LOCUS       NM_001311062             856 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus nicotinamide N-methyltransferase (Nnmt), transcript
            variant 2, mRNA.
ACCESSION   NM_001311062 XM_006510078
VERSION     NM_001311062.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 856)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 856)
  AUTHORS   Zhen,X., Sun,Y., Lin,H., Huang,Y., Liu,T., Li,Y. and Peng,H.
  TITLE     Elucidating the role of nicotinamide N-methyltransferase-p53 axis
            in the progression of chronic kidney disease
  JOURNAL   PeerJ 11, e16301 (2023)
   PUBMED   37953778
  REMARK    GeneRIF: Elucidating the role of nicotinamide
            N-methyltransferase-p53 axis in the progression of chronic kidney
            disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 856)
  AUTHORS   Yoda,M., Mizuno,R., Izumi,Y., Takahashi,M., Bamba,T. and Kawaoka,S.
  TITLE     Nicotinamide-N-methyltransferase regulates lipid metabolism via SAM
            and 1-methylnicotinamide in the AML12 hepatocyte cell line
  JOURNAL   J Biochem 174 (1), 89-98 (2023)
   PUBMED   37014628
  REMARK    GeneRIF: Nicotinamide-N-methyltransferase regulates lipid
            metabolism via SAM and 1-methylnicotinamide in the AML12 hepatocyte
            cell line.
REFERENCE   4  (bases 1 to 856)
  AUTHORS   Mizuno,R., Hojo,H., Takahashi,M., Kashio,S., Enya,S., Nakao,M.,
            Konishi,R., Yoda,M., Harata,A., Hamanishi,J., Kawamoto,H.,
            Mandai,M., Suzuki,Y., Miura,M., Bamba,T., Izumi,Y. and Kawaoka,S.
  TITLE     Remote solid cancers rewire hepatic nitrogen metabolism via host
            nicotinamide-N-methyltransferase
  JOURNAL   Nat Commun 13 (1), 3346 (2022)
   PUBMED   35705545
  REMARK    GeneRIF: Remote solid cancers rewire hepatic nitrogen metabolism
            via host nicotinamide-N-methyltransferase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 856)
  AUTHORS   Xu,W., Hou,L., Li,P. and Li,L.
  TITLE     Effect of nicotinamide N-methyltransferase on lipid accumulation in
            3T3-L1 adipocytes
  JOURNAL   Bioengineered 13 (5), 12421-12434 (2022)
   PUBMED   35603729
  REMARK    GeneRIF: Effect of nicotinamide N-methyltransferase on lipid
            accumulation in 3T3-L1 adipocytes.
REFERENCE   6  (bases 1 to 856)
  AUTHORS   Yaguchi,H., Togawa,K., Moritani,M. and Itakura,M.
  TITLE     Identification of candidate genes in the type 2 diabetes modifier
            locus using expression QTL
  JOURNAL   Genomics 85 (5), 591-599 (2005)
   PUBMED   15820311
REFERENCE   7  (bases 1 to 856)
  AUTHORS   Thompson,M.A., Moon,E., Kim,U.J., Xu,J., Siciliano,M.J. and
            Weinshilboum,R.M.
  TITLE     Human indolethylamine N-methyltransferase: cDNA cloning and
            expression, gene cloning, and chromosomal localization
  JOURNAL   Genomics 61 (3), 285-297 (1999)
   PUBMED   10552930
REFERENCE   8  (bases 1 to 856)
  AUTHORS   Yan,L., Otterness,D.M., Kozak,C.A. and Weinshilboum,R.M.
  TITLE     Mouse nicotinamide N-methyltransferase gene: molecular cloning,
            structural characterization, and chromosomal localization
  JOURNAL   DNA Cell Biol 17 (8), 659-667 (1998)
   PUBMED   9726248
REFERENCE   9  (bases 1 to 856)
  AUTHORS   Yan,L., Otterness,D.M., Craddock,T.L. and Weinshilboum,R.M.
  TITLE     Mouse liver nicotinamide N-methyltransferase: cDNA cloning,
            expression, and nucleotide sequence polymorphisms
  JOURNAL   Biochem Pharmacol 54 (10), 1139-1149 (1997)
   PUBMED   9464457
REFERENCE   10 (bases 1 to 856)
  AUTHORS   Scheller,T., Orgacka,H., Szumlanski,C.L. and Weinshilboum,R.M.
  TITLE     Mouse liver nicotinamide N-methyltransferase pharmacogenetics:
            biochemical properties and variation in activity among inbred
            strains
  JOURNAL   Pharmacogenetics 6 (1), 43-53 (1996)
   PUBMED   8845860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113548.22.
            
            On Jul 12, 2022 this sequence version replaced NM_001311062.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89377.1, CD240988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC113548.22        59927-60232         c
            307-514             AC113548.22        58476-58683         c
            515-563             AC113548.22        47436-47484         c
            564-856             AC113548.22        47012-47304         c
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.45 cM"
     gene            1..856
                     /gene="Nnmt"
                     /note="nicotinamide N-methyltransferase"
                     /db_xref="GeneID:18113"
                     /db_xref="MGI:MGI:1099443"
     exon            1..306
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..626
                     /gene="Nnmt"
                     /EC_number="2.1.1.1"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="nicotinamide N-methyltransferase isoform 2"
                     /protein_id="NP_001297991.1"
                     /db_xref="CCDS:CCDS80991.1"
                     /db_xref="GeneID:18113"
                     /db_xref="MGI:MGI:1099443"
                     /translation="MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKN
                     LFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEP
                     GAFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQEPGQSAQARRLPGDGRCPEE"
     exon            307..514
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            515..563
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            564..856
                     /gene="Nnmt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      832..837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nnmt"
                     /note="hexamer: ATTAAA"
     polyA_site      856
                     /gene="Nnmt"
                     /note="major polyA site"
ORIGIN      
        1 agtatttagc aaacatctgt ctctaaggga tgggccgagc tggaggaaga ttggcagctc
       61 taagactcca aaagccaact tcacagggtg actccctgct tctggaggag gggacaggag
      121 agcatcaggc tggtgcacgg agctgagaca cgatggaatc tggcttcacc tccaaggaca
      181 cttatctaag tcattttaat cctcgggatt acttggaaaa atattacagc tttgggtcca
      241 gacactgtgc agaaaacgag atcctcagac atctgctgaa aaatcttttt aagatattct
      301 gcctgggtgc tgtaaaagga gaactcctga ttgacattgg ctctggcccc accatctatc
      361 agcttctctc tgcctgtgag tccttcacgg agatcattgt ctctgactac acagaccaga
      421 acctctggga gctgcagaaa tggctgaaga aggaaccagg agcctttgac tggtccccag
      481 tggtcaccta tgtgtgtgat cttgaaggca acagaatgaa gggacctgag aaggaggaga
      541 agttgaggcg tgcaatcaag caggaacctg ggcagtctgc tcaagccagg aggcttcctg
      601 gtgatggtag atgccctgaa gagtagctac tacatgattg gggagcagaa gttttccagc
      661 cttcccctgg gatgggagac tgttcgagat gctgtggaag aggccggtta caccattgag
      721 cagtttgagg tgatttctca aaattactct tctaccacat ccaataatga aggactcttc
      781 tccctagtgg ggcgaaagcc aggcagatct gaatgacatc ctgtgatccc tattaaaggc
      841 ctgctggttc atttca
//
