LOCUS       NM_001290761            1453 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus NmrA-like family domain containing 1 (Nmral1),
            transcript variant 2, mRNA.
ACCESSION   NM_001290761 XM_006522492
VERSION     NM_001290761.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1453)
  AUTHORS   Zang,W., Yang,C., Li,T., Liao,L. and Zheng,X.
  TITLE     Cellular redox sensor HSCARG negatively regulates the translesion
            synthesis pathway and exacerbates mammary tumorigenesis
  JOURNAL   Proc Natl Acad Sci U S A 116 (51), 25624-25633 (2019)
   PUBMED   31796584
REFERENCE   3  (bases 1 to 1453)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1453)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1453)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1453)
  AUTHORS   Ajioka,I., Maeda,T. and Nakajima,K.
  TITLE     Identification of ventricular-side-enriched molecules regulated in
            a stage-dependent manner during cerebral cortical development
  JOURNAL   Eur J Neurosci 23 (2), 296-308 (2006)
   PUBMED   16420439
REFERENCE   7  (bases 1 to 1453)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX527978.1, AK146521.1 and BC030039.1.
            
            On Mar 19, 2014 this sequence version replaced XM_006522492.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            5' coding region, compared to variant 1. It encodes isoform 2,
            which is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146521.1, BU515501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               BX527978.1         2-248
            248-974             AK146521.1         3-729
            975-1425            AK146521.1         731-1181
            1426-1453           BC030039.1         1159-1186
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.46 cM"
     gene            1..1453
                     /gene="Nmral1"
                     /gene_synonym="1110025F24Rik"
                     /note="NmrA-like family domain containing 1"
                     /db_xref="GeneID:67824"
                     /db_xref="MGI:MGI:1915074"
     exon            1..462
                     /gene="Nmral1"
                     /gene_synonym="1110025F24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1322
                     /gene="Nmral1"
                     /gene_synonym="1110025F24Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nmrA-like family domain-containing protein 1"
                     /codon_start=1
                     /product="nmrA-like family domain-containing protein 1
                     isoform 2"
                     /protein_id="NP_001277690.1"
                     /db_xref="CCDS:CCDS70678.1"
                     /db_xref="GeneID:67824"
                     /db_xref="MGI:MGI:1915074"
                     /translation="MADRKLVVVFGATGAQGGSVARALLEDGTFRIRVVTRNPEQRAA
                     KELKQQGAEVVRGDQDDAASMELALAGAHATFIVTNYWETCSQDREVQQGKLLADLAK
                     RLGLHYVVYSGLENIRKLTAGKLAAGHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLL
                     SYFLPQKAADGKSFLLDLPMGDVPMDGMSVSDLGPVVLSLLKKPEEYVGQNIGLSTCR
                     HTAEEYAALLSKHTGKAVHHAKTTPEDYEKLGFQGAQDLANMFRFYTLKPDRNIHLTL
                     RLNPKAQTLDQWLEQHKGDFAQL"
     exon            463..701
                     /gene="Nmral1"
                     /gene_synonym="1110025F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            702..951
                     /gene="Nmral1"
                     /gene_synonym="1110025F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1142
                     /gene="Nmral1"
                     /gene_synonym="1110025F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1429
                     /gene="Nmral1"
                     /gene_synonym="1110025F24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1407..1412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nmral1"
                     /gene_synonym="1110025F24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1429
                     /gene="Nmral1"
                     /gene_synonym="1110025F24Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaaccatca ggccatggag cacgggggag ggcaggttga gtgagcaaga gaagggccag
       61 gaccaggacc tcaggcgccc ccctggaagc gtggcaactg gcaggtcaca cactggcgcg
      121 gtctgaacgg gctctgttag ggtagaaggg ttccagtagg ggctggcggc ttgcacagaa
      181 ttgcatcccc cctttttagt ggactctgct gtaggcctgc agatcccgcc aaagcccatt
      241 ctcggaccct tgttttagcc ttttgtcacc cgagttgtgg tctggggact tggtactggg
      301 tattgccaga cagaatctcg ggacgcgttc agggaccgga cgtctcaggg tagagattct
      361 gcccttcgcc aactctgcca ccccaggcct ctttggatca cgctctttgg gctctggacc
      421 ccatggctga taggaaactg gtggtggttt ttggagccac aggtgcgcaa ggtggctctg
      481 tggcccgtgc attgctagaa gatgggacat tcaggattcg agtggtaaca agaaaccctg
      541 agcagagggc agccaaagag ctgaagcagc aaggtgctga ggtagtgcga ggagaccagg
      601 acgatgcagc tagcatggag ctggccttgg ctggagccca tgccaccttc attgtgacca
      661 attactggga gacgtgcagc caggaccgag aagtgcagca gggcaagctt ctagccgatc
      721 tagccaaacg cttgggcctc cattatgtag tgtacagtgg cctggagaac atcaggaagc
      781 tgacggctgg gaagctggcc gcaggacact ttgatggcaa aggggaggtg gaggaatact
      841 tccgagacat cggtgttccc atgaccagtg tgcggctgcc ttgctatttc gagaatctcc
      901 tttcctattt cctgccccag aaagctgcag atggaaaaag cttcttgctg gacttgccca
      961 tgggtgacgt ccccatggat ggaatgtctg tgagtgacct gggccccgtg gtgctcagct
     1021 tgctgaagaa gccagaagag tacgtagggc agaacatcgg gctcagtacc tgcaggcaca
     1081 ccgcagagga gtatgctgcc ttgcttagca agcacactgg caaggctgta catcatgcca
     1141 agacaactcc tgaggattac gagaaacttg gtttccaggg ggctcaagac ttggccaaca
     1201 tgttccgttt ctacaccctg aaacctgatc ggaacattca tctgaccctg cgactcaacc
     1261 ccaaagccca gacactggac cagtggctgg agcagcacaa aggggacttt gcacagctgt
     1321 gatcttgaag catttgtagg gacaacaagc acaacaaaca ctctttcttg tatacagttc
     1381 tgtgtttggg ttttttttcc ctcccaaata aaaccattgt tatcacaaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaa
//
