LOCUS       NM_178071               2385 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus NME/NM23 family member 7 (Nme7), transcript variant 2,
            mRNA.
ACCESSION   NM_178071
VERSION     NM_178071.6
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Wang,C.H., Ma,N., Lin,Y.T., Wu,C.C., Hsiao,M., Lu,F.L., Yu,C.C.,
            Chen,S.Y. and Lu,J.
  TITLE     A shRNA functional screen reveals Nme6 and Nme7 are crucial for
            embryonic stem cell renewal
  JOURNAL   Stem Cells 30 (10), 2199-2211 (2012)
   PUBMED   22899353
  REMARK    GeneRIF: Nme6 or Nme7 can regulate several critical processes in
            embryonic stem cell renewal.
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   Lai,C.K., Gupta,N., Wen,X., Rangell,L., Chih,B., Peterson,A.S.,
            Bazan,J.F., Li,L. and Scales,S.J.
  TITLE     Functional characterization of putative cilia genes by high-content
            analysis
  JOURNAL   Mol Biol Cell 22 (7), 1104-1119 (2011)
   PUBMED   21289087
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   8  (bases 1 to 2385)
  AUTHORS   Vogel,P., Read,R., Hansen,G.M., Freay,L.C., Zambrowicz,B.P. and
            Sands,A.T.
  TITLE     Situs inversus in Dpcd/Poll-/-, Nme7-/-, and Pkd1l1-/- mice
  JOURNAL   Vet Pathol 47 (1), 120-131 (2010)
   PUBMED   20080492
  REMARK    GeneRIF: situs inversus in Nme7-/- knockout mice
            GeneRIF: Situs inversus and hydrocephalus observed in Nme7-/- mice
REFERENCE   9  (bases 1 to 2385)
  AUTHORS   Ikeda,T.
  TITLE     NDP kinase 7 is a conserved microtubule-binding protein
            preferentially expressed in ciliated cells
  JOURNAL   Cell Struct Funct 35 (1), 23-30 (2010)
   PUBMED   20215702
  REMARK    GeneRIF: The nucleoside diphosphate kinase 7 in tracheal epithelia
            was found in the cell body but not in cilia and directly bind to
            microtubules.
REFERENCE   10 (bases 1 to 2385)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133221.1 and AK085222.1.
            
            On Jun 7, 2014 this sequence version replaced NM_178071.5.
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to isoform 1. The resulting isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085222.1, AK164652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AK133221.1         469-523
            56-2385             AK085222.1         4-2333
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.63 cM"
     gene            1..2385
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /note="NME/NM23 family member 7"
                     /db_xref="GeneID:171567"
                     /db_xref="MGI:MGI:2449121"
     exon            1..83
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            84..274
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            275..357
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1131
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /EC_number="2.7.4.6"
                     /note="isoform 2 is encoded by transcript variant 2; NDK
                     7; NDP kinase 7; nucleoside-diphosphate kinase; nucleoside
                     diphosphate kinase 7; non-metastatic cells 7, protein
                     expressed in (nucleoside-diphosphate kinase); protein
                     kinase NME7; NDP kinase homolog 7; 3'-5' exonuclease NME7;
                     nucleoside diphosphate kinase homolog 7"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase homolog 7 isoform
                     2"
                     /protein_id="NP_835172.1"
                     /db_xref="CCDS:CCDS78731.1"
                     /db_xref="GeneID:171567"
                     /db_xref="MGI:MGI:2449121"
                     /translation="MRACQQGRSSSLVSPYMAPKNQSERFAFIAEWYDPNASLLRRYE
                     LLFYPTDGSVEMHDVKNRRTFLKRTKYEDLRLEDLFIGNKVNVFSRQLVLIDYGDQYT
                     ARQLGSRKEKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHH
                     SRPFYNELIQFITSGPVIAMEILRDDAICEWKRLLGPANSGLSRTDAPGSIRALFGTD
                     GVRNAAHGPDTFASAAREMELFFPSSGGCGPANTAKFTNCTCCIIKPHAISEDLFIHY
                     M"
     exon            358..465
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            466..632
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            633..743
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            744..794
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1002
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1108
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..2385
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2104..2109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /note="hexamer: AATAAA"
     polyA_site      2127
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /note="major polyA site"
ORIGIN      
        1 gccagagtaa ccggatcatt ggtggtggtg tagtcttcct gtgtacagga atctatttcc
       61 tgtgctgaga tctacaaact atgcttgcag acccttatcg acgtggtgct gtctcaacac
      121 taacttggat ctgaatctcc ctgagtgctg gagtcagttc tcccaagcgg tggagttcta
      181 ccttgcatct cctaccagga ccgcttagta atagctgtct gctggctcag cgtctagttc
      241 atttcatact ttccagatca ctgtgtttta gcagccggcg ttgcatcctc gggcagtatg
      301 agagcctgtc agcagggaag aagttccagt ttggtttctc catatatggc acccaagaat
      361 cagagcgaga gattcgcttt cattgcagag tggtatgatc caaatgcttc attgctccga
      421 cgctatgagc tgctgtttta ccccacagac ggatctgttg aaatgcatga tgtaaagaat
      481 cgtcgcacct tcttaaagcg gaccaagtat gaggacctgc gcctggaaga tctatttata
      541 ggcaacaaag tcaatgtgtt ttctcgacag ctggtgttga ttgactatgg ggaccaatac
      601 acagcccgcc agctgggcag caggaaagag aaaactttag ccctgatcaa accagatgca
      661 gtgtcaaagg ccggagaaat cattgagatg ataaacaaaa gtggatttac tataaccaaa
      721 ctccgaatga tgactctgac aaggaaagaa gcagcggact ttcatgtaga ccatcactca
      781 agaccttttt ataacgaact gatccagttt atcacaagtg ggcctgttat tgccatggag
      841 atcttaagag atgacgcgat ctgtgagtgg aaaaggttgc ttggacccgc aaactctggg
      901 ctatcacgga cagatgcccc cggaagcatc cgagccctct ttgggacaga tggcgtgaga
      961 aatgcagctc acggccctga tacttttgca tctgctgcca gagaaatgga attgtttttt
     1021 ccttcaagtg gaggctgtgg gccagcgaac actgctaaat ttaccaattg cacctgttgc
     1081 atcattaagc ctcatgctat cagtgaagat ttatttattc attatatgta agtacactgt
     1141 agctgtcttc agacgctcca gaagatggtt gtaagccacc atgtggttgc tgggatttga
     1201 actccggaac ttcggaagag cagtcgggtg ctcttaccca ctgagccatc tcaccagccc
     1261 tgttcttctt gctataaaca aatcttgctt ctgtgctttg aatcttctgt ctttccaacc
     1321 acataactga ggttcactct cttctcttta cttaaagcac tgtgtgtacg gctggagacg
     1381 taactcacca gttaagtgtc attattgttt ttgcaaagga cctgggtttg gttcccagca
     1441 cccacatagt ggctcacaac taaccacaac tccagttcca ggggatctga tgccctcctc
     1501 tgaccttgag gggaaaagca tataagttta ttacatctag agcgtatctt tactgagaga
     1561 gttggagata ctgcctctag tcctcagtat ctgaaacagt tctttgatgg acatgaatat
     1621 ctatctatgt atctacctac ctatctctat ctctatctct gtccacattc ataggcatat
     1681 gtggatatgc acacatatac actgggtcag taaaagttca ccccttgctt ttatctcttt
     1741 ttccatctat ttgtttgagt caattgtgtg catctccatc tgatactcca agttgttttg
     1801 gaaataatac gaataattta aaaaatactc cttggaaaat ggaatatact gagtaacata
     1861 cacattagag tggagttttt aatgtgttct aagcatacat atagtagaaa aacttgaaaa
     1921 ttgtaataca tatttgtaca agagacaata aaagtttacc taaaccgggc acagtggtac
     1981 acacttagaa tcttagcatt cagaagtctg agacaggaca atggtgcgtt ttaagccatc
     2041 ctgagctaca tagtgagttt gaggccagac tggacgatat attaggaaga tcttgttgca
     2101 aaaaataaaa gctgctttct atcagaattg ttattgttaa tagtttggta tgtttctttc
     2161 tgcatttgtg agtgtgtgtg tgtgtatgca tatataatac atatgagtgc agtgtagctg
     2221 agatgtgtat ctatattctg tttctgtcat ttaatttttg tgagcatttc tgaccttctt
     2281 tgagggttca tgaatatttt aatgattaat tgaatatttc ataacaatca tatgtatgat
     2341 atttgggtta tttctgtttt ttttaattaa aaataagttt ctcct
//
