LOCUS       NM_001141949            1368 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus N-myc (and STAT) interactor (Nmi), transcript variant
            1, mRNA.
ACCESSION   NM_001141949
VERSION     NM_001141949.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1368)
  AUTHORS   Jing X, Yao Y, Wu D, Hong H, Feng X, Xu N, Liu Y and Liang H.
  TITLE     IFP35 family proteins promote neuroinflammation and multiple
            sclerosis
  JOURNAL   Proc Natl Acad Sci U S A 118 (32) (2021)
   PUBMED   34362845
  REMARK    GeneRIF: IFP35 family proteins promote neuroinflammation and
            multiple sclerosis.
REFERENCE   2  (bases 1 to 1368)
  AUTHORS   Ouyang W, Cen M, Yang L, Zhang W, Xia J and Xu F.
  TITLE     NMI Facilitates Influenza A Virus Infection by Promoting
            Degradation of IRF7 through TRIM21
  JOURNAL   Am J Respir Cell Mol Biol 65 (1), 30-40 (2021)
   PUBMED   33761305
  REMARK    GeneRIF: NMI Facilitates Influenza A Virus Infection by Promoting
            Degradation of IRF7 through TRIM21.
REFERENCE   3  (bases 1 to 1368)
  AUTHORS   Pruitt HC, Metge BJ, Weeks SE, Chen D, Wei S, Kesterson RA, Shevde
            LA and Samant RS.
  TITLE     Conditional knockout of N-Myc and STAT interactor disrupts normal
            mammary development and enhances metastatic ability of mammary
            tumors
  JOURNAL   Oncogene 37 (12), 1610-1623 (2018)
   PUBMED   29326438
  REMARK    GeneRIF: Nmi has a distinct role in the differentiation process of
            mammary luminal epithelial cell compartment and developmental
            aberrations resulting from Nmi absence contribute to metastasis.
REFERENCE   4  (bases 1 to 1368)
  AUTHORS   Xiahou Z, Wang X, Shen J, Zhu X, Xu F, Hu R, Guo D, Li H, Tian Y,
            Liu Y and Liang H.
  TITLE     NMI and IFP35 serve as proinflammatory DAMPs during cellular
            infection and injury
  JOURNAL   Nat Commun 8 (1), 950 (2017)
   PUBMED   29038465
  REMARK    GeneRIF: Damage-associated molecular patterns (DAMP) are important
            mediators of innate immunity. Here the authors show that N-myc and
            STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act
            as DAMPs to promote inflammation by activating macrophages via the
            Toll-like receptor 4 and NF-kappaB pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1368)
  AUTHORS   Saito Y, Yukawa A, Matozaki M, Mikami H, Yamagami T, Yamagishi N,
            Kuga T, Hatayama T and Nakayama Y.
  TITLE     Nmi interacts with Hsp105beta and enhances the Hsp105beta-mediated
            Hsp70 expression
  JOURNAL   Exp Cell Res 327 (1), 163-170 (2014)
   PUBMED   25088258
REFERENCE   6  (bases 1 to 1368)
  AUTHORS   Wang J, Yang B, Hu Y, Zheng Y, Zhou H, Wang Y, Ma Y, Mao K, Yang L,
            Lin G, Ji Y, Wu X and Sun B.
  TITLE     Negative regulation of Nmi on virus-triggered type I IFN production
            by targeting IRF7
  JOURNAL   J Immunol 191 (6), 3393-3399 (2013)
   PUBMED   23956435
  REMARK    GeneRIF: These findings suggest that Nmi is a negative regulator of
            the virus-triggered induction of type I IFNs that targets IRF7
REFERENCE   7  (bases 1 to 1368)
  AUTHORS   Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S,
            Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA and
            Xu S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   8  (bases 1 to 1368)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 1368)
  AUTHORS   Farber CR, Corva PM and Medrano JF.
  TITLE     Genome-wide isolation of growth and obesity QTL using mouse speed
            congenic strains
  JOURNAL   BMC Genomics 7, 102 (2006)
   PUBMED   16670015
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY013052.1, AK146577.1, AF019249.2, AL929026.10 and AA217628.1.
            
            [WARNING] On May 26, 2023 this sequence was replaced by
            NM_001141949.2.
