LOCUS       NM_027120               1840 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus nicotinamide riboside kinase 2 (Nmrk2), mRNA.
ACCESSION   NM_027120 XM_125745 XM_911077 XM_987893
VERSION     NM_027120.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Marzook,H., Gupta,A., Tomar,D., Saleh,M.A., Patil,K., Semreen,M.H.,
            Hamoudi,R., Soares,N.C., Qaisar,R. and Ahmad,F.
  TITLE     Nicotinamide riboside kinase-2 regulates metabolic adaptation in
            the ischemic heart
  JOURNAL   J Mol Med (Berl) 101 (3), 311-326 (2023)
   PUBMED   36808555
  REMARK    GeneRIF: Nicotinamide riboside kinase-2 regulates metabolic
            adaptation in the ischemic heart.
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Sonntag,T., Ancel,S., Karaz,S., Cichosz,P., Jacot,G., Giner,M.P.,
            Sanchez-Garcia,J.L., Pannerec,A., Moco,S., Sorrentino,V., Canto,C.
            and Feige,J.N.
  TITLE     Nicotinamide riboside kinases regulate skeletal muscle fiber-type
            specification and are rate-limiting for metabolic adaptations
            during regeneration
  JOURNAL   Front Cell Dev Biol 10, 1049653 (2022)
   PUBMED   36438552
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1840)
  AUTHORS   Sasaki,Y., Zhu,J., Shi,Y., Gu,W., Kobe,B., Ve,T., DiAntonio,A. and
            Milbrandt,J.
  TITLE     Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor
            promoting axonal protection
  JOURNAL   Exp Neurol 345, 113842 (2021)
   PUBMED   34403688
REFERENCE   5  (bases 1 to 1840)
  AUTHORS   Tannous,C., Deloux,R., Karoui,A., Mougenot,N., Burkin,D., Blanc,J.,
            Coletti,D., Lavery,G., Li,Z. and Mericskay,M.
  TITLE     NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required
            for Cardiac Function and NAD Levels during Aging
  JOURNAL   Int J Mol Sci 22 (7), 3534 (2021)
   PUBMED   33805532
  REMARK    GeneRIF: NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and
            Required for Cardiac Function and NAD Levels during Aging.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1840)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1840)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   8  (bases 1 to 1840)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 1840)
  AUTHORS   Li,J., Rao,H., Burkin,D., Kaufman,S.J. and Wu,C.
  TITLE     The muscle integrin binding protein (MIBP) interacts with
            alpha7beta1 integrin and regulates cell adhesion and laminin matrix
            deposition
  JOURNAL   Dev Biol 261 (1), 209-219 (2003)
   PUBMED   12941630
  REMARK    GeneRIF: functions in the control of myogenic differentiation by
            regulating alpha7beta1 integrin-mediated cell interactions with
            laminin matrix and intracellular signaling through paxillin.
REFERENCE   10 (bases 1 to 1840)
  AUTHORS   Li,J., Mayne,R. and Wu,C.
  TITLE     A novel muscle-specific beta 1 integrin binding protein (MIBP) that
            modulates myogenic differentiation
  JOURNAL   J Cell Biol 147 (7), 1391-1398 (1999)
   PUBMED   10613898
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK137483.1.
