LOCUS       NM_008704                986 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus NME/NM23 nucleoside diphosphate kinase 1 (Nme1),
            transcript variant 1, mRNA.
ACCESSION   NM_008704 XM_914818
VERSION     NM_008704.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 986)
  AUTHORS   Kaur,G., Helmer,R.A., Martinez-Marin,D., Sennoune,S.R.,
            Washburn,R.L., Martinez-Zaguilan,R., Dufour,J.M. and Chilton,B.S.
  TITLE     Helicase-like transcription factor (Hltf)-deletion activates
            Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic beta
            cells resulting in neonatal lethality
  JOURNAL   PLoS One 18 (8), e0286109 (2023)
   PUBMED   37624843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 986)
  AUTHORS   Eliason,S., Hong,L., Sweat,Y., Chalkley,C., Cao,H., Liu,Q., Qi,H.,
            Xu,H., Zhan,F. and Amendt,B.A.
  TITLE     Extracellular vesicle expansion of PMIS-miR-210 expression inhibits
            colorectal tumour growth via apoptosis and an XIST/NME1 regulatory
            mechanism
  JOURNAL   Clin Transl Med 12 (9), e1037 (2022)
   PUBMED   36116139
  REMARK    GeneRIF: Extracellular vesicle expansion of PMIS-miR-210 expression
            inhibits colorectal tumour growth via apoptosis and an XIST/NME1
            regulatory mechanism.
REFERENCE   3  (bases 1 to 986)
  AUTHORS   Leonard,M.K., Puts,G.S., Pamidimukkala,N., Adhikary,G., Xu,Y.,
            Kwok,E., Jin,Y., Snyder,D., Matsangos,N., Novak,M., Mahurkar,A.,
            Shetty,A.C., Slominski,R.M., De Fabo,E.C., Noonan,F.P., Day,C.P.,
            Rigi,M., Slominski,A.T., Webb,M.G., Craig,D.W., Merlino,G.,
            Eckert,R.L., Carpten,J.D., Manojlovic,Z. and Kaetzel,D.M.
  TITLE     Comprehensive molecular profiling of UV-induced metastatic melanoma
            in Nme1/Nme2-deficient mice reveals novel markers of survival in
            human patients
  JOURNAL   Oncogene 40 (45), 6329-6342 (2021)
   PUBMED   34433909
  REMARK    GeneRIF: Comprehensive molecular profiling of UV-induced metastatic
            melanoma in Nme1/Nme2-deficient mice reveals novel markers of
            survival in human patients.
            Erratum:[Oncogene. 2021 Nov;40(45):6394. doi:
            10.1038/s41388-021-02045-4.. PMID: 34635800]
REFERENCE   4  (bases 1 to 986)
  AUTHORS   Pamidimukkala,N., Puts,G.S., Kathryn Leonard,M., Snyder,D.,
            Dabernat,S., De Fabo,E.C., Noonan,F.P., Slominski,A., Merlino,G.
            and Kaetzel,D.M.
  TITLE     Nme1 and Nme2 genes exert metastasis-suppressor activities in a
            genetically engineered mouse model of UV-induced melanoma
  JOURNAL   Br J Cancer 124 (1), 161-165 (2021)
   PUBMED   33024267
  REMARK    GeneRIF: Nme1 and Nme2 genes exert metastasis-suppressor activities
            in a genetically engineered mouse model of UV-induced melanoma.
REFERENCE   5  (bases 1 to 986)
  AUTHORS   Gong,H., Fan,Z., Yi,D., Chen,J., Li,Z., Guo,R., Wang,C., Fang,W.
            and Liu,S.
  TITLE     Histidine kinase NME1 and NME2 are involved in TGF-beta1-induced
            HSC activation and CCl4-induced liver fibrosis
  JOURNAL   J Mol Histol 51 (5), 573-581 (2020)
   PUBMED   32860079
  REMARK    GeneRIF: Histidine kinase NME1 and NME2 are involved in
            TGF-beta1-induced HSC activation and CCl4-induced liver fibrosis.
REFERENCE   6  (bases 1 to 986)
  AUTHORS   Parker,C. and Sherbet,G.V.
  TITLE     Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7
            alter the expression of metastasis-associated genes MTS1 and NM23
            in metastatic variants of the B16 murine melanoma
  JOURNAL   Melanoma Res 2 (5-6), 337-343 (1992)
   PUBMED   1337998
REFERENCE   7  (bases 1 to 986)
  AUTHORS   Caligo,M.A., Cipollini,G., Cope Di Valromita,A., Bistocchi,M. and
            Bevilacqua,G.
