LOCUS       NM_019515                828 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neuromedin U (Nmu), mRNA.
ACCESSION   NM_019515
VERSION     NM_019515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 828)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 828)
  AUTHORS   Zheng,R., Wang,S., Wang,J., Zhou,M., Shi,Q. and Liu,B.
  TITLE     Neuromedin U regulates the anti-tumor activity of CD8+ T cells and
            glycolysis of tumor cells in the tumor microenvironment of
            pancreatic ductal adenocarcinoma in an NMUR1-dependent manner
  JOURNAL   Cancer Sci 115 (2), 334-346 (2024)
   PUBMED   38071753
  REMARK    GeneRIF: Neuromedin U regulates the anti-tumor activity of CD8[+] T
            cells and glycolysis of tumor cells in the tumor microenvironment
            of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
REFERENCE   3  (bases 1 to 828)
  AUTHORS   Li,Y., Liu,S., Zhou,K., Wang,Y., Chen,Y., Hu,W., Li,S., Li,H.,
            Wang,Y., Wang,Q., He,D. and Xu,H.
  TITLE     Neuromedin U programs eosinophils to promote mucosal immunity of
            the small intestine
  JOURNAL   Science 381 (6663), 1189-1196 (2023)
   PUBMED   37708282
  REMARK    GeneRIF: Neuromedin U programs eosinophils to promote mucosal
            immunity of the small intestine.
REFERENCE   4  (bases 1 to 828)
  AUTHORS   Medrano,M., Allaoui,W., Van Bulck,M., Thys,S.,
            Makrini-Maleville,L., Seuntjens,E., De Vos,W.H., Valjent,E.,
            Gaszner,B., Van Eeckhaut,A., Smolders,I. and De Bundel,D.
  TITLE     Neuroanatomical characterization of the Nmu-Cre knock-in mice
            reveals an interconnected network of unique neuropeptidergic cells
  JOURNAL   Open Biol 13 (6), 220353 (2023)
   PUBMED   37311538
REFERENCE   5  (bases 1 to 828)
  AUTHORS   Liu,W., Wang,S., Wang,J., Zheng,R., Wang,D., Yu,R. and Liu,B.
  TITLE     Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1
            Pathway during Acute Respiratory Syncytial Virus Infection
  JOURNAL   Am J Respir Cell Mol Biol 68 (3), 256-266 (2023)
   PUBMED   36227802
  REMARK    GeneRIF: Neuromedin U Induces Pulmonary ILC2 Activation via the
            NMUR1 Pathway during Acute Respiratory Syncytial Virus Infection.
REFERENCE   6  (bases 1 to 828)
  AUTHORS   Nakahara,K., Kojima,M., Hanada,R., Egi,Y., Ida,T., Miyazato,M.,
            Kangawa,K. and Murakami,N.
  TITLE     Neuromedin U is involved in nociceptive reflexes and adaptation to
            environmental stimuli in mice
  JOURNAL   Biochem Biophys Res Commun 323 (2), 615-620 (2004)
   PUBMED   15369794
  REMARK    GeneRIF: results suggest that endogenous NMU may be involved in
            reflexes and adaptation to environmental stimuli
REFERENCE   7  (bases 1 to 828)
  AUTHORS   Thompson,E.L., Murphy,K.G., Todd,J.F., Martin,N.M., Small,C.J.,
            Ghatei,M.A. and Bloom,S.R.
  TITLE     Chronic administration of NMU into the paraventricular nucleus
            stimulates the HPA axis but does not influence food intake or body
            weight
  JOURNAL   Biochem Biophys Res Commun 323 (1), 65-71 (2004)
   PUBMED   15351702
REFERENCE   8  (bases 1 to 828)
  AUTHORS   Hanada,R., Teranishi,H., Pearson,J.T., Kurokawa,M., Hosoda,H.,
            Fukushima,N., Fukue,Y., Serino,R., Fujihara,H., Ueta,Y., Ikawa,M.,
            Okabe,M., Murakami,N., Shirai,M., Yoshimatsu,H., Kangawa,K. and
            Kojima,M.
  TITLE     Neuromedin U has a novel anorexigenic effect independent of the
            leptin signaling pathway
  JOURNAL   Nat Med 10 (10), 1067-1073 (2004)
   PUBMED   15448684
  REMARK    GeneRIF: NMU plays an important role in the regulation of feeding
            behavior and energy metabolism independent of the leptin signaling
            pathway.