            
            On Apr 5, 2007 this sequence version replaced NM_027120.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137483.1, AK009352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1840              AK137483.1         3-1842
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1840
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /note="nicotinamide riboside kinase 2"
                     /db_xref="GeneID:69564"
                     /db_xref="MGI:MGI:1916814"
     exon            1..87
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..649
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /EC_number="2.7.1.22"
                     /EC_number="2.7.1.173"
                     /note="muscle-specific beta 1 integrin binding protein;
                     NRK 2; RNK 2; nmR-K 2; ribosylnicotinamide kinase 2;
                     ribosylnicotinic acid kinase 2; muscle integrin-binding
                     protein; nicotinic acid riboside kinase 2; integrin beta 1
                     binding protein 3"
                     /codon_start=1
                     /product="nicotinamide riboside kinase 2"
                     /protein_id="NP_081396.1"
                     /db_xref="CCDS:CCDS24046.1"
                     /db_xref="GeneID:69564"
                     /db_xref="MGI:MGI:1916814"
                     /translation="MKLIIGIGGVTNGGKTTLTNSLLKALPNCCVIHQDDFFKPQDQI
                     AVGEDGFKQWDVLESLDMETMLSTVQAWVKDPHKFARAHGVSLQSGASDTHVLLLEGF
                     LLYSYRPLVDLYSQRYFLTVPYEECKRRRRSRTYMVPDPPGLFDGHVWPMYQKYRREM
                     EQDGVEVVYLDGMKSPEGLFHQVLEDIQNRLLNTS"
     exon            88..178
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /inference="alignment:Splign:2.1.0"
     exon            179..227
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /inference="alignment:Splign:2.1.0"
     exon            228..384
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /inference="alignment:Splign:2.1.0"
     exon            385..456
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /inference="alignment:Splign:2.1.0"
     exon            457..563
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /inference="alignment:Splign:2.1.0"
     exon            564..1840
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      796..801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /note="hexamer: ATTAAA"
     polyA_site      819
                     /gene="Nmrk2"
                     /gene_synonym="2310015C21Rik; Itgb1bp3; Mibp"
                     /note="major polyA site"
ORIGIN      
        1 agcgcagcgc agcgcagtgc agcaggggcc acctcaggac cagtcacctc cagtccccaa
       61 gatgaaactc atcataggca ttggaggggt gaccaacggt gggaagacca ccctgaccaa
      121 cagcctcctc aaggcgctgc ccaactgctg cgtgatccat caggatgact tcttcaagcc
      181 ccaggaccaa atagcagtcg gagaggacgg ctttaaacag tgggacgtgc ttgagtccct
      241 ggacatggag accatgctca gcacggtgca ggcctgggtg aaggatccac acaagtttgc
      301 acgcgctcat ggcgtcagcc ttcagtcagg tgcctcggac acccacgtac tcctcctcga
      361 gggtttccta ctgtacagct acaggcccct ggtggacttg tacagccaac gctacttcct
      421 gaccgtgccg tatgaggaat gcaagcggag gagaagaagc cgtacttaca tggtccctga
      481 tcctcctggc ctgtttgatg gtcacgtgtg gcccatgtac cagaagtata gacgggagat
      541 ggagcaggac ggggtggaag tggtctattt agatggcatg aagtccccgg agggactctt
      601 ccatcaagtt ctggaggata ttcaaaacag actgctcaac acatcctagc aagacgcagg
      661 tcctggacag cagggcctga gatgttctga ctggacgcag tggctcttcg cctataggaa
      721 atctgtacat aggagggcat gtccccacac acgtgcagtg ggcacggaca ctgtgagatt
      781 ttctagcacc tcaacattaa agtggactct gttttttaac ctggcgtcct gtatggtccc
      841 tatgaggtga acctctctca gaccctttac tggcacctgg tggcctctgt gggtaacctt
      901 gttgatgtgc ctcagtttcc ctaaaggaga cattcctcat gaacttgggt aaggagaaac
      961 aacatctacc ctaatgtaga caggcacaga gaggtcacct ttggtactca gaattacaca
     1021 gtaagttggt gtgtccagct agaaagcttc tctgcctaaa taggatggaa ttctagagag
     1081 ttcccgaggg attcctgaga tctttcttct ctcatctgag cctccctcta cttctttcgg
     1141 aaaccaaagc caagtctcac tctatagggt tatttggaat ctcctaaata cacacacaca
     1201 acacatgctg cctgtcctgc aaccagcata cctgtctcct ctcacacaca accatacacc
     1261 ccctgaacca tggtgacagt ctcagtgtga tttttttttg tttttttgtt ttttgttttt
     1321 tgttttgttt ttcgagacag ggtttctctt tatagctctg gctgtcctgg aactcactct
     1381 gtagaccagt ctggcctcaa actcagaaat ccacctgcct ctgcctccca agtgctggga
     1441 ttaaaggcgt gtgccaccat tgcccagctc ggtgtgtttt ttattacttg tgtggacttc
     1501 ataaaaggga aaactgaggc tctgagcaga acatttcggt ggtgctggaa tgtagatgtg
     1561 gaggagagtc ggcttcagag attttattct ttggcctgag ggtgacacct aatggccatc
     1621 tgtggaattg caatgacaga atcccaatta catatagaaa aatgctatag tagatgagtg
     1681 gatggatgga ttaatgggtg gattgatgga tggatggacc gacggacgga cggacagatg
     1741 gatggacgag tgactgagta gtagtgttct gctaaataac aagtctgaag cctccttgtc
     1801 tacataagac tttgaaaata aaattgttgc ttgtaatttt
//