  TITLE     Decreasing expression of NM23 gene in metastatic murine mammary
            tumors of viral etiology (MMTV)
  JOURNAL   Anticancer Res 12 (3), 969-973 (1992)
   PUBMED   1320361
REFERENCE   8  (bases 1 to 986)
  AUTHORS   Varesco,L., Caligo,M.A., Simi,P., Black,D.M., Nardini,V.,
            Casarino,L., Rocchi,M., Ferrara,G., Solomon,E. and Bevilacqua,G.
  TITLE     The NM23 gene maps to human chromosome band 17q22 and shows a
            restriction fragment length polymorphism with BglII
  JOURNAL   Genes Chromosomes Cancer 4 (1), 84-88 (1992)
   PUBMED   1377015
REFERENCE   9  (bases 1 to 986)
  AUTHORS   Leone,A., Flatow,U., King,C.R., Sandeen,M.A., Margulies,I.M.,
            Liotta,L.A. and Steeg,P.S.
  TITLE     Reduced tumor incidence, metastatic potential, and cytokine
            responsiveness of nm23-transfected melanoma cells
  JOURNAL   Cell 65 (1), 25-35 (1991)
   PUBMED   2013093
REFERENCE   10 (bases 1 to 986)
  AUTHORS   Rosengard,A.M., Krutzsch,H.C., Shearn,A., Biggs,J.R., Barker,E.,
            Margulies,I.M., King,C.R., Liotta,L.A. and Steeg,P.S.
  TITLE     Reduced Nm23/Awd protein in tumour metastasis and aberrant
            Drosophila development
  JOURNAL   Nature 342 (6246), 177-180 (1989)
   PUBMED   2509941
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662838.12.
            
            On Mar 12, 2020 this sequence version replaced NM_008704.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U85511.1, DV064653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL662838.12        50976-51027         c
            53-182              AL662838.12        48563-48692         c
            183-284             AL662838.12        45982-46083         c
            285-397             AL662838.12        43423-43535         c
            398-986             AL662838.12        41680-42268         c
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.89 cM"
     gene            1..986
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
                     /note="NME/NM23 nucleoside diphosphate kinase 1"
                     /db_xref="GeneID:18102"
                     /db_xref="MGI:MGI:97355"
     exon            1..52
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
                     /inference="alignment:Splign:2.1.0"
     exon            53..182
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
                     /inference="alignment:Splign:2.1.0"
     exon            183..284
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
                     /inference="alignment:Splign:2.1.0"
     exon            285..397
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
                     /inference="alignment:Splign:2.1.0"
     exon            398..986
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      660..665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
                     /note="hexamer: ATTAAA"
     polyA_site      679
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
                     /note="major polyA site"
     regulatory      968..973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
                     /note="hexamer: AATAAA"
     polyA_site      986
                     /gene="Nme1"
                     /gene_synonym="NDPK-A; NM23-M1; NM23A"
ORIGIN      
        1 gtttccggtg cgggcagtcg cagccggcgg taaagccttg tcatctgaag gggaccatgg
       61 ccaacagtga gcgcaccttc attgccatca agcctgatgg ggtccagcgg gggctggtgg
      121 gcgagatcat caagcggttc gagcagaagg ggttccgcct tgttggtctg aagtttctgc
      181 aggcttcaga ggaccttctc aaggagcact acactgacct gaaggaccgc cccttcttta
      241 ctggcctggt gaaatacatg cactcaggac cagtggttgc tatggtctgg gagggtctga
      301 atgtggtgaa gacaggccgc gtgatgcttg gagagaccaa ccccgcagac tctaagcctg
      361 ggaccatacg aggagacttc tgcatccaag ttggcaggaa catcattcat ggcagcgatt
      421 ctgtaaagag cgcagagaag gagatcagct tgtggtttca gcctgaggag ctggtggagt
      481 acaagagctg tgcgcagaac tggatctatg agtgacagga cggtgctggt tttctacctg
      541 cttactcttg ttctcacagg caggggacca gcaaccctag atatttctgg aacttctttg
      601 acctggaagg aacctttggg agctgtgact ccctgtgcag tgttacgtgc cactgttaga
      661 ttaaagtgtt taatctgtac tttgtattgc tgtacagctc tgcattcctt acctccttca
      721 ggcttctgga taatctgagt ggacagaatg taaatgtttt acaaattact tatattggcc
      781 tcatgtgcac acagagattc ttttcatttg tggtttgagc caccaccctg agacacaagg
      841 gcatttcttt gtctatctcc cttcctatca cctgtgttct gttctctcct ggcacagtca
      901 gacaacaatt tgtgtggagg atgtgtgagg ttgtgaaaac tgttctggga acagagaatt
      961 cattagaaat aaagatgcca agccaa
//
