LOCUS       NM_138314               1740 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus NME/NM23 family member 7 (Nme7), transcript variant 1,
            mRNA.
ACCESSION   NM_138314
VERSION     NM_138314.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (bases 1 to 1740)
  AUTHORS   Wang,C.H., Ma,N., Lin,Y.T., Wu,C.C., Hsiao,M., Lu,F.L., Yu,C.C.,
            Chen,S.Y. and Lu,J.
  TITLE     A shRNA functional screen reveals Nme6 and Nme7 are crucial for
            embryonic stem cell renewal
  JOURNAL   Stem Cells 30 (10), 2199-2211 (2012)
   PUBMED   22899353
  REMARK    GeneRIF: Nme6 or Nme7 can regulate several critical processes in
            embryonic stem cell renewal.
REFERENCE   6  (bases 1 to 1740)
  AUTHORS   Lai,C.K., Gupta,N., Wen,X., Rangell,L., Chih,B., Peterson,A.S.,
            Bazan,J.F., Li,L. and Scales,S.J.
  TITLE     Functional characterization of putative cilia genes by high-content
            analysis
  JOURNAL   Mol Biol Cell 22 (7), 1104-1119 (2011)
   PUBMED   21289087
REFERENCE   7  (bases 1 to 1740)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   8  (bases 1 to 1740)
  AUTHORS   Vogel,P., Read,R., Hansen,G.M., Freay,L.C., Zambrowicz,B.P. and
            Sands,A.T.
  TITLE     Situs inversus in Dpcd/Poll-/-, Nme7-/-, and Pkd1l1-/- mice
  JOURNAL   Vet Pathol 47 (1), 120-131 (2010)
   PUBMED   20080492
  REMARK    GeneRIF: situs inversus in Nme7-/- knockout mice
            GeneRIF: Situs inversus and hydrocephalus observed in Nme7-/- mice
REFERENCE   9  (bases 1 to 1740)
  AUTHORS   Ikeda,T.
  TITLE     NDP kinase 7 is a conserved microtubule-binding protein
            preferentially expressed in ciliated cells
  JOURNAL   Cell Struct Funct 35 (1), 23-30 (2010)
   PUBMED   20215702
  REMARK    GeneRIF: The nucleoside diphosphate kinase 7 in tracheal epithelia
            was found in the cell body but not in cilia and directly bind to
            microtubules.
REFERENCE   10 (bases 1 to 1740)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133221.1 and BU609451.1.
            
            On Jun 7, 2014 this sequence version replaced NM_138314.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049225.1, AK144915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1687              AK133221.1         469-2155
            1688-1740           BU609451.1         2-54                c
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.63 cM"
     gene            1..1740
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /note="NME/NM23 family member 7"
                     /db_xref="GeneID:171567"
                     /db_xref="MGI:MGI:2449121"
     exon            1..83
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            84..274
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            275..360
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1488
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /EC_number="2.7.4.6"
                     /note="isoform 1 is encoded by transcript variant 1; NDK
                     7; NDP kinase 7; nucleoside-diphosphate kinase; nucleoside
                     diphosphate kinase 7; non-metastatic cells 7, protein
                     expressed in (nucleoside-diphosphate kinase); protein
                     kinase NME7; NDP kinase homolog 7; 3'-5' exonuclease NME7;
                     nucleoside diphosphate kinase homolog 7"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase homolog 7 isoform
                     1"
                     /protein_id="NP_612187.2"
                     /db_xref="CCDS:CCDS15436.2"
                     /db_xref="GeneID:171567"
                     /db_xref="MGI:MGI:2449121"
