LOCUS       NM_009834               3069 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus nocturnin (Noct), mRNA.
ACCESSION   NM_009834 XM_915138
VERSION     NM_009834.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3069)
  AUTHORS   Kulshrestha,S. and Devkar,R.
  TITLE     Circadian control of Nocturnin and its regulatory role in health
            and disease
  JOURNAL   Chronobiol Int 40 (7), 970-981 (2023)
   PUBMED   37400970
  REMARK    GeneRIF: Circadian control of Nocturnin and its regulatory role in
            health and disease.
            Review article
REFERENCE   2  (bases 1 to 3069)
  AUTHORS   Laothamatas,I., Gao,P., Wickramaratne,A., Quintanilla,C.G.,
            Dino,A., Khan,C.A., Liou,J. and Green,C.B.
  TITLE     Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its
            role in oxidative stress response
  JOURNAL   Proc Natl Acad Sci U S A 117 (2), 993-999 (2020)
   PUBMED   31879354
  REMARK    GeneRIF: The Noct gene encodes a protein (NOC) that is highly
            conserved with the endonuclease/exonuclease/phosphatase (EEP)
            domain-containing CCR4 family of deadenylases, but highly purified
            NOC possesses little or no ribonuclease activity. NOC utilizes the
            dinucleotide NADP(H) as a substrate, removing the 2' phosphate to
            generate NAD(H), and is a direct regulator of oxidative stress
            response through its NADPH 2' phosphatase activ
REFERENCE   3  (bases 1 to 3069)
  AUTHORS   Stubblefield,J.J., Gao,P., Kilaru,G., Mukadam,B., Terrien,J. and
            Green,C.B.
  TITLE     Temporal Control of Metabolic Amplitude by Nocturnin
  JOURNAL   Cell Rep 22 (5), 1225-1235 (2018)
   PUBMED   29386110
  REMARK    GeneRIF: posttranscriptional control by Nocturnin regulates the
            amplitude of critical metabolic pathways, and loss of this activity
            results in increased metabolic flux and reduced obesity
REFERENCE   4  (bases 1 to 3069)
  AUTHORS   Sinturel,F., Gerber,A., Mauvoisin,D., Wang,J., Gatfield,D.,
            Stubblefield,J.J., Green,C.B., Gachon,F. and Schibler,U.
  TITLE     Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome
            Assembly Cycles
  JOURNAL   Cell 169 (4), 651-663 (2017)
   PUBMED   28475894
REFERENCE   5  (bases 1 to 3069)
  AUTHORS   Kojima,S., Gendreau,K.L., Sher-Chen,E.L., Gao,P. and Green,C.B.
  TITLE     Changes in poly(A) tail length dynamics from the loss of the
            circadian deadenylase Nocturnin
  JOURNAL   Sci Rep 5, 17059 (2015)
   PUBMED   26586468
  REMARK    GeneRIF: Data suggest that Nocturnin (NOC) exerts strong effects on
            physiology through direct and indirect control of target mRNAs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3069)
  AUTHORS   Cao,S.X., Dhahbi,J.M., Mote,P.L. and Spindler,S.R.
  TITLE     Genomic profiling of short- and long-term caloric restriction
            effects in the liver of aging mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (19), 10630-10635 (2001)
   PUBMED   11535822
REFERENCE   7  (bases 1 to 3069)
  AUTHORS   Dupressoir,A., Morel,A.P., Barbot,W., Loireau,M.P., Corbo,L. and
            Heidmann,T.
  TITLE     Identification of four families of yCCR4- and Mg2+-dependent
            endonuclease-related proteins in higher eukaryotes, and
            characterization of orthologs of yCCR4 with a conserved
            leucine-rich repeat essential for hCAF1/hPOP2 binding
  JOURNAL   BMC Genomics 2, 9 (2001)
   PUBMED   11747467
REFERENCE   8  (bases 1 to 3069)
  AUTHORS   Wang,Y., Osterbur,D.L., Megaw,P.L., Tosini,G., Fukuhara,C.,
            Green,C.B. and Besharse,J.C.
  TITLE     Rhythmic expression of Nocturnin mRNA in multiple tissues of the
            mouse
  JOURNAL   BMC Dev Biol 1, 9 (2001)
   PUBMED   11394964
  REMARK    GeneRIF: nocturnin exhibits circadian rhythmicity of mRNA abundance
            with peak levels at the time of light offset in the retina, spleen,
            heart, kidney and liver.
