LOCUS       NM_019836               2303 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus nitric oxide associated 1 (Noa1), mRNA.
ACCESSION   NM_019836
VERSION     NM_019836.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2303)
  AUTHORS   Al-Furoukh,N., Kardon,J.R., Kruger,M., Szibor,M., Baker,T.A. and
            Braun,T.
  TITLE     NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour
            prior to mitochondrial import
  JOURNAL   PLoS One 9 (7), e103141 (2014)
   PUBMED   25072814
  REMARK    GeneRIF: Our results uncovered an unexpected, mandatory detour of
            NOA1 through the nucleolus before uptake into mitochondria.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2303)
  AUTHORS   Al-Furoukh,N., Goffart,S., Szibor,M., Wanrooij,S. and Braun,T.
  TITLE     Binding to G-quadruplex RNA activates the mitochondrial GTPase NOA1
  JOURNAL   Biochim Biophys Acta 1833 (12), 2933-2942 (2013)
   PUBMED   23933583
  REMARK    GeneRIF: NOA1 binds specifically to oligonucleotides that fold into
            guanine tetrads (G-quadruplexes).
REFERENCE   3  (bases 1 to 2303)
  AUTHORS   Heidler,J., Al-Furoukh,N., Kukat,C., Salwig,I., Ingelmann,M.E.,
            Seibel,P., Kruger,M., Holtz,J., Wittig,I., Braun,T. and Szibor,M.
  TITLE     Nitric oxide-associated protein 1 (NOA1) is necessary for
            oxygen-dependent regulation of mitochondrial respiratory complexes
  JOURNAL   J Biol Chem 286 (37), 32086-32093 (2011)
   PUBMED   21771794
REFERENCE   4  (bases 1 to 2303)
  AUTHORS   Kolanczyk,M., Pech,M., Zemojtel,T., Yamamoto,H., Mikula,I.,
            Calvaruso,M.A., van den Brand,M., Richter,R., Fischer,B., Ritz,A.,
            Kossler,N., Thurisch,B., Spoerle,R., Smeitink,J., Kornak,U.,
            Chan,D., Vingron,M., Martasek,P., Lightowlers,R.N., Nijtmans,L.,
            Schuelke,M., Nierhaus,K.H. and Mundlos,S.
  TITLE     NOA1 is an essential GTPase required for mitochondrial protein
            synthesis
  JOURNAL   Mol Biol Cell 22 (1), 1-11 (2011)
   PUBMED   21118999
  REMARK    GeneRIF: data show that NOA1 is required for mitochondrial protein
            synthesis, likely due to its yet unidentified role in mitoribosomal
            biogenesis; NOA1 is required for such basal mitochondrial functions
            as adenosine triphosphate (ATP) synthesis and apoptosis
REFERENCE   5  (bases 1 to 2303)
  AUTHORS   Parihar,A., Parihar,M.S., Chen,Z. and Ghafourifar,P.
  TITLE     mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells
  JOURNAL   Life Sci 82 (21-22), 1077-1082 (2008)
   PUBMED   18456285
REFERENCE   6  (bases 1 to 2303)
  AUTHORS   Zemojtel,T., Kolanczyk,M., Kossler,N., Stricker,S., Lurz,R.,
            Mikula,I., Duchniewicz,M., Schuelke,M., Ghafourifar,P.,
            Martasek,P., Vingron,M. and Mundlos,S.
  TITLE     Mammalian mitochondrial nitric oxide synthase: characterization of
            a novel candidate
  JOURNAL   FEBS Lett 580 (2), 455-462 (2006)
   PUBMED   16380119
  REMARK    Erratum:[FEBS Lett. 2007 May 15;581(10):2072-3]
REFERENCE   7  (bases 1 to 2303)
  AUTHORS   Brun,C., Dang,Q. and Miassod,R.
  TITLE     Studies of an 800-kilobase DNA stretch of the Drosophila X
            chromosome: comapping of a subclass of scaffold-attached regions
            with sequences able to replicate autonomously in Saccharomyces
            cerevisiae
  JOURNAL   Mol Cell Biol 10 (10), 5455-5463 (1990)
   PUBMED   2118999
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141469.4, AK017793.1 and AA681543.1.
