LOCUS       NM_019730                724 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus NME/NM23 nucleoside diphosphate kinase 3 (Nme3), mRNA.
ACCESSION   NM_019730
VERSION     NM_019730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 724)
  AUTHORS   Chen,C.W., Su,C., Huang,C.Y., Huang,X.R., Cuili,X., Chao,T.,
            Fan,C.H., Ting,C.W., Tsai,Y.W., Yang,K.C., Yeh,T.Y., Hsieh,S.T.,
            Chen,Y.J., Feng,Y., Hunter,T. and Chang,Z.F.
  TITLE     NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia
  JOURNAL   Nat Commun 15 (1), 2264 (2024)
   PUBMED   38480688
  REMARK    GeneRIF: NME3 is a gatekeeper for DRP1-dependent mitophagy in
            hypoxia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 724)
  AUTHORS   Zurkirchen,L., Varum,S., Giger,S., Klug,A., Hausel,J., Bossart,R.,
            Zemke,M., Cantu,C., Atak,Z.K., Zamboni,N., Basler,K. and Sommer,L.
  TITLE     Yin Yang 1 sustains biosynthetic demands during brain development
            in a stage-specific manner
  JOURNAL   Nat Commun 10 (1), 2192 (2019)
   PUBMED   31097699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 724)
  AUTHORS   Hoff,S., Epting,D., Falk,N., Schroda,S., Braun,D.A., Halbritter,J.,
            Hildebrandt,F., Kramer-Zucker,A., Bergmann,C., Walz,G. and
            Lienkamp,S.S.
  TITLE     The nucleoside-diphosphate kinase NME3 associates with
            nephronophthisis proteins and is required for ciliary function
            during renal development
  JOURNAL   J Biol Chem 293 (39), 15243-15255 (2018)
   PUBMED   30111592
REFERENCE   4  (bases 1 to 724)
  AUTHORS   Mathews,C.K.
  TITLE     Deoxyribonucleotide metabolism, mutagenesis and cancer
  JOURNAL   Nat Rev Cancer 15 (9), 528-539 (2015)
   PUBMED   26299592
  REMARK    Review article
REFERENCE   5  (bases 1 to 724)
  AUTHORS   Bauer,H., Schindler,S., Charron,Y., Willert,J., Kusecek,B. and
            Herrmann,B.G.
  TITLE     The nucleoside diphosphate kinase gene Nme3 acts as quantitative
            trait locus promoting non-Mendelian inheritance
  JOURNAL   PLoS Genet 8 (3), e1002567 (2012)
   PUBMED   22438820
  REMARK    GeneRIF: NME3 protein interacts with RHO signaling cascades to
            impair sperm motility through hyperactivation of SMOK, the
            wild-type form of the responder.
REFERENCE   6  (bases 1 to 724)
  AUTHORS   Amrein,L., Barraud,P., Daniel,J.Y., Perel,Y. and Landry,M.
  TITLE     Expression patterns of nm23 genes during mouse organogenesis
  JOURNAL   Cell Tissue Res 322 (3), 365-378 (2005)
   PUBMED   16082520
REFERENCE   7  (bases 1 to 724)
  AUTHORS   Matsui,T., Hayashi-Kisumi,F., Kinoshita,Y., Katahira,S., Morita,K.,
            Miyachi,Y., Ono,Y., Imai,T., Tanigawa,Y., Komiya,T. and Tsukita,S.
  TITLE     Identification of novel keratinocyte-secreted peptides
            dermokine-alpha/-beta and a new stratified epithelium-secreted
            protein gene complex on human chromosome 19q13.1
  JOURNAL   Genomics 84 (2), 384-397 (2004)
   PUBMED   15234001
REFERENCE   8  (bases 1 to 724)
  AUTHORS   Masse,K., Dabernat,S., Bourbon,P.M., Larou,M., Amrein,L.,
            Barraud,P., Perel,Y., Camara,M., Landry,M., Lacombe,M.L. and
            Daniel,J.Y.
  TITLE     Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes:
            comparison with their human orthologs
  JOURNAL   Gene 296 (1-2), 87-97 (2002)
   PUBMED   12383506
REFERENCE   9  (bases 1 to 724)
  AUTHORS   Erent,M., Gonin,P., Cherfils,J., Tissier,P., Raschella,G.,
            Giartosio,A., Agou,F., Sarger,C., Lacombe,M.L., Konrad,M. and
            Lascu,I.
