LOCUS       NM_021303               2785 bp    mRNA    linear   ROD 20-DEC-2022
DEFINITION  Mus musculus NOC2 like nucleolar associated transcriptional
            repressor (Noc2l), transcript variant 1, mRNA.
ACCESSION   NM_021303
VERSION     NM_021303.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2785)
  AUTHORS   Duteil D, Tourrette Y, Eberlin A, Willmann D, Patel D, Friedrichs
            N, Muller JM and Schule R.
  TITLE     The histone acetyltransferase inhibitor Nir regulates epidermis
            development
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29490983
  REMARK    GeneRIF: Data define Nir as a key regulator of skin development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2785)
  AUTHORS   Ma CA, Pusso A, Wu L, Zhao Y, Hoffmann V, Notarangelo LD, Fowlkes
            BJ and Jain A.
  TITLE     Novel INHAT repressor (NIR) is required for early lymphocyte
            development
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13930-13935 (2014)
   PUBMED   25201955
  REMARK    GeneRIF: results show that NIR cooperate with p53 to impose
            checkpoint for the generation of mature B and T lymphocytes.
REFERENCE   3  (bases 1 to 2785)
  AUTHORS   Hublitz P, Kunowska N, Mayer UP, Muller JM, Heyne K, Yin N,
            Fritzsche C, Poli C, Miguet L, Schupp IW, van Grunsven LA, Potiers
            N, van Dorsselaer A, Metzger E, Roemer K and Schule R.
  TITLE     NIR is a novel INHAT repressor that modulates the transcriptional
            activity of p53
  JOURNAL   Genes Dev 19 (23), 2912-2924 (2005)
   PUBMED   16322561
  REMARK    GeneRIF: Upon recruitment by p53, NIR represses transcription of
            both p53-dependent reporters and endogenous target genes
REFERENCE   4  (bases 1 to 2785)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (bases 1 to 2785)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133834.1 and AK157765.1.
            
            [WARNING] On Oct 18, 2023 this sequence was replaced by
            NM_021303.3.
            
            On Jan 31, 2007 this sequence version replaced NM_021303.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157765.1, BC020013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               AK133834.1         1-331
            332-748             AK157765.1         324-740
            749-1604            AK133834.1         749-1604
            1605-2785           AK157765.1         1598-2778
FEATURES             Location/Qualifiers
     source          1..2785
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..2785
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /note="NOC2 like nucleolar associated transcriptional
                     repressor"
                     /db_xref="GeneID:57741"
                     /db_xref="MGI:MGI:1931051"
     exon            1..61
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2288
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleolar complex protein 2 homolog; nucleolar complex
                     associated 2 homolog; NOC2-like protein; protein NOC2
                     homolog; novel INHAT repressor"
                     /codon_start=1
                     /product="nucleolar complex protein 2 homolog isoform 1"
                     /protein_id="NP_067278.2"
                     /db_xref="CCDS:CCDS57322.1"
                     /db_xref="GeneID:57741"
                     /db_xref="MGI:MGI:1931051"
                     /translation="MAASRAPRRRLEDLSVDEFLASGFESGSESELEGAAEAAAEERR
                     ARGAAWNRERRGARTSPGPAGRPRKGRASEHKDQLSRLKDRDPEFYKFLQENDRSLLD
                     FSDSDSSAEEEEPFHSLPDTLEEASETEEDGGEDSDALPRGLRSKKNEPVPVTLAMVE
                     RWRQGSRHHLSPRLFHEVVQAFRAAVATTQGEQEAAETCRFQVADSAVFNALVTFCIR
                     DLCGCLQKLLFGKTPKDSNRLLPSSSPLWGKLRVDVKTYLSAVVQLVACLAEATVSAA
                     VLQHISSLVPYYLTFPKQCRMLLKRMVVLWSTGEESLRVLAFLVLIRVCRHKKEAFLG
                     PILKQMYIMYVRNCKFTSPSTLPLISFMQRTLTEMLALDPSVSYQHAFLYIRQLAVHL
                     RNAMTAGKKETHQSVYNWQYVHCLYLWCRVLSTLGSSEILQPLLYPLSQIIIGCIKLL
                     PTARFYPLRMHCVRALTLLSQTIGTFIPVLPFILEIFQQVDFNRRPGRMSSKPINFSV
                     ILKLSSTNLQEKAYRDGLLEQLCDLTLEYLHSQAHSIAFPELVLPTVLQLKSFLRECK
                     VANYCRQVRQLLEKVQENAQHIQSLRQSATFSVSDQMAVDAWEKQVREEGTPLTRYYG
                     HWKKLRDREIQLEISGKERLEDLNFPEIKRRKVEDRKDEDRKELKDLFELDSSEGEDS
                     TDFFERGVPRLPEAHQGLKEDQEEEDKEEGDSDSEDGDTDTGVDLSELWQLAQGPQDE
                     LEDLQLSEED"
     exon            62..232
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            233..407
