LOCUS       NM_010923               1254 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus neuronatin (Nnat), transcript variant 1, mRNA.
ACCESSION   NM_010923
VERSION     NM_010923.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1254)
  AUTHORS   Yu,V., Yong,F., Marta,A., Khadayate,S., Osakwe,A., Bhattacharya,S.,
            Varghese,S.S., Chabosseau,P., Tabibi,S.M., Chen,K., Georgiadou,E.,
            Parveen,N., Suleiman,M., Stamoulis,Z., Marselli,L., De Luca,C.,
            Tesi,M., Ostinelli,G., Delgadillo-Silva,L., Wu,X., Hatanaka,Y.,
            Montoya,A., Elliott,J., Patel,B., Demchenko,N., Whilding,C.,
            Hajkova,P., Shliaha,P., Kramer,H., Ali,Y., Marchetti,P., Sladek,R.,
            Dhawan,S., Withers,D.J., Rutter,G.A. and Millership,S.J.
  TITLE     Differential CpG methylation at Nnat in the early establishment of
            beta cell heterogeneity
  JOURNAL   Diabetologia 67 (6), 1079-1094 (2024)
   PUBMED   38512414
REFERENCE   2  (bases 1 to 1254)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1254)
  AUTHORS   Bohuslavova,R., Fabriciova,V., Smolik,O., Lebron-Mora,L.,
            Abaffy,P., Benesova,S., Zucha,D., Valihrach,L., Berkova,Z.,
            Saudek,F. and Pavlinkova,G.
  TITLE     NEUROD1 reinforces endocrine cell fate acquisition in pancreatic
            development
  JOURNAL   Nat Commun 14 (1), 5554 (2023)
   PUBMED   37689751
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1254)
  AUTHORS   Deng,Y., Lu,L., Liang,X., Li,J., Zhu,D., Huang,H., Zhang,Y.,
            Zhang,X., Chen,Y., Liu,X. and Fu,Y.
  TITLE     DNA methylation-mediated silencing of Neuronatin promotes
            hepatocellular carcinoma proliferation through the PI3K-Akt
            signaling pathway
  JOURNAL   Life Sci 312, 121266 (2023)
   PUBMED   36473542
  REMARK    GeneRIF: DNA methylation-mediated silencing of Neuronatin promotes
            hepatocellular carcinoma proliferation through the PI3K-Akt
            signaling pathway.
REFERENCE   5  (bases 1 to 1254)
  AUTHORS   Scott,W.R., Gelegen,C., Chandarana,K., Karra,E., Yousseif,A.,
            Amouyal,C., Choudhury,A.I., Andreelli,F., Withers,D.J. and
            Batterham,R.L.
  TITLE     Differential pre-mRNA splicing regulates Nnat isoforms in the
            hypothalamus after gastric bypass surgery in mice
  JOURNAL   PLoS One 8 (3), e59407 (2013)
   PUBMED   23527188
  REMARK    GeneRIF: Nnat expression in hypothalamus is regulated by short-term
            nutrient availability, but unaltered by diet-induced obesity or
            calorie restriction.
REFERENCE   6  (bases 1 to 1254)
  AUTHORS   Williamson,C.M., Beechey,C.V., Ball,S.T., Dutton,E.R.,
            Cattanach,B.M., Tease,C., Ishino,F. and Peters,J.
  TITLE     Localisation of the imprinted gene neuronatin, Nnat, confirms and
            refines the location of a second imprinting region on mouse
            chromosome 2
  JOURNAL   Cytogenet Cell Genet 81 (1), 73-78 (1998)
   PUBMED   9691180
REFERENCE   7  (bases 1 to 1254)
  AUTHORS   Kikyo,N., Williamson,C.M., John,R.M., Barton,S.C., Beechey,C.V.,
            Ball,S.T., Cattanach,B.M., Surani,M.A. and Peters,J.
  TITLE     Genetic and functional analysis of neuronatin in mice with maternal
            or paternal duplication of distal Chr 2
  JOURNAL   Dev Biol 190 (1), 66-77 (1997)
   PUBMED   9331332
REFERENCE   8  (bases 1 to 1254)
  AUTHORS   Kagitani,F., Kuroiwa,Y., Wakana,S., Shiroishi,T., Miyoshi,N.,
            Kobayashi,S., Nishida,M., Kohda,T., Kaneko-Ishino,T. and Ishino,F.
  TITLE     Peg5/Neuronatin is an imprinted gene located on sub-distal
            chromosome 2 in the mouse
  JOURNAL   Nucleic Acids Res 25 (17), 3428-3432 (1997)
   PUBMED   9254699
REFERENCE   9  (bases 1 to 1254)
  AUTHORS   Sornson,M.W., Wu,W., Dasen,J.S., Flynn,S.E., Norman,D.J.,
            O'Connell,S.M., Gukovsky,I., Carriere,C., Ryan,A.K., Miller,A.P.,
            Zuo,L., Gleiberman,A.S., Andersen,B., Beamer,W.G. and
            Rosenfeld,M.G.
