LOCUS       NM_133435               2240 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus nicotinamide nucleotide adenylyltransferase 1
            (Nmnat1), transcript variant 1, mRNA.
ACCESSION   NM_133435 XM_207858 XM_359223
VERSION     NM_133435.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Hasegawa,K., Tamaki,M., Sakamaki,Y. and Wakino,S.
  TITLE     Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic
            Nephropathy Mediated by Transcriptional Repressor HIC1
  JOURNAL   Int J Mol Sci 25 (12), 6384 (2024)
   PUBMED   38928090
  REMARK    GeneRIF: Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic
            Nephropathy Mediated by Transcriptional Repressor HIC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Dong,H., Guo,W., Yue,R., Sun,X. and Zhou,Z.
  TITLE     Nuclear Nicotinamide Adenine Dinucleotide Deficiency by Nmnat1
            Deletion Impaired Hepatic Insulin Signaling, Mitochondrial
            Function, and Hepatokine Expression in Mice Fed a High-Fat Diet
  JOURNAL   Lab Invest 104 (3), 100329 (2024)
   PUBMED   38237740
  REMARK    GeneRIF: Nuclear Nicotinamide Adenine Dinucleotide Deficiency by
            Nmnat1 Deletion Impaired Hepatic Insulin Signaling, Mitochondrial
            Function, and Hepatokine Expression in Mice Fed a High-Fat Diet.
REFERENCE   4  (bases 1 to 2240)
  AUTHORS   Yamaguchi,S., Kojima,D., Iqbal,T., Kosugi,S., Franczyk,M.P., Qi,N.,
            Sasaki,Y., Yaku,K., Kaneko,K., Kinouchi,K., Itoh,H., Hayashi,K.,
            Nakagawa,T. and Yoshino,J.
  TITLE     Adipocyte NMNAT1 expression is essential for nuclear NAD+
            biosynthesis but dispensable for regulating thermogenesis and
            whole-body energy metabolism
  JOURNAL   Biochem Biophys Res Commun 674, 162-169 (2023)
   PUBMED   37421924
  REMARK    GeneRIF: Adipocyte NMNAT1 expression is essential for nuclear
            NAD[+] biosynthesis but dispensable for regulating thermogenesis
            and whole-body energy metabolism.
REFERENCE   5  (bases 1 to 2240)
  AUTHORS   Karim,M., Iqbal,T., Nawaz,A., Yaku,K. and Nakagawa,T.
  TITLE     Deletion of Nmnat1 in Skeletal Muscle Leads to the Reduction of
            NAD+ Levels but Has No Impact on Skeletal Muscle Morphology and
            Fiber Types
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 69 (3), 184-189 (2023)
   PUBMED   37394423
  REMARK    GeneRIF: Deletion of Nmnat1 in Skeletal Muscle Leads to the
            Reduction of NAD[+] Levels but Has No Impact on Skeletal Muscle
            Morphology and Fiber Types.
REFERENCE   6  (bases 1 to 2240)
  AUTHORS   Fernando,F.S., Conforti,L., Tosi,S., Smith,A.D. and Coleman,M.P.
  TITLE     Human homologue of a gene mutated in the slow Wallerian
            degeneration (C57BL/Wld(s)) mouse
  JOURNAL   Gene 284 (1-2), 23-29 (2002)
   PUBMED   11891043
REFERENCE   7  (bases 1 to 2240)
  AUTHORS   Mack,T.G., Reiner,M., Beirowski,B., Mi,W., Emanuelli,M., Wagner,D.,
            Thomson,D., Gillingwater,T., Court,F., Conforti,L., Fernando,F.S.,
            Tarlton,A., Andressen,C., Addicks,K., Magni,G., Ribchester,R.R.,
            Perry,V.H. and Coleman,M.P.
  TITLE     Wallerian degeneration of injured axons and synapses is delayed by
            a Ube4b/Nmnat chimeric gene
  JOURNAL   Nat Neurosci 4 (12), 1199-1206 (2001)
   PUBMED   11770485
REFERENCE   8  (bases 1 to 2240)
  AUTHORS   Wang,M., Wu,Y., Culver,D.G. and Glass,J.D.
