LOCUS       NM_001409262            1083 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript
            variant 3, mRNA.
ACCESSION   NM_001409262 XM_011242417
VERSION     NM_001409262.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1083)
  AUTHORS   Zhen,X., Sun,Y., Lin,H., Huang,Y., Liu,T., Li,Y. and Peng,H.
  TITLE     Elucidating the role of nicotinamide N-methyltransferase-p53 axis
            in the progression of chronic kidney disease
  JOURNAL   PeerJ 11, e16301 (2023)
   PUBMED   37953778
  REMARK    GeneRIF: Elucidating the role of nicotinamide
            N-methyltransferase-p53 axis in the progression of chronic kidney
            disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1083)
  AUTHORS   Yoda,M., Mizuno,R., Izumi,Y., Takahashi,M., Bamba,T. and Kawaoka,S.
  TITLE     Nicotinamide-N-methyltransferase regulates lipid metabolism via SAM
            and 1-methylnicotinamide in the AML12 hepatocyte cell line
  JOURNAL   J Biochem 174 (1), 89-98 (2023)
   PUBMED   37014628
  REMARK    GeneRIF: Nicotinamide-N-methyltransferase regulates lipid
            metabolism via SAM and 1-methylnicotinamide in the AML12 hepatocyte
            cell line.
REFERENCE   4  (bases 1 to 1083)
  AUTHORS   Mizuno,R., Hojo,H., Takahashi,M., Kashio,S., Enya,S., Nakao,M.,
            Konishi,R., Yoda,M., Harata,A., Hamanishi,J., Kawamoto,H.,
            Mandai,M., Suzuki,Y., Miura,M., Bamba,T., Izumi,Y. and Kawaoka,S.
  TITLE     Remote solid cancers rewire hepatic nitrogen metabolism via host
            nicotinamide-N-methyltransferase
  JOURNAL   Nat Commun 13 (1), 3346 (2022)
   PUBMED   35705545
  REMARK    GeneRIF: Remote solid cancers rewire hepatic nitrogen metabolism
            via host nicotinamide-N-methyltransferase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1083)
  AUTHORS   Xu,W., Hou,L., Li,P. and Li,L.
  TITLE     Effect of nicotinamide N-methyltransferase on lipid accumulation in
            3T3-L1 adipocytes
  JOURNAL   Bioengineered 13 (5), 12421-12434 (2022)
   PUBMED   35603729
  REMARK    GeneRIF: Effect of nicotinamide N-methyltransferase on lipid
            accumulation in 3T3-L1 adipocytes.
REFERENCE   6  (bases 1 to 1083)
  AUTHORS   Yaguchi,H., Togawa,K., Moritani,M. and Itakura,M.
  TITLE     Identification of candidate genes in the type 2 diabetes modifier
            locus using expression QTL
  JOURNAL   Genomics 85 (5), 591-599 (2005)
   PUBMED   15820311
REFERENCE   7  (bases 1 to 1083)
  AUTHORS   Thompson,M.A., Moon,E., Kim,U.J., Xu,J., Siciliano,M.J. and
            Weinshilboum,R.M.
  TITLE     Human indolethylamine N-methyltransferase: cDNA cloning and
            expression, gene cloning, and chromosomal localization
  JOURNAL   Genomics 61 (3), 285-297 (1999)
   PUBMED   10552930
REFERENCE   8  (bases 1 to 1083)
  AUTHORS   Yan,L., Otterness,D.M., Kozak,C.A. and Weinshilboum,R.M.
  TITLE     Mouse nicotinamide N-methyltransferase gene: molecular cloning,
            structural characterization, and chromosomal localization
  JOURNAL   DNA Cell Biol 17 (8), 659-667 (1998)
   PUBMED   9726248
REFERENCE   9  (bases 1 to 1083)
  AUTHORS   Yan,L., Otterness,D.M., Craddock,T.L. and Weinshilboum,R.M.
