LOCUS       NM_153079               3276 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus neuromedin U receptor 2 (Nmur2), mRNA.
ACCESSION   NM_153079
VERSION     NM_153079.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3276)
  AUTHORS   Yadav,K., Yadav,A., Rajpoot,A. and Mishra,R.K.
  TITLE     Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and
            NMUR2 expression in mouse testis
  JOURNAL   Peptides 159, 170899 (2023)
   PUBMED   36336170
  REMARK    GeneRIF: Postnatal ontogeny of Neuromedin S and its receptors NMUR1
            and NMUR2 expression in mouse testis.
REFERENCE   2  (bases 1 to 3276)
  AUTHORS   Vallof,D., Kalafateli,A.L. and Jerlhag,E.
  TITLE     Brain region-specific neuromedin U signalling regulates
            alcohol-related behaviours and food intake in rodents
  JOURNAL   Addict Biol 25 (3), e12764 (2020)
   PUBMED   31069918
  REMARK    GeneRIF: Brain region-specific neuromedin U signalling regulates
            alcohol-related behaviours and food intake in rodents.
REFERENCE   3  (bases 1 to 3276)
  AUTHORS   Hsiao,Y.T., Jestes,K.J., Jackson,K.L., Zukosky,T., Squire,M.E.,
            Hum,J.M. and Lowery,J.W.
  TITLE     Neuromedin U (NMU) regulates osteoblast differentiation and
            activity
  JOURNAL   Biochem Biophys Res Commun 524 (4), 890-894 (2020)
   PUBMED   32057362
  REMARK    GeneRIF: Neuromedin U (NMU) regulates osteoblast differentiation
            and activity.
REFERENCE   4  (bases 1 to 3276)
  AUTHORS   Gilbert,A.K., Puma,C., Xu,X. and Laird,J.M.
  TITLE     Neuromedin U receptor 2 does not play a role in the development of
            neuropathic pain following nerve injury in mice
  JOURNAL   Eur J Pain 17 (8), 1147-1155 (2013)
   PUBMED   23349076
  REMARK    GeneRIF: The present data do not support a significant contribution
            of NMUR2 to the development of hypersensitivity after nerve injury
            or tissue inflammation
REFERENCE   5  (bases 1 to 3276)
  AUTHORS   Rao,S.M., Auger,J.L., Gaillard,P., Weissleder,R., Wada,E.,
            Torres,R., Kojima,M., Benoist,C., Mathis,D. and Binstadt,B.A.
  TITLE     The neuropeptide neuromedin U promotes autoantibody-mediated
            arthritis
  JOURNAL   Arthritis Res Ther 14 (1), R29 (2012)
   PUBMED   22314006
  REMARK    GeneRIF: Data show that deficiency of neuromedin receptors NMUR1
            and NMUR2 had no impact on arthritis severity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3276)
  AUTHORS   Fang,L., Zhang,M., Li,C., Dong,S. and Hu,Y.
  TITLE     Chemical genetic analysis reveals the effects of NMU2R on the
            expression of peptide hormones
  JOURNAL   Neurosci Lett 404 (1-2), 148-153 (2006)
   PUBMED   16781063
  REMARK    GeneRIF: molecular basis of the NMU2R regulation of food intake and
            body weight in mice
REFERENCE   7  (bases 1 to 3276)
  AUTHORS   Prendergast,C.E., Morton,M.F., Figueroa,K.W., Wu,X. and
            Shankley,N.P.
  TITLE     Species-dependent smooth muscle contraction to Neuromedin U and
            determination of the receptor subtypes mediating contraction using
            NMU1 receptor knockout mice
  JOURNAL   Br J Pharmacol 147 (8), 886-896 (2006)
   PUBMED   16474416
REFERENCE   8  (bases 1 to 3276)
  AUTHORS   Graham,E.S., Littlewood,P., Turnbull,Y., Mercer,J.G., Morgan,P.J.
            and Barrett,P.
  TITLE     Neuromedin-U is regulated by the circadian clock in the SCN of the
            mouse
  JOURNAL   Eur J Neurosci 21 (3), 814-819 (2005)
   PUBMED   15733101
  REMARK    GeneRIF: The circadian rhythm of neuromedin U expression in the
            suprachiasmatic nucleus does not drive a circadian rhythm of
            corticotrophin-releasing factor in the paraventricular nucleus.
REFERENCE   9  (bases 1 to 3276)
  AUTHORS   Mori,K., Miyazato,M., Ida,T., Murakami,N., Serino,R., Ueta,Y.,
            Kojima,M. and Kangawa,K.