            
            Transcript Variant: This variant (1) represents the longest
            variant.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146577.1, SRR13862101.509212.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               BY013052.1         1-208
            209-1146            AK146577.1         6-943
            1147-1360           AF019249.2         919-1132
            1361-1362           AL929026.10        92318-92319         c
            1363-1368           AA217628.1         236-241
FEATURES             Location/Qualifiers
     source          1..1368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..1368
                     /gene="Nmi"
                     /note="N-myc (and STAT) interactor"
                     /db_xref="GeneID:64685"
                     /db_xref="MGI:MGI:1928368"
     exon            1..300
                     /gene="Nmi"
                     /inference="alignment:Splign:2.1.0"
     exon            301..340
                     /gene="Nmi"
                     /inference="alignment:Splign:2.1.0"
     exon            341..430
                     /gene="Nmi"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1291
                     /gene="Nmi"
                     /note="N-mcy (and STAT) interactor"
                     /codon_start=1
                     /product="N-myc-interactor"
                     /protein_id="NP_001135421.1"
                     /db_xref="CCDS:CCDS16031.1"
                     /db_xref="GeneID:64685"
                     /db_xref="MGI:MGI:1928368"
                     /translation="MDADKDNIKQACDERSAEMDDMRGEQSMGLVHEIMSENKELDEE
                     IKKLEAELQSDAREFQIKENVPEKKLKLTSVESPKDGCHFSNSSCSFQVSSQILYELQ
                     EGQALITFEKEEVAQNVISMGNHVVQMEGTPVKVSAHPVPLNTGVRFQVHVDISKMKI
                     NVTGIPDELSEEQTRDKLELSFCKSRNGGGEVESVDYDRKSRSAVITFVETGVVDKIL
                     KKKTYPLYMNQKCHSVAVSPCIERCLEKYQVFSAVSKKTVLLTGLEGIPVDEETGEDL
                     LNIHFQRKNNGGGEVEVVKCSLDQSFAAYFKEEARETI"
     exon            431..526
                     /gene="Nmi"
                     /inference="alignment:Splign:2.1.0"
     exon            527..689
                     /gene="Nmi"
                     /inference="alignment:Splign:2.1.0"
     exon            690..796
                     /gene="Nmi"
                     /inference="alignment:Splign:2.1.0"
     exon            797..983
                     /gene="Nmi"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1090
                     /gene="Nmi"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1368
                     /gene="Nmi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaggattt gcatagagag ctctggtttc catccagctt ttcaacagcg tgttccgcat
       61 aatgcacata aataagcttt tctaagcagg tctcggagtt actgccaata ataagagaca
      121 gcagcaatgg cgccctggac gaagtcctca gggcatggag cagaagcatc ctgtttctaa
      181 taaccgaaag tgaaagtaag gcctgggact gagcgctgct cgtcgctgaa gccaggttag
      241 tgttttcgag gtagagttca gttctaaggc accggcttcc gggagctgcg cagcgagcgg
      301 gtgctgagtt ctgtagtcct gcctcacttt ttcagaatat agagtcatgg atgctgataa
      361 agacaacata aagcaagctt gtgatgagcg ctcagcagag atggacgata tgagaggcga
      421 acagagcatg ggattggttc atgaaattat gagtgaaaac aaagaactag acgaggagat
      481 caaaaaactt gaagctgaat tgcagtcgga tgccagagaa ttccaaatta aagagaatgt
      541 accagaaaaa aagcttaaat tgacctcagt ggagagtcct aaggatggct gccatttctc
      601 aaatagctcc tgttcctttc aagtgagctc acaaattctc tatgagctgc aggaaggcca
      661 agcgctcatc acctttgaga aggaagaagt cgcacaaaat gtgatatcga tggggaatca
      721 tgtcgtgcag atggaaggca ccccagtgaa ggtctctgca cacccagtcc cactaaacac
      781 aggcgtcaga ttccaggttc atgtggacat ttctaaaatg aagatcaatg ttacgggaat
      841 tcccgatgag ctgtctgagg agcagacaag ggacaaactg gagctgagct tctgtaagtc
      901 caggaatggc ggcggcgaag tggaaagcgt ggattatgac aggaagtcca gaagcgctgt
      961 catcactttt gtggaaactg gcgttgttga caagattttg aaaaagaaaa cctatcctct
     1021 ctacatgaat cagaagtgcc atagcgttgc tgtttctcca tgtatagaac gatgcttaga
     1081 aaagtaccag gtgttttcag ctgtgtccaa aaagacagtg cttctgaccg gattagaagg
     1141 cattcctgta gatgaggaga ctggggagga cttactcaac atccacttcc aacggaagaa
     1201 taacggaggg ggagaagtgg aggtggtcaa gtgttctcta gaccagtcct tcgcagcgta
     1261 ttttaaagaa gaggccagag aaaccatatg aaacttatag ccttgaacta aaatcactgc
     1321 caacatttac aaaatattgt tttccataaa acaaaaaatt aatttgtc
//