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            408..536
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            537..657
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            658..748
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            749..824
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            825..935
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1049
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1238
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1378
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1490
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1604
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1706
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1850
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1964
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2100
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2187
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2785
                     /gene="Noc2l"
                     /gene_synonym="NIR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccggaag tgcggcgcac gcggctgggc gcgccatggc tgcgtctcgc gctccccgca
       61 ggcgcctgga ggacctcagt gtggacgagt tcctggcttc cggcttcgag tccggatccg
      121 agtcggagct ggagggcgcc gcggaggcgg cggcggagga gcgcagggcg cgaggagccg
      181 cgtggaaccg ggagcggcgg ggcgcgcgca cctccccggg ccccgcagga cgcccgcgta
      241 agggccgcgc ctctgagcac aaagaccagc tctctcggct gaaggacaga gaccccgagt
      301 tctacaagtt cctgcaggag aatgaccgga gcctactgga cttcagtgac tcggacagct
      361 ctgcggaaga agaagagcca ttccactccc tgccagacac gctggaggaa gcgagcgaaa
      421 cagaggaaga cggaggagag gacagtgacg cgttgcccag agggctgagg agcaagaaga
      481 atgagcctgt acccgtgacc ctcgccatgg tggaaaggtg gaggcagggc tccaggcacc
      541 accttagtcc caggctgttc catgaagttg tacaggcgtt ccgagcagct gtagccacca
      601 cccaaggaga gcaggaagct gctgagactt gcaggttcca ggttgcagat agtgctgtgt
      661 tcaatgctct ggttactttc tgcattcgag acctctgtgg ttgccttcag aagctgctgt
      721 ttggaaagac accaaaggat agcaataggc tgctgccatc cagtagccca ctgtggggga
      781 agctccgtgt ggatgtcaag acatacctaa gtgcggtggt gcagctggta gcctgtctag
      841 cggaagccac ggtgtctgca gctgtcctgc agcatatcag cagcttggtt ccttactacc
      901 tgacattccc taagcagtgc cgaatgttgc tcaagaggat ggtggttctg tggagcacgg
      961 gtgaagaatc tctgcgggtc ctggccttcc tggtactcat cagagtctgc cggcacaaga
     1021 aggaagcctt ccttggtccc attctgaagc aaatgtacat catgtatgtg agaaactgca
     1081 agttcacctc ccccagtacc ctccccctca taagcttcat gcaacggaca ctgactgaaa
     1141 tgcttgcctt ggaccccagc gtctcctatc agcacgcctt cctctacatc cgacagcttg
     1201 ccgtccacct gcggaatgct atgaccgcag gcaagaagga gacacaccag tctgtgtaca
     1261 actggcagta tgtgcactgc ctctacctgt ggtgtcgagt cctgagtacc cttggttcca
     1321 gtgagatcct gcagccgcta ctctaccctc tctcacagat catcattggc tgtatcaagt
     1381 tgttgcccac tgctcgattt tatccattgc gcatgcattg tgtacgtgcc ctgacactgc
     1441 tgtcccagac catcggcacc ttcatacctg tcctgccctt cattctcgag attttccagc
     1501 aggtggactt caataggcgg ccaggtcgca tgagttccaa gcccatcaac ttctctgtga
     1561 tcttgaagct gtccagcacc aacctgcagg agaaggcgta ccgggacggg ctgctggaac
     1621 agctgtgtga ccttactctg gaatacctgc acagccaggc ccacagcatc gctttcccag
     1681 agttggtgtt gcctactgtt ctacagctga aatcttttct ccgggagtgc aaagtggcta
     1741 actactgccg gcaggtgcgc cagctgctgg agaaagtgca agagaatgca caacatatcc
     1801 aaagtcttcg acagagcgcg accttcagcg tgtctgacca gatggcagtg gatgcgtggg
     1861 agaagcaggt tcgtgaagag gggaccccac tcaccagata ctacggccac tggaagaagc
     1921 tgagggaccg tgagatccag ctggaaatca gtggcaaaga gcggctagaa gacctgaact
     1981 tcccagagat caaaaggcgg aaggtggaag acaggaagga tgaagacagg aaagaattaa
     2041 aggacctgtt tgagttggac agttctgagg gcgaggacag caccgacttc tttgagagag
     2101 gagtacctag gctcccagaa gctcaccaag gactgaaaga agatcaggaa gaagaagata
     2161 aagaagaagg tgacagcgat tcagaggatg gagacacaga cacgggagtg gatctgagcg
     2221 aactgtggca gctggctcag ggaccacaag atgagctgga ggatcttcag ctctcagaag
     2281 aggactgagg cctcctgctg cctcctggag gcctcgacag caactgtgcg gcgagaggac
     2341 agcagagcgt aaacaggctt ttattgttac agcacagcag aacaagtgta ctaggagcca
     2401 ttttgaccct gaaagggagg gaactgtttc tgcagagcct tctgctgccg gaagccgaag
     2461 gctgaccctg acgttgtccc agttcagagt ggggagggcg gctccatggc ctctcctctc
     2521 cactttgtct ttggtttgtc tgcagagcac tgcagttacc tctagaagat aaacccatta
     2581 cttttgtttg tttgtttgtt tgtttgtttt ttcgagacag ggtgtctctg tgtagccctg
     2641 gctatcctgg aactcacttt gtagaccagg ctggccgcga actctgaaat ccgcctgcct
     2701 ctgcctccca agtgctggga ttaaaggcgt gcgccacctc tgcccagctc attgcttttc
     2761 ttcttaagcc ttatgttttc ctttt
//
