LOCUS       NM_001409696            1198 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus NME/NM23 nucleoside diphosphate kinase 6 (Nme6),
            transcript variant 4, mRNA.
ACCESSION   NM_001409696 XM_036155118
VERSION     NM_001409696.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1198)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1198)
  AUTHORS   Wang,Y., Yasmin,L., Li,L., Gao,P., Xu,X., Sun,X. and Godbout,R.
  TITLE     DDX1 vesicles control calcium-dependent mitochondrial activity in
            mouse embryos
  JOURNAL   Nat Commun 13 (1), 3794 (2022)
   PUBMED   35778392
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1198)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1198)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1198)
  AUTHORS   Wang,C.H., Ma,N., Lin,Y.T., Wu,C.C., Hsiao,M., Lu,F.L., Yu,C.C.,
            Chen,S.Y. and Lu,J.
  TITLE     A shRNA functional screen reveals Nme6 and Nme7 are crucial for
            embryonic stem cell renewal
  JOURNAL   Stem Cells 30 (10), 2199-2211 (2012)
   PUBMED   22899353
  REMARK    GeneRIF: Nme6 or Nme7 can regulate several critical processes in
            embryonic stem cell renewal.
REFERENCE   6  (bases 1 to 1198)
  AUTHORS   Mehus,J.G., Deloukas,P. and Lambeth,D.O.
  TITLE     NME6: a new member of the nm23/nucleoside diphosphate kinase gene
            family located on human chromosome 3p21.3
  JOURNAL   Hum Genet 104 (6), 454-459 (1999)
   PUBMED   10453732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163619.2.
            
            On Jul 21, 2022 this sequence version replaced XM_036155118.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR15390196.343030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC163619.2         126841-126967
            128-227             AC163619.2         127275-127374
            228-382             AC163619.2         129339-129493
            383-485             AC163619.2         133687-133789
            486-525             AC163619.2         135555-135594
            526-686             AC163619.2         136006-136166
            687-1198            AC163619.2         136531-137042
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.79 cM"
     gene            1..1198
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /note="NME/NM23 nucleoside diphosphate kinase 6"
                     /db_xref="GeneID:54369"
                     /db_xref="MGI:MGI:1861676"
     exon            1..127
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            128..227
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            228..382
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            383..485
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            486..525
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            526..686
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            687..1198
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1173..1178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /note="hexamer: AATAAA"
     polyA_site      1198
                     /gene="Nme6"
                     /gene_synonym="NDK 6; nm23-M6"
                     /note="major polyA site"
ORIGIN      
        1 atcttgctca gtgcctggtg accaggagga ttggcgggag taccaggtga acccagaacc
       61 cgggctcgct ttggagaccg aataactgag tctggtgtgg gcttcggcct gtagtagaga
      121 agcccagatc gccggtcctc ccaggagacc ccttagcagc ctggccttgg aatggctaga
      181 tcaggttcat gcactgattc atccagctaa gatctgtgga aatccaggta gaaggtgctg
      241 agagctcaat gctgcgtagt ccttaaccca gctctctgat gccagggcag agatgacctc
      301 catcttgcga agtccccaag ctcttcagct cacactagcc ctgatcaagc ctgatgcagt
      361 tgcccaccca ctgatcctgg aggctgttca tcagcagatt ctgagcaaca agttcctcat
      421 tgtacgaacg agggaactgc agtggaagct ggaggactgc cggaggtttt accgagagca
      481 tgaagggcgt tttttctatc agcggctggt ggagttcatg acaagtgggc caatccgagc
      541 ctatatcctt gcccacaaag atgccatcca actttggagg acactgatgg gacccaccag
      601 agtatttcga gcacgctata tagccccaga ttcaattcgt ggaagtttgg gcctcactga
      661 cacccgaaat actacccatg gctcagactc cgtggtttcc gccagcagag agattgcagc
      721 cttcttccct gacttcagtg aacagcgctg gtatgaggag gaggaacccc agctgcggtg
      781 tggtcctgtg cactacagtc cagaggaagg tatccactgt gcagctgaaa caggaggcca
      841 caaacaacct aacaaaacct aggagaccca gccaagtaaa gtcccgagga ctggtcgcag
      901 tgttcagccc ttcctcctag ggtcagggaa ggtggtctga aggcactgtc cctgttggac
      961 ccctccatga gctggcaggt ctagccgacc acagctcagc tgctgcagtc cagttctatc
     1021 tacctctcct gtggagtact catgggtgtt caggaaggat ggtgacgcct ctttttacaa
     1081 aggactatcc tccttcctca agaaagagcc tgcctgttga ctagtcagga aaatgcagtg
     1141 cctgggtaac cagcatccga cctggcttcc ttaataaatt ctgcttccga atgctcca
//
