LOCUS       NM_145497               1637 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus nicotinamide riboside kinase 1 (Nmrk1), mRNA.
ACCESSION   NM_145497 XM_357057
VERSION     NM_145497.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1637)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1637)
  AUTHORS   Cercillieux,A., Ratajczak,J., Joffraud,M., Sanchez-Garcia,J.L.,
            Jacot,G., Zollinger,A., Metairon,S., Giroud-Gerbetant,J.,
            Rumpler,M., Ciarlo,E., Valera-Alberni,M., Sambeat,A. and Canto,C.
  TITLE     Nicotinamide riboside kinase 1 protects against diet and
            age-induced pancreatic beta-cell failure
  JOURNAL   Mol Metab 66, 101605 (2022)
   PUBMED   36165811
  REMARK    GeneRIF: Nicotinamide riboside kinase 1 protects against diet and
            age-induced pancreatic beta-cell failure.
REFERENCE   3  (bases 1 to 1637)
  AUTHORS   Sonntag,T., Ancel,S., Karaz,S., Cichosz,P., Jacot,G., Giner,M.P.,
            Sanchez-Garcia,J.L., Pannerec,A., Moco,S., Sorrentino,V., Canto,C.
            and Feige,J.N.
  TITLE     Nicotinamide riboside kinases regulate skeletal muscle fiber-type
            specification and are rate-limiting for metabolic adaptations
            during regeneration
  JOURNAL   Front Cell Dev Biol 10, 1049653 (2022)
   PUBMED   36438552
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1637)
  AUTHORS   Sasaki,Y., Zhu,J., Shi,Y., Gu,W., Kobe,B., Ve,T., DiAntonio,A. and
            Milbrandt,J.
  TITLE     Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor
            promoting axonal protection
  JOURNAL   Exp Neurol 345, 113842 (2021)
   PUBMED   34403688
REFERENCE   5  (bases 1 to 1637)
  AUTHORS   Tannous,C., Deloux,R., Karoui,A., Mougenot,N., Burkin,D., Blanc,J.,
            Coletti,D., Lavery,G., Li,Z. and Mericskay,M.
  TITLE     NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required
            for Cardiac Function and NAD Levels during Aging
  JOURNAL   Int J Mol Sci 22 (7), 3534 (2021)
   PUBMED   33805532
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1637)
  AUTHORS   Fan,R., Cui,J., Ren,F., Wang,Q., Huang,Y., Zhao,B., Wei,L., Qian,X.
            and Xiong,X.
  TITLE     Overexpression of NRK1 ameliorates diet- and age-induced hepatic
            steatosis and insulin resistance
  JOURNAL   Biochem Biophys Res Commun 500 (2), 476-483 (2018)
   PUBMED   29678570
  REMARK    GeneRIF: adenoviral delivery of NRK1 in diet- and age-induced mice
            elevates hepatic NAD(+) levels, reduces hepatic steatosis, and
            improves glucose tolerance and insulin sensitivity.
REFERENCE   7  (bases 1 to 1637)
  AUTHORS   Zhang,K., Kim,H., Fu,Z., Qiu,Y., Yang,Z., Wang,J., Zhang,D.,
            Tong,X., Yin,L., Li,J., Wu,J., Qi,N.R., Houten,S.M. and Zhang,R.
  TITLE     Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced
            Hepatic Steatosis in Mice
  JOURNAL   Gastroenterology 154 (1), 224-237 (2018)
   PUBMED   28923496
REFERENCE   8  (bases 1 to 1637)
  AUTHORS   Fletcher,R.S., Ratajczak,J., Doig,C.L., Oakey,L.A., Callingham,R.,
            Da Silva Xavier,G., Garten,A., Elhassan,Y.S., Redpath,P.,
            Migaud,M.E., Philp,A., Brenner,C., Canto,C. and Lavery,G.G.
  TITLE     Nicotinamide riboside kinases display redundancy in mediating
            nicotinamide mononucleotide and nicotinamide riboside metabolism in
            skeletal muscle cells
  JOURNAL   Mol Metab 6 (8), 819-832 (2017)
   PUBMED   28752046
  REMARK    GeneRIF: NRK1 KO myotubes revealed redundancy in the NRK1/2
            dependent metabolism of nicotinamide riboside to NAD+.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1637)
  AUTHORS   Ratajczak,J., Joffraud,M., Trammell,S.A., Ras,R., Canela,N.,
            Boutant,M., Kulkarni,S.S., Rodrigues,M., Redpath,P., Migaud,M.E.,
            Auwerx,J., Yanes,O., Brenner,C. and Canto,C.
  TITLE     NRK1 controls nicotinamide mononucleotide and nicotinamide riboside
            metabolism in mammalian cells
  JOURNAL   Nat Commun 7, 13103 (2016)
   PUBMED   27725675
  REMARK    GeneRIF: nicotinamide riboside kinase 1 (NRK1) is necessary and
            rate-limiting for the use of exogenous nicotinamide riboside and
            nicotinamide mononucleotide for NAD(+) synthesis.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1637)
  AUTHORS   Belenky,P., Racette,F.G., Bogan,K.L., McClure,J.M., Smith,J.S. and
            Brenner,C.
  TITLE     Nicotinamide riboside promotes Sir2 silencing and extends lifespan
            via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
  JOURNAL   Cell 129 (3), 473-484 (2007)
   PUBMED   17482543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134906.3.