REFERENCE   9  (bases 1 to 828)
  AUTHORS   Graham,E.S., Turnbull,Y., Fotheringham,P., Nilaweera,K.,
            Mercer,J.G., Morgan,P.J. and Barrett,P.
  TITLE     Neuromedin U and Neuromedin U receptor-2 expression in the mouse
            and rat hypothalamus: effects of nutritional status
  JOURNAL   J Neurochem 87 (5), 1165-1173 (2003)
   PUBMED   14622096
  REMARK    GeneRIF: Analysis of NMU expression in ob/ob mice revealed elevated
            NMU mRNA levels in the dorsomedial hypothalamic (DMH) nucleus of
            ob/ob mice compared to lean litter-mates. NMU mRNA levels were
            elevated in the DMH of mice fasted for 24 h relative to controls
REFERENCE   10 (bases 1 to 828)
  AUTHORS   Wilsbacher,L.D., Sangoram,A.M., Antoch,M.P. and Takahashi,J.S.
  TITLE     The mouse Clock locus: sequence and comparative analysis of 204 kb
            from mouse chromosome 5
  JOURNAL   Genome Res 10 (12), 1928-1940 (2000)
   PUBMED   11116088
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF203444.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF203444.1, AK077478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 40.93 cM"
     gene            1..828
                     /gene="Nmu"
                     /note="neuromedin U"
                     /db_xref="GeneID:56183"
                     /db_xref="MGI:MGI:1860476"
     exon            1..223
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..630
                     /gene="Nmu"
                     /function="stimulates the contraction of smooth muscle"
                     /note="neuromedin U precursor-related peptide/neuromedin U
                     preproprotein"
                     /codon_start=1
                     /product="neuromedin-U precursor"
                     /protein_id="NP_062388.1"
                     /db_xref="CCDS:CCDS19362.1"
                     /db_xref="GeneID:56183"
                     /db_xref="MGI:MGI:1860476"
                     /translation="MSRAAGHRPGLSAGQLAAATASPLLSLLLLLACCADACKGVPIS
                     PQRLQPEQELQLWNEIHEACASFLSIDSRPQASVALRELCRIVMEISQKPQEQSEKDN
                     TKRFLFHYSKTQKLGNSNVVSSVVHPLLQLVPQLHERRMKRFKAEYQSPSVGQSKGYF
                     LFRPRNGKRSTSFI"
     exon            224..282
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            283..330
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            331..390
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            391..420
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            421..471
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            472..540
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            541..594
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            595..634
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     exon            635..817
                     /gene="Nmu"
                     /inference="alignment:Splign:2.1.0"
     regulatory      794..799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nmu"
                     /note="hexamer: AATAAA"
     polyA_site      817
                     /gene="Nmu"
                     /note="major polyA site"
ORIGIN      
        1 gagctcagca agaggaggcg cacaggacac gctgagggac agctaaaaca cccgcacaac
       61 acagggtacc aggtccccag tccagagccg cttggaggga aggagatgtc gcgagcagcg
      121 ggtcaccgtc cagggctgtc cgcaggacaa ttggctgctg caaccgcatc tcctctcctg
      181 tcactgctgc tgctgctcgc ctgctgtgca gacgcttgca aaggtgtgcc aatatcacct
      241 caaagattgc agccagaaca agaactacaa ttgtggaatg agattcatga agcttgtgcg
      301 tcctttctgt ccattgattc caggcctcag gcatctgttg cactgaggga gctttgccgt
      361 atagtgatgg agatttccca gaagcctcag gaacaaagtg agaaagataa tactaagagg
      421 ttcttatttc actattcaaa gacacagaag ttgggaaatt caaatgttgt gtcctctgtt
      481 gtgcatccgt tgctgcagct cgtccctcaa ctgcatgaga gaagaatgaa gagattcaaa
      541 gcagaatacc agagtccttc cgtgggtcaa agtaagggat actttttatt caggccacgc
      601 aacgggaaga ggtcaacaag tttcatttaa aatggatgtg aaatgatctt tcattgaaaa
      661 ctctgctatg ggatataaaa tgtactcaaa ttttgttctc acaaatgatc cctcctaaat
      721 ttactctctt gcaaacccct gtattgtaac attctctgcg atggttgaga ttataaatgt
      781 ttaatttgtt gaaaataaaa cagcatcttg aaatgtaaaa aaaaaaaa
//
