LOCUS       NM_080637                875 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus NME/NM23 family member 5 (Nme5), transcript variant 1,
            mRNA.
ACCESSION   NM_080637
VERSION     NM_080637.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 875)
  AUTHORS   Zhang,X., Xiao,Z., Zhang,J., Xu,C., Liu,S., Cheng,L., Zhou,S.,
            Zhao,S., Zhang,Y., Wu,J., Wang,Y. and Liu,M.
  TITLE     Differential requirements of IQUB for the assembly of radial spoke
            1 and the motility of mouse cilia and flagella
  JOURNAL   Cell Rep 41 (8), 111683 (2022)
   PUBMED   36417862
REFERENCE   2  (bases 1 to 875)
  AUTHORS   Liu,S., Zhang,J., Kherraf,Z.E., Sun,S., Zhang,X., Cazin,C.,
            Coutton,C., Zouari,R., Zhao,S., Hu,F., Fourati Ben Mustapha,S.,
            Arnoult,C., Ray,P.F. and Liu,M.
  TITLE     CFAP61 is required for sperm flagellum formation and male fertility
            in human and mouse
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34792097
REFERENCE   3  (bases 1 to 875)
  AUTHORS   Yoke,H., Ueno,H., Narita,A., Sakai,T., Horiuchi,K., Shingyoji,C.,
            Hamada,H. and Shinohara,K.
  TITLE     Rsph4a is essential for the triplet radial spoke head assembly of
            the mouse motile cilia
  JOURNAL   PLoS Genet 16 (3), e1008664 (2020)
   PUBMED   32203505
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 875)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   5  (bases 1 to 875)
  AUTHORS   Wu,Y., Wei,F.Y., Kawarada,L., Suzuki,T., Araki,K., Komohara,Y.,
            Fujimura,A., Kaitsuka,T., Takeya,M., Oike,Y., Suzuki,T. and
            Tomizawa,K.
  TITLE     Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is
            Required for Mitochondrial Translation and Is Involved in
            Reversible Infantile Liver Injury
  JOURNAL   PLoS Genet 12 (9), e1006355 (2016)
   PUBMED   27689697
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 875)
  AUTHORS   Vogel,P., Read,R.W., Hansen,G.M., Payne,B.J., Small,D., Sands,A.T.
            and Zambrowicz,B.P.
  TITLE     Congenital hydrocephalus in genetically engineered mice
  JOURNAL   Vet Pathol 49 (1), 166-181 (2012)
   PUBMED   21746835
  REMARK    GeneRIF: Situs inversus, hydrocephalus, suppurative
            rhinosinusitis,and sperm flagellar defects in Nme5 null mice are
            indicative of defective ciliogenesis
REFERENCE   7  (bases 1 to 875)
  AUTHORS   Choi,Y.J., Cho,S.K., Hwang,K.C., Park,C., Kim,J.H., Park,S.B.,
            Hwang,S. and Kim,J.H.
  TITLE     Nm23-M5 mediates round and elongated spermatid survival by
            regulating GPX-5 levels
  JOURNAL   FEBS Lett 583 (8), 1292-1298 (2009)
   PUBMED   19303412
  REMARK    GeneRIF: results reveal that expression of Nm23-M5 plays a critical
            role in spermiogenesis by increasing the cellular levels of GPX-5
            to eliminate reactive oxygen species
REFERENCE   8  (bases 1 to 875)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Nme5 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   9  (bases 1 to 875)
  AUTHORS   Hwang,K.C., Ok,D.W., Hong,J.C., Kim,M.O. and Kim,J.H.
  TITLE     Cloning, sequencing, and characterization of the murine nm23-M5
            gene during mouse spermatogenesis and spermiogenesis
  JOURNAL   Biochem Biophys Res Commun 306 (1), 198-207 (2003)
   PUBMED   12788088
  REMARK    GeneRIF: nm23-M5 gene plays an important role in late
            spermiogenesis by elevating the ability of late-stage spermatids to
            eliminate reactive oxygen species
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074335.11, AK131722.1 and BC049625.1.
            
            On Oct 28, 2017 this sequence version replaced NM_080637.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131722.1, BY706418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC074335.11        133039-133047       c
            10-838              AK131722.1         2-830
            839-875             BC049625.1         723-759
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.69 cM"
     gene            1..875
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /note="NME/NM23 family member 5"
                     /db_xref="GeneID:75533"
                     /db_xref="MGI:MGI:1922783"
     exon            1..39
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /inference="alignment:Splign:2.1.0"
     exon            40..249
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..756
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /EC_number="2.7.4.6"
                     /note="expressed in non-metastatic cells 5; NDK-H 5; NDP
                     kinase homolog 5; non-metastatic cells 5, protein
                     expressed in (nucleoside-diphosphate kinase); rsph23;
                     3'-5' exonuclease NME5"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase homolog 5"
                     /protein_id="NP_542368.2"
                     /db_xref="CCDS:CCDS29130.1"
                     /db_xref="GeneID:75533"
                     /db_xref="MGI:MGI:1922783"
                     /translation="MEVSMPLPQIYVEKTLALIKPDVVDKEEEIQDIILGSGFTIIQR
                     RKLHLSPEHCSNFYVEQYGKMFFPNLTAYMSSGPLVAMILARHKAISYWKELMGPSNS
                     LVAKETHPDSLRAIYGTDELRNALHGSNDFAASEREIRFMFPAVIIEPIPIGQAAKDY
                     INLYVAPTLLQGLTELCKEKPPDPYLWLADWLMKNNPNKPKLCHFPVTEEP"
     exon            250..455
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /inference="alignment:Splign:2.1.0"
     exon            456..556
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /inference="alignment:Splign:2.1.0"
     exon            557..675
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /inference="alignment:Splign:2.1.0"
     exon            676..845
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      820..825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /note="hexamer: ATTAAA"
     polyA_site      843
                     /gene="Nme5"
                     /gene_synonym="1700019D05Rik; Nm23-M5"
                     /note="major polyA site"
ORIGIN      
        1 gggtctctta gcaacgggct ttgacaacac ctgaacagag ctgattttgg gaccaggact
       61 cctgtcgttg ctgtggataa ctggttagga gatttgaaaa ttgtaccgga aaacgccaga
      121 atggaggtat caatgcccct gcctcagata tatgtagaaa aaaccctagc ccttatcaag
      181 ccagatgttg ttgacaaaga agaggagata caggatatta ttctgggatc tggattcacc
      241 attattcaga gacggaaact acacctgagc cccgagcact gtagtaactt ttatgtggag
      301 cagtatggga aaatgttttt cccaaactta acagcttata tgagctctgg acctcttgtt
      361 gctatgatat tagctagaca taaggccatc tcctactgga aagaacttat gggaccaagt
      421 aacagtttag tagccaagga gacacacccg gacagcttaa gggcgatata cggtacagac
      481 gagctcagga acgcacttca tgggagcaat gacttcgctg cctcagagcg agagatcagg
      541 ttcatgtttc cagccgtgat tattgaaccc attccaattg gacaagccgc taaggactac
      601 ataaacttgt acgtagcgcc aaccctactt caaggactca cagagctttg taaggaaaag
      661 ccaccagacc cttacctctg gctcgctgat tggctgatga aaaataatcc caacaaacct
      721 aaactttgtc atttcccagt gacagaagag ccttagattg ctcctcagag cgagagccaa
      781 gttaccttac tgtaagaagc cgctccccat gttctttaca ttaaaagcat atatgtgtct
      841 ctgtgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