            
            [WARNING] On Apr 6, 2024 this sequence was replaced by NM_019836.4.
            
            On Jul 21, 2009 this sequence version replaced NM_019836.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128920.1, BC017154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC141469.4         117271-117298       c
            29-2205             AK017793.1         2-2178
            2206-2303           AA681543.1         1-98                c
FEATURES             Location/Qualifiers
     source          1..2303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 41.64 cM"
     gene            1..2303
                     /gene="Noa1"
                     /gene_synonym="2610024G14Rik; AtNOS1; mAtNOS1"
                     /note="nitric oxide associated 1"
                     /db_xref="GeneID:56412"
                     /db_xref="MGI:MGI:1914306"
     exon            1..1180
                     /gene="Noa1"
                     /gene_synonym="2610024G14Rik; AtNOS1; mAtNOS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2112
                     /gene="Noa1"
                     /gene_synonym="2610024G14Rik; AtNOS1; mAtNOS1"
                     /codon_start=1
                     /product="nitric oxide-associated protein 1"
                     /protein_id="NP_062810.1"
                     /db_xref="CCDS:CCDS19373.1"
                     /db_xref="GeneID:56412"
                     /db_xref="MGI:MGI:1914306"
                     /translation="MLPARLACGLLCGLRRGPAPAAACYGPARWLLEGKCEVPIRQRA
                     SSLGRRVPPSSTATEDYAEGPDTEERFLFPEYVPERTPEEQVRELQELRELQQLQQEK
                     ERERLQQREERLQQKLRAGFRTLPVPEFPDASVPPSGIYCSGCGAELHCQHPGLPGYL
                     PEEKFRDAAQAEGGPARTVCQRCWLLVHHGRALRLQVSRDQYLELVSAALRRPGPALV
                     LYMVNLLDLPDALLPDLPKLVGPKQLIVLGNKVDLLPQDAPGYLKRLRKRLWDDCIRA
                     GLVVAPGHQGPQYPAGDEPLEEIKNQNPSSRSRTVVKDVRLISAKTGYGVEEMISALQ
                     RSWRYRGDVYLVGTTNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKF
                     PICNPTPYRMFKRQRRLQEDATKAEEDLSEEEQSQLNQLKKHGYIVGRVGRTFSYSRE
                     QDEVPFEFDADSLAFDMGSEPVVSVCKSTKQIELTPEDVKDAHWFYDTPGITKESCIL
                     NLLTEKEINTVLPTHSIIPRTFVLKPGMVLFLGGIARIDFLQGNQSAWFTVVASNFLP
                     VHITSLDKADALYEKHAGHELLLVPMGGKERMAQFPPLVAEDITLKGGGKFEAVADIK
                     FSSAGWVAVTPYSEGTLHLRGHTPEGTALTVHPPVLPYIVNVKGQRMKKSVAYKTKKP
                     PSLVHNLKKHR"
     exon            1181..1345
                     /gene="Noa1"
                     /gene_synonym="2610024G14Rik; AtNOS1; mAtNOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1548
                     /gene="Noa1"
                     /gene_synonym="2610024G14Rik; AtNOS1; mAtNOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1680
                     /gene="Noa1"
                     /gene_synonym="2610024G14Rik; AtNOS1; mAtNOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1797
                     /gene="Noa1"
                     /gene_synonym="2610024G14Rik; AtNOS1; mAtNOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1915
                     /gene="Noa1"
