LOCUS       NM_144533               2173 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus nicotinamide nucleotide adenylyltransferase 3
            (Nmnat3), transcript variant 1, mRNA.
ACCESSION   NM_144533
VERSION     NM_144533.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2173)
  AUTHORS   Mahmood,A., Yaku,K., Hikosaka,K., Gulshan,M., Inoue,S.I.,
            Kobayashi,F. and Nakagawa,T.
  TITLE     Nmnat3 deficiency in hemolytic anemia exacerbates malaria infection
  JOURNAL   Biochem Biophys Res Commun 637, 58-65 (2022)
   PUBMED   36375251
REFERENCE   2  (bases 1 to 2173)
  AUTHORS   Sasaki,Y., Kakita,H., Kubota,S., Sene,A., Lee,T.J., Ban,N.,
            Dong,Z., Lin,J.B., Boye,S.L., DiAntonio,A., Boye,S.E., Apte,R.S.
            and Milbrandt,J.
  TITLE     SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death
            and retinal degeneration
  JOURNAL   Elife 9, e62027 (2020)
   PUBMED   33107823
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2173)
  AUTHORS   Yaku,K., Okabe,K., Gulshan,M., Takatsu,K., Okamoto,H. and
            Nakagawa,T.
  TITLE     Metabolism and biochemical properties of nicotinamide adenine
            dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD)
            and nicotinamide hypoxanthine dinucleotide (NHD)
  JOURNAL   Sci Rep 9 (1), 13102 (2019)
   PUBMED   31511627
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2173)
  AUTHORS   van Lier,M., Smit-Rigter,L., Krimpenfort,R., Saiepour,M.H.,
            Ruimschotel,E., Kamphuis,W., Heimel,J.A. and Levelt,C.N.
  TITLE     NMNAT Proteins that Limit Wallerian Degeneration Also Regulate
            Critical Period Plasticity in the Visual Cortex
  JOURNAL   eNeuro 6 (1) (2019)
   PUBMED   30671537
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2173)
  AUTHORS   Kuribayashi,H., Baba,Y., Iwagawa,T., Arai,E., Murakami,A. and
            Watanabe,S.
  TITLE     Roles of Nmnat1 in the survival of retinal progenitors through the
            regulation of pro-apoptotic gene expression via histone acetylation
  JOURNAL   Cell Death Dis 9 (9), 891 (2018)
   PUBMED   30166529
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2173)
  AUTHORS   Gilley,J., Adalbert,R., Yu,G. and Coleman,M.P.
  TITLE     Rescue of peripheral and CNS axon defects in mice lacking NMNAT2
  JOURNAL   J Neurosci 33 (33), 13410-13424 (2013)
   PUBMED   23946398
REFERENCE   7  (bases 1 to 2173)
  AUTHORS   Hicks,A.N., Lorenzetti,D., Gilley,J., Lu,B., Andersson,K.E.,
            Miligan,C., Overbeek,P.A., Oppenheim,R. and Bishop,C.E.
  TITLE     Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2)
            regulates axon integrity in the mouse embryo
  JOURNAL   PLoS One 7 (10), e47869 (2012)
   PUBMED   23082226
REFERENCE   8  (bases 1 to 2173)
  AUTHORS   Yahata,N., Yuasa,S. and Araki,T.
  TITLE     Nicotinamide mononucleotide adenylyltransferase expression in
            mitochondrial matrix delays Wallerian degeneration
  JOURNAL   J Neurosci 29 (19), 6276-6284 (2009)
   PUBMED   19439605
  REMARK    GeneRIF: results suggest that axonal protection by NMNAT expression
            in neurons is provided by modifying mitochondrial functionNMNAT
            activity does lead to axonal protection phenotype in vivo
REFERENCE   9  (bases 1 to 2173)
  AUTHORS   Sasaki,Y., Araki,T. and Milbrandt,J.
  TITLE     Stimulation of nicotinamide adenine dinucleotide biosynthetic
            pathways delays axonal degeneration after axotomy
  JOURNAL   J Neurosci 26 (33), 8484-8491 (2006)
   PUBMED   16914673
REFERENCE   10 (bases 1 to 2173)
  AUTHORS   Mulligan,M.K., Ponomarev,I., Hitzemann,R.J., Belknap,J.K.,
            Tabakoff,B., Harris,R.A., Crabbe,J.C., Blednov,Y.A., Grahame,N.J.,
            Phillips,T.J., Finn,D.A., Hoffman,P.L., Iyer,V.R., Koob,G.F. and
            Bergeson,S.E.
  TITLE     Toward understanding the genetics of alcohol drinking through
            transcriptome meta-analysis
  JOURNAL   Proc Natl Acad Sci U S A 103 (16), 6368-6373 (2006)
   PUBMED   16618939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121597.2 and AC144809.2.