  TITLE     Pituitary lineage determination by the Prophet of Pit-1 homeodomain
            factor defective in Ames dwarfism
  JOURNAL   Nature 384 (6607), 327-333 (1996)
   PUBMED   8934515
REFERENCE   10 (bases 1 to 1254)
  AUTHORS   Wijnholds,J., Chowdhury,K., Wehr,R. and Gruss,P.
  TITLE     Segment-specific expression of the neuronatin gene during early
            hindbrain development
  JOURNAL   Dev Biol 171 (1), 73-84 (1995)
   PUBMED   7556909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672259.9, AK160626.1, BQ030646.1 and BU705167.1.
            
            On Mar 26, 2014 this sequence version replaced NM_010923.2.
            
            Transcript Variant: This variant (1) lacks an alternate exon but
            contains a different exon that results in a frameshift in the 3'
            coding region, compared to variant 3. The encoded isoform (alpha,
            also known as Neuronatin-3) has a distinct C-terminus and is
            shorter than isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160626.1, X83570.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 9254699
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL672259.9         152673-152704
            33-1163             AK160626.1         1-1131
            1164-1245           BQ030646.1         14-95               c
            1246-1254           BU705167.1         507-515
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.4 cM"
     gene            1..1254
                     /gene="Nnat"
                     /gene_synonym="5730414I02Rik; Peg5"
                     /note="neuronatin"
                     /db_xref="GeneID:18111"
                     /db_xref="MGI:MGI:104716"
     exon            1..183
                     /gene="Nnat"
                     /gene_synonym="5730414I02Rik; Peg5"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..357
                     /gene="Nnat"
                     /gene_synonym="5730414I02Rik; Peg5"
                     /note="isoform alpha is encoded by transcript variant 1"
                     /codon_start=1
                     /product="neuronatin isoform alpha"
                     /protein_id="NP_035053.1"
                     /db_xref="CCDS:CCDS38306.1"
                     /db_xref="GeneID:18111"
                     /db_xref="MGI:MGI:104716"
                     /translation="MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGT
                     QPIARSEVFRYSLQKLAHTVSRTGRQVLGERRQRAPN"
     exon            184..264
                     /gene="Nnat"
                     /gene_synonym="5730414I02Rik; Peg5"
                     /inference="alignment:Splign:2.1.0"
     exon            265..1248
                     /gene="Nnat"
                     /gene_synonym="5730414I02Rik; Peg5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1245
                     /gene="Nnat"
                     /gene_synonym="5730414I02Rik; Peg5"
                     /note="major polyA site"
ORIGIN      
        1 ggtacttaag gcacggccac cggggctgcg gcattgcgcc cagcagcgga ctccgagacc
       61 agtagacctc ggcgaaccct tgctctcgac cacccaccca ctttcggaac catggccgca
      121 gtggcagcag cctcggcaga actgctcatc atcggctggt acatcttccg cgtgctgctg
      181 caggtgttcc tggaatgctg catttactgg gtaggattcg cttttcgaaa tcctccaggg
      241 acacagccca ttgcgagaag tgaggtgttc aggtactccc tgcagaagct ggcgcacacg
      301 gtgtcccgga ccgggcggca ggtgctgggg gagcgcaggc agcgagcccc caactgaggc
      361 cccagctccc agccctgggc ggccgtgtca tcaggtgctc ctgtgcttct cgaccagcat
      421 gggagccagt gccgcgcagg aatggggggt cccctgtgtt ccctcgtcag aggagcactt
      481 gccaaggtca gtgaggggcc ggtaggcccc cagaaaagca gcaccgacaa tgatgaagat
      541 atcagttccc ttcccagccc ctttgcccct gtcccactac cggcgggtgg gagaggaggg
      601 gggaagaggg gagcaaccct cgagatatgg gcgtaggcac cacattctga tctggaccaa
      661 gtcggaacag taccatctca gccgcacaag atcctaccat gaagatcgaa cagcccatca
      721 accagcagaa tggacattct gacatcacca gctgaagccc tacatctcgg tgcagaagag
      781 aaagtgtcaa ctgtgtgcag catgggggga gtggagggcg tgggtggtgg aggaagaggg
      841 ttaagaaaac tagtggggcc cccttgctgc cccttgccta tggcacacat attcctgcct
      901 tgctccctca tttccccttt tccccccgcc ttcgaaagcc ctccccaaaa tgtgtcactt
      961 gatttggata tattcaacca gtaattgaat cccaccttta ccaaaacacg ttctctaacc
     1021 cccggccctt cactgatctt gcttatccct ggtctcacgc agcagttgtg gtcaatattg
     1081 tggtagtcgc taattgtact ggtttaagtg tgcattagta gtgtctcccc agctagattg
     1141 taagctcctg gagacaggga ccacctccac caaaaataaa aaaatggacc tctcctgtct
     1201 tgtagtgtcc taggaccctg cagggcagtg ggggtgcacc aaaaagttaa aaaa
//