  TITLE     Identification of neuromedin S and its possible role in the
            mammalian circadian oscillator system
  JOURNAL   EMBO J 24 (2), 325-335 (2005)
   PUBMED   15635449
REFERENCE   10 (bases 1 to 3276)
  AUTHORS   Funes,S., Hedrick,J.A., Yang,S., Shan,L., Bayne,M., Monsma,F.J. Jr.
            and Gustafson,E.L.
  TITLE     Cloning and characterization of murine neuromedin U receptors
  JOURNAL   Peptides 23 (9), 1607-1615 (2002)
   PUBMED   12217421
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL671969.39.
            
            On May 1, 2007 this sequence version replaced NM_153079.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036756.1, BC137611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-806               AL671969.39        46958-47763         c
            807-891             AL671969.39        39716-39800         c
            892-1017            AL671969.39        36281-36406         c
            1018-3276           AL671969.39        31766-34024         c
FEATURES             Location/Qualifiers
     source          1..3276
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 33.39 cM"
     gene            1..3276
                     /gene="Nmur2"
                     /gene_synonym="Nmu2r"
                     /note="neuromedin U receptor 2"
                     /db_xref="GeneID:216749"
                     /db_xref="MGI:MGI:2441765"
     exon            1..806
                     /gene="Nmur2"
                     /gene_synonym="Nmu2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1292
                     /gene="Nmur2"
                     /gene_synonym="Nmu2r"
                     /note="NMU-R2"
                     /codon_start=1
                     /product="neuromedin-U receptor 2"
                     /protein_id="NP_694719.2"
                     /db_xref="CCDS:CCDS24716.1"
                     /db_xref="GeneID:216749"
                     /db_xref="MGI:MGI:2441765"
                     /translation="MGKLENASWIHDSLMKYLNSTEEYLAYLCGPKRSDLSLPVSVVY
                     ALIFVVGVIGNLLVCLVIARHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEVYELWHNY
                     PFLFGPVGCYFKTALFETVCFASILSVTTVSIERYVAIVHPFRAKLESTRRRALRILS
                     LVWSFSVVFSLPNTSIHGIKFQQFPNGSSVPGSATCTVTKPIWVYNFIIQATSFLFYI
                     LPMTLISVLYYLMGLRLKRDESLEADKVTVNIHRPSRKSVTKMLFVLVLVFAICWTPF
                     HVDRLFFSFVDEWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVV
                     SPSCKWCHPQHRPQGPPAQKVIFLTECHLVELTEDAGPQFPCQSSIHNTQLTTVPCVE
                     EVP"
     exon            807..891
                     /gene="Nmur2"
                     /gene_synonym="Nmu2r"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1017
                     /gene="Nmur2"
                     /gene_synonym="Nmu2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..3276
                     /gene="Nmur2"
                     /gene_synonym="Nmu2r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaccttct tcaggagcct cggctttcag actctttctg gctcagcttg agacagagcc
       61 tcaagagcaa gggatacccg tggtcgtgga ttttaagctc agtaatggga aaacttgaaa
      121 atgcttcctg gatccacgat tctctcatga agtacttgaa cagcacagag gagtacttgg
      181 cctacctgtg tggacccaag cgcagtgacc tatcccttcc agtgtctgtg gtctatgcgc
      241 tgatcttcgt ggtgggggtg ataggcaatc ttctggtgtg cctggtgatt gcccgacatc
      301 aaactttgaa gacacccacc aactactatc tcttcagctt ggcagtctca gacttgctgg
      361 tcctgctctt aggtatgcca ctggaggtct acgagttgtg gcacaattat cccttcctgt
      421 ttgggccggt gggatgctac ttcaagacag cccttttcga gactgtgtgc tttgcctcca
