LOCUS       NM_001011684            1019 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus neuromedin S (Nms), transcript variant 1, mRNA.
ACCESSION   NM_001011684 XM_488892
VERSION     NM_001011684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1019)
  AUTHORS   Yadav,K., Yadav,A., Rajpoot,A. and Mishra,R.K.
  TITLE     Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and
            NMUR2 expression in mouse testis
  JOURNAL   Peptides 159, 170899 (2023)
   PUBMED   36336170
  REMARK    GeneRIF: Postnatal ontogeny of Neuromedin S and its receptors NMUR1
            and NMUR2 expression in mouse testis.
REFERENCE   2  (bases 1 to 1019)
  AUTHORS   Yamaguchi,Y., Murai,I., Takeda,M., Doi,S., Seta,T., Hanada,R.,
            Kangawa,K., Okamura,H., Miyake,T. and Doi,M.
  TITLE     Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting
            of Circadian Locomotor Activity
  JOURNAL   Biol Pharm Bull 45 (8), 1172-1179 (2022)
   PUBMED   35908898
  REMARK    GeneRIF: Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced
            Light-Resetting of Circadian Locomotor Activity.
REFERENCE   3  (bases 1 to 1019)
  AUTHORS   Cheng,A.H., Fung,S.W., Hegazi,S., Abdalla,O.H.M.H. and Cheng,H.M.
  TITLE     SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic
            Nucleus
  JOURNAL   Int J Mol Sci 23 (1), 229 (2021)
   PUBMED   35008655
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1019)
  AUTHORS   Roome,R.B., Bourojeni,F.B., Mona,B., Rastegar-Pouyani,S., Blain,R.,
            Dumouchel,A., Salesse,C., Thompson,W.S., Brookbank,M., Gitton,Y.,
            Tessarollo,L., Goulding,M., Johnson,J.E., Kmita,M., Chedotal,A. and
            Kania,A.
  TITLE     Phox2a Defines a Developmental Origin of the Anterolateral System
            in Mice and Humans
  JOURNAL   Cell Rep 33 (8), 108425 (2020)
   PUBMED   33238113
REFERENCE   5  (bases 1 to 1019)
  AUTHORS   Nakahara,K., Akagi,A., Shimizu,S., Tateno,S., Qattali,A.W.,
            Mori,K., Miyazato,M., Kangawa,K. and Murakami,N.
  TITLE     Involvement of endogenous neuromedin U and neuromedin S in
            thermoregulation
  JOURNAL   Biochem Biophys Res Commun 470 (4), 930-935 (2016)
   PUBMED   26826380
  REMARK    GeneRIF: These results suggest that NMU and NMS are involved in
            thermoregulation via the prostaglandin E2 and beta3 adrenergic
            receptors, but that endogenous NMS might play a more predominant
            role than NMU.
REFERENCE   6  (bases 1 to 1019)
  AUTHORS   Lee,I.T., Chang,A.S., Manandhar,M., Shan,Y., Fan,J., Izumo,M.,
            Ikeda,Y., Motoike,T., Dixon,S., Seinfeld,J.E., Takahashi,J.S. and
            Yanagisawa,M.
  TITLE     Neuromedin s-producing neurons act as essential pacemakers in the
            suprachiasmatic nucleus to couple clock neurons and dictate
            circadian rhythms
  JOURNAL   Neuron 85 (5), 1086-1102 (2015)
   PUBMED   25741729
REFERENCE   7  (bases 1 to 1019)
  AUTHORS   Sakamoto,T., Nakahara,K., Maruyama,K., Katayama,T., Mori,K.,
            Miyazato,M., Kangawa,K. and Murakami,N.
  TITLE     Neuromedin S regulates cardiovascular function through the
            sympathetic nervous system in mice
  JOURNAL   Peptides 32 (5), 1020-1026 (2011)
   PUBMED   21356261
  REMARK    GeneRIF: Results suggest that endogenous NMS may regulate
            cardiovascular function by activating the sympathetic nervous
            system.
REFERENCE   8  (bases 1 to 1019)
  AUTHORS   Novak,C.M.
  TITLE     Neuromedin S and U
  JOURNAL   Endocrinology 150 (7), 2985-2987 (2009)
   PUBMED   19549882
REFERENCE   9  (bases 1 to 1019)
  AUTHORS   Miyazato,M., Mori,K., Ida,T., Kojima,M., Murakami,N. and Kangawa,K.
  TITLE     Identification and functional analysis of a novel ligand for G
            protein-coupled receptor, Neuromedin S
  JOURNAL   Regul Pept 145 (1-3), 37-41 (2008)
   PUBMED   17870195
  REMARK    GeneRIF: NMS is implicated in the regulation of circadian rhythm
            and feeding behavior
REFERENCE   10 (bases 1 to 1019)
  AUTHORS   Mori,K., Miyazato,M., Ida,T., Murakami,N., Serino,R., Ueta,Y.,
            Kojima,M. and Kangawa,K.
