LOCUS       NM_021315               3977 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus NOC3 like DNA replication regulator (Noc3l), mRNA.
ACCESSION   NM_021315
VERSION     NM_021315.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3977)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3977)
  AUTHORS   Ochiai,N., Nishizuka,M., Osada,S. and Imagawa,M.
  TITLE     Fad24, a Positive Regulator of Adipogenesis, Is Required for S
            Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved
            in p27(Kip1) Expression at the Protein Level
  JOURNAL   Biol Pharm Bull 39 (5), 807-814 (2016)
   PUBMED   26902224
  REMARK    GeneRIF: fad24 may have an important role in the S phase re-entry
            of quiescent C2C12 cells through the regulation of p27(Kip1) at the
            protein level
REFERENCE   3  (bases 1 to 3977)
  AUTHORS   Imagawa,M.
  TITLE     [Molecular Mechanisms of Early-stage Adipocyte Differentiation and
            Multi-functional Roles of Newly Isolated Adipogenic Factors]
  JOURNAL   Yakugaku Zasshi 136 (4), 649-658 (2016)
   PUBMED   27040346
  REMARK    GeneRIF: It contributes not only to adipogenesis but also to other
            physiological events like pre-implantation in embryonic
            developments.
            Review article
REFERENCE   4  (bases 1 to 3977)
  AUTHORS   Ochiai,N., Nishizuka,M., Miyamoto,T., Miyoshi,I., Ikawa,M.,
            Osada,S. and Imagawa,M.
  TITLE     Targeted disruption of fad24, a regulator of adipogenesis, causes
            pre-implantation embryonic lethality due to the growth defect at
            the blastocyst stage
  JOURNAL   Biochem Biophys Res Commun 438 (2), 301-305 (2013)
   PUBMED   23886952
  REMARK    GeneRIF: fad24 is essential for pre-implantation in embryonic
            development, particularly for the progression to the blastocyst
            stage
REFERENCE   5  (bases 1 to 3977)
  AUTHORS   Johmura,Y., Osada,S., Nishizuka,M. and Imagawa,M.
  TITLE     FAD24, a regulator of adipogenesis, is required for the regulation
            of DNA replication in cell proliferation
  JOURNAL   Biol Pharm Bull 31 (6), 1092-1095 (2008)
   PUBMED   18520036
  REMARK    GeneRIF: fad24 plays positive roles in the proliferation of
            pre-confluent cells as well as adipogenesis
REFERENCE   6  (bases 1 to 3977)
  AUTHORS   Johmura,Y., Suzuki,M., Osada,S., Nishizuka,M. and Imagawa,M.
  TITLE     FAD24, a regulator of adipogenesis and DNA replication, inhibits
            H-RAS-mediated transformation by repressing NF-kappaB activity
  JOURNAL   Biochem Biophys Res Commun 369 (2), 464-470 (2008)
   PUBMED   18284919
  REMARK    GeneRIF: Taken together, these results reveal a novel role for
            fad24 in the repression of NF-kappaB activity and H-ras-mediated
            transformation.
REFERENCE   7  (bases 1 to 3977)
  AUTHORS   Johmura,Y., Osada,S., Nishizuka,M. and Imagawa,M.
  TITLE     FAD24 acts in concert with histone acetyltransferase HBO1 to
            promote adipogenesis by controlling DNA replication
  JOURNAL   J Biol Chem 283 (4), 2265-2274 (2008)
   PUBMED   18029353
  REMARK    GeneRIF: FAD24 controls DNA replication by recruiting HBO1 to
            origins of DNA replication and is required for MCE during adipocyte
            differentiation.
REFERENCE   8  (bases 1 to 3977)
  AUTHORS   Tominaga,K., Johmura,Y., Nishizuka,M. and Imagawa,M.
  TITLE     Fad24, a mammalian homolog of Noc3p, is a positive regulator in
            adipocyte differentiation
  JOURNAL   J Cell Sci 117 (Pt 25), 6217-6226 (2004)
   PUBMED   15564382
  REMARK    GeneRIF: Fad24, a mammalian homolog of Noc3p, is a positive
            regulator in adipocyte differentiation
REFERENCE   9  (bases 1 to 3977)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3977)
  AUTHORS   Tidhar,A., Reichenstein,M., Cohen,D., Faerman,A., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Shani,M.
