LOCUS       NM_172729               4327 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus nucleotide-binding oligomerization domain containing 1
            (Nod1), transcript variant 1, mRNA.
ACCESSION   NM_172729
VERSION     NM_172729.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4327)
  AUTHORS   Rodrigues E-Lacerda,R., Barra,N.G., Fang,H., Anhe,G.F. and
            Schertzer,J.D.
  TITLE     NOD2 protects against allergic lung inflammation in obese female
            mice
  JOURNAL   iScience 27 (11), 111130 (2024)
   PUBMED   39507249
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4327)
  AUTHORS   Han,J.H., Karki,R., Malireddi,R.K.S., Mall,R., Sarkar,R.,
            Sharma,B.R., Klein,J., Berns,H., Pisharath,H., Pruett-Miller,S.M.,
            Bae,S.J. and Kanneganti,T.D.
  TITLE     NINJ1 mediates inflammatory cell death, PANoptosis, and lethality
            during infection conditions and heat stress
  JOURNAL   Nat Commun 15 (1), 1739 (2024)
   PUBMED   38409108
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4327)
  AUTHORS   Qiu,J., Wu,J., Chen,W., Ruan,Y., Mao,J., Li,S., Tang,X., Zhao,L.,
            Li,S., Li,K., Liu,D. and Duan,Y.
  TITLE     NOD1 deficiency ameliorates the progression of diabetic retinopathy
            by modulating bone marrow-retina crosstalk
  JOURNAL   Stem Cell Res Ther 15 (1), 38 (2024)
   PUBMED   38336763
  REMARK    GeneRIF: NOD1 deficiency ameliorates the progression of diabetic
            retinopathy by modulating bone marrow-retina crosstalk.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4327)
  AUTHORS   Iwamura,C., Ohnuki,H., Flomerfelt,F.A., Zheng,L., Carletti,A.,
            Wakashin,H., Mikami,Y., Brooks,S.R., Kanno,Y., Gress,R.E.,
            Tosato,G., Nakayama,T., O'Shea,J.J., Sher,A. and Jankovic,D.
  TITLE     Microbial ligand-independent regulation of lymphopoiesis by NOD1
  JOURNAL   Nat Immunol 24 (12), 2080-2090 (2023)
   PUBMED   37957354
  REMARK    GeneRIF: Microbial ligand-independent regulation of lymphopoiesis
            by NOD1.
REFERENCE   5  (bases 1 to 4327)
  AUTHORS   Tran,L.S., Ying,L., D'Costa,K., Wray-McCann,G., Kerr,G., Le,L.,
            Allison,C.C., Ferrand,J., Chaudhry,H., Emery,J., De Paoli,A.,
            Colon,N., Creed,S., Kaparakis-Liaskos,M., Como,J., Dowling,J.K.,
            Johanesen,P.A., Kufer,T.A., Pedersen,J.S., Mansell,A.,
            Philpott,D.J., Elgass,K.D., Abud,H.E., Nachbur,U., Croker,B.A.,
            Masters,S.L. and Ferrero,R.L.
  TITLE     NOD1 mediates interleukin-18 processing in epithelial cells
            responding to Helicobacter pylori infection in mice
  JOURNAL   Nat Commun 14 (1), 3804 (2023)
   PUBMED   37365163
  REMARK    GeneRIF: NOD1 mediates interleukin-18 processing in epithelial
            cells responding to Helicobacter pylori infection in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4327)
  AUTHORS   Viala,J., Chaput,C., Boneca,I.G., Cardona,A., Girardin,S.E.,
            Moran,A.P., Athman,R., Memet,S., Huerre,M.R., Coyle,A.J.,
            DiStefano,P.S., Sansonetti,P.J., Labigne,A., Bertin,J.,
            Philpott,D.J. and Ferrero,R.L.
