LOCUS       NM_001308506            3666 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus nicotinamide nucleotide transhydrogenase (Nnt),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001308506 NR_003544
VERSION     NM_001308506.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3666)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 3666)
  AUTHORS   Callahan,J.W., Morales,J.C., Atherton,J.F., Wang,D., Kostic,S. and
            Bevan,M.D.
  TITLE     Movement-related increases in subthalamic activity optimize
            locomotion
  JOURNAL   Cell Rep 43 (8), 114495 (2024)
   PUBMED   39068661
REFERENCE   3  (bases 1 to 3666)
  AUTHORS   Sirbulescu,R.F., Nicholson,K., Kawai,K., Hilton,O.M., Sobell,D.,
            Jin,G., Verrill,D.E., Dwyer,L.J., Xiong,Y., Bachanova,P., Kim,S.E.,
            Gallup,S., Gelevski,D., Daley,H., Hernandez Rodriguez,D.E.,
            Negre,H., Sturtevant,O., Nikiforow,S., Ritz,J., Chen,Y.B.,
            Reeves,P.M., Sluder,A.E., Berry,J.D., Sadri-Vakili,G., Cudkowicz,M.
            and Poznansky,M.C.
  TITLE     Allogeneic B cell immunomodulatory therapy in amyotrophic lateral
            sclerosis
  JOURNAL   FASEB J 38 (13), e23796 (2024)
   PUBMED   38967302
REFERENCE   4  (bases 1 to 3666)
  AUTHORS   Dautan,D., Monai,A., Maltese,F., Chang,X., Molent,C., Mauro,D.,
            Galbusera,A., Vecchia,D., Antonelli,F., Benedetti,A., Drago,F.,
            Leggio,G.M., Pagani,M., Fellin,T., Gozzi,A., Schumann,G., Manago,F.
            and Papaleo,F.
  TITLE     Cortico-cortical transfer of socially derived information gates
            emotion recognition
  JOURNAL   Nat Neurosci 27 (7), 1318-1332 (2024)
   PUBMED   38769153
REFERENCE   5  (bases 1 to 3666)
  AUTHORS   Mao,R., Cavelli,M.L., Findlay,G., Driessen,K., Peterson,M.J.,
            Marshall,W., Tononi,G. and Cirelli,C.
  TITLE     Behavioral and cortical arousal from sleep, muscimol-induced coma,
            and anesthesia by direct optogenetic stimulation of cortical
            neurons
  JOURNAL   iScience 27 (6), 109919 (2024)
   PUBMED   38812551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3666)
  AUTHORS   Arkblad,E.L., Betsholtz,C., Mandoli,D. and Rydstrom,J.
  TITLE     Characterization of a nicotinamide nucleotide transhydrogenase gene
            from the green alga Acetabularia acetabulum and comparison of its
            structure with those of the corresponding genes in mouse and
            Caenorhabditis elegans
  JOURNAL   Biochim Biophys Acta 1520 (2), 115-123 (2001)
   PUBMED   11513952
REFERENCE   7  (bases 1 to 3666)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   8  (bases 1 to 3666)
  AUTHORS   Zuberi,A.R., Christianson,G.J., Dave,S.B., Bradley,J.A. and
            Roopenian,D.C.
  TITLE     Expression screening of a yeast artificial chromosome contig
            refines the location of the mouse H3a minor histocompatibility
            antigen gene
  JOURNAL   J Immunol 161 (2), 821-828 (1998)
   PUBMED   9670959
REFERENCE   9  (bases 1 to 3666)
  AUTHORS   Arkblad,E.L., Helou,K., Levan,G. and Rydstrom,J.
  TITLE     Mapping of the rat and mouse nicotinamide nucleotide
            transhydrogenase gene
  JOURNAL   Mamm Genome 8 (9), 703 (1997)
   PUBMED   9271681
REFERENCE   10 (bases 1 to 3666)
  AUTHORS   Arkblad,E.L., Betsholtz,C. and Rydstrom,J.
  TITLE     The cDNA sequence of proton-pumping nicotinamide nucleotide
            transhydrogenase from man and mouse
  JOURNAL   Biochim Biophys Acta 1273 (3), 203-205 (1996)
   PUBMED   8616157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154550.2, BY093825.1, BY078900.1, AK054332.1 and BP768059.1.
            
            On May 7, 2015 this sequence version replaced NR_003544.1.
