagta tagtcacctt ctgttagcag
     3241 agaaagtcac cccattgccg tctggaattg acttttcccg aggagtcgtg atggttggtc
     3301 ttggttgtta actgcactga cttaagagac tcatgagccg agaggaccgc gtttctgcct
     3361 ctaaagagga tcaccgtgca gaattagtga ctggaagggg aaaggccctc actgcatgtg
     3421 ggtgacacaa tcctctctgg ttgccccgtg ggaggaagat ggaggaggag gaagacaggg
     3481 tatgcttgca tatgtgagca tttcttctga gtgaggacag ctgtggctgc tgccctcatg
     3541 tttgaacagc agactccagc gtctttggcc attcaacatg gacccatcac cagtgatgtt
     3601 ttagggagtt ttcaggcctg gagcttgatg gaacgtgagg tgtcgagctt ctccagctga
     3661 gaaggttctc tgcctctcca ctgttggact actctatctg gatggtactc caagcactgg
     3721 atgagctcaa gcaggccacc cccaccccca cccccacccc cgcccccatt actatgttgc
     3781 tggcctctgg ctggtcaagc agattcccct gatactatgt tgctggcctc tgaatggcca
     3841 ggattctgaa gggttcagtg gaaagcatgg atgttaactg aacgcctgtt gctgtggatc
     3901 cacatacaag acgccttcct cctccttttt gaagaggagt attcaggaag cagctctggc
     3961 cgtgtctgga ctcactctct aaggccatcc cactctgata cctccacttg tcctgcctga
     4021 ggcccaacag gactcaactt cgacaaccaa cataataccc cgctctcctt tcttaacaca
     4081 aacaacagtc ctttgccccc aggatgttct agatttataa gaaaaaatgt gaccacactc
     4141 cagctgggat cacacatggc ctttggtttc cagtaacatc aattactcta tagtttgagc
     4201 ctttggaatc agttcctccc tcaactgcag ctctttagaa ttaatctggg ccagaatttc
     4261 aaacgacccc accaggcccg gagtcggtgc ctatgaactg aactctgaca acagacttct
     4321 gaaacatatt cctgaaagac agctccattt tatttatgac aatgctttag gacatggagt
     4381 tggggcttgg aggcttgcag gggacaaaac caagcccttc tttctgagca aggtctttct
     4441 gtggtttttc aaaatgtcac ctttgtaatt tttaaattgt acaagtttta ctacctccat
     4501 tttatttagc gtgaaagcgg gttaatattt ataaatggca ctgttttatt ttaagttggt
     4561 gcttttatag aaaatgcgat catgaacttc cggctataaa taatcacaga ggtgaaagct
     4621 a
//