  TITLE     Nod1 responds to peptidoglycan delivered by the Helicobacter pylori
            cag pathogenicity island
  JOURNAL   Nat Immunol 5 (11), 1166-1174 (2004)
   PUBMED   15489856
REFERENCE   7  (bases 1 to 4327)
  AUTHORS   Chamaillard,M., Hashimoto,M., Horie,Y., Masumoto,J., Qiu,S.,
            Saab,L., Ogura,Y., Kawasaki,A., Fukase,K., Kusumoto,S.,
            Valvano,M.A., Foster,S.J., Mak,T.W., Nunez,G. and Inohara,N.
  TITLE     An essential role for NOD1 in host recognition of bacterial
            peptidoglycan containing diaminopimelic acid
  JOURNAL   Nat Immunol 4 (7), 702-707 (2003)
   PUBMED   12796777
  REMARK    GeneRIF: NOD1 mediates selective recognition of bacteria through
            detection of iE-DAP-containing peptidoglycan.
REFERENCE   8  (bases 1 to 4327)
  AUTHORS   Girardin,S.E., Boneca,I.G., Carneiro,L.A., Antignac,A., Jehanno,M.,
            Viala,J., Tedin,K., Taha,M.K., Labigne,A., Zahringer,U.,
            Coyle,A.J., DiStefano,P.S., Bertin,J., Sansonetti,P.J. and
            Philpott,D.J.
  TITLE     Nod1 detects a unique muropeptide from gram-negative bacterial
            peptidoglycan
  JOURNAL   Science 300 (5625), 1584-1587 (2003)
   PUBMED   12791997
REFERENCE   9  (bases 1 to 4327)
  AUTHORS   Inohara,N., Koseki,T., del Peso,L., Hu,Y., Yee,C., Chen,S.,
            Carrio,R., Merino,J., Liu,D., Ni,J. and Nunez,G.
  TITLE     Nod1, an Apaf-1-like activator of caspase-9 and nuclear
            factor-kappaB
  JOURNAL   J Biol Chem 274 (21), 14560-14567 (1999)
   PUBMED   10329646
REFERENCE   10 (bases 1 to 4327)
  AUTHORS   Anderson-MacKenzie,J.M., Billingham,M.E. and Bailey,A.J.
  TITLE     Collagen remodeling in the anterior cruciate ligament associated
            with developing spontaneous murine osteoarthritis
  JOURNAL   Biochem Biophys Res Commun 258 (3), 763-767 (1999)
   PUBMED   10329460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137585.1, AY160222.1 and AI645572.1.
            
            On Jan 13, 2010 this sequence version replaced NM_172729.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137585.1, SRR10662772.3058709.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1832              AK137585.1         6-1837
            1833-1833           AY160222.1         1368-1368
            1834-4313           AK137585.1         1839-4318
            4314-4327           AI645572.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..4327
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.22 cM"
     gene            1..4327
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /note="nucleotide-binding oligomerization domain
                     containing 1"
                     /db_xref="GeneID:107607"
                     /db_xref="MGI:MGI:1341839"
     exon            1..344
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..666
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..841
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..2666
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2750
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2834