REFERENCE   9  (bases 1 to 3069)
  AUTHORS   Dupressoir,A., Barbot,W., Loireau,M.P. and Heidmann,T.
  TITLE     Characterization of a mammalian gene related to the yeast CCR4
            general transcription factor and revealed by transposon insertion
  JOURNAL   J Biol Chem 274 (43), 31068-31075 (1999)
   PUBMED   10521507
REFERENCE   10 (bases 1 to 3069)
  AUTHORS   Puech,A., Dupressoir,A., Loireau,M.P., Mattei,M.G. and Heidmann,T.
  TITLE     Characterization of two age-induced intracisternal
            A-particle-related transcripts in the mouse liver. Transcriptional
            read-through into an open reading frame with similarities to the
            yeast ccr4 transcription factor
  JOURNAL   J Biol Chem 272 (9), 5995-6003 (1997)
   PUBMED   9038221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087790.1, AK084516.1 and BB261546.1.
            
            On Nov 30, 2007 this sequence version replaced NM_009834.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087790.1, AF183960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2716              AK087790.1         1-2716
            2717-3037           AK084516.1         2238-2558
            3038-3069           BB261546.1         252-283
FEATURES             Location/Qualifiers
     source          1..3069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 22.12 cM"
     gene            1..3069
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l"
                     /note="nocturnin"
                     /db_xref="GeneID:12457"
                     /db_xref="MGI:MGI:109382"
     exon            1..841
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l"
                     /inference="alignment:Splign:2.1.0"
     CDS             658..1947
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l"
                     /EC_number="3.1.3.108"
                     /note="CCR4 protein homolog; carbon catabolite repression
                     4 homolog; circadian deadenylase NOC; CCR4 carbon
                     catabolite repression 4-like; carbon catabolite repression
                     4-like protein"
                     /codon_start=1
                     /product="nocturnin"
                     /protein_id="NP_033964.1"
                     /db_xref="CCDS:CCDS17336.1"
                     /db_xref="GeneID:12457"
                     /db_xref="MGI:MGI:109382"
                     /translation="MYQSPRRLCSALLLRDAPGLRRTLVPGPRRTLAPPVLGSRPKSP
                     QLQAAAASGAARSRPRTVSSMGNGTSRLYSALAKTVNSSAAAQHPEYLVSTDPEHLEP
                     IDPKELLEECRAVLHTRPPRYQRDFVDLRTDCSSSHSPIRVMQWNILAQALGEGKDNF
                     VQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKP
                     WSPCLDVEHNNGPDGCALFFLQNRFKLISSTNIRLTAMTLKTNQVAIAQTLECKESGR
                     QFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKH
                     FASSSLNLNSAYKLLSPDGQSEPPYTTWKIRTSGECRHTLDYIWYSRHALSVTSALDL
                     LTEEQIGPNRLPSFHYPSDHLSLVCDFSFNEEPHELF"
     exon            842..1111
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..3069
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3019..3024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l"
                     /note="hexamer: AATAAA"
     polyA_site      3048
                     /gene="Noct"
                     /gene_synonym="Ccr4; Ccrn4l"
                     /note="major polyA site"
ORIGIN      
        1 aggactgacg ctcaacgccc tgcagtccgt ttccgcctct cgtgcctgag gggcggatgc
       61 ttgtcgcagc cgccacacaa gtagccagcg cgtcctggtg cctaatctcc ttcagcaccg
      121 cggagcgtgg agcccacagc tcggggagga cgttctccca gacacgcgct cgcacacact
