LOCUS       NP_612187                395 aa            linear   ROD 19-SEP-2024
DEFINITION  nucleoside diphosphate kinase homolog 7 isoform 1 [Mus musculus].
ACCESSION   NP_612187
VERSION     NP_612187.2
DBSOURCE    REFSEQ: accession NM_138314.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 395)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 395)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 395)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (residues 1 to 395)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (residues 1 to 395)
  AUTHORS   Wang,C.H., Ma,N., Lin,Y.T., Wu,C.C., Hsiao,M., Lu,F.L., Yu,C.C.,
            Chen,S.Y. and Lu,J.
  TITLE     A shRNA functional screen reveals Nme6 and Nme7 are crucial for
            embryonic stem cell renewal
  JOURNAL   Stem Cells 30 (10), 2199-2211 (2012)
   PUBMED   22899353
  REMARK    GeneRIF: Nme6 or Nme7 can regulate several critical processes in
            embryonic stem cell renewal.
REFERENCE   6  (residues 1 to 395)
  AUTHORS   Lai,C.K., Gupta,N., Wen,X., Rangell,L., Chih,B., Peterson,A.S.,
            Bazan,J.F., Li,L. and Scales,S.J.
  TITLE     Functional characterization of putative cilia genes by high-content
            analysis
  JOURNAL   Mol Biol Cell 22 (7), 1104-1119 (2011)
   PUBMED   21289087
REFERENCE   7  (residues 1 to 395)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   8  (residues 1 to 395)
  AUTHORS   Vogel,P., Read,R., Hansen,G.M., Freay,L.C., Zambrowicz,B.P. and
            Sands,A.T.
  TITLE     Situs inversus in Dpcd/Poll-/-, Nme7-/-, and Pkd1l1-/- mice
  JOURNAL   Vet Pathol 47 (1), 120-131 (2010)
   PUBMED   20080492
  REMARK    GeneRIF: situs inversus in Nme7-/- knockout mice
            GeneRIF: Situs inversus and hydrocephalus observed in Nme7-/- mice
REFERENCE   9  (residues 1 to 395)
  AUTHORS   Ikeda,T.
  TITLE     NDP kinase 7 is a conserved microtubule-binding protein
            preferentially expressed in ciliated cells
  JOURNAL   Cell Struct Funct 35 (1), 23-30 (2010)
   PUBMED   20215702
  REMARK    GeneRIF: The nucleoside diphosphate kinase 7 in tracheal epithelia
            was found in the cell body but not in cilia and directly bind to
            microtubules.
REFERENCE   10 (residues 1 to 395)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133221.1 and BU609451.1.
            
            On May 8, 2009 this sequence version replaced NP_612187.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049225.1, AK144915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.63 cM"
     Protein         1..395
                     /product="nucleoside diphosphate kinase homolog 7 isoform
                     1"
                     /EC_number="2.7.4.6"
                     /note="NDK 7; NDP kinase 7; nucleoside-diphosphate kinase;
                     nucleoside diphosphate kinase 7; non-metastatic cells 7,
                     protein expressed in (nucleoside-diphosphate kinase);
                     protein kinase NME7; NDP kinase homolog 7; 3'-5'
                     exonuclease NME7; nucleoside diphosphate kinase homolog 7"
                     /calculated_mol_wt=44304
     Region          22..110
                     /region_name="DM10"
                     /note="Domains in hypothetical proteins in Drosophila, C.
                     elegans and mammals. Occurs singly in some nucleoside
                     diphosphate kinases; smart00676"
                     /db_xref="CDD:128921"
     Region          111..241
                     /region_name="NDPk7A"
                     /note="Nucleoside diphosphate kinase 7 domain A (NDPk7A):
                     The nm23-H7 class of nucleoside diphosphate kinase (NDPk7)
                     consists of an N-terminal DM10 domain and two functional
                     catalytic NDPk modules, NDPk7A and NDPk7B. The function of
                     the DM10 domain, which also...; cd04415"
                     /db_xref="CDD:239878"
     Site            order(118,156,164,192,198,212,222,225,227..228,236)
                     /site_type="active"
                     /db_xref="CDD:239878"
     Site            order(122,125..127,130,133,142..144)
                     /site_type="other"
                     /note="multimer interface [polypeptide binding]"
                     /db_xref="CDD:239878"
     Region          257..390
                     /region_name="NDPk7B"
                     /note="Nucleoside diphosphate kinase 7 domain B (NDPk7B):
                     The nm23-H7 class of nucleoside diphosphate kinase (NDPk7)
                     consists of an N-terminal DM10 domain and two functional
                     catalytic NDPk modules, NDPk7A and NDPk7B. The function of
                     the DM10 domain, which also...; cd04412"
                     /db_xref="CDD:239875"
     Site            order(264,304,313,341,347,361,371,374,376..377,385)
                     /site_type="active"
                     /db_xref="CDD:239875"
     Site            order(268,273..275,278,281,290..292)
                     /site_type="other"
                     /note="multimer interface [polypeptide binding]"
                     /db_xref="CDD:239875"
     CDS             1..395
                     /gene="Nme7"
                     /gene_synonym="D530024H21Rik; nm23-H7; Nm23-M7; Nm23-r7"
                     /coded_by="NM_138314.4:301..1488"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS15436.2"
                     /db_xref="GeneID:171567"
                     /db_xref="MGI:MGI:2449121"
ORIGIN      
        1 mracqqgrss slvspymapk nqserfafia ewydpnasll rryellfypt dgsvemhdvk
       61 nrrtflkrtk yedlrledlf ignkvnvfsr qlvlidygdq ytarqlgsrk ektlalikpd
      121 avskageiie minksgftit klrmmtltrk eaadfhvdhh srpfyneliq fitsgpviam
      181 eilrddaice wkrllgpans glsrtdapgs iralfgtdgv rnaahgpdtf asaaremelf
      241 fpssggcgpa ntakftnctc ciikphaise gmlgkiliai rdacfgmsai qmfnldranv
      301 eefyevykgv vseyndmvte lcsgpcvaie iqqsnptktf refcgpadpe iarhlrpetl
      361 raifgktkvq navhctdlpe dgllevqyff kildn
//