            
            Transcript Variant: This variant (2) represents the sequence
            transcribed from this locus in C57BL/6, which lacks five in-frame
            internal exons, compared to variant 1. The encoded isoform (2) is
            shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054332.1, AK052234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC154550.2         10613-10646
            35-119              BY093825.1         1-85
            120-260             BY078900.1         87-227
            261-3643            AK054332.1         1-3383
            3644-3666           BP768059.1         33-55               c
FEATURES             Location/Qualifiers
     source          1..3666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 67.21 cM"
     gene            1..3666
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /note="nicotinamide nucleotide transhydrogenase"
                     /db_xref="GeneID:18115"
                     /db_xref="MGI:MGI:109279"
     exon            1..355
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            356..558
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..2915
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /EC_number="7.1.1.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     NAD(P) transhydrogenase, mitochondrial; pyridine
                     nucleotide transhydrogenase"
                     /codon_start=1
                     /product="NAD(P) transhydrogenase, mitochondrial isoform
                     2"
                     /protein_id="NP_001295435.1"
                     /db_xref="CCDS:CCDS84067.1"
                     /db_xref="GeneID:18115"
                     /db_xref="MGI:MGI:109279"
                     /translation="MAHLLKTVVAGCSCPFLSNLGSSKVLPGKRDFVRTLRTHQALWC
                     KSPVKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQALVKQGFNVVVESGAGEASKFP
                     DDLYRAAGAQIQGMKEVLASDLVVKVRAPMVNPTLGAHEADFLKPSGTLISFIYPAQN
                     PDLLNKLSERKTTVLAMDQVPRVTIAQGYDALSSMANISGYKAVVLAANHFGRFFTGQ
                     ITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAVVRGFDTRAAALEQFKSLGAEPLEV
                     DLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGGFLVTQRMLDMF
                     KRPTDPPEYNYLYLLPGGTFVGGYLAALYGGYNIEEIMYLGSGLCCVGALGGLSTQGT
                     ARLGNALGMIGVAGGLAATLGGLKPDPQLLAQMSGAMAMGGTIGLTIAKRIQISDLPQ
                     LVAAFHSLVGLAAVLTCMAEYIVEYPHFAMDATSNFTKIVAYLGTYIGGVTFSGSLVA
                     YGKLQGILKSAPLLLPGRHALNAGLLAASVGGIIPFMADPSFTTGITCLGSVSALSTL
                     MGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYI
                     MCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAVEMIREANSIVITPGY
                     GLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMD
                     EINSDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGY
                     AAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK"
     exon            559..788
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1006
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1094
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1183
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1371
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1517
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1713
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1947
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2108
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2288
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2448
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2530
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2649
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2765
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..3645
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3623..3628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3645
                     /gene="Nnt"
                     /gene_synonym="4930423F13Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgcgg gcctggggcc ctggcagaga caaaggggct tcagcggcca cccggagggg
       61 accagctgct gcgctgtaag cgtgcatctg gtggagtctt tttctccttt gcagactggc
      121 gatcgggcca agcgggtttg gcaggaggct cggggagggg gagaaggggt gccgaaaggg
      181 ggcgcgggtc cgggtctagg cagccctgtg tcacgtggtc gccgccgccg cctcaaagtt
