LOCUS       NM_019731                863 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Mus musculus NME/NM23 nucleoside diphosphate kinase 4 (Nme4), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_019731
VERSION     NM_019731.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 863)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 863)
  AUTHORS   Xie,S., Yuan,L., Sui,Y., Feng,S., Li,H. and Li,X.
  TITLE     NME4 mediates metabolic reprogramming and promotes nonalcoholic
            fatty liver disease progression
  JOURNAL   EMBO Rep 25 (1), 378-403 (2024)
   PUBMED   38177901
  REMARK    GeneRIF: NME4 mediates metabolic reprogramming and promotes
            nonalcoholic fatty liver disease progression.
REFERENCE   3  (bases 1 to 863)
  AUTHORS   Lacombe,M.L., Lamarche,F., De Wever,O., Padilla-Benavides,T.,
            Carlson,A., Khan,I., Huna,A., Vacher,S., Calmel,C., Desbourdes,C.,
            Cottet-Rousselle,C., Hininger-Favier,I., Attia,S.,
            Nawrocki-Raby,B., Raingeaud,J., Machon,C., Guitton,J., Le Gall,M.,
            Clary,G., Broussard,C., Chafey,P., Therond,P., Bernard,D.,
            Fontaine,E., Tokarska-Schlattner,M., Steeg,P., Bieche,I.,
            Schlattner,U. and Boissan,M.
  TITLE     The mitochondrially-localized nucleoside diphosphate kinase D
            (NME4) is a novel metastasis suppressor
  JOURNAL   BMC Biol 19 (1), 228 (2021)
   PUBMED   34674701
  REMARK    GeneRIF: The mitochondrially-localized nucleoside diphosphate
            kinase D (NME4) is a novel metastasis suppressor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 863)
  AUTHORS   Ernst,O., Sun,J., Lin,B., Banoth,B., Dorrington,M.G., Liang,J.,
            Schwarz,B., Stromberg,K.A., Katz,S., Vayttaden,S.J.,
            Bradfield,C.J., Slepushkina,N., Rice,C.M., Buehler,E.,
            Khillan,J.S., McVicar,D.W., Bosio,C.M., Bryant,C.E.,
            Sutterwala,F.S., Martin,S.E., Lal-Nag,M. and Fraser,I.D.C.
  TITLE     A genome-wide screen uncovers multiple roles for mitochondrial
            nucleoside diphosphate kinase D in inflammasome activation
  JOURNAL   Sci Signal 14 (694) (2021)
   PUBMED   34344832
  REMARK    GeneRIF: A genome-wide screen uncovers multiple roles for
            mitochondrial nucleoside diphosphate kinase D in inflammasome
            activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 863)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 863)
  AUTHORS   Amrein,L., Barraud,P., Daniel,J.Y., Perel,Y. and Landry,M.
  TITLE     Expression patterns of nm23 genes during mouse organogenesis
  JOURNAL   Cell Tissue Res 322 (3), 365-378 (2005)
   PUBMED   16082520
REFERENCE   7  (bases 1 to 863)
  AUTHORS   Cai,J., Ash,D., Kotch,L.E., Jabs,E.W., Attie-Bitach,T., Auge,J.,
            Mattei,G., Etchevers,H., Vekemans,M., Korshunova,Y., Tidwell,R.,
            Messina,D.N., Winston,J.B. and Lovett,M.
  TITLE     Gene expression in pharyngeal arch 1 during human embryonic
            development
  JOURNAL   Hum Mol Genet 14 (7), 903-912 (2005)
   PUBMED   15703188
REFERENCE   8  (bases 1 to 863)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 863)
  AUTHORS   Gallagher,B.C., Parrott,K.A., Szabo,G. and de S Otero,A.
  TITLE     Receptor activation regulates cortical, but not vesicular
            localization of NDP kinase
  JOURNAL   J Cell Sci 116 (Pt 15), 3239-3250 (2003)
   PUBMED   12829743
REFERENCE   10 (bases 1 to 863)
  AUTHORS   Masse,K., Dabernat,S., Bourbon,P.M., Larou,M., Amrein,L.,
            Barraud,P., Perel,Y., Camara,M., Landry,M., Lacombe,M.L. and
            Daniel,J.Y.