  TITLE     Mouse liver nicotinamide N-methyltransferase: cDNA cloning,
            expression, and nucleotide sequence polymorphisms
  JOURNAL   Biochem Pharmacol 54 (10), 1139-1149 (1997)
   PUBMED   9464457
REFERENCE   10 (bases 1 to 1083)
  AUTHORS   Scheller,T., Orgacka,H., Szumlanski,C.L. and Weinshilboum,R.M.
  TITLE     Mouse liver nicotinamide N-methyltransferase pharmacogenetics:
            biochemical properties and variation in activity among inbred
            strains
  JOURNAL   Pharmacogenetics 6 (1), 43-53 (1996)
   PUBMED   8845860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113548.22.
            
            On Jul 12, 2022 this sequence version replaced XM_011242417.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM936660.1, SRR7345562.977374.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN04095722
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC113548.22        62658-62780         c
            124-402             AC113548.22        59927-60205         c
            403-610             AC113548.22        58476-58683         c
            611-1083            AC113548.22        47012-47484         c
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.45 cM"
     gene            1..1083
                     /gene="Nnmt"
                     /note="nicotinamide N-methyltransferase"
                     /db_xref="GeneID:18113"
                     /db_xref="MGI:MGI:1099443"
     exon            1..123
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            124..402
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1043
                     /gene="Nnmt"
                     /EC_number="2.1.1.1"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="nicotinamide N-methyltransferase isoform 1"
                     /protein_id="NP_001396191.1"
                     /db_xref="GeneID:18113"
                     /db_xref="MGI:MGI:1099443"
                     /translation="MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKN
                     LFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEP
                     GAFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVSLPPADCL
                     LSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSYYMIGEQKFSSLPLGW
                     ETVRDAVEEAGYTIEQFEVISQNYSSTTSNNEGLFSLVGRKPGRSE"
     exon            403..610
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            611..1083
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1059..1064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nnmt"
                     /note="hexamer: ATTAAA"
     polyA_site      1083
                     /gene="Nnmt"
                     /note="major polyA site"
ORIGIN      
        1 gcttttgaat tcggacagat ctaaaacagg gcggtggccg agtcgctgaa gcatgcctgt
       61 gcctcagtct cctcacatgc tgacatggag gtgacagtcc taactcacac aactgctgtc
      121 aggggatggg ccgagctgga ggaagattgg cagctctaag actccaaaag ccaacttcac
      181 agggtgactc cctgcttctg gaggagggga caggagagca tcaggctggt gcacggagct
      241 gagacacgat ggaatctggc ttcacctcca aggacactta tctaagtcat tttaatcctc
      301 gggattactt ggaaaaatat tacagctttg ggtccagaca ctgtgcagaa aacgagatcc
      361 tcagacatct gctgaaaaat ctttttaaga tattctgcct gggtgctgta aaaggagaac
      421 tcctgattga cattggctct ggccccacca tctatcagct tctctctgcc tgtgagtcct
      481 tcacggagat cattgtctct gactacacag accagaacct ctgggagctg cagaaatggc
      541 tgaagaagga accaggagcc tttgactggt ccccagtggt cacctatgtg tgtgatcttg
      601 aaggcaacag aatgaaggga cctgagaagg aggagaagtt gaggcgtgca atcaagcagg
      661 tactaaagtg tgatgtgacc cagagccagc ctctgggtgg ggtctctctg cctcctgctg
      721 actgcttgct cagcacgctg tgcctggatg ctgcctgccc tgacctcccg gcctatcgca
      781 ctgccctcag gaacctgggc agtctgctca agccaggagg cttcctggtg atggtagatg
      841 ccctgaagag tagctactac atgattgggg agcagaagtt ttccagcctt cccctgggat
      901 gggagactgt tcgagatgct gtggaagagg ccggttacac cattgagcag tttgaggtga
      961 tttctcaaaa ttactcttct accacatcca ataatgaagg actcttctcc ctagtggggc
     1021 gaaagccagg cagatctgaa tgacatcctg tgatccctat taaaggcctg ctggttcatt
     1081 tca
//