  TITLE     A novel transgenic marker for migrating limb muscle precursors and
            for vascular smooth muscle cells
  JOURNAL   Dev Dyn 220 (1), 60-73 (2001)
   PUBMED   11146508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101775.10, AC158131.4 and AC111023.12.
            
            On May 16, 2008 this sequence version replaced NM_021315.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168944.1, BC031132.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC101775.10        12501-12645         c
            146-353             AC101775.10        11346-11553         c
            354-486             AC101775.10        8991-9123           c
            487-644             AC101775.10        8094-8251           c
            645-698             AC101775.10        7489-7542           c
            699-829             AC158131.4         248-378
            830-991             AC158131.4         2263-2424
            992-1085            AC158131.4         2621-2714
            1086-1261           AC158131.4         5021-5196
            1262-1390           AC158131.4         5507-5635
            1391-1522           AC158131.4         8192-8323
            1523-1603           AC158131.4         13332-13412
            1604-1704           AC158131.4         13724-13824
            1705-1777           AC158131.4         16853-16925
            1778-1841           AC158131.4         17021-17084
            1842-1913           AC158131.4         17165-17236
            1914-2095           AC158131.4         17569-17750
            2096-2224           AC158131.4         18489-18617
            2225-2322           AC158131.4         19924-20021
            2323-2407           AC111023.12        226819-226903       c
            2408-3977           AC111023.12        224659-226228       c
FEATURES             Location/Qualifiers
     source          1..3977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 33.42 cM"
     gene            1..3977
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /note="NOC3 like DNA replication regulator"
                     /db_xref="GeneID:57753"
                     /db_xref="MGI:MGI:1932610"
     exon            1..145
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2560
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /note="NOC3-like protein; NOC3 protein homolog; factor for
                     adipocyte differentiation 24; nucleolar complex-associated
                     protein 3-like protein; nucleolar complex associated 3
                     homolog"
                     /codon_start=1
                     /product="nucleolar complex protein 3 homolog"
                     /protein_id="NP_067290.2"
                     /db_xref="CCDS:CCDS37974.1"
                     /db_xref="GeneID:57753"
                     /db_xref="MGI:MGI:1932610"
                     /translation="MKARRNKKQVPSFRKLIKTSKVKLENKLKNKQFKQQSTIKKYRK
                     EQRKLRQAVKDAVSKKPIPLEDPKSKRPVKRMEREEDEEEEALPLDMMDEDDLQLMKD
                     LGQKASFLTRDLSSSEPVHIKKRKHESVIEKYEKVPRTLQTAPEKELIHLLPIKDKSG
                     IIPQAREKPVTDVQQEEEAEEELEDEEEVIEDPRKELTIEEHVIERKKKLQDKKIQIA
                     ALASAILSDPESHIKKLKELRSMLMEQDPDVAVTVRKLVIISLMELFKDITPSYKIRP
                     LTEAEKSTKIRKETQKLREFEEGLVSQYKFYLENLEQIVKDWKQRKLKKSNVVSLKAY
                     KGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDGSKPVSEMCCEAVKKLFKQDK
                     LGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKRFMTFK
                     EKRKTLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTETLNIVFVTYFRILKKA