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2918
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3002
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3086
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3170
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3254
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..4322
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4296..4301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /note="hexamer: AATAAA"
     polyA_site      4315
                     /gene="Nod1"
                     /gene_synonym="C230079P11; Card4; F830007N14Rik; mNod1;
                     Nlrc1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtcaccc ctgggcgaac tgcgaggcct gcccactccc actgcgcagt ggccgctcgt
       61 ccgatgcagt gtgcggcggc tccttcccgg gaaacgagac aggggggcag cgctacggat
      121 ggtccccgcc tcctccgccc gctccgccct gttccctccc cggagcccac ccgagcccag
      181 gcgcggccgg ccgtagacac agccagctcc tgatcccgga ccgcgagcgg tagcgccctc
      241 cctcccagct gttgtcccgc ccgatccgcg accctagtcc ccggatcccc ttgctgagag
      301 tcaccgtact ccagggccaa ctgagccaaa gtcctgccaa cttgggtcag caatgaaagg
      361 caggatcccg ggtggtggcc ctgaatcctg atttgtctgc cctgccagcg agacacatgt
      421 ggtcaaagat gaatttgaga aaagtagctg ctggctactt gaacaatgga ggaacacggc
      481 catcatgaga tggaaggcac cccattgggt tgtcactccc acattaaact gctgaagatc
      541 aacagggaac atctggtcac caacattcgg aacactcagt gtctggtgga caacttgctg
      601 gagaatggct acttctcagc cgaagatgca gagattgtgt gtgcctgtcc caccaagcct
      661 gacaaggtcc gaaagatcct tgacctggtg cagagcaaag gcgaggaggt gtctgagttc
      721 ttcctctacg tgctgcagca gctggaggat gcttacgtgg acctcaggct gtggctctca
      781 gaaattggct tctccccttc ccagctcatt cggaccaaaa ctatcgtcaa tactgaccca
      841 gtaagcaggt atacccaaca gctgcgacac caactgggcc gcgactccaa gttcatgctg
      901 tgctacgccc agaaggagga cctgctgctg gaggagacct atatggacac actcatggag
      961 ctggtaggct tcaacaatga aaacctgggc agcctaggag gcctggattg cctgctggac
     1021 cacagtacgg gcgtcctcaa cgagcatggc gagactgtct tcgtgttcgg ggacgcggga
     1081 gtgggcaagt ccatgctgct gcagaggttg cagagcctct gggcgtcagg caggttgacc
     1141 tccacagcca aattcttctt ccacttccgc tgccgcatgt tcagctgctt caaggagagc
     1201 gacatgctga gtctgcagga cctgctcttc aagcatttct gctacccgga gcaggacccc
     1261 gaggaggtgt tctccttctt gctgcgcttt ccccacacag cgctcttcac ttttgacggc
     1321 ctggatgagc tgcactcaga cttcgacctg agccgcgtgc cggatagctg ctgcccctgg
     1381 gagccggctc accctctggt cctgctggct aacctcctaa gtgggaggct gctcaagggt
     1441 gccggcaaat tgctcactgc tcgcacaggc gtggaggtcc cccgccagct cctgcgcaaa
     1501 aaggtgctgc tccggggctt ctccccaagt cacctgcgcg cctatgcccg ccggatgttc
     1561 cccgagcgca cagcgcagga gcatctgctg cagcagctgg atgccaaccc caacctctgc
     1621 agcctgtgcg gggtgccgct cttctgttgg atcatcttcc gttgtttcca gcacttccag
     1681 acggtcttcg agggctcctc ttcacagttg ccggactgtg ctgtgaccct gaccgatgtc
     1741 tttctgctgg tcactgaggt gcatctgaac aggccgcagc ccagcagcct ggtgcagcgc
     1801 aacacgcgca gcccggcgga aaccctacgt gcaggctggc gcacgctgca tgcgctggga
     1861 gaggtggctc accgaggcac cgacaagagc ctctttgtgt ttggccagga ggaggtgcag