  TITLE     Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes:
            comparison with their human orthologs
  JOURNAL   Gene 296 (1-2), 87-97 (2002)
   PUBMED   12383506
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF153451.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF153451.1, BC027277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.06 cM"
     gene            1..863
                     /gene="Nme4"
                     /gene_synonym="2610027N22Rik; 2810024O08Rik;
                     5730493H09Rik; NDK; NDPKD; NM23-M4; Nm23M4"
                     /note="NME/NM23 nucleoside diphosphate kinase 4"
                     /db_xref="GeneID:56520"
                     /db_xref="MGI:MGI:1931148"
     exon            1..106
                     /gene="Nme4"
                     /gene_synonym="2610027N22Rik; 2810024O08Rik;
                     5730493H09Rik; NDK; NDPKD; NM23-M4; Nm23M4"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..579
                     /gene="Nme4"
                     /gene_synonym="2610027N22Rik; 2810024O08Rik;
                     5730493H09Rik; NDK; NDPKD; NM23-M4; Nm23M4"
                     /EC_number="2.7.4.6"
                     /note="expressed in non-metastatic cells 4, protein;
                     nucleoside diphosphate kinase, mitochondrial; NDP kinase,
                     mitochondrial; nucleoside diphosphate kinase D;
                     non-metastatic cells 4, protein expressed in"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase, mitochondrial
                     precursor"
                     /protein_id="NP_062705.1"
                     /db_xref="CCDS:CCDS28544.1"
                     /db_xref="GeneID:56520"
                     /db_xref="MGI:MGI:1931148"
                     /translation="MGSLFGRVAALRALLCGPRFQCLLVRPSSGGPPWPQERTLVAVK
                     PDGVQRRLVGTVIQRFERRGFKLVGMKMLQAPESILAEHYRDLQRKPFYPALISYMSS
                     GPVVAMVWEGPNVVHISRAMIGHTDSTEAAPGTIRGDFSVHISRNVIHASDSVDGAQR
                     EIELWFQSSELLNWADGGHHSSCYPA"
     exon            107..240
                     /gene="Nme4"
                     /gene_synonym="2610027N22Rik; 2810024O08Rik;
                     5730493H09Rik; NDK; NDPKD; NM23-M4; Nm23M4"
                     /inference="alignment:Splign:2.1.0"
     exon            241..342
                     /gene="Nme4"
                     /gene_synonym="2610027N22Rik; 2810024O08Rik;
                     5730493H09Rik; NDK; NDPKD; NM23-M4; Nm23M4"
                     /inference="alignment:Splign:2.1.0"
     exon            343..455
                     /gene="Nme4"
                     /gene_synonym="2610027N22Rik; 2810024O08Rik;
                     5730493H09Rik; NDK; NDPKD; NM23-M4; Nm23M4"
                     /inference="alignment:Splign:2.1.0"
     exon            456..863
                     /gene="Nme4"
                     /gene_synonym="2610027N22Rik; 2810024O08Rik;
                     5730493H09Rik; NDK; NDPKD; NM23-M4; Nm23M4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcgccag cccgcaacat gggcagcctt ttcgggcgcg tcgcggcgct gcgggcgctg
       61 ttgtgcgggc cacgctttca gtgcctgctg gtgcgcccca gttccggagg ccccccctgg
      121 ccccaagagc ggacgctggt tgctgtgaag ccagatgggg tacagaggag actagtgggg
      181 actgtgatac aacgctttga gaggcggggc ttcaagctcg tggggatgaa gatgctgcag
      241 gcaccagaaa gcatccttgc tgagcactac cgggacctac agaggaagcc attctaccca
      301 gctcttatca gctacatgag ctctgggcct gtggtggcca tggtctggga aggccccaat
      361 gtggtccata tctcaagggc catgatagga cacaccgact caacagaggc agcccccggg
      421 acaatcaggg gcgacttcag tgttcacatc agcaggaacg tcatccatgc tagcgattct
      481 gtggatgggg cccagaggga gatcgagctg tggtttcaga gcagcgaact gttgaactgg
      541 gcagatggtg gtcaccacag cagctgctac cctgcctgag ggcttgcact gccttctgca
      601 cttcaggtct acccatgacc tactacctct gtcaacaaga agtcaagccc ccatgcttcc
      661 catgtcccca aaccactccc tactcccgct ctacccaact ccagcccagg ggagtctaag
      721 cctcaactct atgtgccttt ttgtatccta agtcaataca atattggacc atgtccttgt
      781 gtacaaaagt gccagacaac ctttggggca ttgtcaaagg tgacttcacc tgcctcaaag
      841 gagagacatt aaaattttat gct
//