                     QKSPLLPAVLEGLAKFAHLINVEFFDDLLVVLHTLIESGELSYQESLHCVQTAFHILS
                     GQGDVLNIDPMKFYTHLYKTLFTLHAGATNDGIEIVLHCLDVMLSKRRKQVSHQRALA
                     FIKRLCTLALQVLPNSSIGLLATTRILMHTFPRTDLLLDNESQGSGVFLPELEEPEYC
                     NAQNTALWELHTLRRHYHPIVRRFAAHLLAGAPSEGSEALKPELSRRSAVELFETYSM
                     AAMTFNPPVESSHSKRKDKFLPGDSFLNEDLNQLIKRYCNEAAPETPLDFAKCLESSS
                     RQYRVNGLS"
     exon            146..353
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            354..486
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            487..644
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            645..698
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            699..829
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            830..991
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1085
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1261
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1390
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1522
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1603
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1704
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1777
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1841
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1913
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2095
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2224
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2322
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2407
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..3977
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2946..2951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /note="hexamer: AATAAA"
     polyA_site      2974
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /note="major polyA site"
     regulatory      3956..3961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /note="hexamer: AATAAA"
     polyA_site      3977
                     /gene="Noc3l"
                     /gene_synonym="Fad24"
                     /note="major polyA site"
ORIGIN      
        1 agaaaggggg agaggctgaa agcgtcttcc ggtttgggaa aggttgcgct cagtgcacgt
       61 gtgtcttttc cacccggctc ctgcgtgttc ctctgtccga gtgatcttgt ctgtggtact
      121 cctcgcaggc ctaaggatga aggcgagaag aaataaaaag caggtcccaa gctttcgcaa
      181 gttgataaaa actagtaaag tgaaacttga aaacaaattg aaaaataagc aatttaaaca
      241 acaaagtacc atcaagaagt accgaaaaga gcagaggaaa ctaaggcaag ctgtaaaaga
      301 tgctgtgtct aaaaaaccca ttccgctgga ggacccaaag agcaaacggc cagttaaaag
      361 gatggagagg gaggaggacg aggaggaaga agccctgcct ttggatatga tggacgagga
      421 tgacctacag ctgatgaagg atttaggaca aaaggcatct tttctcacaa gagatctctc
      481 ttctagtgaa ccagtccata tcaagaaacg aaagcatgag agtgtgatag agaaatatga
      541 aaaagtgcca agaactctgc aaaccgcacc ggagaaggag ttgattcacc tgctccctat
      601 caaggacaag agtggcatca tccctcaggc tcgggagaag ccggtcactg acgtgcagca
      661 agaagaggag gctgaggaag agctggaaga tgaggaagag gtcattgaag accccaggaa
      721 ggagctgacc atagaagagc atgtgatcga gagaaagaag aaactgcagg acaagaaaat
      781 acagattgca gccttagcat ctgctattct gtcagatcca gaaagtcata ttaaaaaact
      841 gaaagagttg cgttccatgc tgatggagca ggaccctgat gtggctgtca ctgtccggaa
      901 gttggttatc atctcactga tggagctgtt taaggacatc actccctcgt ataaaatccg
      961 gcctctaacc gaagcagaaa aatctaccaa gattcgtaaa gaaacccaga agttaagaga
     1021 atttgaagaa ggcctggtta gccaatacaa attttatttg gaaaatctgg agcaaatagt
     1081 taaagactgg aagcaaagga agctgaagaa gagcaatgtg gtgtccttaa aggcctacaa