     1921 gcgtcgaagc tgcaggaagg agatctgcag ctgggcttcc tgcgggcttt gcccgatgtg
     1981 ggccctgagc agggccagtc ttacgaattt ttccacctta cgctccaggc cttcttcacc
     2041 gccttcttcc tggtagcaga tgacaaagtg agcacccggg agttgctgag gttctttcga
     2101 gaatggacgt ctcctggaga ggcaacaagc tcgtcctgcc attcttcctt cttctccttc
     2161 cagtgcctgg gcggcagaag ccggttgggc cctgatcctt tcaggaacaa agatcacttc
     2221 cagttcacca acctcttcct gtgcgggcta ctggccaaag cccgacagaa actccttcgg
     2281 cagctggtgc ccaaggctat cctgaggagg aagcgcaagg ccctgtgggc tcacctgttt
     2341 gctagcctgc gctcctactt gaagagccta cctcgggtcc agtctggagg ctttaaccag
     2401 gtgcatgcca tgcccacatt cctgtggatg ctgcgctgca tctatgagac gcagagccag
     2461 aaggtggggc gcctcgccgc caggggcatc agtgcggact acctcaagct ggccttttgc
     2521 aacgcttgct ctgcggactg cagcgccctg tccttcgtcc tgcatcactt ccacaggcag
     2581 ctggccctag acctggacaa caacaacctc aatgactatg gcgtgcagga gctgcagcct
     2641 tgctttagcc gtctcacggt tatcagactc agcgtcaacc agatcaccga cacgggggtg
     2701 aaggtgctat gtgaggaact gaccaagtat aagatcgtga cgttcctggg tttatacaac
     2761 aaccagataa ctgatatcgg agccaggtat gtggcccaaa tcctggatga atgcagaggc
     2821 ctcaagcacc ttaaactagg gaaaaacaga ataacaagtg agggcgggaa gtgtgtggct
     2881 ttggctgtga agaacagcac ctccatcgtt gatgttggga tgtggggtaa tcagattgga
     2941 gacgaagggg caaaggcctt cgcagaggca ttgaaggacc accccagcct gaccactctc
     3001 agtcttgcat tcaatggcat ctctccggag ggagggaaga gccttgcgca ggccctgaag
     3061 cagaacacca cactgacagt aatctggctg accaaaaatg aacttaatga tgagtctgca
     3121 gagtgcttcg ctgagatgct gagagtgaac cagacgctac ggcatttatg gctgatccag
     3181 aatcgcatca cagccaaggg gacagcgcag ctggcgaggg cactgcagaa gaacacagcc
     3241 ataacagaga tttgtctcaa tggaaacttg attaagcccg aggaggccaa agtcttcgag
     3301 aatgagaaga gaatcatctg cttctgacgg acgctcctgg gcaggatctt tgtcctaggt
     3361 tgctcctcag tcacagacag cactgtgcag tcagcagggt agcaggatgc tgtgcagcgc
     3421 ctgcagcaag gtgcctgtca ggagcccaca cctccacagt gcacaccgat gtcccctgct
     3481 catgcttgga ctggtagcac ccgcgccgcg gctgagaccc tgcagacgca gggagtctta
     3541 ggaaccatcg tcaccactca aagccagcag ggcatcttct gtacaaagat ctccctgcat
     3601 atccactaga cggaagctga aggaacgcaa cagcagagga ggccaacaga cgcctggctg
     3661 aaggctccgt gggaccaacg gtgtcacctt cagaaaagag ctgggaactt gagcagagcc
     3721 gatggtaact tcttggggaa agaaggcacc cagtgactgc atggttattc tgagtcctcc
     3781 ttcctctgct tagtccctct cactgtacag gtctgtttct tcctcgcagc tgtggctgct
     3841 gaagtaggtc cactgtgggg agagctcatc acagactttg gttcggttct ggattctcag
     3901 tggtggcaac cgagagtcag acgataccct ctaggtcagt ctcagaggat ctctatgctg
     3961 tgagagggtt gagggcccac ccagaatttt ttttttttac cagtttttac tgtgcctgcc
     4021 ccaggaggga gaattacttc ccagcctcca cagcagcagg catggcttgc ctcaatggtc
     4081 ctgagatccc aacaaaactc tctcccttgc ctgtgagcag aaagtatctt catgtcctca
     4141 gaagttggag ggtgactgga cacagttaag actcagagag ccagctgata gctcaaagca
     4201 aagcatggca catacccacc accataccat ggtgcgcatg ggatgggaca gttggaatgt
     4261 tgcagataac gtgttctttt gccagttcat ttgttaataa aatatttaaa acgttcactg
     4321 ttaaaaa
//