      241 ggggctgttc ttccgggttg gaggcacaac gccgcgggcc aaccccgggt ctgctagctc
      301 ggcgtggcgt ttgctcgcag cccggggtcg ccatctgtcc cgcctgccgg tccagtaatc
      361 caccttcaag gaattgggga tccgaaacgt tgggagcata aagcagcatg gcgcacctac
      421 tgaagacggt ggtggctggc tgttcatgtc ctttccttag caacttgggg tcctctaagg
      481 ttctacctgg gaagagagac tttgtacgaa cgcttcgtac tcaccaggca ctgtggtgta
      541 aatccccggt aaagccagga attccatata agcagttgac agttggggtc cccaaggaga
      601 ttttccaaaa cgagaagcga gttgcattgt ctcctgcggg ggtccaggcc ctggtcaagc
      661 agggcttcaa tgttgtcgtg gaatcaggcg caggcgaagc ttccaagttc ccagatgacc
      721 tctacagagc agcaggggcc cagatccaag ggatgaagga agttctggct tctgatctgg
      781 tggtcaaagt gagggccccc atggtgaacc cgacgttagg cgctcacgaa gctgactttt
      841 taaagccatc aggaactcta attagcttca tctacccagc ccaaaatcca gacttgctca
      901 ataaactttc tgaaagaaaa accacagttc tggcgatgga ccaggttcca agagtgacaa
      961 tagctcaggg ctatgatgct ctcagttcca tggccaacat ctctggttat aaggctgttg
     1021 ttttagcagc gaatcatttt gggaggtttt tcactgggca gatcacagct gctggaaaag
     1081 ttccccctgc gaagatcctg atagttggtg gtggcgttgc tgggctcgct tctgcggggg
     1141 cagcaaagtc gatgggcgca gttgtccgag gatttgatac aagagctgct gctttggaac
     1201 agttcaaatc ccttggtgct gaacccttgg aggttgactt gaaggaatct ggtgagggcc
     1261 aaggaggata cgcgaaagag atgtccaaag agttcattga agctgaaatg aagctctttg
     1321 ctcaacagtg caaggaggtg gacatcctta tcagcacagc tctgattcca ggtggttttc
     1381 tggtgactca gagaatgctg gacatgttca agcgacccac ggaccctcca gagtataatt
     1441 atctgtatct gctccctggt ggcaccttcg taggtggata tttagctgct ctctacggtg
     1501 gctataacat cgaagaaatc atgtacctgg gctcaggctt gtgctgtgtt ggggccctgg
     1561 gcggcctttc cactcaggga acagctcgac tcggcaatgc cttgggcatg atcggggttg
     1621 caggaggcct ggcagccacc cttggaggcc tgaagccgga cccgcagctg ttagctcaga
     1681 tgtctggagc aatggcaatg ggtggcacca tcggcctgac gatcgcaaag cggatccaga
     1741 tttccgactt gcctcagttg gtcgctgctt tccacagttt ggtggggctg gcagcagttc
     1801 ttacctgcat ggccgagtac atcgtagagt atccacattt tgcaatggat gccacgtcaa
     1861 atttcaccaa gattgtggct taccttggca cttacatcgg cggagtcacc tttagtgggt
     1921 ctcttgttgc ctacggaaaa ttacagggta ttttgaaatc agctcctctg ctgctccctg
     1981 gaaggcacgc actcaatgca ggcctgctgg ctgctagcgt gggtgggata atcccattta
     2041 tggctgaccc tagctttacc acgggcatca cctgtctggg ctctgtgtcc gcactctcta
     2101 ctctcatggg tgtgactttg acggctgcta ttggtggtgc tgacatgcct gtcgtcatca
     2161 ccgtgctaaa cagctactcg ggctgggctc tgtgtgccga gggcttcctg ctcaacaaca
     2221 acctgctgac catcgtgggc gcgctcatcg gctcctctgg tgcaatcctg tcgtacatca
     2281 tgtgtgtggc catgaaccgc tccctggcta atgtcattct tggaggctat ggcacaacgt
     2341 caacagctgg tggaaaaccc atggaaattt ctggcacaca tacagaaatc aacctggaca
     2401 acgcagttga gatgatccgg gaagctaaca gcattgttat tactccaggg tatgggctct
     2461 gtgctgctaa agctcagtac cccattgccg atttggtgaa gatgcttact gaacaaggca
     2521 aaaaagtcag gtttggaatc cacccagttg cgggccgaat gcctggtcag cttaatgtgc
     2581 tcctggccga ggcgggagtg ccctatgata ttgtgttaga aatggatgag atcaacagtg
     2641 attttccaga caccgacttg gttcttgtca ttggagcaaa cgacactgtg aattcagcgg
     2701 ctcaagaaga ccccaattct ataattgcag gcatgccggt ccttgaggtc tggaagtcca
     2761 aacaggtcat tgtcatgaag aggtcccttg gcgttggcta cgctgccgtg gacaatccga
     2821 tcttctacaa acctaacaca gctatgcttc tgggggacgc caagaagaca tgtgacgctc
     2881 tgcaggccaa agttcgggaa tcctatcaga agtgaagatt gaagatccag ccgatgcctt
     2941 cggttgcagg aacagagaaa ggaggcgttc atagatgagc aaagctctca agacccaaag
     3001 aagcctcaca aaacaatgga gattttcaag atcagcaccc catgcttctc aaaaagcatt
     3061 ggaaattctc atcgcctacc tatgtactgt cgccattgcc caaaaagcaa gagtattttg
     3121 tccacagtga aaaagcagcc tcactttaga tgcaacccca ctggattctt aaaattccct
     3181 ttcagtagct agaaatcagt tcagaagttg aatgttcgag atttcaggat atgggttggt
     3241 ctgaaaaata ttacacaata tgatcattgt agacacctgc atttagtgcc tttttttctt
     3301 ttttcttttc accagatgtg actaatttga aacctttatc aactcctgac ctgttctctt
     3361 gcatcttagc catactccgg attgatcatg ccaaatctgc agcaggttat cagccttcac
     3421 tatagactct agattccaaa gatctatttt ctcacttcta ttttaatatg taaaaggtct
     3481 agatagttta agtaataact taaacataat aagttgtatt tttgaaagtc ccattgccaa
     3541 ttggtctctt taactgcaat caactaagtg ttcttgaatg gactgtatta agtgcgcttg
     3601 aatggaatgc aaccatctga gtaataaatg agttcataaa agtgaaaaaa aaaaaaaaaa
     3661 aaaaaa
//