  TITLE     Structural and catalytic properties and homology modelling of the
            human nucleoside diphosphate kinase C, product of the DRnm23 gene
  JOURNAL   Eur J Biochem 268 (7), 1972-1981 (2001)
   PUBMED   11277919
REFERENCE   10 (bases 1 to 724)
  AUTHORS   Kargul,G.J., Nagaraja,R., Shimada,T., Grahovac,M.J., Lim,M.K.,
            Nakashima,H., Waeltz,P., Ma,P., Chen,E., Schlessinger,D. and
            Ko,M.S.
  TITLE     Eleven densely clustered genes, six of them novel, in 176 kb of
            mouse t-complex DNA
  JOURNAL   Genome Res 10 (7), 916-923 (2000)
   PUBMED   10899141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166102.2 and AK007399.1.
            
            On Aug 5, 2009 this sequence version replaced NM_019730.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007399.1, AU035459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC166102.2         45835-45838         c
            5-715               AK007399.1         5-715
            716-724             AC166102.2         44807-44815         c
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..724
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
                     /note="NME/NM23 nucleoside diphosphate kinase 3"
                     /db_xref="GeneID:79059"
                     /db_xref="MGI:MGI:1930182"
     exon            1..60
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..524
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
                     /EC_number="2.7.4.6"
                     /note="expressed in non-metastatic cells 3; nucleoside
                     diphosphate kinase DR-nm23; non-metastatic cells 3,
                     protein expressed in; nucleoside diphosphate kinase 3; NDK
                     3; NDPKC; NDP kinase 3; nucleoside diphosphate kinase C"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase 3 precursor"
                     /protein_id="NP_062704.2"
                     /db_xref="CCDS:CCDS28503.1"
                     /db_xref="GeneID:79059"
                     /db_xref="MGI:MGI:1930182"
                     /translation="MICLVLTIFANLFPSAYSGVNERTFLAVKPDGVQRRLVGEIVRR
                     FERKGFKLVALKLVQASEELLREHYVELREKPFYSRLVKYMSSGPVVAMVWQGLDVVH
                     ASRALIGATDPGDAMPGTIRGDFCMEVGKNVIHGSDSVESAHREIALWFREAELLCWE
                     DSAGHWLYE"
     exon            61..191
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..293
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
                     /inference="alignment:Splign:2.1.0"
     exon            294..406
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
                     /inference="alignment:Splign:2.1.0"
     exon            407..724
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      676..681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
                     /note="hexamer: AATAAA"
     polyA_site      697
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
                     /note="major polyA site"
     polyA_site      724
                     /gene="Nme3"
                     /gene_synonym="1810009F08Rik; DR-nm23; Ndk3; Nm23-DR;
                     Nm23-M3"
ORIGIN      
        1 ccccatccgc cgccatgatc tgtctggtgc tgaccatctt tgctaacctc ttcccctcag
       61 cctacagcgg cgtgaacgag cgcacgttct tggcagtgaa gcccgacggc gtgcagcggc
      121 ggctggtggg cgagatcgtg cgtcgctttg agaggaaggg cttcaagctg gtggcactga
      181 agctagtgca ggcctccgaa gagctactgc gggagcatta tgtcgagctg cgcgagaaac
      241 ccttctacag ccgactggtt aaatacatga gttctggccc cgtggtggcc atggtgtggc
      301 aagggctgga tgtcgtgcat gcttcgcgag ccctcatagg ggccactgac ccaggggacg
      361 ccatgcccgg tacgatccgt ggggatttct gcatggaggt tggcaagaat gtaattcatg
      421 gcagcgactc ggtggaaagt gctcacagag aaatcgctct ttggttccgt gaggccgagc
      481 ttctgtgctg ggaggacagc gccggacatt ggctatatga gtagatgtta ttgcagtcag
      541 cattaccaat ctggaggttg ttggtcttct gtgatcttca cagagctcag catcagtaac
      601 agtgctgtgt gagtgcaggt caacccaacc tagtcggtcc agggacaacc actcccaccc
      661 cttgttgcct ttcataataa aactgcagaa aacccttgtg cgctggtgaa gtttcaagac
      721 aaaa
//
