LOCUS       NM_008705               1027 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus NME/NM23 nucleoside diphosphate kinase 2 (Nme2),
            transcript variant 1, mRNA.
ACCESSION   NM_008705
VERSION     NM_008705.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1027)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1027)
  AUTHORS   Iuso,D., Garcia-Saez,I., Coute,Y., Yamaryo-Botte,Y., Boeri Erba,E.,
            Adrait,A., Zeaiter,N., Tokarska-Schlattner,M., Jilkova,Z.M.,
            Boussouar,F., Barral,S., Signor,L., Couturier,K., Hajmirza,A.,
            Chuffart,F., Bourova-Flin,E., Vitte,A.L., Bargier,L., Puthier,D.,
            Decaens,T., Rousseaux,S., Botte,C., Schlattner,U., Petosa,C. and
            Khochbin,S.
  TITLE     Nucleoside diphosphate kinases 1 and 2 regulate a protective liver
            response to a high-fat diet
  JOURNAL   Sci Adv 9 (36), eadh0140 (2023)
   PUBMED   37672589
REFERENCE   3  (bases 1 to 1027)
  AUTHORS   Leonard,M.K., Puts,G.S., Pamidimukkala,N., Adhikary,G., Xu,Y.,
            Kwok,E., Jin,Y., Snyder,D., Matsangos,N., Novak,M., Mahurkar,A.,
            Shetty,A.C., Slominski,R.M., De Fabo,E.C., Noonan,F.P., Day,C.P.,
            Rigi,M., Slominski,A.T., Webb,M.G., Craig,D.W., Merlino,G.,
            Eckert,R.L., Carpten,J.D., Manojlovic,Z. and Kaetzel,D.M.
  TITLE     Comprehensive molecular profiling of UV-induced metastatic melanoma
            in Nme1/Nme2-deficient mice reveals novel markers of survival in
            human patients
  JOURNAL   Oncogene 40 (45), 6329-6342 (2021)
   PUBMED   34433909
  REMARK    GeneRIF: Comprehensive molecular profiling of UV-induced metastatic
            melanoma in Nme1/Nme2-deficient mice reveals novel markers of
            survival in human patients.
            Erratum:[Oncogene. 2021 Nov;40(45):6394. doi:
            10.1038/s41388-021-02045-4.. PMID: 34635800]
REFERENCE   4  (bases 1 to 1027)
  AUTHORS   Pamidimukkala,N., Puts,G.S., Kathryn Leonard,M., Snyder,D.,
            Dabernat,S., De Fabo,E.C., Noonan,F.P., Slominski,A., Merlino,G.
            and Kaetzel,D.M.
  TITLE     Nme1 and Nme2 genes exert metastasis-suppressor activities in a
            genetically engineered mouse model of UV-induced melanoma
  JOURNAL   Br J Cancer 124 (1), 161-165 (2021)
   PUBMED   33024267
  REMARK    GeneRIF: Nme1 and Nme2 genes exert metastasis-suppressor activities
            in a genetically engineered mouse model of UV-induced melanoma.
REFERENCE   5  (bases 1 to 1027)
  AUTHORS   Chatterjee,A., Eshwaran,R., Poschet,G., Lomada,S., Halawa,M.,
            Wilhelm,K., Schmidt,M., Hammes,H.P., Wieland,T. and Feng,Y.
  TITLE     Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial
            Damage via Activation of the Hexosamine Biosynthesis Pathway and
            Suppression of O-GlcNAcase Activity
  JOURNAL   Cells 9 (10), 2324 (2020)
   PUBMED   33086728
  REMARK    GeneRIF: Involvement of NDPK-B in Glucose Metabolism-Mediated
            Endothelial Damage via Activation of the Hexosamine Biosynthesis
            Pathway and Suppression of O-GlcNAcase Activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1027)
  AUTHORS   Schaertl,S., Konrad,M. and Geeves,M.A.
  TITLE     Substrate specificity of human nucleoside-diphosphate kinase
            revealed by transient kinetic analysis
  JOURNAL   J Biol Chem 273 (10), 5662-5669 (1998)
   PUBMED   9488696
REFERENCE   7  (bases 1 to 1027)
  AUTHORS   Huijzer,J.C., McFarland,M., Niles,R.M. and Meadows,G.G.
  TITLE     Phorbol 12-myristate 13-acetate enhances nm23 gene expression in
            murine melanocytes but not in syngeneic B16-BL6 melanoma variants
  JOURNAL   J Cell Physiol 166 (3), 487-494 (1996)
   PUBMED   8600152
REFERENCE   8  (bases 1 to 1027)
  AUTHORS   Jiang,X.P., Tang,Z.Y., Liu,K.D., Zhou,X.D., Lin,Z.Y., Ling,M.Y. and
            Wu,X.F.
