LOCUS       NM_008703               2417 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus neuromedin B receptor (Nmbr), mRNA.
ACCESSION   NM_008703
VERSION     NM_008703.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2417)
  AUTHORS   Bento-Bernardes,T., Rossetti,C.L., Borba Vieira de Andrade,C.,
            Lopes de Souza,L., Wilieman Cabral,M., Silva Monteiro de Paula,G.,
            Woyames,J., Jesus Oliveira,K., Seixas da-Silva,W. and Cabanelas
            Pazos-Moura,C.
  TITLE     Disruption of neuromedin B receptor improves mitochondrial
            oxidative phosphorylation capacity in gastrocnemius muscle of
            female mice
  JOURNAL   Am J Physiol Endocrinol Metab 322 (3), E250-E259 (2022)
   PUBMED   35068177
  REMARK    GeneRIF: Disruption of neuromedin B receptor improves mitochondrial
            oxidative phosphorylation capacity in gastrocnemius muscle of
            female mice.
REFERENCE   2  (bases 1 to 2417)
  AUTHORS   Meng,Q.T., Liu,X.Y., Liu,X.T., Liu,J., Munanairi,A., Barry,D.M.,
            Liu,B., Jin,H., Sun,Y., Yang,Q., Gao,F., Wan,L., Peng,J., Jin,J.H.,
            Shen,K.F., Kim,R., Yin,J., Tao,A. and Chen,Z.F.
  TITLE     BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR
            crosstalk
  JOURNAL   Elife 10, e71689 (2021)
   PUBMED   34919054
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2417)
  AUTHORS   Li,F., Jiang,H., Shen,X., Yang,W., Guo,C., Wang,Z., Xiao,M.,
            Cui,L., Luo,W., Kim,B.S., Chen,Z., Huang,A.J.W. and Liu,Q.
  TITLE     Sneezing reflex is mediated by a peptidergic pathway from nose to
            brainstem
  JOURNAL   Cell 184 (14), 3762-3773 (2021)
   PUBMED   34133943
REFERENCE   4  (bases 1 to 2417)
  AUTHORS   Yang,G., Huang,H., Tang,M., Cai,Z., Huang,C., Qi,B. and Chen,J.L.
  TITLE     Role of neuromedin B and its receptor in the innate immune
            responses against influenza A virus infection in vitro and in vivo
  JOURNAL   Vet Res 50 (1), 80 (2019)
   PUBMED   31601264
  REMARK    GeneRIF: NMB-treated mice were less susceptible to virus challenge,
            as evidenced by increased survival, increased body weight, and
            decreased viral NP expression compared with the control animals. As
            expected, opposing effects were observed in the NMBR
            antagonist-treated cells and mice, which further confirmed the
            effects of NMB.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2417)
  AUTHORS   de Paula,G.S.M., Wilieman,M., Silva,K.R., Baptista,L.S.,
            Boudina,S., de Souza,L.L., Bento-Bernardes,T., Asensi,K.D.,
            Goldenberg,R.C.D.S. and Pazos-Moura,C.C.
  TITLE     Neuromedin B receptor disruption impairs adipogenesis in mice and
            3T3-L1 cells
  JOURNAL   J Mol Endocrinol 63 (1), 93-102 (2019)
   PUBMED   31067509
  REMARK    GeneRIF: Data show genetically disruption of NB-R in mice ASC or
            pharmacological antagonism of NB-R in 3T3-L1 cells impairs
            adipogenesis.
REFERENCE   6  (bases 1 to 2417)
  AUTHORS   Yamano,M., Ogura,H., Okuyama,S. and Ohki-Hamazaki,H.
  TITLE     Modulation of 5-HT system in mice with a targeted disruption of
            neuromedin B receptor
  JOURNAL   J Neurosci Res 68 (1), 59-64 (2002)
   PUBMED   11933049
REFERENCE   7  (bases 1 to 2417)
  AUTHORS   Yamada,K., Santo-Yamada,Y., Wada,E. and Wada,K.
