LOCUS       NM_153570               2039 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NOC4 like (Noc4l), mRNA.
ACCESSION   NM_153570
VERSION     NM_153570.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2039)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2039)
  AUTHORS   Qin,Y., Jia,L., Liu,H., Ma,W., Ren,X., Li,H., Liu,Y., Li,H., Ma,S.,
            Liu,M., Li,P., Yan,J., Zhang,J., Guo,Y., You,H., Guo,Y.,
            Rahman,N.A., Wolczynski,S., Kretowski,A., Li,D., Li,X., Ren,F. and
            Li,X.
  TITLE     Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal
            and leads to insulin resistance
  JOURNAL   Nat Commun 12 (1), 6121 (2021)
   PUBMED   34675215
  REMARK    GeneRIF: Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF
            signal and leads to insulin resistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2039)
  AUTHORS   Zhu,X., Zhang,W., Guo,J., Zhang,X., Li,L., Wang,T., Yan,J.,
            Zhang,F., Hou,B., Gao,N., Gao,G.F. and Zhou,X.
  TITLE     Noc4L-Mediated Ribosome Biogenesis Controls Activation of
            Regulatory and Conventional T Cells
  JOURNAL   Cell Rep 27 (4), 1205-1220 (2019)
   PUBMED   31018134
  REMARK    GeneRIF: Genetic ablation of Noc4L in Regulatory T cells results in
            a Severe Autoimmune Disease.
REFERENCE   4  (bases 1 to 2039)
  AUTHORS   Qin,Y., Li,H., Jia,L., Yan,J., Gao,G.F. and Li,X.
  TITLE     Targeted disruption of Noc4l leads to preimplantation embryonic
            lethality in mice
  JOURNAL   Protein Cell 8 (3), 230-235 (2017)
   PUBMED   28012024
REFERENCE   5  (bases 1 to 2039)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK052601.1.
            
            On Jun 19, 2003 this sequence version replaced NM_153570.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052601.1, AK090024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.69 cM"
     gene            1..2039
                     /gene="Noc4l"
                     /note="NOC4 like"
                     /db_xref="GeneID:100608"
                     /db_xref="MGI:MGI:2140843"
     exon            1..160
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1594
                     /gene="Noc4l"
                     /note="NOC4-like protein; NOC4 protein homolog; nucleolar
                     complex-associated protein 4-like protein; nucleolar
                     complex associated 4 homolog"
                     /codon_start=1
                     /product="nucleolar complex protein 4 homolog"
                     /protein_id="NP_705798.2"
                     /db_xref="CCDS:CCDS19527.1"
                     /db_xref="GeneID:100608"
                     /db_xref="MGI:MGI:2140843"
                     /translation="MERHPASASSRQELGRLLEAVLTSRGQANAVFDILAVLQSEEPE
                     EIEEGVRTCSRLFGTLLEREELFVGSLPSEDTALAGSQGATYKYKVWIRHRYHSCCNR
                     LEELLAHPTFQVKELALKTLMKFVQLEGAKPLEKPQWESHYLFPRTLFRAVVGGLLTP
                     EDDHSLLISHFCEYLEYDDIRYHTMQVATSIMARATSQQPEVSLTLWNNAFTLLSAVS
                     LPLQECELTNFYVKHAQTSDKWKVVHLKEHKKAFQEMWLGFLKHKLPLSLYKKVLVAM
                     HDSILPHLAQPTLMIDFLTSACDVGGAISLLALNGLFILIHKHNLEYPDFYQKLYGLL
                     DPSIFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPLIC
                     NLLRRHPACRVMVHRPQGPELDADPYDPTEKDPARSRALESCLWELQTLQQHYHPEVS
                     KAASVINQVLSVPEVSIAPLLELTAYEIFEQDLKKKMPESVPLEFIPAKGLLGRQDDL
                     CTQFFCLS"
     exon            161..281
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            282..388
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            389..496