     1141 agggctggct gaagtggcag tgaagagcct gtgtgagctg ttggtggccc tgccccattt
     1201 taactttcac aacaacatca ttgtactgat tgtccctctg atgaacgatg ggtcaaaacc
     1261 ggtatctgaa atgtgttgcg aagcagtaaa gaaactcttt aaacaagata aattaggcca
     1321 agcttctctg ggtgtcatta aagtcatctc tggttttgta aagggcagaa attacgaagt
     1381 taggccagag atgttaaaaa catttttatg cctgcggatc aaggaggtag aagtgaaaaa
     1441 agatacagag gacattaaca agcccaaaag gttcatgact ttcaaggaga agagaaaaac
     1501 tctatcaaga atgcaaagaa agtggaagaa agcagaagag aaactagagc gggaacttcg
     1561 ggaggccgaa gcttcggaaa gcactgagaa aaagctgaaa ctgcacaccg agactctgaa
     1621 tattgtgttt gtgacctact tcagaatact gaagaaggcc cagaagtcac ctcttctgcc
     1681 agcggttcta gaaggccttg ccaagtttgc acatcttata aatgtggagt tttttgatga
     1741 tttattagtg gttcttcata ccctcattga gtctggggag ctaagttatc aagaaagtct
     1801 ccactgtgtt caaactgctt ttcatattct ttctggacaa ggtgatgttt taaatattga
     1861 cccgatgaaa ttctatacac atctctacaa gacactgttc acattacatg caggtgccac
     1921 caacgacggc attgagattg tgctccactg cctcgatgtc atgctaagca agcgcagaaa
     1981 gcaggtttct catcagcgag ctcttgcctt catcaaacgc ctttgtacac ttgctctgca
     2041 ggttcttcca aattcaagca ttggcctttt agcaactacc aggatattga tgcatacttt
     2101 tcccagaaca gatctcttgc ttgataacga gtctcagggc agcggggtgt ttctacctga
     2161 gctggaggag ccagagtact gtaatgcaca gaacaccgca ctgtgggagc tgcacacgct
     2221 tcggagacat taccatccca ttgtgcgaag gtttgcagca catctgcttg ctggggcacc
     2281 atccgaaggc tctgaggccc tcaagcccga gctgagccga agatctgcag ttgaactttt
     2341 tgagacttac agcatggcag caatgacatt caatccgcct gttgaatctt cacactccaa
     2401 aaggaaggat aaatttttac caggagactc atttttgaat gaagatttaa atcaactaat
     2461 caaaagatac tgtaatgaag ctgctcctga gacaccgctg gatttcgcca agtgtttgga
     2521 aagctcatcc cggcagtaca gagtgaatgg actgtcttag atatctgcat gtgcatggca
     2581 gagacacaag gatatgtgag ggcctgtttc tgtttgtaca aggaagactt cctaagaatg
     2641 attatttgag aactggagca gggccacaga agaccctgct cattggcttg cttttcatgc
     2701 cttgctcggc ctgccttttt atacagtcca caccaacttg tccaggaatg gcactgccca
     2761 tcagtcatga aatctacaaa tgccctgcag acgtgccata gtctagtctg tggaggcagt
     2821 ccttcagttg agatttcctc tgctcaggtt actccagtta agtagacaaa acctaaacaa
     2881 gacagctatt aaattctctt tataactaaa aaaatattgt tattgcagca ccatagttga
     2941 aagcaaataa aatattttgt gggttttttt ttaaccttca tggttttttt tttttatttg
     3001 atttaatttg atttgaattt tttatgaatt tatttactta ttcactttac atccccatcg
     3061 tagatccctt tccttccagt ccccctcccc ccatgactcc tccctcccac cccctccctg
     3121 tcatttctaa aggaatgaag gttcccccct gggtatctac ccaccctggc acctcaagtc
     3181 actacaggac taggtacatc ctcttttagt gagttcagac aagacagccc aggtaggaga
     3241 acagggtcca cgggcaggca acagagtcag ggtaggacca gctccggttg ttgggggatc
     3301 cgatgaagac cagcctgtac atctgctaca tatgggggga gggctaggtt cagccctctg
     3361 tgctctttgg ttggtggttc agtctctggg agcccccaat tttgtgaatt ttttgataaa
     3421 taagttaaag ttatactctt gttcattggc tcttgttgaa tgacacaagg aatgaccaaa
     3481 tctgaccttt aaggaggaat gagtgctctc attgctagtg tgagagagag tatgagtcag
     3541 aatctagagt ctttgaagtt gggttaactt attacctgag agtgataggg gaaaattgct
     3601 cagtaagatg aaaggtccaa gatttccatt gtgccatagg aatatcggtt cctgtccaac
     3661 caggaaagtg tttttctctt aaattctttg ttgttgttgt tttgttttgt tttctttttt
     3721 gagacagggt tttgtagacc aggctgacct tgaactcaga aatccacctg cctctgcctc
     3781 ccaagtgctg ggattaaaga cgtgcgccac caccgcccac cttaaattct tacagataaa
     3841 aactgtatat gtttataaat agttataaag aactatttta tataatagct attatcattg
     3901 tagaaatgac ttacaaatac aaaatgtgta tgtaaatact ttctgctatt aactgaataa
     3961 agtagcttcg attttta
//