  TITLE     The gene for slow Wallerian degeneration (Wld(s)) is also
            protective against vincristine neuropathy
  JOURNAL   Neurobiol Dis 8 (1), 155-161 (2001)
   PUBMED   11162249
REFERENCE   9  (bases 1 to 2240)
  AUTHORS   Conforti,L., Tarlton,A., Mack,T.G., Mi,W., Buckmaster,E.A.,
            Wagner,D., Perry,V.H. and Coleman,M.P.
  TITLE     A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the
            slow Wallerian degeneration (WldS) mouse
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11377-11382 (2000)
   PUBMED   11027338
REFERENCE   10 (bases 1 to 2240)
  AUTHORS   Coleman,M.P., Conforti,L., Buckmaster,E.A., Tarlton,A., Ewing,R.M.,
            Brown,M.C., Lyon,M.F. and Perry,V.H.
  TITLE     An 85-kb tandem triplication in the slow Wallerian degeneration
            (Wlds) mouse
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 9985-9990 (1998)
   PUBMED   9707587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606973.29, AK152407.1, AK011137.1, AK012194.1 and BY516711.1.
            
            On Oct 3, 2017 this sequence version replaced NM_133435.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcripts. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138502.1, AK011137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL606973.29        240368-240375       c
            9-47                AK152407.1         1-39
            48-453              AK011137.1         2-407
            454-1210            AK012194.1         620-1376
            1211-1907           AL606973.29        223067-223763       c
            1908-2238           BY516711.1         85-415
            2239-2240           AL606973.29        222734-222735       c
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 79.47 cM"
     gene            1..2240
                     /gene="Nmnat1"
                     /gene_synonym="2610529L11Rik; 5730441G13Rik; D4Cole1e;
                     nmnat"
                     /note="nicotinamide nucleotide adenylyltransferase 1"
                     /db_xref="GeneID:66454"
                     /db_xref="MGI:MGI:1913704"
     exon            1..102
                     /gene="Nmnat1"
                     /gene_synonym="2610529L11Rik; 5730441G13Rik; D4Cole1e;
                     nmnat"
                     /inference="alignment:Splign:2.1.0"
     exon            103..270
                     /gene="Nmnat1"
                     /gene_synonym="2610529L11Rik; 5730441G13Rik; D4Cole1e;
                     nmnat"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1013
                     /gene="Nmnat1"
                     /gene_synonym="2610529L11Rik; 5730441G13Rik; D4Cole1e;
                     nmnat"
                     /EC_number="2.7.7.1"
                     /EC_number="2.7.7.18"
                     /note="nicotinamide mononucleotide adenylyltransferase 1;
                     NMN/NaMN adenylyltransferase 1; nicotinamide/nicotinate
                     mononucleotide adenylyltransferase 1; NMN
                     adenylyltransferase 1; naMN adenylyltransferase 1;
                     nicotinate-nucleotide adenylyltransferase 1; nicotinamide
                     mononucleotide adenylyl transferase"
                     /codon_start=1
                     /product="nicotinamide/nicotinic acid mononucleotide
                     adenylyltransferase 1"
                     /protein_id="NP_597679.1"
                     /db_xref="CCDS:CCDS18960.1"
                     /db_xref="GeneID:66454"
                     /db_xref="MGI:MGI:1913704"
                     /translation="MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVI
                     KGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYH
                     QEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADL
                     LESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWI
                     TNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAA
                     EAKHNHSTL"
     exon            271..454
                     /gene="Nmnat1"
                     /gene_synonym="2610529L11Rik; 5730441G13Rik; D4Cole1e;
                     nmnat"
                     /inference="alignment:Splign:2.1.0"
     exon            455..597
                     /gene="Nmnat1"
                     /gene_synonym="2610529L11Rik; 5730441G13Rik; D4Cole1e;
                     nmnat"
                     /inference="alignment:Splign:2.1.0"
     exon            598..2240
                     /gene="Nmnat1"
                     /gene_synonym="2610529L11Rik; 5730441G13Rik; D4Cole1e;
                     nmnat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1181..1186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nmnat1"
                     /gene_synonym="2610529L11Rik; 5730441G13Rik; D4Cole1e;
                     nmnat"
                     /note="hexamer: ATTAAA"
     polyA_site      1212
                     /gene="Nmnat1"
                     /gene_synonym="2610529L11Rik; 5730441G13Rik; D4Cole1e;
                     nmnat"
                     /note="major polyA site"
ORIGIN      
        1 ctgtgtgggg ccaatgagag caaggcggcg gtgttccctg cgctggcgtc cgggccgagg
       61 ttgtctcctg gaggactagg gccgtttggc cttcaaggcc tgacaacatc gctgtcagag
      121 ggttgcatgt aggtcaacac caccaacttc tccccatgga ctcatccaag aagacagagg
      181 tggttctcct ggcctgtggc tcttttaacc ccatcaccaa catgcacctc aggctgttcg
      241 agctggccaa ggactatatg catgctacag gaaaatacag tgttatcaaa ggcattatct
      301 caccggtcgg tgatgcgtac aagaagaaag ggctcatccc agcccaccac cgaatcatca
      361 tggcagaact tgccaccaag aactcacact gggtggaagt ggatacgtgg gaaagtcttc
      421 agaaggagtg ggtggagact gtgaaggtgc tcagatacca tcaggagaag ctggcaactg
      481 gcagctgcag ttacccacaa agctcacctg cactggaaaa gcctgggcgg aagaggaagt
      541 gggctgatca aaagcaagat tctagcccac agaagcccca agagcccaaa ccaacaggtg
      601 tgcccaaggt gaaattgctg tgtggggcag atttactgga gtccttcagc gtgcccaact
      661 tgtggaagat ggaggacatc acgcaaatcg tggccaactt tgggctcatc tgtatcactc
      721 gggctggcag tgacgctcag aaattcatct acgagtccga tgtgctgtgg agacatcaga
      781 gcaacatcca cctggtgaac gagtggatca ccaatgacat ctcgtccacc aagatccgga
      841 gggcgctcag gaggggccag agcatccgct acttggtacc ggacctggtc caagagtaca
      901 ttgagaagca tgagctgtac aacacggaga gcgaaggcag gaatgctggg gtcaccctgg
      961 ctcctctgca gaggaacgcc gcagaggcca agcacaacca ttccactctg tgacacaggg
     1021 cacggcgtcc gccagaggct cgtctggaga ctcgaaactc agggaaggac ttgccatcat
     1081 cctgtttcat caactgaaag ataaaggttc gatttaaaaa aaaaaacaaa ccaccaggga
     1141 attaagatcc gtgactgaga tgaatgtttt aaataagacc attaaaaaaa aggatgtaat
     1201 tcacctttca aataacagct cagtcactaa aatgaaatgt taatgacgct aactttaaat
     1261 caatttttct agaaaggacc tcatgctctg ccgcacaaga gaagcaaacg tgatgagcaa
     1321 gtccattcac aagccactct tttttttttt ttaaagattt atttattgat tatatgtaag
     1381 tacactgtag ctgtcttcag acactctaga agagggagtc agatcttgtt ggggatggtt
     1441 gtgagccacc atgtggttgc tgggatttga actctggacc ttcggaagag cagtcgggtg
     1501 ctcttaccca ctgagccatc ttgccagccc ccacaagcta ctctttaggg gctggagaga
     1561 tggctctgag gttaagagca cagactgccc ttccagagca cccagactca gctcccagca
     1621 cctgcatggc agctctcagc tgtctgtaac tacagtttca ggagatctga tgccctctct
     1681 gtcctctgtg gagtctgggc catatatgct tcaggcaaaa gacacacaca cacacacaca
     1741 cacacacaca catttgccac acaaagagaa agagcagcct cactctagcc aggctcaccg
     1801 atgcccacct gcagccccag ctgcactagg agctgaggtc agagaatcac tttgaaccca
     1861 ggagtcaaag atgaccctag gcaagaaaac aaaacagaat cctagcacta gttatgaaga
     1921 gaactgacac gtccttagtg cttagtgaca accatcttta tccagaatag acaaaggaag
     1981 gaattcttta agatgtgacc ttggctgggc atgtgactca gttggtagag cactggccta
     2041 gcaggcctga ggccctggat tagatcacca cacctgggca tggcaatgca cacctttaat
     2101 gctggccctt ggaaggtgga agcagaagga tcaaaggctc aaggtatcct tgacaatccg
     2161 caagtctgag gtcatcaagg gacgctgagg accctgtgtc taaattaaac aaataaataa
     2221 atgatcccgc aaaattcacc
//