                     /gene_synonym="2610024G14Rik; AtNOS1; mAtNOS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2303
                     /gene="Noa1"
                     /gene_synonym="2610024G14Rik; AtNOS1; mAtNOS1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgaggcccc gccctcctcg cgctgtccac atgctgcccg cgcgcctggc ttgcgggctg
       61 ctctgcgggc tccggcgggg ccccgcgccg gccgctgcgt gctacggccc agcacggtgg
      121 cttctggagg ggaagtgtga ggtccccatc cgccagcgtg catcatcctt gggccgtcgg
      181 gttcccccga gctccacggc gaccgaggac tatgcagaag gcccggacac ggaggaacgc
      241 tttctgttcc cggagtacgt cccggagcgg accccggagg aacaagtgcg ggagttgcag
      301 gagctgcggg agttgcagca gctgcagcag gagaaggaac gagagagatt gcagcagcgg
      361 gaggagcggc ttcagcagaa gctgcgggcg ggcttccgga cgctgcctgt cccggagttt
      421 ccagacgcct cggtgccgcc cagcggcatc tactgctcgg gctgcggagc cgagctgcac
      481 tgccagcatc ccggcctgcc gggctacctg ccggaggaga agttccgcga cgctgcccag
      541 gcggaaggcg gcccggcgcg gaccgtgtgc caacgctgct ggctgctggt gcaccacgga
      601 cgagccctgc gcctgcaggt aagccgcgat cagtacctgg agcttgtgag cgcagcgctg
      661 cggcgtcccg ggccggctct ggtgctctat atggtgaatc ttctagacct gccggacgcc
      721 ctgctgcccg acctgcccaa gctggtgggc cccaagcaac tcatcgtgct ggggaacaaa
      781 gtggacctgc tgccccagga cgctcccggc tacttgaagc ggctgcggaa gcggctgtgg
      841 gacgattgca tccgcgccgg gctcgtggtg gctcctggtc atcaaggacc acagtaccct
      901 gccggggatg agccactgga ggagataaag aatcagaatc cgtcctccag gtcccgcacg
      961 gtagtcaagg acgtgcgact gatcagcgcc aagacgggct atggagttga agaaatgatc
     1021 tctgctcttc agcgctcctg gcgctaccgt ggtgatgtct acctggtggg caccactaat
     1081 gctggcaagt ccactctctt taacacactc ctggagtctg attactgcac cgccaagggc
     1141 tccgaagcca tcgaccgggc caccatctcc ccctggccag gcaccacatt aaacctcctg
     1201 aagtttccta tttgcaaccc gactccttac agaatgttca aaagacaaag aaggcttcaa
     1261 gaagatgcga ccaaagctga ggaagatctt agtgaggaag aacaaagtca gctcaatcaa
     1321 ctgaaaaagc acggctacat agtaggaaga gttggaagaa cattctcgta ctccagagaa
     1381 caggacgaag ttccctttga gtttgatgcc gactccctgg cctttgacat gggaagtgaa
     1441 ccagttgtgt ctgtgtgcaa aagcaccaag caaatagagc taaccccaga ggacgtgaaa
     1501 gacgcccact ggttttatga cacccctgga attacaaaag aaagctgtat tttaaatctt
     1561 ctaacagaaa aagaaataaa tactgttttg ccgacacatt ctattatccc aagaaccttt
     1621 gtcctcaagc caggaatggt tttatttttg ggtgggatag cccgaataga tttcctacag
     1681 ggaaatcagt cagcctggtt cacagttgtg gcttccaact tccttcctgt tcatattact
     1741 tccttggaca aggcagatgc tctgtatgag aaacatgcag gtcacgagct actgctggtt
     1801 ccaatgggtg gaaaagaacg aatggcccag tttccccctc ttgttgctga agacattaca
     1861 ttaaagggag gtggaaaatt tgaagcagta gctgatatca agttctcctc tgcaggttgg
     1921 gttgcagtaa caccttattc tgagggcacg ctgcatctcc gaggtcacac acctgaaggg
     1981 actgctctga ctgtccaccc ccctgtcttg ccatatatcg ttaatgtcaa aggacagcgc
     2041 atgaagaaaa gtgtggccta taaaaccaag aagcctccgt ccctggtgca caacctgaag
     2101 aagcacagat gagtgaggca gacatgggtc ccactgggca gtgagtactg aaatgtgtga
     2161 aatgtactaa acacaaaaat aataaagaca cgcaaaaact tattgttaaa gatcttaaaa
     2221 agtcaagttt tttaactatt tgagactatg cttatataat aattatttat aaataaaaat
     2281 ctttctttct tagtgtccat gta
//