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            497..646
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            647..746
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            747..781
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            782..832
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            833..944
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1005
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1116
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1277
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1360
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1474
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..2039
                     /gene="Noc4l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1854..1859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Noc4l"
                     /note="hexamer: AATAAA"
     polyA_site      1873
                     /gene="Noc4l"
                     /note="major polyA site"
ORIGIN      
        1 acttcggttt ccaggaaccg ggagcagcat cggcggcggc ggcatggagc ggcacccagc
       61 ttcggcgagc tccaggcaag agctcggccg cctcctggag gcagtgctga cgagtcgtgg
      121 ccaagcgaac gcggtgttcg acatcttggc tgtgcttcag tccgaggagc ccgaggaaat
      181 cgaggaagga gtgcgcacgt gcagccgact cttcggtacc ttgctggagc gggaagagct
      241 gttcgtgggc tcgctgccga gcgaagacac ggccctggca gggtcccagg gagccacata
      301 caaatacaag gtgtggataa gacatcgata ccacagctgc tgtaaccgcc tagaggaact
      361 cctggcccat cccaccttcc aggtcaagga actggccctc aagacactca tgaagtttgt
      421 gcagctggaa ggagcaaaac cactggagaa gcctcagtgg gaaagccact acctcttccc
      481 ccgcacactc ttcagggcag tggtaggagg cctgctcaca ccagaggacg accacagcct
      541 gcttatctcc catttctgtg agtacttgga atatgatgac atccggtacc acacaatgca
      601 ggtggccact agcatcatgg cccgggccac cagccagcaa cctgaggtgt ccctcaccct
      661 ctggaacaat gccttcacat tgctgtctgc tgtgagccta cccctccaag agtgtgaact
      721 caccaacttc tatgtgaagc atgcacagac atcagacaag tggaaggtcg ttcacttgaa
      781 ggagcacaag aaagctttcc aggagatgtg gcttggcttc ctcaagcaca agctgcccct
      841 cagcctctac aagaaggtgc tggtggccat gcatgactcc atcctgcccc acctggccca
      901 acccacactc atgattgact tcctcacaag tgcctgtgat gtgggtggtg ccatcagcct
      961 cctggccttg aacgggcttt tcatcctaat ccataaacac aacctggagt accctgactt
     1021 ctaccagaag ctctatggtc tcctggatcc atccatcttt catgtcaagt accgagcccg
     1081 tttcttccac ttggctgacc tcttcctttc atcctcccac ctccctgcct acctggtggc
     1141 tgcctttgcc aaacgcctgg ctcggctggc gctaacagca cctcctgagg ccctacttat
     1201 ggtcctgcct ttaatctgca acttgctgcg tagacaccct gcctgccgag ttatggtgca
     1261 ccgcccacag ggccctgagc tagatgctga tccatatgac ccaacggaga aggacccagc
     1321 cagaagccgt gccctggaga gctgcttgtg ggaactgcag accctccagc agcactacca
     1381 ccctgaggtg tcgaaagccg ccagtgtcat caaccaggtg ctgtctgtcc ctgaggtcag
     1441 catcgcgcca ctcctggaac ttactgcata tgagatcttt gagcaggacc tgaagaagaa
     1501 gatgcctgag tcagtgcccc tggagttcat ccccgctaaa ggcctattgg gtcgacagga
     1561 cgacctctgt acccagttct tctgtctcag ctgaccgggc tgtcacttct cctcctaaga
     1621 attgtttttg tgtgtctgag acaggatctc actatgtgag ggtagcctgt atcttgtggt
     1681 actcctgcct aagcctcccc agtactgtat gggtgttttg attgcatgga tgtctgttta
     1741 tcacatgtag gccaggtgag ggtgtcagat cccctataac gagaattaca gacacttgtg
     1801 agccaccgtg ttggtggtgt gaactgaacc cagatactct ggaagagcaa ccaaataaag
     1861 ggtttgtttt ggatttggtt ttttagtgtg gtttggtttg ggttttgttt gtttttccca
     1921 atgcttctct atgtagccct ggctgtcctg gacctctgta gaccaggcta gccttgaacc
     1981 caatcagata tctgactgcc tctgcttctt gagtgctggg attaaaggtg tgcaccacc
//