            
            On Oct 27, 2017 this sequence version replaced NM_144533.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005737.1, SRR7345562.3614607.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               AC121597.2         59032-59442         c
            412-557             AC121597.2         1848-1993           c
            558-741             AC144809.2         31793-31976         c
            742-821             AC144809.2         27819-27898         c
            822-2173            AC144809.2         20004-21355         c
FEATURES             Location/Qualifiers
     source          1..2173
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.35 cM"
     gene            1..2173
                     /gene="Nmnat3"
                     /gene_synonym="4933408N02Rik; PNAT3"
                     /note="nicotinamide nucleotide adenylyltransferase 3"
                     /db_xref="GeneID:74080"
                     /db_xref="MGI:MGI:1921330"
     exon            1..411
                     /gene="Nmnat3"
                     /gene_synonym="4933408N02Rik; PNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            412..557
                     /gene="Nmnat3"
                     /gene_synonym="4933408N02Rik; PNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..741
                     /gene="Nmnat3"
                     /gene_synonym="4933408N02Rik; PNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            742..821
                     /gene="Nmnat3"
                     /gene_synonym="4933408N02Rik; PNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            822..2173
                     /gene="Nmnat3"
                     /gene_synonym="4933408N02Rik; PNAT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2149..2154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nmnat3"
                     /gene_synonym="4933408N02Rik; PNAT3"
                     /note="hexamer: AATAAA"
     polyA_site      2173
                     /gene="Nmnat3"
                     /gene_synonym="4933408N02Rik; PNAT3"
                     /note="major polyA site"
ORIGIN      
        1 cacagcagga agctgggagc gcaaggtcaa gttcactcgc ggctccgccc ccagcctggg
       61 tcaagactag ttagtcttag ggcgatctgc ggggtgaccc atcctggtcg agcagcagat
      121 ccgcggtccc tgttgactct gagcggagcc ccgcgacgcg caggtaagca cagccagcga
      181 ccttggctgc ctgcttcgcc cgcgtgggtg tccacgaagc cttgagtccc cgcgtaccta
      241 ccaggcccac gtgactctcg ggggcggcga ctcgggcgcg cgcgcgcacg acagagtcag
      301 atggctgtgg agcgcagaac cacgctagcc ccacggtcac ttttctgacc gattggctcg
      361 agctgacacg ggttcggatc ccccctgcag cacgtttaca gtcagttaaa acagggtggc
      421 cactgcgggt gtggaggtgt gtgacagcat gaagaaccga atccctgtgg tgcttctggc
      481 ctgtggttcc ttcaacccca tcacgaatat gcacctgcgc ttgtttgagg tggccagaga
      541 ccacctacac caaacaggaa ggtaccaggt gattgagggc atcatctcac ccgtcaatga
      601 cagctatggg aagaaagacc tggtggcttc ccatcaccga gtggccatgg cccggctggc
      661 cctgcagaca tctgactgga ttcgggtgga cccctgggag agtgagcagg cgcagtggat
      721 ggaaacggtg aaggtgctga ggcaccatca cagggagctg ctcagatcct cagcccagat
      781 ggatggccca gaccccagca agacaccatc agcctctgca gcactgccag agttgaaact
      841 cctctgcgga gctgatgtcc tcaagacctt ccagaccccc aacctctgga aagacacgca
      901 catccaggaa atagtggaga agttcggctt ggtgtgcgtg agcaggagcg gtcatgaccc
      961 ggaaaggtac atctcggact cgcccatcct ccagcagttt cagcacaaca ttcacctggc
     1021 cagggaaccc gttctgaacg agatcagtgc cacatacgtc aggaaagcct tgggacaagg
     1081 gcagagcgtg aagtacctcc tccctgaggc cgtcatcacc tacatcaggg accagggcct
     1141 ctacatcaat gacggttcct ggaaagggaa aggaaagact ggctagaggg cctcctgggg
     1201 agtaggggta ttctgctctg ggttctgggt ttgtttccac agtggttttt ttttaccatg
     1261 ggtgacttcc tactccagga agagatcgtg cctgtggcag agacagtcga gtatcagagc
     1321 aacttaagag gcatgacagg tcataagatt agggtcacta aggaggagac ctgcttactg
     1381 tgtaaatggc agtcatggga ggcacactga tgctgtcctg agcatggttg gcccctgagg
     1441 ggtccatcaa gtcgccttcg ttcgggtttt gtttttgttt tttgttttat aactcgggcc
     1501 aggtgcagca tgctggtctt gataggcaga gtttgacagg gcgctaatta ctgagcagag
     1561 gaccttttca acatcctcgg ctcaaacaat aatagcaagt gaggattcag aaatctggaa
     1621 acagaacatc attgatttcc aatgtatcct cccttgtaac catggcctgc ctgcctgtct
     1681 gtctgtctgc cacctgcctg tggtgtaaca taaaattttt gactaccttc tttctatgtt
     1741 gtggtcaagc aatatgtgtt taagatctgt tttatcatat gagcgtatgt gtgtgtgtgc
     1801 atgtgtcttt acatgcgtgt gtacatgcac atgggaggga catcagagtg cctgaaaccc
     1861 aagttactgg cagttgtgag ccccctgatg tgggtgctgg aacccaaact ccagtcttag
     1921 ggaagagcag caagagagtt cttaaccact aagctgtctc tccagccccc tcaagcaata
     1981 tttttgatac accatgtatt tttacactgc tatactctaa gcaccagggt tcccaatatc
     2041 ctgatttcta aaagggaacc gaagtaaaac agatgcctga ctgttttaga agatcttttg
     2101 aatgttttat gactgcctgc ttgtttgaat attggcaaaa agataaataa taaattgaca
     2161 tcaaaaatac taa
//