  TITLE     Role of bombesin (BN)-like peptides/receptors in emotional behavior
            by comparison of three strains of BN-like peptide receptor knockout
            mice
  JOURNAL   Mol Psychiatry 7 (1), 113-117 (2002)
   PUBMED   11803457
  REMARK    GeneRIF: NMB-R-deficient mice exhibited decreased behavior in both
            the L-D box and elevated plus maze tests.
REFERENCE   8  (bases 1 to 2417)
  AUTHORS   Ohki-Hamazaki,H., Sakai,Y., Kamata,K., Ogura,H., Okuyama,S.,
            Watase,K., Yamada,K. and Wada,K.
  TITLE     Functional properties of two bombesin-like peptide receptors
            revealed by the analysis of mice lacking neuromedin B receptor
  JOURNAL   J Neurosci 19 (3), 948-954 (1999)
   PUBMED   9920658
REFERENCE   9  (bases 1 to 2417)
  AUTHORS   Ohki-Hamazaki,H., Watase,K., Yamamoto,K., Ogura,H., Yamano,M.,
            Yamada,K., Maeno,H., Imaki,J., Kikuyama,S., Wada,E. and Wada,K.
  TITLE     Mice lacking bombesin receptor subtype-3 develop metabolic defects
            and obesity
  JOURNAL   Nature 390 (6656), 165-169 (1997)
   PUBMED   9367152
REFERENCE   10 (bases 1 to 2417)
  AUTHORS   Ohki-Hamazaki,H., Wada,E., Matsui,K. and Wada,K.
  TITLE     Cloning and expression of the neuromedin B receptor and the third
            subtype of bombesin receptor genes in the mouse
  JOURNAL   Brain Res 762 (1-2), 165-172 (1997)
   PUBMED   9262170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111044.9.
            
            On Feb 14, 2019 this sequence version replaced NM_008703.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119237.1, SRR7652917.932892.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-764               AC111044.9         126143-126906       c
            765-1113            AC111044.9         119828-120176       c
            1114-2417           AC111044.9         115395-116698       c
FEATURES             Location/Qualifiers
     source          1..2417
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 5.5 cM"
     gene            1..2417
                     /gene="Nmbr"
                     /note="neuromedin B receptor"
                     /db_xref="GeneID:18101"
                     /db_xref="MGI:MGI:1100525"
     exon            1..764
                     /gene="Nmbr"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1515
                     /gene="Nmbr"
                     /note="NMB-R; neuromedin-B-preferring bombesin receptor"
                     /codon_start=1
                     /product="neuromedin-B receptor"
                     /protein_id="NP_032729.1"
                     /db_xref="CCDS:CCDS23707.1"
                     /db_xref="GeneID:18101"
                     /db_xref="MGI:MGI:1100525"
                     /translation="MPPRSLSNLSFPTEANESELVPEVWEKDFLPDSDGTTAELVIRC
                     VIPSLYLIIISVGLLGNIMLVKIFLTNSAMRNVPNIFISNLAAGDLLLLLTCVPVDAS
                     RYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVLLWT
                     SLKAVGIWVVSVLLAVPEAVFSEVARIGSLDNSSFTACIPYPQTDELHPKIHSVLIFL
                     VYFLIPLVIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFV
                     FCWFPNHVLYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKH
                     FNSQLCCGRKSYPERSTSYLLSSSAVRMTSLKSNTKNVVTNSVLLNGHSTKQEIAL"
     exon            765..1113
                     /gene="Nmbr"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..2417