  TITLE     Identification of neuromedin S and its possible role in the
            mammalian circadian oscillator system
  JOURNAL   EMBO J 24 (2), 325-335 (2005)
   PUBMED   15635449
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC101277.16, BU609935.1 and
            BQ175462.1.
            
            On May 15, 2009 this sequence version replaced NM_001011684.1.
            
            Summary: This gene encodes a member of the neuromedin family of
            neuropeptides. The encoded protein is a precursor that is
            proteolytically processed to generate a biologically active
            neuropeptide that plays a role in the regulation of circadian
            rhythm, anorexigenic action, antidiuretic action, cardiovascular
            function and stimulation of oxytocin and vasopressin release. Mice
            lacking the encoded neuropeptide exhibit decreased heart rate
            without any accompanying changes in blood pressure. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms that may undergo similar processing to generate the mature
            peptide. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB164466.1, BC138922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC101277.16        110201-110254       c
            55-320              BU609935.1         1-266
            321-344             AC101277.16        105442-105465       c
            345-495             BU609935.1         267-417
            496-1019            BQ175462.1         1-524               c
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 17.31 cM"
     gene            1..1019
                     /gene="Nms"
                     /note="neuromedin S"
                     /db_xref="GeneID:433292"
                     /db_xref="MGI:MGI:3583618"
     exon            1..213
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..599
                     /gene="Nms"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; neuromedin S precursor-related
                     peptide/neuromedin S preproprotein"
                     /codon_start=1
                     /product="neuromedin-S isoform 1 preproprotein"
                     /protein_id="NP_001011684.3"
                     /db_xref="CCDS:CCDS14902.1"
                     /db_xref="GeneID:433292"
                     /db_xref="MGI:MGI:3583618"
                     /translation="MKHPLPHYSPILFIYCFCMLQIPSSGASPPLADSPDGLDIVDPE
                     RLAYFLKQREIHSNQPKENQDVYKRFLFHYSRTRKPTHPVSAEFAPVHPLMRLAAKLA
                     SRRMKRLPRLLRLDSRMATVDFPKKDPTTSLGRPFFLFRPRNGRYTDNNFQ"
     exon            214..269
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     exon            270..320
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     exon            321..344
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     exon            345..398
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     exon            399..482
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     exon            483..518
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     exon            519..560
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     exon            561..607
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     exon            608..1001
                     /gene="Nms"
                     /inference="alignment:Splign:2.1.0"
     regulatory      983..988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nms"
                     /note="hexamer: ATTAAA"
     polyA_site      1001
                     /gene="Nms"
                     /note="major polyA site"
ORIGIN      
        1 aataaaggct cctactgccc tgggctggat agatgcaggg cagagggtca tctctgcctc
       61 tggaccctcg ggaaatgctc atcacctctc tgaacagaac gtatctgtgg tctgcaaaga
      121 gaatccagag cttgaagatg aaacacccgc tcccccacta ttctccaatc ctgttcatct
      181 actgcttctg tatgctacag attccctcct caggagcttc cccaccttta gctgattctc
      241 ccgacggctt ggatattgtg gatcctgagc gactggcata ctttctgaag cagagggaaa
      301 tacattctaa ccaacctaag gaaaaccagg atgtatacaa aaggttttta tttcactact
      361 ccagaactcg gaaaccgaca catccagtta gcgctgagtt tgctccggtc catccattga
      421 tgcgcctggc tgccaagctc gccagcagaa ggatgaaaag actgccgcga ttgctgcgcc
      481 tcgattccag gatggctact gtggacttcc ctaagaagga tcctactacc agcctgggga
      541 ggccattttt ccttttcagg cctaggaatg gaagatacac cgacaacaac ttccagtaga
      601 cagcaagagt cccatgtcac cagacggtgt gcgcctttgg aggaaatgcc aagagttact
      661 tcatgtttat atttagccat atttctgttg tcccatgctc tccaaaatgc ttagttgtac
      721 aaaaaaataa agtggcactg atgtgtcatc tttattgatg ctggaagact gtgggaatag
      781 gtacatccca tgaatatatt tctaagaatt tactgatttg ggcatggaac aatcgaacta
      841 acttgttgat ggctgaacac atagataggg gataagctaa aaccctgata tcagatgcta
      901 actctgtttg ctttctagtt gagtggctgt gatatattat aagtcagttt ccatgtctgt
      961 agtaaatacc tgttatgtat taattaaaaa catagaagat taaaaaaaaa aaaaaaaaa
//