      181 cagcgctggc accaacccgg gattcccagc ctgtggacgc tcccattgca gccggcggga
      241 ggggacagag gctcccggaa cgcctctcta acgaatcccc gcggtgtcag ccagccccca
      301 gcctccgccc cgtgggagat ctacagtcgc tgtcactgat ccagacggtc cattctcggc
      361 cggagctgtc cgggtctgac tgcgccctgg tcgtgcgcgc ggatcccccc ctctgcagcc
      421 accgcgtggt agcgcccgct ccgccgccgc tcgccggttg ctccccggcg ctagctccct
      481 cgcctcagtg agccgccgct gctgccgccg ccgcgtctgc ctcccggcac agctcgcccg
      541 gtcggcgccg agggacgagg aggaaggaac accccgcagc gcagcggtcc cgcgccaccc
      601 ccaccccacc gtcgcccgcc cagctcggcc cggctcgtca gcgcggcggc gcccggcatg
      661 tatcagagcc cgcggcggct ctgctcggcc ctgctgctca gggacgcccc cggcctgcgc
      721 cgcacactcg tgcccggccc gcgccgaacg ctcgccccgc cggtgctcgg atctcggccc
      781 aagtccccgc aactgcaggc ggcggcggcc tcgggcgccg cgaggtcgcg tccccgaaca
      841 gtgagttcca tgggaaacgg caccagtcga ctctacagtg ctctcgccaa gaccgtcaac
      901 agcagtgcag ctgctcagca cccggagtac ttggtgtcaa ctgaccccga acatctggag
      961 cccatcgatc ctaaggaact tctggaggaa tgcagggctg ttctgcacac tcggccaccc
     1021 cgctaccagc gggattttgt ggacctgagg acagattgct ccagcagcca ctctcccatt
     1081 cgcgtcatgc agtggaacat cctcgcccaa gctctcggag aaggcaaaga caactttgtg
     1141 cagtgccccg tggaagcgct caaatgggaa gagaggaagt gcctgatcct ggaggagatc
     1201 ctggcttacc agccagacat actgtgcctc caggaagtgg accactactt tgacaccttc
     1261 cagccactcc tcagtagact gggctaccaa ggcacgtttt tccccaagcc ctggtcacca
     1321 tgtctagatg tggaacacaa caacggtcca gatggctgtg ccttattttt tctccaaaac
     1381 cgattcaagc ttatcagcag caccaatatt aggctgacag ccatgaccct aaaaaccaat
     1441 caggtggcca tcgcacagac cctggagtgc aaggagtctg ggcgacagtt ctgcattgct
     1501 gtcacccact taaaagcccg cactggctgg gagcggttcc ggtcagctca gggctgtgac
     1561 ctcctccaga acctgcagaa catcacccag ggagcaaaga tccccctgat cgtctgcggg
     1621 gacttcaacg cagagccaac cgaagaggtc tacaaacact ttgcgtcctc cagcctcaac
     1681 ctcaacagcg cctacaagct gctgagtccc gatggacagt cggagcctcc ctacacaacc
     1741 tggaagatcc ggacctcagg cgagtgtcgc cacacgctgg actatatctg gtactccaga
     1801 catgctctga gtgtcacgtc cgccctggat ctactcactg aagaacagat tgggcccaac
     1861 cggctcccat ccttccatta cccctcggac cacctgtccc tggtgtgtga cttcagcttt
     1921 aacgaggagc cccatgagct cttttaatca caagcgtctt aaccagggat gttttgggaa
     1981 actgaactag gataggaagt tgcctggaaa aggacaccca gtttctgcca ctactctcca
     2041 tcatttccag catgcccttg aaaaaacatt gttcacaaac ctttccagct aaaacccgca
     2101 ttgaaaaggt gtttgcactc cagtttgagc ttgttgttca tctgtgtacc atcctctacc
     2161 atttaggggc attagtagca taggctttct tgttttttag ttgagggtat tataaaaacc
     2221 cagtttgtaa gcccttcaga attaaagtaa gatgtaggaa gttttctaga catcatttca
     2281 agttatttat ttgtgggatt tttaaatgtc agtgggaaaa aaaatgcatg gtaatattta
     2341 tttttttata tcttaatgta aaataaagtg gattatctag cattgtggac attttagaac
     2401 catgcaggta cagtcttaat tccttaaaaa ttaaaatgtc tctatttgct gatcgaacag
     2461 gatgtacact aaggaactat ttagccctgg gggattggtg actttgtgtg tacattcttc
     2521 acaaataatt cctgtttgct atgcctttga cttctctgtt gtgttttaaa gaaattccgt
     2581 agcattcagt tctttagttt ccactgttta gtcactgcta ggcacttgtg ccttttctgt
     2641 tgtgatgacg ttggtagacg tgtgaagatt actccaatca cttctcctgg gatgtgcttt
     2701 ttataagtag ctttaggaac agctctggaa cagttgctaa gaatattagt gagaaacctt
     2761 gccaagacga cagacatgag cccaacattc agctgagaca agaaagctca cgtcttggag
     2821 gccagcttgg gctatatgtc aagacccttt cttgaaaaag ccagatgact ggattcaagt
     2881 tttctagaaa aatataagag tcaaaaagat aacctggagt tctctttcaa ttgttgaagc
     2941 ctcttccaaa caaaatatcc ttccagtggt aaaatggtaa atatcttaat gtatgagttc
     3001 taaatattac ttaaggttaa taaatggact tacaaagagt gcttttaata tcttgtctct
     3061 ttggtctaa
//