                     /gene="Nmbr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2384..2389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nmbr"
                     /note="hexamer: AATAAA"
     polyA_site      2412
                     /gene="Nmbr"
                     /note="major polyA site"
ORIGIN      
        1 ataggcaggt atggctctgg gtcccacagg gactgacctt tgttctcccg ctctctaata
       61 gcggaaacta agccttaaag atagaaaaaa ggctctgctg ctttgctttt tgttttgagt
      121 ttaaatcgca aaccagcggc agtgaaggga acctctccta ggggaagctc tggagcgcag
      181 cgcgcacaga cttctctgca ggacgagcgc ggtggctcag tcccaggagc cacaaacttg
      241 ccaggatcag agacaaatta actaaaccca cgtcgtgctc actgcacttt cgagacgcgc
      301 gagtgcaaga aaactcctgc gagttccctg ggaaaagaaa ccatgccccc caggtctctc
      361 tccaacctct cctttcccac agaggcgaat gagagcgagc tggtacccga ggtgtgggaa
      421 aaggatttcc tgcccgactc agatgggacc accgcggagt tggtgatccg ctgtgtgata
      481 ccatccctct acctaatcat catctcggtg ggtttgctgg gcaacatcat gctggtgaag
      541 atattcctca ccaacagcgc catgcggaat gtccctaaca tcttcatctc taacctggcg
      601 gctggggacc tgctgctgct gctgacctgc gttccagtgg acgcctcccg ttacttcttt
      661 gatgaatggg tgttcggcaa gctgggctgc aaactcatcc cggccatcca gctcacctcg
      721 gtgggggttt ctgtgttcac tctcactgct ctcagcgctg acaggtacag agctatcgtg
      781 aaccccatgg acatgcagac gtccggtgtg ttgctgtgga ccagtttgaa ggcagtgggc
      841 atctgggtgg tctctgtgtt gttggcggtc cctgaagctg tgttttcaga agtagcacgc
      901 attggtagct tggataacag cagtttcaca gcatgcatac cctacccaca aacagatgag
      961 ttacatccaa agattcattc agtgctcatt tttcttgtct atttcctcat accccttgtt
     1021 atcatcagca tttattatta tcatattgca aagactttaa ttaaaagtgc acacaatctt
     1081 cctggagaat acaatgaaca taccaaaaag cagatggaga cacggaaacg cctggctaag
     1141 attgttctgg tctttgtggg ctgctttgtc ttctgctggt ttcccaacca cgtcctctac
     1201 ttgtataggt ctttcaacta caaggagata gatccttctc tcgggcacat gatcgtcacc
     1261 ttagtggccc gggttctgag tttcagcaat tcctgtgtca atccctttgc tctttacctg
     1321 ctcagcgaaa gctttaggaa gcacttcaac agccagctct gttgtgggcg gaagtcctat
     1381 cccgagaggt ccaccagcta cctcctcagc tcgtcagcag taagaatgac ttctttgaaa
     1441 agcaatacaa agaatgtggt gaccaattct gtcctgctca atggacatag cacaaagcaa
     1501 gaaatagcac tgtgatggga tacgatctaa ttcactcttg gaaaatacca ttttcaaagt
     1561 ttttccatta ttacgtagca aagcagaact aaataatgtc cacatttata ctgctcccta
     1621 gctaattcat caggagagct catgattgac tcaagtgcaa agcaaatact tttgtctgaa
     1681 tagaaagaat tttacattac accatacaca tctatactgc acacacataa ctcacatatc
     1741 ttctgctaac attggtttac aaattccctt gagatttaag gtgtttcaac aagcaaatgt
     1801 ggcatattta ctttaaattc cttttatctt aaatcataga gaacatttcc ataatgactc
     1861 tgtaatttaa tgagaggtaa taattaaact cctattattt gaaatataaa ttacatcatt
     1921 cttcctagta aattttatcc ataattagta tatatatgta tatatgcata tatattagat
     1981 atatatatct taatttgaaa aaattttcaa agtggagctt agtaattgtt cattaatatt
     2041 tattgttctt tgtgtaatta taatttatag aaaggtttgt aagttctaga tattgtattg
     2101 gaaagtgtga tggtatttta ttatgaatta taaattgata tatgaatgtg agtcaccttg
     2161 tatgtgtaaa agaaatacaa tatgctccaa atttcaatac tgttacttat atgtttgcat
     2221 gacaattttt gtgaacacct aaatttgtta caaattgact ggttctgcat aaataataag
     2281 atttgtataa ttctgatgag catttgctct tgtatctgcc aacttacaag tgtatgggat
     2341 ctcaggcatt ttttttctct gcatgatatc acacttttct ccaaataaac atctttccat
     2401 ttgtaagcaa aatataa
//
