LOCUS       NM_010341               1218 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus neuromedin U receptor 1 (Nmur1), transcript variant 2,
            mRNA.
ACCESSION   NM_010341
VERSION     NM_010341.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1218)
  AUTHORS   Rao,Z., Liu,S., Li,Z., Wang,Q., Gao,F., Peng,H., Ren,D., Zang,Y.,
            Li,H., Li,Y., Hu,Q., He,D. and Xu,H.
  TITLE     Alarmin-loaded extracellular lipid droplets induce airway
            neutrophil infiltration during type 2 inflammation
  JOURNAL   Immunity 57 (11), 2514-2529 (2024)
   PUBMED   39366382
REFERENCE   2  (bases 1 to 1218)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1218)
  AUTHORS   Zheng,R., Wang,S., Wang,J., Zhou,M., Shi,Q. and Liu,B.
  TITLE     Neuromedin U regulates the anti-tumor activity of CD8+ T cells and
            glycolysis of tumor cells in the tumor microenvironment of
            pancreatic ductal adenocarcinoma in an NMUR1-dependent manner
  JOURNAL   Cancer Sci 115 (2), 334-346 (2024)
   PUBMED   38071753
  REMARK    GeneRIF: Neuromedin U regulates the anti-tumor activity of CD8[+] T
            cells and glycolysis of tumor cells in the tumor microenvironment
            of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
REFERENCE   4  (bases 1 to 1218)
  AUTHORS   Li,Y., Liu,S., Zhou,K., Wang,Y., Chen,Y., Hu,W., Li,S., Li,H.,
            Wang,Y., Wang,Q., He,D. and Xu,H.
  TITLE     Neuromedin U programs eosinophils to promote mucosal immunity of
            the small intestine
  JOURNAL   Science 381 (6663), 1189-1196 (2023)
   PUBMED   37708282
  REMARK    GeneRIF: Neuromedin U programs eosinophils to promote mucosal
            immunity of the small intestine.
REFERENCE   5  (bases 1 to 1218)
  AUTHORS   Yadav,K., Yadav,A., Rajpoot,A. and Mishra,R.K.
  TITLE     Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and
            NMUR2 expression in mouse testis
  JOURNAL   Peptides 159, 170899 (2023)
   PUBMED   36336170
  REMARK    GeneRIF: Postnatal ontogeny of Neuromedin S and its receptors NMUR1
            and NMUR2 expression in mouse testis.
REFERENCE   6  (bases 1 to 1218)
  AUTHORS   Mori,K., Miyazato,M., Ida,T., Murakami,N., Serino,R., Ueta,Y.,
            Kojima,M. and Kangawa,K.
  TITLE     Identification of neuromedin S and its possible role in the
            mammalian circadian oscillator system
  JOURNAL   EMBO J 24 (2), 325-335 (2005)
   PUBMED   15635449
REFERENCE   7  (bases 1 to 1218)
  AUTHORS   Choi,M.Y., Fuerst,E.J., Rafaeli,A. and Jurenka,R.
  TITLE     Identification of a G protein-coupled receptor for pheromone
            biosynthesis activating neuropeptide from pheromone glands of the
            moth Helicoverpa zea
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9721-9726 (2003)
   PUBMED   12888624
REFERENCE   8  (bases 1 to 1218)
  AUTHORS   Valenzuela,D.M., Murphy,A.J., Frendewey,D., Gale,N.W.,
            Economides,A.N., Auerbach,W., Poueymirou,W.T., Adams,N.C.,
            Rojas,J., Yasenchak,J., Chernomorsky,R., Boucher,M., Elsasser,A.L.,
            Esau,L., Zheng,J., Griffiths,J.A., Wang,X., Su,H., Xue,Y.,
            Dominguez,M.G., Noguera,I., Torres,R., Macdonald,L.E.,
            Stewart,A.F., DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     High-throughput engineering of the mouse genome coupled with
            high-resolution expression analysis
  JOURNAL   Nat Biotechnol 21 (6), 652-659 (2003)
   PUBMED   12730667
REFERENCE   9  (bases 1 to 1218)
  AUTHORS   Howard,A.D., Wang,R., Pong,S.S., Mellin,T.N., Strack,A., Guan,X.M.,
            Zeng,Z., Williams,D.L. Jr., Feighner,S.D., Nunes,C.N., Murphy,B.,
            Stair,J.N., Yu,H., Jiang,Q., Clements,M.K., Tan,C.P., McKee,K.K.,
            Hreniuk,D.L., McDonald,T.P., Lynch,K.R., Evans,J.F., Austin,C.P.,
            Caskey,C.T., Van der Ploeg,L.H. and Liu,Q.
  TITLE     Identification of receptors for neuromedin U and its role in
            feeding
  JOURNAL   Nature 406 (6791), 70-74 (2000)
   PUBMED   10894543
REFERENCE   10 (bases 1 to 1218)
  AUTHORS   Tan,C.P., McKee,K.K., Liu,Q., Palyha,O.C., Feighner,S.D.,
            Hreniuk,D.L., Smith,R.G. and Howard,A.D.