                     /translation="MRACQQGRSSSLVSPYMAPKNQSERFAFIAEWYDPNASLLRRYE
                     LLFYPTDGSVEMHDVKNRRTFLKRTKYEDLRLEDLFIGNKVNVFSRQLVLIDYGDQYT
                     ARQLGSRKEKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHH
                     SRPFYNELIQFITSGPVIAMEILRDDAICEWKRLLGPANSGLSRTDAPGSIRALFGTD
                     GVRNAAHGPDTFASAAREMELFFPSSGGCGPANTAKFTNCTCCIIKPHAISEGMLGKI
                     LIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQS
                     NPTKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFKI
                     LDN"
     exon            361..468
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            469..635
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            636..746
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            747..797
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1005
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1111
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1176
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1245
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1347
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1455
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1740
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /note="hexamer: AATAAA"
     polyA_site      1740
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /note="major polyA site"
ORIGIN      
        1 gccagagtaa ccggatcatt ggtggtggtg tagtcttcct gtgtacagga atctatttcc
       61 tgtgctgaga tctacaaact atgcttgcag acccttatcg acgtggtgct gtctcaacac
      121 taacttggat ctgaatctcc ctgagtgctg gagtcagttc tcccaagcgg tggagttcta
      181 ccttgcatct cctaccagga ccgcttagta atagctgtct gctggctcag cgtctagttc
      241 atttcatact ttccagatca ctgtgtttta gcagcagccg gcgttgcatc ctcgggcagt
      301 atgagagcct gtcagcaggg aagaagttcc agtttggttt ctccatatat ggcacccaag
      361 aatcagagcg agagattcgc tttcattgca gagtggtatg atccaaatgc ttcattgctc
      421 cgacgctatg agctgctgtt ttaccccaca gacggatctg ttgaaatgca tgatgtaaag
      481 aatcgtcgca ccttcttaaa gcggaccaag tatgaggacc tgcgcctgga agatctattt
      541 ataggcaaca aagtcaatgt gttttctcga cagctggtgt tgattgacta tggggaccaa
      601 tacacagccc gccagctggg cagcaggaaa gagaaaactt tagccctgat caaaccagat
      661 gcagtgtcaa aggccggaga aatcattgag atgataaaca aaagtggatt tactataacc
      721 aaactccgaa tgatgactct gacaaggaaa gaagcagcgg actttcatgt agaccatcac
      781 tcaagacctt tttataacga actgatccag tttatcacaa gtgggcctgt tattgccatg
      841 gagatcttaa gagatgacgc gatctgtgag tggaaaaggt tgcttggacc cgcaaactct
      901 gggctatcac ggacagatgc ccccggaagc atccgagccc tctttgggac agatggcgtg
      961 agaaatgcag ctcacggccc tgatactttt gcatctgctg ccagagaaat ggaattgttt
     1021 tttccttcaa gtggaggctg tgggccagcg aacactgcta aatttaccaa ttgcacctgt
     1081 tgcatcatta agcctcatgc tatcagtgaa ggaatgttgg gaaagatttt aatagctatt
     1141 cgggatgcat gctttggaat gtcagcgata cagatgttca atttggatcg ggctaatgtt
     1201 gaagaattct atgaagtcta taaaggtgta gtgtctgagt ataatgatat ggtgacagag
     1261 ctgtgctccg gcccttgcgt agcaatagag atccaacaga gcaaccctac aaagacattt
     1321 cgagaattct gcggacctgc tgatcctgaa atcgcccggc atttacgacc tgagaccctc
     1381 agggcaattt ttggtaaaac taaggttcaa aatgctgttc attgcacgga tctgccggag
     1441 gatgggctcc tggaggtcca gtatttcttc aagatcttgg ataattagct ctccagagta
     1501 aagacgacac agactgagac gcccagacaa tcgagtcaca cacgtgagga atgtgttcat
     1561 tcttttattg tccgttgtgt taacctgact gacacaagat caacaagagc actgtactcc
     1621 tggcaattat tacatatgct agaacatgga tttgcactgt agacaacact taacaccagt
     1681 ctatggggta ctgcattgct ttttataaag ttcaaaataa agatttttat tttcaaacaa
//