  TITLE     mRNA levels of nm23 in murine ascites hepatoma (H22) clones with
            different lymphatic metastatic potential
  JOURNAL   J Cancer Res Clin Oncol 122 (1), 55-58 (1996)
   PUBMED   8543593
REFERENCE   9  (bases 1 to 1027)
  AUTHORS   Parker,C. and Sherbet,G.V.
  TITLE     Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7
            alter the expression of metastasis-associated genes MTS1 and NM23
            in metastatic variants of the B16 murine melanoma
  JOURNAL   Melanoma Res 2 (5-6), 337-343 (1992)
   PUBMED   1337998
REFERENCE   10 (bases 1 to 1027)
  AUTHORS   Urano,T., Takamiya,K., Furukawa,K. and Shiku,H.
  TITLE     Molecular cloning and functional expression of the second mouse
            nm23/NDP kinase gene, nm23-M2
  JOURNAL   FEBS Lett 309 (3), 358-362 (1992)
   PUBMED   1325378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066995.1 and BC086893.1.
            
            On Oct 19, 2013 this sequence version replaced NM_008705.4.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066995.1, AI386309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1008              BC066995.1         1-1008
            1009-1027           BC086893.1         634-652
FEATURES             Location/Qualifiers
     source          1..1027
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.88 cM"
     gene            1..1027
                     /gene="Nme2"
                     /gene_synonym="NM23-H2; nm23-M2; NM23B"
                     /note="NME/NM23 nucleoside diphosphate kinase 2"
                     /db_xref="GeneID:18103"
                     /db_xref="MGI:MGI:97356"
     exon            1..431
                     /gene="Nme2"
                     /gene_synonym="NM23-H2; nm23-M2; NM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            432..561
                     /gene="Nme2"
                     /gene_synonym="NM23-H2; nm23-M2; NM23B"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..894
                     /gene="Nme2"
                     /gene_synonym="NM23-H2; nm23-M2; NM23B"
                     /EC_number="2.7.4.6"
                     /EC_number="2.7.13.3"
                     /note="nucleoside-diphosphate kinase 2; expressed in
                     non-metastatic cells 2 protein; P18; NDK B; NDP kinase B;
                     histidine protein kinase NDKB; non-metastatic cells 2,
                     protein (NM23B) expressed in"
                     /codon_start=1
                     /product="nucleoside diphosphate kinase B"
                     /protein_id="NP_032731.1"
                     /db_xref="CCDS:CCDS25246.1"
                     /db_xref="GeneID:18103"
                     /db_xref="MGI:MGI:97356"
                     /translation="MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRAS
                     EEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPG
                     TIRGDFCIQVGRNIIHGSDSVESAEKEIHLWFKPEELIDYKSCAHDWVYE"
     exon            562..663
                     /gene="Nme2"
                     /gene_synonym="NM23-H2; nm23-M2; NM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            664..776
                     /gene="Nme2"
                     /gene_synonym="NM23-H2; nm23-M2; NM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1009
                     /gene="Nme2"
                     /gene_synonym="NM23-H2; nm23-M2; NM23B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggctga atttcggaga taggaaaaac tcggggtatc ccagagcatg gagagtccag
       61 ctgggcgcgg atgtctcagg gaagcttgaa tgcagatgtc tcctggaata aattcaggac
      121 ctggtctcca aagctgaagc ctttagctgc aaagaacagg cggacttggg tggagaacaa
      181 atcacttcct gccccgcagc cctccgcagc cctgcaagga gagggcgtgc accgcgagcc
      241 tttgggcggg gacagagacg actggcaaga ccaggcagcc tgagcgtccc gggttgggca
      301 gcggggtcct ccggggtgtg gcgtctctcg tcccgccccg cgtccctcct ctctccgcgc
      361 cggctggtgg tcgttctatt ctctttgctt ctgtcgctca tcgcagacac cagccgaccc
      421 accggctttc ggaccatggc caacctcgag cgtaccttca ttgccatcaa gccagatggc
      481 gtgcagcgcg gcctggtggg cgagatcatc aaacggttcg agcagaaggg gttccgcctg
      541 gtggccatga agttccttcg ggcctctgaa gaacacctga agcagcatta catcgacctg
      601 aaagaccgtc ctttcttccc ggggctggtg aagtacatga actcggggcc cgtggtggcc
      661 atggtctggg aggggctcaa tgtggtgaaa acgggccgag tgatgctggg ggagaccaat
      721 ccagctgatt caaaaccagg caccatccgt ggggatttct gcattcaagt tggcaggaac
      781 atcattcatg gcagtgattc agtggagagt gctgagaaag agatccatct gtggtttaag
      841 cccgaagaac tgatcgacta caagtcttgt gcccatgact gggtgtacga gtagacatga
      901 agaaaccaga atccttttca gcactactga tgggtttctg gacagagctc ttcatcccac
      961 tgacaggatg gatcatcttt tctaaaacaa taaagacttt ggaactgaga aaaaaaaaaa
     1021 aaaaaaa
//