  TITLE     Cloning and characterization of a human and murine T-cell orphan
            G-protein-coupled receptor similar to the growth hormone
            secretagogue and neurotensin receptors
  JOURNAL   Genomics 52 (2), 223-229 (1998)
   PUBMED   9782091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF044602.1.
            
            Transcript Variant: This variant (2) differs in the UTRs and uses a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (2) has a shorter N-terminus than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF044602.1, BC120822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.94 cM"
     gene            1..1218
                     /gene="Nmur1"
                     /gene_synonym="FM-3; Gpr66; NmU-R; NMU-R1; NMU1R"
                     /note="neuromedin U receptor 1"
                     /db_xref="GeneID:14767"
                     /db_xref="MGI:MGI:1341898"
     CDS             1..1218
                     /gene="Nmur1"
                     /gene_synonym="FM-3; Gpr66; NmU-R; NMU-R1; NMU1R"
                     /note="isoform 2 is encoded by transcript variant 2;
                     non-AUG (CUG) translation initiation codon; G
                     protein-coupled receptor 66"
                     /codon_start=1
                     /product="neuromedin-U receptor 1 isoform 2"
                     /protein_id="NP_034471.1"
                     /db_xref="CCDS:CCDS83570.1"
                     /db_xref="GeneID:14767"
                     /db_xref="MGI:MGI:1341898"
                     /translation="MVCNISEFKWPYQPEDLNLTDEALRLKYLGPQQMKQFVPICVTY
                     LLIFVVGTLGNGLTCTVILRNKTMRTPTNFYLFSLAVSDMLVLLVGLPLELYEMQQNY
                     PFQLGASACYFRILLLETVCLASVLNVTALSVERYVAVVRPLQAKSVMTRAHVRRMVG
                     AIWVLATLFSLPNTSLHGLSQLTVPCRGPVPDSAICSLVGPMDFYKLVVLTTALLFFC
                     LPMVTISVLYLLIGLRLRRERMLLQVEVKGRKTAATQETSHRRIQLQDRGRRQVTKML
                     FALVVVFGICWAPFHADRIMWSLVYGHSTEGLHLAYQCVHIASGIFFYLGSAANPVLY
                     SLMSTRFRETFLQALGLGTQCCHRRQPYHGSHNHIRLTTGSTLCDVGHRNSRDEPLAV
                     NEDPGCQQETDPS"
     exon            1..829
                     /gene="Nmur1"
                     /gene_synonym="FM-3; Gpr66; NmU-R; NMU-R1; NMU1R"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1218
                     /gene="Nmur1"
                     /gene_synonym="FM-3; Gpr66; NmU-R; NMU-R1; NMU1R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtctgca atatcagtga gttcaagtgg ccctatcaac ctgaggatct gaaccttacc
       61 gatgaggccc tgaggctgaa gtatttgggg ccacagcaga tgaaacagtt tgtccccatc
      121 tgtgtcacgt acctgctgat cttcgtggtg ggcactctgg gcaacgggct gacctgcacc
      181 gtcatcctgc gcaacaagac tatgcgcacg cccaccaact tctacctctt cagcctcgct
      241 gtgtccgata tgctggtgct cctggtgggc ttgcctctgg agctttatga gatgcagcaa
      301 aattacccgt tccagctggg tgcgagtgcc tgctacttcc gaatactgct cttagagacc
      361 gtctgcctag cttcagtgct caatgtcaca gccctgagtg tggagcgtta tgtggccgtg
      421 gtgcgcccac tccaagccaa gtctgtgatg acacgggccc atgtgcgccg catggtgggg
      481 gccatctggg tcctcgctac tctcttctct ctgcccaaca ccagcctgca tggcctcagt
      541 caactaactg tgccctgccg ggggccggtg cccgactcag ctatatgttc gctggtgggt
      601 cccatggact tctacaagtt ggtggtactg actaccgcac tgctcttctt ctgtctgccc
      661 atggtcacca tcagtgtgct gtatctgctc attgggctgc ggctgcggag ggagaggatg
      721 ttgctccaag tggaggtcaa gggcaggaaa accgcagcaa cccaggagac ctcccacaga
      781 aggattcagc tgcaagatag gggacggaga caggtgacca agatgctgtt tgcactggtt
      841 gtggtattcg gcatctgctg ggctccattc catgctgacc gtatcatgtg gagcctggtg
      901 tatggacact caacggaagg cctgcacctg gcctaccagt gtgtccacat tgcctctggc
      961 atcttcttct atctcggctc agcagccaac ccggtgctct acagcctcat gtctactcgc
     1021 ttccgagaga ccttcctgca agccctgggc cttggaaccc agtgctgtca tcgccgccaa
     1081 ccctatcatg gctcccataa ccacatcagg ttgaccacag gcagcaccct gtgtgacgtg
     1141 ggccacagga acagcaggga cgaacctctg gctgtgaatg aggatccagg gtgtcagcaa
     1201 gagacagacc cctcctga
//