      481 ttctcagtgt caccacggtt agcattgagc gctacgtggc cattgtccat ccgttccgag
      541 ccaagctgga gagcacacgg cgacgggccc tcaggatcct cagcctagtc tggagcttct
      601 ctgtggtctt ttctttgccc aacaccagca tccatggcat caagttccag cagtttccca
      661 acgggtcctc tgtgcccggc tctgccacct gcacagtcac caaacccata tgggtgtata
      721 acttcatcat ccaagctacc tccttcctct tctacatcct cccgatgacc ctcatcagcg
      781 tcctctacta tctcatgggg ctcaggctga agagagatga atctcttgag gcagacaaag
      841 tgactgtgaa tattcacaga ccctccagaa aatcagtcac caagatgctg tttgtcttgg
      901 tcctcgtgtt tgctatctgt tggacccctt tccatgtgga caggctcttc ttcagctttg
      961 tggacgagtg gactgagtcc ctggctgctg tgttcaacct catccacgtg gtatcaggtg
     1021 tctttttcta tctgagctcc gctgtcaacc ccattatata taacctcctg tctcggcgct
     1081 tccgggcggc ctttcggaat gttgtctctc cttcctgcaa atggtgccat ccccagcatc
     1141 gcccacaggg gcctccagcc cagaaggtta tcttcttgac agaatgccac cttgtggagc
     1201 tgacagagga tgcgggcccc cagttccctt gtcagtcatc catccacaac acccaactta
     1261 ccaccgtccc ctgtgttgaa gaggtaccat gaaaggagtg gtcagaaggc cacttcggaa
     1321 ggcctggctt ctgtgattga catttctcta catgtcagca ctgcaaggag gagcactctg
     1381 tcacctctgc ctccttgcat gtcattagag aagtaatgtg gctcttagat tccacctact
     1441 ctttactttt tttaatgttg aaactcagac ttcgctctgg gtcccagcgc agacattaca
     1501 ctccatcttt ctgcattgta attttttttt ataactgtga ttgtaatgtg ccatgggagt
     1561 ctcacttaaa gatgctctca tgatgggtgg gtttagccta gtaaaggtgt tgtagagtag
     1621 ctaagcagca caatacagtt atcctaacct ccatacccag gatgcaggag agaccactgg
     1681 gtaggaactg cccgcaaaag cctaaccctc caaaagttag gacttttggg agtttgttgt
     1741 caaataagca atggcttaaa atcagtccta gcagaaatat ttatgctaca gaaattaaca
     1801 agctctctaa atcagggcta aataattttt atcccctgga gagttggccc atgagcaggt
     1861 tgagagctat taatgagctg gcgctgtgcc tactcgttgc gatgtgtggg acttgttttt
     1921 agaagaaatg ctgcttatgc tgtaattatg aactacttag agtcgtggct aactcggaaa
     1981 aatatgctat ggactagatt taaaaacaaa acaaaacaaa aatgttccta cacaaaaata
     2041 agcgaaatac tgctaattaa gccaatggaa gcagcatcag catttataat taacctggag
     2101 tggaaagatt atttttggat gccatccatt aacattaatg cagcaaacag caatggactg
     2161 ggtgttattt tccctctcac gtctgtgttt gcagagccca aaggatgtgt tgtcaaagca
     2221 gatgactttt ctgtatgcat ctccacttgg ctgcagattt gttttgttct tgccctgtgg
     2281 tgtaggactg gagggatgac acagtagaca aaagcacttg ccaccgagcc tcaggatctg
     2341 aattccatac ccggaactca cgtggtggga ggagagagaa ctgacttctc aagttgtccc
     2401 ttgaccccac caaacatgca ccatggcata ccacacccca acactcacca caataaataa
     2461 gttcatatta aaaaattaaa gaaatatgtt atgaatccac agtgtggaag ctaacaacta
     2521 cactatcttc tagaagccta gtaaatcaaa atccgcagac agagcagcct tccaggcccc
     2581 tccttccctt tcccaccctc agtggatgta caaatgctcc atggagtccg cttctgacac
     2641 tccacccatg ccatatggaa gcactctcaa ggcaatgttg gtgcttgaaa gttttgacta
     2701 atttacatat gggatagata ttatagagta tacctaaatg acgtacccgg atttccctgc
     2761 tagtgaaata cattctctga gagggttaga aagatggaca agtccaaagt ccaggactaa
     2821 gagaaagcaa agctggagag aatagtaatt aatgtctcat gggcaaagac atttgcacat
     2881 aagcctgctg atccaagttc cttgattgag gacgagatcc aacaccttaa gttgttctct
     2941 gacctctgtg tcaccatggc ttgtgtagca atgccccctc acacataata ataaaagtat
     3001 tgctttaaag aaaagcaatt taccctttca aacacattcg gtgtctgcta tgaaactaca
     3061 tggatgaata gataagaaat tctgtgagta aaagccactt ggaacctaga tcttaaaagg
     3121 cttcatagaa caccacttat tcgtatattt tcacaacata aagatatctc ttatcaacac
     3181 tttctgcttt gttttataaa tgctgaaaat ttcagctcct gaccttgacc accaccgatt
     3241 cctcagtaat aaaatggaat aaaggttgtc ctgtgc
//