            
            On Mar 21, 2007 this sequence version replaced NM_145497.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016495.1, AK050579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC134906.3         117920-117985       c
            67-130              AC134906.3         113859-113922       c
            131-221             AC134906.3         110393-110483       c
            222-270             AC134906.3         110067-110115       c
            271-418             AC134906.3         108730-108877       c
            419-490             AC134906.3         108527-108598       c
            491-597             AC134906.3         107721-107827       c
            598-681             AC134906.3         104863-104946       c
            682-1637            AC134906.3         97810-98765         c
FEATURES             Location/Qualifiers
     source          1..1637
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 13.17 cM"
     gene            1..1637
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /note="nicotinamide riboside kinase 1"
                     /db_xref="GeneID:225994"
                     /db_xref="MGI:MGI:2147434"
     exon            1..66
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            67..130
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..689
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /EC_number="2.7.1.22"
                     /EC_number="2.7.1.173"
                     /note="NRK 1; RNK 1; nmR-K 1; ribosylnicotinamide kinase
                     1; ribosylnicotinic acid kinase 1; nicotinic acid riboside
                     kinase 1"
                     /codon_start=1
                     /product="nicotinamide riboside kinase 1"
                     /protein_id="NP_663472.1"
                     /db_xref="CCDS:CCDS37931.1"
                     /db_xref="GeneID:225994"
                     /db_xref="MGI:MGI:2147434"
                     /translation="MKRFVIGIGGVTNGGKTTLAKSLQKHLPNCSVISQDDFFKPESE
                     IDIDENGFLQYDVLEALNMEKMMSAVSCWMENPGSSAGPAALESAQGVPILIIEGFLL
                     FNYKPLDTIWNRSYFLTVPYEECKRRRSTRVYEPPDPPGYFDGHVWPMYLKHRQEMSS
                     ITWDIVYLDGTRSEEDLFSQVYEDVKQELEKQNGL"
     exon            131..221
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..270
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..418
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..490
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..597
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..681
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1637
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1353..1358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /note="hexamer: CATAAA"
     polyA_site      1377
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /note="major polyA site"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
                     /note="hexamer: AATAAA"
     polyA_site      1612
                     /gene="Nmrk1"
                     /gene_synonym="D630020N23Rik; Nrk1"
ORIGIN      
        1 ggtaggcatg aaacgctctt gaagcttgct ctgcgaccct gctgggaagg attcgaaccc
       61 gcttcggata tattaggaag gtgtgatttc caaagccagt tatgaagaga tttgtcattg
      121 gaattggtgg tgtgacaaac ggagggaaga cgacactggc taagagcttg cagaagcacc
      181 ttcccaactg cagcgtcata tctcaggatg acttcttcaa gccagagtct gagatagaca
      241 tagatgaaaa tggttttttg cagtatgatg tgcttgaagc gctaaatatg gaaaaaatga
      301 tgtcagcagt ttcctgttgg atggaaaacc caggaagctc tgcgggacca gcagccttgg
      361 aaagtgctca aggggttccc attttaatta ttgaaggttt ccttctcttt aattataagc
      421 ctctggacac catatggaac agaagttact tcctgaccgt tccatatgaa gaatgtaaga
      481 ggagaaggag taccagagta tatgagcctc cagaccctcc agggtacttc gatggccacg
      541 tgtggcccat gtacctaaag cacagacagg aaatgagctc catcacctgg gacattgttt
      601 acctggatgg aacaaggtct gaagaggacc tcttctctca ggtgtatgaa gatgtcaagc
      661 aggaactaga gaagcaaaat ggtttgtgat aacaccacac agatggagtg cagcaagttc
      721 ccgggatgga ttcagatact tgaagggcta ttctgaagga catttacagg gatgcagtat
      781 gtcctgcagg acagtggcag ctcgtctgta tgttcacttt tgtgccattg tccccaacat
      841 ccagagccat gtgttgccat gccgtcagac agaaacccct cctgaaagca agaatggctt
      901 gacctcaccc tgcaggaggc acagcacagt tcatgcacag agggtcagtt cctctatagg
      961 aacaaaagcc aagagctcct gactgttacc tagcaccaaa agaccattgt cgtctaggcc
     1021 aacaatgggt gctatgctgt gtatgcttct gcgtttgtgt gtatagttgt gtgtccaagt
     1081 ttgtatgtat atttctgtat gtatacatat actccaagac tacaaaatga accttgtata
     1141 ctacacagaa tgtttttttc cagttttcat tttgtttgta ttgattataa tatataattt
     1201 gaaaaattgt ctcatagtaa tgccgccaca cacacacaca cacacacaca cacacacaca
     1261 cacctgcaac cagcaacatt acctgaagta atggtctcac attgactgag tcagcagttt
     1321 actgcagagc ctggagactt tgtgcttgta gccataaatt cacttgtaat tgttaaatac
     1381 tgtgtgtctc tgtgagattt ttttatatca atagaagtgt ttggtagggg gctggtgaga
     1441 tggctcagcg gttaagagtg ccgactgctc ttccaaaggt cctgagttca aatcccagca
     1501 accacatggt ggctcacaac catctgtaat gagatctgat gccctcttct ggagtgtctg
     1561 aagacagcta cagtgtactt acaaataata aatgaataaa tattaaataa aagagaaaga
     1621 tgttatctaa aaaaaaa
//
